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Protective Effects of KH-204 in the Bladder of Androgen-Deprived Rats
Woong Jin Bae,U Syn Ha,Jin Bong Choi,Kang Sup Kim,Su Jin Kim,Hyuk Jin Cho,Sung Hoo Hong,Ji Youl Lee,Zhiping Wang,Sung Yeoun Hwang,Sae Woong Kim 대한남성과학회 2015 The World Journal of Men's Health Vol.33 No.2
Purpose: We investigated the protective effects of the herbal formulation KH-204 in the bladder of androgen-deprived rats. Materials and Methods: Male rats aged eight weeks were randomly divided into four groups, containing eight rats each: sham operation only (normal control group), androgen-deprived only (androgen-deprived control group), and androgen-deprived followed by treatment with 200 mg/kg or 400 mg/kg of KH-204. After 0.5 mg/kg of leuprorelin was subcutaneously injected in the androgen-deprived groups, the oral administration of either distilled water in the two control groups or KH-204 in the treatment group was continued for four weeks. Serum testosterone levels, RhoGEF levels, nitric oxide (NO)-cyclic guanosine monophosphate (cGMP)-related parameters, oxidative stress, and histologic changes were evaluated after treatment. Results: Treatment with the herbal formulation KH-204 (1) increased serum testosterone levels; (2) restored the expression of RhoGEFs, endothelial NO synthase, and neuronal NO synthase; (3) increased the expression of superoxide dismutase; and (4) decreased bladder fibrosis. Conclusions: Our results suggest that the positive effects of KH-204 on the urinary bladder may be attributed to its antioxidant effects or to an elevation in NO-cGMP activity.
Bae, Woong Jin,Ha, U. Syn,Choi, Jin Bong,Kim, Kang Sup,Kim, Su Jin,Cho, Hyuk Jin,Hong, Sung Hoo,Lee, Ji Youl,Wang, Zhiping,Hwang, Sung Yeoun,Kim, Sae Woong Hindawi Publishing Corporation 2016 Oxidative medicine and cellular longevity Vol.2016 No.-
<P>Higher testicular temperature results in altered spermatogenesis due to heat-related oxidative stress. We examined the effects of decursin extracted from<I> Angelica gigas</I> Nakai on antioxidant activity<I> in vitro</I> and in a cryptorchidism-induced infertility rat model. TM3 Leydig cell viability was measured based on oxidative stress according to treatment. Either distilled water or AG 400 mg/kg of<I> A. gigas</I> extract was administered orally for 4 weeks after unilateral cryptorchidism was induced. After 1, 2, and 4 weeks, six rats from the control group and six rats from treatment group were sacrificed. Testicular weight, semen quality, antioxidant activities, nuclear factor erythroid 2-related factor 2 (Nrf2) protein, and mRNA expression of Nrf2-regulated genes were analyzed. Treatment with<I> A. gigas</I> extract (1) protected TM3 cells against oxidative stress in a dose-dependent manner, (2) improved the mean weight of the cryptorchid testis, (3) maintained sperm counts, motility, and spermatogenic cell density, (4) decreased levels of 8-hydroxy-2-deoxyguanosine (8-OHdG) and increased levels of superoxide dismutase (SOD), (5) significantly increased Nrf2 and heme oxygenase-1 (HO-1), and (6) significantly decreased apoptosis. This study suggests that decursin extracted from<I> A. gigas</I> is a supplemental agent that can reduce oxidative stress by Nrf2-mediated upregulation of HO-1 in rat experimentally induced unilateral cryptorchidism and may improve cryptorchidism-induced infertility.</P>
Kim, Su Jin,Jeon, Seung Hwan,Kwon, Eun Bi,Jeong, Hyun Cheol,Choi, Sae Woong,Bae, Woong Jin,Cho, Hyuk Jin,Ha, U-Syn,Hong, Sung Hoo,Lee, Ji Youl,Hwang, Sung Yeoun,Kim, Sae Woong Korean Society for Sexual Medicine and Andrology 2017 The World Journal of Men's Health Vol.35 No.3
