Behavior of steel-concrete jacketed corrosion-damaged RC columns subjected to eccentric load

Jiyue Hu,Hong-Jun Liang,Yi-Yan Lu 국제구조공학회 2018 Steel and Composite Structures, An International J Vol.29 No.6

Corrosion of steel reinforcement is a principal cause of deterioration of RC columns. Making these corrosion-damaged columns conform to new safety regulations and functions is a tremendous technological challenge. This study presented an experimental investigation on steel-concrete jacketed corrosion-damaged RC columns. The influences of steel jacket thickness and concrete strength on the enhancement performance of the strengthened specimens were investigated. The results showed that the use of steel-concrete jacketing is efficient since the stub strengthened columns behaved in a more ductile manner. Moreover, the ultimate strength of the corrosion-damaged RC columns is increased by an average of 5.3 times, and the ductility is also significantly improved by the strengthening method. The bearing capacity of the strengthening columns increases with the steel tube thickness increasing, and the strengthening concrete strength has a positive impact on both bearing capacity, whereas a negative influence on the ductility. Subsequently, a numerical model was developed to predict the behavior of the retrofitted columns. The model takes into account corrosion-damage of steel rebar and confining enhancement supplied by the steel tube. Comparative results with the experimental results indicated that the developed numerical model is an effective simulation. Based on extensive verified numerical studies, a design equation was proposed and found to predict well the ultimate eccentric strength of the strengthened columns.

miRNA-103a-3p Promotes Human Gastric Cancer Cell Proliferation by Targeting and Suppressing ATF7 in vitro

Hu, Xiaoyi,Miao, Jiyu,Zhang, Min,Wang, Xiaofei,Wang, Zhenzhen,Han, Jia,Tong, Dongdong,Huang, Chen Korean Society for Molecular and Cellular Biology 2018 Molecules and cells Vol.41 No.5

Studies have revealed that miR-103a-3p contributes to tumor growth in several human cancers, and high miR-103a-3p expression is associated with poor prognosis in advanced gastric cancer (GC) patients. Moreover, bioinformatics analysis has shown that miR-103a-3p is upregulated in The Cancer Genome Atlas (TCGA) stomach cancer cohort. These results suggest that miR-103a-3p may function as an oncogene in GC. The present study aimed to investigate the role of miR-103a-3p in human GC. miR-103a-3p expression levels were increased in 33 clinical GC specimens compared with adjacent nontumor stomach tissues. Gain- and loss-of-function studies were performed to identify the correlation between miR-103a-3p and tumorigenesis in human GC. Inhibiting miR-103a-3p suppressed GC cell proliferation and blocked the S-G2/M transition in MKN-45/SGC-7901 cells, whereas miR-103a-3p overexpression improved GC cell proliferation and promoted the S-G2/M transition in vitro. Bioinformatics and dual-luciferase reporter assays confirmed that ATF7 is a direct target of miR-103a-3p. Analysis of the TCGA stomach cancer cohort further revealed that miR-103a-3p expression was inversely correlated with ATF7 expression. Notably, silencing ATF7 showed similar cellular and molecular effects as miR-103a-3p overexpression, namely, increased GC cell proliferation, improved CDK2 expression and decreased P27 expression. ATF7 overexpression eliminated the effects of miR-103a-3p expression. These findings indicate that miR-103a-3p promotes the proliferation of GC cell by targeting and suppressing ATF7 in vitro.

miRNA-103a-3p Promotes Human Gastric Cancer Cell Proliferation by Targeting and Suppressing ATF7 in vitro

Xiaoyi Hu,Jiyu Miao,Min Zhang,Xiaofei Wang,Zhenzhen Wang,Jia Han,Dongdong Tong,Chen Huang 한국분자세포생물학회 2018 Molecules and cells Vol.41 No.5

