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Diaoyu Zhou,Taotao Li,Jing Fan 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.6
Effects of plastic deformation on the corrosion behaviors of AA6061 aluminum alloy have been investigated in this work. AA6061 was severely deformed by cold rolling processes and the corrosion behaviors were measured using electrochemicaltests in 3.5 wt% NaCl neutral solution. The microstructures were characterized by SEM combined with EDS. The resultsshowed that plastic deformation induced the decrease of average pitting potential and increase of corrosion rate of AA6061due to the number increase and size decrease of second-phase particles, which formed "small cathode-large anode" microbatterycorrosion mechanism with the aluminum alloy matrix. The influence of crystallographic texture on corrosion propertyis analyzed and a simple relation between average pitting corrosion coefficient and texture coefficient is built and supportedby experiments to elucidate the effects of plastic deformation on corrosion.
Zhou Zhongcheng,Wu Bin,Chen Jing,Shen Yiyu,Wang Jing,Chen Xujian,Fei Faming,Li Liang 한국유전학회 2023 Genes & Genomics Vol.45 No.11
Background Metastasis of liver cancer (LC) is the main cause of its high mortality. ETV4 is a critical regulatory factor in promoting LC progression, but the mechanism that ETV4 impacts LC proliferation, migration, and invasion is poorly understood. Objective Investigation of the molecular mechanism of LC metastasis is conducive to developing effective drugs that prevent LC metastasis. Methods Expression of ETV4 and its target gene B3GNT3 in LC tissue was analyzed by bioinformatics, and the result was further verified in LC cells by qRT-PCR. In vitro cellular assays evaluated the impact of ETV4 on the proliferation, migration, and invasion of LC cells. Chromatin immunoprecipitation (ChIP) and dual-luciferase reporter gene assay were conducted to analyze the interaction between B3GNT3 and ETV4. SB525334 suppressor was used to treat and access the activation of ETV4 on the TGF-β pathway. Results We discovered that ETV4 and B3GNT3 were evidently up-regulated in LC, and high expression of ETV4 was coupled to the increase of proliferation, migration, and invasion of LC cells and epithelial-mesenchymal transition ability. Besides, ETV4 could bind to the B3GNT3 promoter and activate its transcription. Knockdown of B3GNT3 could prominently suppress the effect of up-regulated ETV4 on LC cells. Meanwhile, ETV4 could activate the TGF-β signaling pathway via B3GNT3, while SB525334 treatment notably repressed the functions of ETV4. Conclusion ETV4 emerges as a driven oncogene in LC, and the ETV4/B3GNT3-TGF-β pathway promotes proliferation, migration, invasion, and epithelial-mesenchymal transition progress of LC. Inhibition of the pathway may provide an underlying method for the prevention and treatment of LC metastasis.
Jing Zhou,Zhanzhao Liu,Lingjing Zhang,Xiao Hu,Zhihua Wang,Hong Ni,Yue Wang,Jun-fang Qin 대한암학회 2020 Cancer Research and Treatment Vol.52 No.3
Purpose Chronic stress and related hormones are key in cancer progression. Peroxisome proliferator- activated receptor ! (PPAR!) and its agonists was reported that inducing anti-tumor effect. However, the function of PPAR! in pro-tumorigenic effects induced by chronic stress in breast cancer remains unknown. Herein, we have characterized a novel role of PPAR! and vascular endothelial growth factor (VEGF)/fibroblast growth factor 2 (FGF2) signals in breast cancer promoted by chronic stress. Materials and Methods We performed experiments in vivo and in vitro and used bioinformatics data to evaluate the therapeutic potential of PPAR! in breast cancer promoted by stress. Results Chronic stress significantly inhibited the PPAR! expression and promoted breast cancer in vivo. VEGF/FGF2-mediated angiogenesis increased in the chronic stress group compared to the control group. PPAR! agonist pioglitazone (PioG) injection offset the pro-tumorigenic effect of chronic stress. Moreover, specific "2-adrenergic receptor ("2R) antagonist ICI11- 8551 inhibited the effect of chronic stress. In vitro, norepinephrine (NE) treatment had a similar tendency to chronic stress. The effect of NE was mediated by the "2R/adenylate cyclase signaling pathway and suppressed by PioG. PPAR! suppressed VEGF/FGF2 through reactive oxygen species inhibition. Bioinformatics data confirmed that there was a low PPAR! expression in breast invasive carcinoma. Lower PPAR! was associated with a significantly worse survival. Conclusion "2R activation induced by chronic stress and related hormones promotes growth and VEGF/ FGF2-mediated angiogenesis of breast cancer by down-regulating PPAR!. Our findings hint that " receptor and PPAR! as two target molecules and the novel role for their agonists or antagonists as clinical medicine in breast cancer therapy.
Jing Zhou,GAOLING ZHAO,Wangwei Lu,Lingtong Zhan,GAORONG HAN 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.2
Nanocarrier-based biological fluorescent probes for ketamine and amphetamine have been prepared by conjugating red and green fluorescent nanoparticles (150-nm-sized) with anti-ketamine and anti-amphetamine antibodies, respectively, with the assistance of carbodiimide/N-hydroxysuccinimide. Biological fluorescent probes for ketamine and amphetamine could simultaneously detect these two drugs within a single fingermark by one-step test. Nanoparticles as carrier played dual-functional roles for not only fingermark visualization but also drug recognition. Latent fingermarks were visualized by the fluorescence signal generated from nanoparticles. The developed fingermarks clearly revealed ridge pattern and sufficient minutiae for individual identification. Ketamine and amphetamine were recognized by simply observing the colors of fluorescent images when the fingermark was checked in red and green channels. Detection limit of ketamine or amphetamine was 50 ng in fingermark. This work therefore provides a novel nanocarrier-based strategy of drug detection as well as personal identification with high selectivity, low background interference and fast testing, which can be further broadened to other drugs and molecules.
Facial Feature Recognition based on ASNMF Method
( Jing Zhou ),( Tianjiang Wang ) 한국인터넷정보학회 2019 KSII Transactions on Internet and Information Syst Vol.13 No.12
Since Sparse Nonnegative Matrix Factorization (SNMF) method can control the sparsity of the decomposed matrix, and then it can be adopted to control the sparsity of facial feature extraction and recognition. In order to improve the accuracy of SNMF method for facial feature recognition, new additive iterative rules based on the improved iterative step sizes are proposed to improve the SNMF method, and then the traditional multiplicative iterative rules of SNMF are transformed to additive iterative rules. Meanwhile, to further increase the sparsity of the basis matrix decomposed by the improved SNMF method, a threshold-sparse constraint is adopted to make the basis matrix to a zero-one matrix, which can further improve the accuracy of facial feature recognition. The improved SNMF method based on the additive iterative rules and threshold-sparse constraint is abbreviated as ASNMF, which is adopted to recognize the ORL and CK+ facial datasets, and achieved recognition rate of 96% and 100%, respectively. Meanwhile, from the results of the contrast experiments, it can be found that the recognition rate achieved by the ASNMF method is obviously higher than the basic NMF, traditional SNMF, convex nonnegative matrix factorization (CNMF) and Deep NMF.