http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Jung, Jang Han,Lee, Hyun Jik,Lee, Hee Seung,Jo, Jung Hyun,Cho, In Rae,Chung, Moon Jae,Park, Jeong Youp,Park, Seung Woo,Song, Si Young,Bang, Seungmin Baishideng Publishing Group Inc 2017 WORLD JOURNAL OF GASTROENTEROLOGY Vol.23 No.18
<P><B>AIM</B></P><P>To clarify the role of neoadjuvant concurrent chemoradiotherapy (NACCRT) followed by surgical resection for localized or locally advanced perihilar cholangiocarcinoma (CCA).</P><P><B>METHODS</B></P><P>We retrospectively reviewed 57 patients who underwent surgical resection with or without NACCRT for perihilar CCA; 12 patients received NACCRT and 45 patients did not received NACCRT. Patients with locally advanced perihilar CCA requiring NACCRT were defined as follows: (1) a mass involving unilateral branches of the portal vein or hepatic artery with insufficient volume of the anticipated remnant lobe; or (2) an infiltrating mass in the main portal vein that was too long for reconstruction, identified at preoperative staging.</P><P><B>RESULTS</B></P><P>The median disease-free survival (DFS) durations of the neoadjuvant and non-neoadjuvant CCRT groups were 26.0 and 15.1 mo, respectively (<I>P</I> = 0.91). The median overall survival (OS) durations of the neoadjuvant and non-neoadjuvant CCRT groups were 32.9 and 27.1 mo, respectively (<I>P</I> = 0.26). The NACCRT group showed a downstaging tendency compared to the non-NACCRT group as compared with the tumor stage confirmed by histological examination after surgery and the tumor stage confirmed by imaging test at the time of diagnosis (<I>P</I> = 0.01).</P><P><B>CONCLUSION</B></P><P>NACCRT does not prolong DFS and OS in localized or locally advanced perihilar CCA. However, NACCRT may allow tumor downstaging and improve tumor resectability.</P>
Regulation of Stem Cell Fate by ROS-mediated Alteration of Metabolism
Ryu, Jung Min,Lee, Hyun Jik,Jung, Young Hyun,Lee, Ki Hoon,Kim, Dah Ihm,Kim, Jeong Yeon,Ko, So Hee,Choi, Gee Euhn,Chai, Ing Ing,Song, Eun Ju,Oh, Ji Young,Lee, Sei-Jung,Han, Ho Jae Korean Society for Stem Cell Research 2015 International journal of stem cells Vol.8 No.1
<P>Stem cells have attracted much attention due to their distinct features that support infinite self-renewal and differentiation into the cellular derivatives of three lineages. Recent studies have suggested that many stem cells both embryonic and adult stem cells reside in a specialized niche defined by hypoxic condition. In this respect, distinguishing functional differences arising from the oxygen concentration is important in understanding the nature of stem cells and in controlling stem cell fate for therapeutic purposes. ROS act as cellular signaling molecules involved in the propagation of signaling and the translation of environmental cues into cellular responses to maintain cellular homeostasis, which is mediated by the coordination of various cellular processes, and to adapt cellular activity to available bioenergetic sources. Thus, in this review, we describe the physiological role of ROS in stem cell fate and its effect on the metabolic regulation of stem cells.</P>
Lee, Hyun Jik,Ryu, Jung Min,Jung, Young Hyun,Oh, Sang Yub,Lee, Sei-Jung,Han, Ho Jae AlphaMed Press 2015 Stem Cells Vol.33 No.7
<P>The control of stem cells by oxygen signaling is an important way to improve various stem cell physiological functions and metabolic nutrient alteration. Lipid metabolism alteration via hypoxia is thought to be a key factor in controlling stem cell fate and function. However, the interaction between hypoxia and the metabolic and functional changes to stem cells is incompletely described. This study aimed to identify hypoxia-inducible lipid metabolic enzymes that can regulate umbilical cord blood (UCB)-derived human mesenchymal stem cell (hMSC) proliferation and migration and to demonstrate the signaling pathway that controls functional change in UCB-hMSCs. Our results indicate that hypoxia treatment stimulates UCB-hMSC proliferation, and expression of two lipogenic enzymes: fatty acid synthase (FASN) and stearoyl-CoA desaturase-1 (SCD1). FASN but not SCD1 is a key enzyme for regulation of UCB-hMSC proliferation and migration. Hypoxia-induced FASN expression was controlled by the hypoxia-inducible factor-1 alpha (HIF-1)/SCAP/SREBP1 pathway. Mammalian target of rapamycin (mTOR) was phosphorylated by hypoxia, whereas