Studies have revealed that miR-103a-3p contributes to tumor growth in several human cancers, and high miR-103a-3p expression is associated with poor prognosis in advanced gastric cancer (GC) patients. Moreover, bioinformatics analysis has shown that miR-103a-3p is upregulated in The Cancer Genome Atlas (TCGA) stomach cancer cohort. These results suggest that miR-103a-3p may function as an oncogene in GC. The present study aimed to investigate the role of miR-103a-3p in human GC. miR-103a-3p expression levels were increased in 33 clinical GC specimens compared with adjacent nontumor stomach tissues. Gain- and loss-of-function studies were performed to identify the correlation between miR-103a-3p and tumorigenesis in human GC. Inhibiting miR-103a-3p suppressed GC cell proliferation and blocked the S-G2/M transition in MKN-45/SGC-7901 cells, whereas miR-103a-3p overexpression improved GC cell proliferation and promoted the S-G2/M transition in vitro. Bioin-formatics and dual-luciferase reporter assays confirmed that ATF7 is a direct target of miR-103a-3p. Analysis of the TCGA stomach cancer cohort further revealed that miR-103a-3p expression was inversely correlated with ATF7 expression. Notably, silencing ATF7 showed similar cellular and molecular effects as miR-103a-3p overexpression, namely, increased GC cell proliferation, improved CDK2 expression and decreased P27 expression. ATF7 overexpression eliminated the effects of miR-103a-3p expression. These findings indicate that miR-103a-3p promotes the proliferation of GC cell by targeting and suppressing ATF7 in vitro.

Durability of CFRP Strengthened Steel Plates Under Wet and Dry Cycles

Shan Li,Jiyue Hu,Yi-Yan Lu,Hong-Jun Liang 한국강구조학회 2018 International Journal of Steel Structures Vol.18 No.2

This paper presents tensile test results of CFRP strengthened steel plates (CS) after wet and dry corrosion. The number of cycle times and strengthened schemes were investigated. The results showed that the CS specimens, subjected to wet–dry corrosion, behaved in a more brittle manner and appeared massive CFRP and adhesive rupturing coincided with the failure. As the wet–dry cycle increasing, the yield strength and ultimate strength of CS strengthened specimens decreased signifi - cantly, while the stiff ness before and beyond yield strength degraded slightly. Furthermore, the yield strength and ultimate strength of double-sided specimens subjected to wet–dry cycles were higher than those of one-sided specimens. Finally, analytical formulas considering wet–dry corrosion were proposed to predict elastic modulus, yield strength, tangent modulus, ultimate strength of CS specimens subjected to wet–dry cycles, respectively. The calculated results were in good agreement with experimental values.

Strength prediction of corrosion reinforced concrete columns strengthened with concrete filled steel tube under axial compression

Hongjun Liang,Yanju Jiang,Yiyan Lu,Jiyue Hu 국제구조공학회 2020 Steel and Composite Structures, An International J Vol.37 No.4

Twenty-two corrosion-damaged columns were simulated through accelerated steel corrosion tests. Eight specimens were directly tested to failure under axial load, and the remaining specimens were tested after concrete-filled steel tube (CFST) strengthening. This study aimed to investigate the damage of RC columns after corrosion and their restoration and enhancement after strengthening. The research parameters included different corrosion degrees of RC columns, diameter-to-thickness ratio of steel tube and the strengthening concrete strength. Experimental results showed that CFST strengthening method could change the failure mode of corrosion-damaged RC columns from brittleness to ductility. In addition to the bearing capacity provided by the strengthening materials, it can also provide an extra 26.7% amplification because of the effective confinement provided by steel tubes. The influence of corrosion on reinforcement and concrete was quantitatively analysed and considered in the design formula. The proposed formula accurately predicted the bearing capacity of the strengthened columns with a maximum error of only 7.68%.

Experimental Study and Confi nement Analysis on RC Stub Columns Strengthened with Circular CFST Under Axial Load

Hong-Jun Liang,Yi-Yan Lu,Jiyue Hu,Jifeng Xue 한국강구조학회 2018 International Journal of Steel Structures Vol.18 No.5

As the excellent mechanical performance and easy construction of concrete fi lled steel tubes (CFST) composite structure, it has the potential to be used to strengthen RC pier columns. Therefore, tests were conducted on 2 reinforcement concrete (RC) stub columns and 9 RC columns strengthened with circular CFST under axial loading. The test results show that the circular CFST strengthening method is eff ective since the mean bearing capacity of the RC columns is increased at least 3.69 times and the ductility index is signifi cantly improved more than 30%. One of the reasons for enhancement is obvious confi nement provided by steel tube besides the additional bearing capacity supplied by the strengthening materials. From the analysis of the enhancement ratio, the strengthening structure has at least an extra 20% amplifi cation except for taking full advantage of the strength of the strengthening material. Through the analysis of confi ning stress provided by steel tube and the stress–strain relationship of confi ned concrete, it is found that the strength of the core concrete can be increased by 21–33% and the ultimate strain can be enhanced to beyond 15,000 με .