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쥐에서 브롬산염 투여에 의한 신부전증의 특성 및 기전 연구
신석준 ( Sin Seog Jun ),박호선 ( Park Ho Seon ),최영진 ( Choe Yeong Jin ),양철우 ( Yang Cheol U ),진동찬 ( Jin Dong Chan ),김용수 ( Kim Yong Su ),김진 ( Kim Jin ),장윤식 ( Jang Yun Sig ),방병기 ( Bang Byeong Gi ) 대한신장학회 2004 Kidney Research and Clinical Practice Vol.23 No.2
목 적 : 브롬산염은 급성 중독시에 용혈성 빈혈과 핍뇨를 동반된 급성 신부전중, 청각장애 및 시작장애를 유발하는 물질로 알려져 있다. 브롬산염에 의한 신손상의 기전으로 브롬산염에 의해 유발된 활성산소족에 의한 신세뇨관 괴사 등이 보고되었으나 아직 기전이 명확히 밝혀지지 않았다. 이 연구에서는 흰쥐에 브롬산칼륨을 투여하여 급성신부전을 유발한 후 신기능과 손상의 특성을 관찰하였다. 방 법 : Sprague-Dawley계 흰쥐 이용하여 정상 대조군은 같은 양의 생리식염수를, 실험군은 브롬산칼륨 ㎎/㎎ (B75군) 또는 150 ㎎/㎏ (B150군)을 복강내 주사한 후 24시간, 48시간, 1주 및 2주에 혈액과 24시간 소변을 수집하여 혈중요소질소, 혈청 크레아티닌 및 크레아티닌 청소율을 측정하고, 신조직의 변화를 PAS 염색으로 관찰하였으며, Na^(+)-K^(+)-ATPasealpha 1 및 aquaporin-2에 대한 면역조직화학 염색을 시행하여 정상 대조군과 비교 분석하였다. 결 과 : 브롬산칼륨을 투여한 쥐는 급성신부전이 유발되었고 B75군은 신기능이 저하되었다가 회복되었으나 B150군은 심한 핍뇨성 급성신부전이 유발되어 48시간 후에 모두 사망하였다. 광학현미경 소견상 브롬산칼륨을 투여한 쥐에서는 신세뇨관의 괴사를 관찰하였고, 괴사 정도는 피질에 비해 바깥수질 속줄무늬층에서, B75군에 비해 B150군에서 더욱 심했다. Na^(+)-K^(+)-ATPase-alpha 1의 발현은 피질 부위에서는 정상 대조군과 실험군의 차이가 없었으나 바깥수질 속줄무늬층 세뇨관에서는 B75군의 경우 48시간에서 발현이 감소하였다가 2주 후에 회복되었고 B150군에서는 24시간과 48시간에서 모두 발현이 감소하였다. 바깥수질 속줄무늬층에서 aquporin-2의 발현은 B75군에서는 증가하였으나 B150군에서는 감소하였다. 결 론 : 브롬산칼륨은 주로 바깥수질 속줄무늬층 굵은 오름부분의 세뇨관 손상을 유발하였다. 저용량 브롬산칼륨 투여시에는 Na+-K+-ATPase-alpha 1의 발현이 감소되어 다뇨성 급성 신부전이 유발되었지만 고용량 브롬산칼륨 투여시에는 심한 세뇨관 괴사에 의한 세뇨관 폐색으로 핍뇨가 발생하였다. Background : Plasma clearance of iohexol (Omnipaque?) which used widely in radiologic procedure is considered as useful method for estimation of GFR because iohexol is neither reabsorbed nor secreted from tubule after filtered as inulin and its extrarenal clearance is negligible. Plasma clearance of iohexol can be calculated from two compartment model or one compartment model with Brochner-Mortensen (B-M) modification which convenient and reliable. But there were controversies about sufficient sampling numbers and times for B-M modification of iohexol clearance. Methods : Nineteen healthy Koren without renal disease underwent measurement of iohexol clearance. Iohexol was given as a single iv dose, and 14 blood sample were drewn up to 300 min. A reference GFR was iohexol clearance calculated from two-compartment model using 14 samples (CL-T). From 8, 3 and 2 samples clearances were calculated by B-M modification (CL-M8, 3 and 2 respectively). The accuracy of estimates was evaluated as percent of estimates falling within 10% above or below the reference GFR. Accuracy of CCr and equations for GFR estimation were also compared. Results : CL-T, CL-M8, CL-M3 and CL-M2 were not different (101.9±24.0, 101.9±18.7, 101.7±18.6, 101.9±19.5 mL/min/1.73 m² respectively). Accuracy of CL-M8, 3 and 2 were not different (74%, 84% and 79% respectively, p>0.05). MDRD equation had higher accuracy (47%) compared with other equations. Conclusion : These results indicate that sampling number for measuring iohexol plasma clearance using simplified method might be reduced to only two without accuracy loss in Korean without renal disease. (Korean J Nephrol 2004;23(2):223-230)