<P><B>Purpose</B></P><P>Many patients with benign prostatic hyperplasia need treatment for remaining storage symptoms after surgery. Therefore, we evaluated the effect of the phytotherapeutic agent WSY-1075 on persistent detrusor overactivity (DO) after the relief of bladder outlet obstruction (BOO).</P><P><B>Materials and Methods</B></P><P>Rats were assigned to 3 groups: control (n=6), persistent DO (n=6), and persistent DO treated with the phytotherapeutic agent WSY-1075 (n=6). Persistent DO after relief of partial BOO was generated in the rat model, and 6 of the rats with this condition were orally administered WSY-1075. After 4 weeks of administration, cystometry was performed. Additionally, 8-hydroxy-2-deoxyguanosine and superoxide dismutase were measured to evaluate oxidative stress in the bladder. Pro-inflammatory cytokines, such as interleukin-8 and tumor necrosis factor-α, were analyzed, as were the M2 and M3 muscarinic receptors of the bladder.</P><P><B>Results</B></P><P>Significantly increased contraction pressure and a decreased contraction interval were observed in the persistent DO group after relief of BOO. Moreover, oxidative stress, pro-inflammatory cytokines, and M3 muscarinic receptors were significantly increased. After treatment with WSY-1075, significantly reduced DO was observed by cystometry in comparison with the persistent DO group. Additionally, significantly decreased levels of oxidative stress, pro-inflammatory cytokines, and M3 muscarinic receptors in the bladder were observed after treatment with WSY-1075.</P><P><B>Conclusions</B></P><P>Treatment with WSY-1075 improved persistent DO after the relief of BOO mediated by antioxidative and anti-inflammatory effects. Further studies are necessary to identify the exact mechanism of the treatment effect of WSY-1075.</P>
Bae, Woong Jin,Park, Hyo Jung,Koo, Hye Cheong,Kim, Do Ram,Ha, U-Syn,Kim, Kang Sup,Kim, Su Jin,Cho, Hyuk Jin,Hong, Sung Hoo,Lee, Ji Youl,Hwang, Sung Yeoun,Kim, Sae Woong Hindawi Publishing Corporation 2016 Evidence-based Complementary and Alternative Medic Vol.2016 No.-
<P>We evaluated the effects of Seoritae extract (SE) on mild to moderate lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH). Seventy-six subjects with mild to moderate LUTS suggestive of BPH were prospectively recruited from the urology outpatient clinic and assigned to either SE (4200 mg or 6 tablets 3 times a day) or matching placebo. The primary outcome variable, the International Prostatic Symptom Score (IPSS), was evaluated at baseline and at 4 and 12 weeks. Postvoid residual volume (PVR), maximum urine flow rate (<I>Q</I><SUB>max</SUB>), and prostate-specific antigen (PSA) levels were evaluated. IPSSs decreased significantly from baseline to 12 weeks within the SE group. Significant improvements in IPSS voiding scores at 4 and 12 weeks were also observed in the SE group compared to the placebo group. IPSS storage and quality of life scores were also significantly decreased at 12 weeks in the SE group. There was no change in <I>Q</I><SUB>max</SUB> or PVR in both groups after 12 weeks. Administration of SE for 12 weeks led to significant improvements in LUTS, and it can be concerned as a reasonable and safe alternative for men with mild to moderate LUTS.</P>
Performance Characteristics of Diode-Bridge Type 6-Pulse Dual Converter
JIN-WOO ANN,CHEUL-U KIM,YOUNG-MOON HWANG 전력전자학회 1989 ICPE(ISPE)논문집 Vol.- No.-
3-phase 6-pulse 4-quadrant dual converter using 6 thy-ristor and diode bridge is suggested and its characteristics depending on their switching nodes is analyzed.<br/> The switching modes of converter operation are identified and analyzed in terms of power factor and haraonic distortion on ac and dc sides.<br/> The circuit has the ability to accept or deliver dc current without changing of nominal dc magnitude or polarity and has the capability not only to change from motonng to generating instantaneously and vice versa, but also to operate as a cycloconverter.<br/>