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Jin Jonghwa,우혜인,장연은,이원길,김정국,Lee In-Kyu,Park Keun-Gyu,Choi Yeon-Kyung 대한당뇨병학회 2023 Diabetes and Metabolism Journal Vol.47 No.3
Background: The Chinese visceral adiposity index (CVAI) and new visceral adiposity index (NVAI) are novel indices of visceral adiposity used to predict metabolic and cardiovascular diseases in Asian populations. However, the relationships of CVAI and NVAI with chronic kidney disease (CKD) have not been investigated. We aimed to characterize the relationships of CVAI and NVAI with the prevalence of CKD in Korean adults.Methods: A total of 14,068 participants in the 7th Korea National Health and Nutrition Examination Survey (6,182 men and 7,886 women) were included. Receiver operating characteristic (ROC) analyses were employed to compare the associations between indices of adiposity and CKD, and a logistic regression model was used to characterize the relationships of CVAI and NVAI with CKD prevalence.Results: The areas under the ROC curves for CVAI and NVAI were significantly larger than for the other indices, including the visceral adiposity index and lipid accumulation product, in both men and women (all <i>P</i><0.001). In addition, high CVAI or NVAI was significantly associated with a high CKD prevalence in both men (odds ratio [OR], 2.14; 95% confidence interval [CI], 1.31 to 3.48 in CVAI and OR, 6.47; 95% CI, 2.91 to 14.38 in NVAI, P<0.05) and women (OR, 4.87; 95% CI, 1.85 to 12.79 in CVAI and OR, 3.03; 95% CI, 1.35 to 6.82 in NVAI, <i>P</i><0.05); this association remained significant after adjustment for multiple confounding factors in men and women.Conclusion: CVAI and NVAI are positively associated with CKD prevalence in a Korean population. CVAI and NVAI may be useful for the identification of CKD in Asian populations, including in Korea.
Targeting glutamine metabolism as a therapeutic strategy for cancer
Jin Jonghwa,Byun Jun-Kyu,Choi Yeon-Kyung,Park Keun-Gyu 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Proliferating cancer cells rely largely on glutamine for survival and proliferation. Glutamine serves as a carbon source for the synthesis of lipids and metabolites via the TCA cycle, as well as a source of nitrogen for amino acid and nucleotide synthesis. To date, many studies have explored the role of glutamine metabolism in cancer, thereby providing a scientific rationale for targeting glutamine metabolism for cancer treatment. In this review, we summarize the mechanism(s) involved at each step of glutamine metabolism, from glutamine transporters to redox homeostasis, and highlight areas that can be exploited for clinical cancer treatment. Furthermore, we discuss the mechanisms underlying cancer cell resistance to agents that target glutamine metabolism, as well as strategies for overcoming these mechanisms. Finally, we discuss the effects of glutamine blockade on the tumor microenvironment and explore strategies to maximize the utility of glutamine blockers as a cancer treatment.
Jin, Jonghwa,Min, Hophil,Kim, Sang Jin,Oh, Sohee,Kim, Kyunggon,Yu, Hyeong Gon,Park, Taesung,Kim, Youngsoo Hindawi Publishing Corporation 2016 Journal of diabetes research Vol.2016 No.-
<P>Diabetic retinopathy (DR) is a common microvascular complication caused by diabetes mellitus (DM) and is a leading cause of vision impairment and loss among adults. Here, we performed a comprehensive proteomic analysis to discover biomarkers for DR. First, to identify biomarker candidates that are specifically expressed in human vitreous, we performed data-mining on both previously published DR-related studies and our experimental data; 96 proteins were then selected. To confirm and validate the selected biomarker candidates, candidates were selected, confirmed, and validated using plasma from diabetic patients without DR (No DR) and diabetics with mild or moderate nonproliferative diabetic retinopathy (Mi or Mo NPDR) using semiquantitative multiple reaction monitoring (SQ-MRM) and stable-isotope dilution multiple reaction monitoring (SID-MRM). Additionally, we performed a multiplex assay using 15 biomarker candidates identified in the SID-MRM analysis, which resulted in merged AUC values of 0.99 (No DR versus Mo NPDR) and 0.93 (No DR versus Mi and Mo NPDR). Although further validation with a larger sample size is needed, the 4-protein marker panel (APO4, C7, CLU, and ITIH2) could represent a useful multibiomarker model for detecting the early stages of DR.</P>
상호텍스트성의 관점에서 본 파트릭 샤무아조의 『크루소의 발자국』
진종화(Jin Jonghwa) 프랑스문화예술학회 2019 프랑스문화예술연구 Vol.70 No.-
본 연구는 상호텍스트성의 관점에서 파트릭 샤무아조 Patrick Chamoiseau의 『크루소의 발자국 L"Empreinte à Crusoé』(2012)을 분석한다. 샤무아조의 소설은 대니얼 디포 Daniel Defoe의 『로빈슨 크루소 Robinson Crusoe』(1719)와 미셸 투르니에 Michel Tournier의 『방드르디, 혹은 태평양의 고성소 Vendredi, ou les limbes du Pacifique』(1967)를 다시 쓰기한 작품이다. 샤무아조 작품에서 흑인화자 로빈슨은 디포작품의 주인공처럼 무인도에서 초기에 지배자, 소유자로 군림하지만 타자의 존재 인식을 계기로 관계적이고 상호의존적 자연관을 갖게 되며 투르니에의 로빈슨처럼 인간중심주의에서 벗어난다.
진종화 ( Jonghwa Jin ),민호필 ( Hophil Min ),권오승 ( Oh-seung Kwon ),오현정 ( Hyun Jeong Oh ),김종원 ( Jongwon Kim ),박철환 ( Chulhwan Park ) 한국화학공학회 2017 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.55 No.1
The determination of disulfide bonds is important for comprehensive understanding of the chemical structure of protein. So far, many strategies for the disulfide bond analysis have been suggested in terms of speed and sensitivity. However, most of these strategies have not considered free thiol residues in the target protein in the process of determining the disulfide bond. We suggested the strategy which was composed of four steps for the identification of disulfide bonds; the first step was the prediction of possible disulfide bonds, the second step was the determination of free cysteine residues, the third step was the analysis of disulfide bond using a high-resolution mass spectrometry, and the final step was the determination of disulfide bonds based on the comprehensive verification. In this study, we performed the characterization of disulfide bonds for the recombinant protein (HRPE1), where 1 and 5 inter- and intra-chain disulfide bonds were identified, respectively.