신미정 ( Sin Mi Jeong ),김형욱 ( Kim Hyeong Ug ),양철우 ( Yang Cheol U ),김용수 ( Kim Yong Su ),김석영 ( Kim Seog Yeong ),최의진 ( Choe Ui Jin ),장윤식 ( Jang Yun Sig ),방병기 ( Bang Byeong Gi ) 대한신장학회 2003 Kidney Research and Clinical Practice Vol.22 No.4
목 적 : Monocyte chemoattractant protein-1 (MCP-1)은 단핵구, T 임파구 및 호염구를 선택적으로 유도하며 다양한 신장질환에서 발현된다. Endothelin-1은 염증성 사구체신염을 비롯한 신장질환의 신장조직 내 발현이 증가되나 그 작용기전은 자세히 알려지지 않았다. 본 연구에서는 횐쥐의 사구체간질세포를 배양하여 endothelin-1 (ET-1), endothelin-2 (ET-2) 및 endothelin-3 (ET-3)의 MCP-1 발현에 대한 효과를 조사하였다. 방 법 : 흰쥐의 사구체간질세포를 배양하여 ET-1, ET-2, 및 ET-3로 자극한 후 사구체간질세포 배양액 내 단핵구 화학주성 활성도는 modified Boyden chamber를 이용한 화학주성검사법으로 측정하고 ET-1, ET-2, 및 ET-3 자극 시간 및 농도에 따른 MCP-1 mRNA의 발현은 Northern blot 검사법을 이용하여 측정하였다. 결 과 : ET-1, ET-2, 및 ET-3로 자극한 후 사구체간질세포에서 분비하는 단핵구 화학주성활성도는 자극 전에 비해 농도에 비례하여 증가하였으며 10^(-9)과 10^(-8) M의 농도에서 유의하게 증가하였다. ET-1, ET-2, 및 ET-3는 높은 농도에서 MCP-1 mRNA 발현을 증가시켰으며 이러한 증가는 4시간부터 시작되어 24시간에 가장 증가되었다. 결 론 : ET-1, ET-2 및 ET-3는 사구체간질세포에서 분비하는 단핵구 화학 주성 활성도와 MCP-1 mRNA 발현을 증가시키며 이를 통해 염증성 신장질환에서 단핵구의 신장 조직 내 침윤에 따른 신 손상에 중요한 역할을 담당할 것으로 생각된다. Background : Monocyte chemoattractant protein-1 (MCP-1) is an important mediator for monocyte/macrophage infiltration in various inflammatory renal diseases and is produced by renal cells. In the process of renal diseases, endothelin-1 (ET-1) is known to play an active role in cell growth, inflammation and fibrosis. The aim of this study was to investigate whether three isoforms of endothelin regulate MCP-1 expression in cultured mesangial cells. Methods : Mesangial cells were incubated with or without various doses of ET-1, ET-2, or ET-3. To determine the monocyte chemotactic activity, chemotaxis assay was performed in modified Boyden chambers using freshly isolated human monocytes. MCP-1 mRAN expression in mesangial cells was measured by Northern blot analysis. Results : ET-1, ET-2, or ET-3 stimulated monocyte chemotactic activity released from mesangial cells in a dose-dependent manner. ET-1, ET-2 and ET-3 also stimulated MCP-1 mRNA expression in a time-dependent manner, which was seen as early as 4 hours and was maintained up to 24 hours. Conclusion : These data suggest that ET-1, ET-2 and ET-3 stimulate MCP-1 expression in mesangial cells and may contribute to the monocyte/macrophage infiltration in inflammatory renal diseases. (Korean J Nephrol 2003;22(4):358-365)
1 ton steam/hr 수관식 보일러에서의 합성가스 혼합 연소 특성 연구
최신영(Sin-Young Choi),양동진(Dong-Jin Yang),방병열(Byung-ryul Bang),양원(Won Yang) 한국연소학회 2009 KOSCOSYMPOSIUM논문집 Vol.- No.39
