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작약(Paeonia lactiflora) 뿌리 추출물의 대식세포에서 p62/SQSTM1 증가를 통한 자가포식 유도
정진부,Jin Boo Jeong 한국자원식물학회 2023 한국자원식물학회지 Vol.36 No.4
본 연구에서 우리는 작약 뿌리 추출물이 TLR4/PI3K/Nrf2 신호전달을 통해 p62/SQSTM1을 증가시켜 대식세포에서 자가포식을 유도한다는 것을 확인하였다. 대식세포의 자가포식 유도는 선천성과 적응성 면역 반응 간의 연결을 강화해 백신 보조제 개발에 있어서 중요한 표적으로 사용되기 때문에, 작약 뿌리 추출물은 백신개발에 필수적인 백신보조제로의 활용이 가능할 것으로 생각된다.
대두 추출물 LES가 DNCB로 유도된 랫드의 알레르기성 접촉피부염에 미치는 영향
Jeong Sook Kim(김정숙),Young Mi Park(박영미),Jin Boo Jeong(정진부),Jae Hwan Lim(임재환),Hyung Jin Jeong(정형진),Eul Won Seo(서을원) 한국생명과학회 2011 생명과학회지 Vol.21 No.5
본 연구에서는 대두 추출물인 LES가 DNCB에 의해 인위적으로 접촉피부염을 유발시킨 랫드의 피부 회복능에 미치는 효과를 조사하였다. 알레르기 접촉피부염이 유발된 피부에 LES 17.6 ㎎/㎖를 3-5회 도포하여 피부 표면을 조직학적 분석하여 본 결과 각질이 제거된 깨끗하고 매끄러운 상태로 되었으며, 비후화된 표피층의 두께도 점차 정상군과 같은 두께로 회복시키는 효과를 나타냈다. 또한 LES는 체내 지질함량을 낮춰 정상수준으로 회복시키는 지질함량의 개선에 효과적으로 작용하고 있으며, 혈장 내 IgE의 수준도 정상군 수준으로 감소시키고 있으며, LES에 의해 염증 반응과 관련된 iNOS와 COX-2의 활성도 감소되어 피부의 과민반응 해소에 관여하는 것으로 생각된다. LES에 포함된 주 성분 중 하나인 lunasin은 세포 침투와 함께 핵 내로 이동하는 것으로 확인되어 전체 유전자 또는 일부 유전자의 발현을 조절하는 데 관여할 것으로 추측된다. 이러한 결과로 보아 LES는 알레르기성 접촉피부염에 매우 효과적인 치료 효과를 나타내고 있기 때문에 기존의 알레르기성 접촉피부염 치료제를 대체할 수 있는 제제로서 응용이 기대된다. In this study, we evaluated whether Lunasin Enriched Soybean (LES) suppressed 1-chloro-2,4-dinitrochlorobenzene (DNCB) induced allergic contact dermatitis in vivo. In the group treated with DNCB alone, erythema and hemorrhage in the skin were observed, while the application of LES after DNCB treatment modulated erythema and hemorrhage similar to the untreated group. In histopathological analysis of the skin, DNCB-treated groups showed increased skin thickness compared to the untreated groups, while the treatment of LES dose-dependently modulated skin thickness. Also, hypertrophy and hyperkeratosis of the epidermis, intracellular edema and infiltration of inflammatory cells were observed in the group treated with DNCB alone, while treatment of LES inhibited these inflammatory changes. DNCB also induced a significant up-regulation of iNOS and COX-2 expression, as compared to the untreated groups. However, the treatment of LES significantly decreased the down-regulation of iNOS and COX-2 expression, as compared to DNCB-treated groups. Also, LES reduced the IgE level in DNCB-stimulated groups. And lunasin from LES translocated the nucleus of the cells in the skin of Sprague-Dawley rats. Taken together, it is thought that LES has the potential to be used as an alternative treatment for allergic contact dermatitis.