inhibition of FASN by cerulenin suppressed hypoxia-induced mTOR phosphorylation as well as UCB-hMSC proliferation and migration. RAPTOR small interfering RNA transfection significantly inhibited hypoxia-induced proliferation and migration. Hypoxia-induced mTOR also regulated CDK2, CDK4, cyclin D1, cyclin E, and F-actin expression as well as that of c-myc, p-cofilin, profilin, and Rho GTPase. Taken together, the results suggest that mTORC1 mainly regulates UCB-hMSC proliferation and migration under hypoxia conditions via control of cell cycle and F-actin organization modulating factors. In conclusion, the HIF-1/FASN/mTORC1 axis is a key pathway linking hypoxia-induced lipid metabolism with proliferation and migration in UCB-hMSCs. Stem Cells 2015;33:2182-2195</P>
Serum alkaline phosphatase and γ-glutamyl transferase in acute pyelonephritis
( Chaehoon Han ),( Young-ki Lee ),( Hayne Cho Park ),( Ajin Cho ),( Sun Ryoung Choi ),( Jong-woo Yoon ),( Ja Ryong Koo ),( Hyung Jik Kim ),( Jung-woo Noh ),( Min-jeong Park ) 대한신장학회 2019 Kidney Research and Clinical Practice Vol.38 No.2
Background: Elevated serum alkaline phosphatase (AP) and γ-glutamyl transferase (γ-GT) are commonly observed in patients with acute pyelonephritis. The goal of this study was to examine the clinical significance of elevated serum AP and γ-GT levels and to explore the mechanisms underlying these changes. Methods: We examined serum AP and γ-GT levels in 438 patients with acute pyelonephritis. Urine AP/creatinine (Cr), urine γ-GT/Cr, fractional excretion of AP, and fractional excretion of γ-GT (FE<sub>γ-GT</sub>) were evaluated in patients with elevated and normal serum levels. AP isoenzymes were also examined. Results: We identified 77 patients (17.6%) with elevated serum AP and 134 patients (30.6%) with elevated serum γ-GT. Among them, both enzymes were elevated in 64 patients (14.6%). Older age, longer hospital stay, elevated baseline serum Cr, and complicated pyelonephritis were associated with increases in serum AP and γ-GT. Multivariate analysis showed that high serum AP levels were significantly correlated with renal impairment (odds ratio, 2.13; 95% confidence interval, 1.08-4.19; P = 0.029). FE<sub>γ-GT</sub> was significantly lower in patients with elevated serum enzyme levels. The liver fraction for AP isoenzyme profile did not increase in patients with elevated serum AP. Conclusion: Our results demonstrated that elevated serum AP and γ-GT levels are associated with complicated pyelonephritis and renal impairment. Lower FE<sub>γ-GT</sub> levels in patients with elevated serum enzymes may be the result of decreased urinary excretion of these enzymes.
고한석 ( Han Suk Ko ),전태환 ( Tae Hwan Jeon ),김병직 ( Byung Jik Kim ),임영 ( Young Lim ),서정국 ( Jung Guk Seo ),주석규 ( Suk Kyu Zoo ),김진환 ( Jin Hwan Kim ) 대한고관절학회 1993 Hip and Pelvis Vol.5 No.1
Acetabulum consisting of the hip joint is the most important weight bearing joint in the lower extremity. The principle of treatment for this fracture must be restored the hip function which require accurate anatomical reduction and firm internal fixation followed by early joint moton. But because of the difficulties in the evaluation <@k classification of the fracture and in the exposure & reduction, treatment of displaced acetabular fracture have been controvirsal. Recently many authors stressed that surgical operation is often required to achieve the accurate anatomical reduction of fractured acetabulum and reported its good results. Authors reviewed and analysed 24 patients with displaced acetabular fractures by surgical treatment who had displacement of minimum 3mm after skeletal traction, which were treated at Department of Orthopedic Surgery, Inje University, Seoul Paik Hospital from Jan. 1987 to Jan. 1992. The results were as follows: l. According to Letournels classification, the most common type was posterior wall fracture, the second was transverse with posterior wall fracture, and pelvic bone fracture was the most common associated injuries. 2. Surgical approaches were Kocher-Langenbeck in 14 cases, Ilioinguinal in 5 cases, Obsorne and Moore in each 2 cases, triradiate trochanteric 1 case. 3. The satisfactory result was achieved in each 17 cases of patients with congruent reduction clinically & radiologically and in 14 cases clinically and in 15 cases radiologically of the patients who underwent surgical treatment.