Combustion characteristics of co-combustion of heavy-oil fuel and syngas was investigated by measuring the temperature and gas-species such as CO, NOx, and O₂ in a water tube boiler furnace. Syngas was made up by mixing H₂ and CO in a small mixing chamber to maintain the desired concentrations. Experiments were performed in the condition of 600,000kcal/h heat capacity and 4% O₂ concentration at the exit of the furnace. Though only one experimental case was done in the co-combustion experiments, outstanding effect of adding the syngas as a auxiliary fuel is that the NOx concentration decreases and CO concentration increases because of temperature rising in the furnace and this result is same as the basic conflicting combustion characteristics of NOx and CO due to temperature rising or decreasing.
A New Sweetpotato Cultivar, "Matnami" suitable for Table Use
Joon Seol Lee,Hag Sin Kim,Young Sup Ahn,Mi Nam Chung,Byeong Choon Jeong,Jin Ki Bang 한국육종학회 2007 한국육종학회지 Vol.39 No.2
“Matnami” is a new sweetpotato variety developed by Mokpo Experiment Station, National Institute of Crop Science (NICS), RDA in 2006, for table use and food processing. This variety was selected from the cross between “Hongmi” and MI9510-12 in 1999. Seedling and line selections were performed from 2000 to 2002. Preliminary and advanced yield trials were carried out from 2003 to 2004. The regional yield trials were conducted at six locations from 2005 to 2006. “Matnami” has cordate leaf, green with purple vine and petiole, elliptic storage root, red skin and yellow flesh color of storage root. The average yield of storage root was 27.0 ton/ha in the regional yield trials, which was 11% higher than that of Yulmi variety. Number of storage roots over 50 gram per plant was 2.6. The average weight of one storage root was 173 gram. This variety is also resistant to fusarium wilt and nematode. In addition, steamed “Matnami” has higher polyphenol contents as 3.3 mg/g dw and higher biological activitiesas, which improve the bioactivity in human. The total sugar content was higher, thereby, sweeter than “Yulmi”. It shows lower (68.6℃) initial temperature of starch gelatinization and slower retrogradation process than “Yulmi”.
이정록 ( Lee Jeong Log ),신영신 ( Sin Yeong Sin ),이승우 ( Lee Seung U ),최현철 ( Choe Hyeon Cheol ),김형욱 ( Kim Hyeong Ug ),박철휘 ( Park Cheol Hwi ),최영진 ( Choe Yeong Jin ),장윤식 ( Jang Yun Sig ),방병기 ( Bang Byeong Gi ) 대한신장학회 2003 Kidney Research and Clinical Practice Vol.22 No.6
A 33-year-old man was admitted with macroscopic hematuria and systemic edema appearing after an acute upper respiratory tract infection. On admission, hypertension, nephrotic syndrome were evident together with a decreased renal function. Renal biopsy showed markedly increased mesangial cells acompanied with increase of endocapillary cells including neutrophils. Immunofluorescence microscopy showed granular deposits of C3 and IgA. Electron Microscopy revealed so-called hump on the subepithelial area. These features were consistent with the coexistence of IgA nephropathy (IgAN) and post-infections glomerulonephritis. It is not clear about the prognosis and the therapeutic regimen in the patient who develop above situation. Although the patient showed still persistent proteinuria, high dose steroid therapy was probably useful for improving the disease. (Korean J Nephrol 2003;22(6):773-776)