차광재배가 눈개승마(Aruncus dioicus var. kamtschaticus)의 성분 및 항산화 특성에 미치는 영향
권정우(Jeong Woo Kwon),박재호(Jae-Ho Park),권기수(Ki Soo Kwon),김대섭(Dae Seup Kim),정진부(Jin Boo Jeong),이희경(Hee Kyung Lee),심영은(Young Eun Sim),김미숙(Mi Suk Kim),윤지용(Ji Young Youn),정규영(Gyu Young Jeong),정형진(Hyung Jin J 한국자원식물학회 2006 한국자원식물학회지 Vol.19 No.1
눈개승마의 총 엽록소, 총 카로테노이드 함량은 무차광에 비하여 차광율이 높을 수록 높았다. 지방산함량은 무차광 재배에 비하여 차광 재배 및 식용 가능시기간의 생육 후기에 감소되었다. 식용가능시기에서의 지방산 종류간의 함량은 oleic acid, palmitc acid, linoleic acid, stearic acid 순으로 높았으며, 무차광에 비하여 차광율이 높을 수록 낮았다. 특히 linoleic산의 함량은 타 지방산에 비하여 차광정도에 따른 함량의 감소율이 매우 높았다. 차광율 및 수확시기간의 휘발성 정유성분의 함량은 차광율이 높을 수록 증가하였고, 초기수확이 높았다. DPPH 소거활성은 6.64-14.49(IC50:㎍/㎖로 항산화 활성이 매우 높게 나타났고 차광정도가 높을 수록 낮았고, 조기 수확 할 수록 높았다. POD 및 SOD 활성은 식물체에 비하여 종자가 매우 낮았고, 무차광에 비하여 차광 재배 시에 증가하였다. POD활성은 식용가능시기의 생육 초기에 비하여 후기에 높았으나, SOD활성은 감소되었다. POD Isozyme band 수는 이식묘의 종자, 잎 및 줄기에서 각 각 6개의 밴드를 나타내었으나, 뿌리에는 없었다. SOD Isozyme band는 송자와 잎에 비하여 뿌리에서 뚜렷하였다. This study was conducted to determine chemical compounds and antioxidant in Aruncus dioicus. Further, effects of cultural practices such as the shading conditions on the general compounds, essential oils and antioxidants. The chemical compounds and antioxidant activity of edible extracts on the shading cultivation and harvesting time were measured by crude fiber, pigments, higher fatty acids, essential oils and DPPH free radical scavenging ability and activities of SOD and POD in edible shooting parts of Aruncus dioicus. The contents of crude fiber, total chlorophyll and total carotenoids in extracts of edible shooting by shading cultivation and later harvesting were higher than those of non-shading cultivation and early harvesting. Phenolic compounds such as benzoic acid were identified as the aromatic compounds in the edible extracts of Aruncus dioicus. The contents of azulene, benzaldehyde and linalool among those compounds on the cultivation conditions increased in shading cultivation. IC50 values of DPPH free radical scavenging activities were high from 6.644 to 14.499m㎍/㎖ in extracts of edible parts and those of edible shooting parts was high such as edible shooting cultivated by 60% shading, 30% shading and non-shading, respectively. The activity of POD and SOD in seeds was lower than that of edible shooting and that by shading cultivation was high in extracts cultivated by non-shading. POD activity of extracts on harvesting time was high in earlier harvesting but SOD activity was low. The numbers of isozyme pattern of POD and SOD in seedling showed 7 bands and 3 bands, respectively, especially, bands of POD and SOD in the first year-growing plant did not show and show a difference according to plant positions, respectively.
정형진 ( Hyung Jin Jeong ),박연경 ( Yeon Gyeong Park ),장태원 ( Tae Won Jang ),김도완 ( Do Wan Kim ),정진부 ( Jin Boo Jeong ),박재호 ( Jae Ho Park ) 대한본초학회 2017 大韓本草學會誌 Vol.32 No.3
Objective : Nelumbo nucifera , its rhizome and semen have been used as a traditional medicine which was studied on antioxidant, hepatoprotective effect, anti-obesity and the others. However, Nelumbinis Flos have not studied. We investigated protective effects on oxidative DNA damage and anti-inflammatory effects of Nelumbinis Flos. Methods : The antioxidant activity was conducted by 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical, 2, 2`-Azino-bis (3-ethylbenzothiazoline-6 sulfonic acid) diammonium salt (ABTS) radical scavenging assay and reducing power assay. Total phenolic content was analyzed. Also, phenolic compounds were detected by HPLC/UV. The inhibitory effect on oxidative DNA damage was determined using ΦX-174 RF I plasmid DNA cleavage assay. The anti-inflammatory effect of Nelumbinis Flos was measured by the amount of nitric-oxide (NO) produced and protein levels of iNOS, and COX-2 in LPS induced RAW 264.7 cells. Results : The results of DPPH and ABTS radical scavenging activity at 200 ㎍/㎖ of extraction were 97.02±0.88% and 96.42±0.25%. Reducing power (fold of L-ascorbic acid as control) was 100.14±0.31 at 200 ㎍/㎖. Total phenol content was 8.70±0.02 ㎎/g. Chlorogenic acid, catechin and epicatechin were found by HPLC. Nelumbinis Flos has inhibitory effect in dose-manner against oxidative DNA damage. In addition, it showed the anti-inflammatory effect by suppression of NO production as well as protein levels of iNOS, and COX-2. Conclusion : This study suggested that Nelumbinis Flos showed potential antioxidant and suppression activities of various factors were related in NO produced. Therefore, Nelumbinis Flos as natural plant resources that may help reduce inflammation and alleviate DNA damage.
인가목(Rosa acicularis Lindl.) 잎 추출물의 대식세포에서 자가포식 유도활성
최정원,정진부,Jeong Won Choi,Jin Boo Jeong 한국자원식물학회 2023 한국자원식물학회지 Vol.36 No.4
Autophagy contributes to enhancing the immune system (innate and adaptive immune system) against foreign pathogens. Autophagy of macrophages is used as a major indicator for developing vaccine adjuvants to increase the adaptive immune response. In this study, water extracts from Rosa acicularis leaves (RAL) increased the production of immunostimulatory mediators and phagocytic activity in RAW264.7 cells. RAL increased p62/SQSTM1 expression. Inhibition of TLR4, JNK, and PI3K/AKT blocked RAL-mediated increase of p62/SQSTM1. RAL activated JNK and PI3K/AKT signaling. RAL-mediated activations of JNK and PI3K/AKT signaling were reversed by TLR4 inhibition. Taken together, it is believed that RAL-mediated autophagy may be dependent on activating via TLR4-dependent activation of JNK and PI3K/AKT signaling in macrophages.