The Existence of a Putative Regulatory Element in 3'-UntranslatedRegion of Proto-oncogene HOX11’s mRNA

Zhao-Zhao Jiang,Wei-Jun Ma,Joseph JY Sung,Yue Li,Hai-Xu Chen,Wai-Keung Leung 한국생화학분자생물학회 2005 BMB Reports Vol.38 No.4

Study on Springback Properties of Different Orthodontic Archwires in Archwire Bending Process

Jiang Jin-gang,Wang Zhao,Zhang Yong-de,Jiang Ji-xiong,Niu Suo-liang,Liu Yi 보안공학연구지원센터 2014 International Journal of Control and Automation Vol.7 No.12

The archwire bending is one of processes the most frequently used in the orthodontic treatment. Furthermore, the springback of sheet metal, which is defined as elastic recovery of the part during unloading, should be taken into consideration so as to produce formed archwire within acceptable tolerance limits. In this paper, the springback angle of different alloy archwires (including NiTi alloy wire, Beta-Ti alloy wires, Chinese stainless steel wires, and Australian stainless steel wires) were performed by the theoretical calculation based on large deformation theory and the finite element analysis. A series of numerical simulations has been conducted for the bending test, which physically simulates the actual bending of alloy archwire with a robotic apparatus. The finite element analysis of springback is shown to be very consistent with the theoretical calculation results.

Efficient algorithm for finding the inverse and the groupinverse of FLS $r$-circulant matrix

Zhao-Lin Jiang,Zong-Ben Xu 한국전산응용수학회 2005 Journal of applied mathematics & informatics Vol.18 No.1-2

An efficient algorithm for finding the inverse and the group inverse of the FLS r-circulant matrix is presented by Euclidean algorithm. Extension is made to compute the inverse of the FLS r-retrocirculant matrix by using the relationship between an FLS r-circulant matrix and an FLS r-retrocirculant matrix. Finally, some examples are given.

Protective effect of Lactobacillus plantarum ATCC8014 on acrylamide-induced oxidative damage in rats

Zhao Sijia,Zhao Xiaoduo,Liu Qingbo,Jiang Yujun,Li Yanhua,Feng Wenxiao,Xu Honghua,Shao Meili 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.4

Acrylamide (AA), which is mainly found in fried foods, causes neurotoxicity, genetic toxicity, carcinogenic effects, and DNA damage. This study confirms that a strain of lactic acid bacteria (Lactobacillus plantarum ATCC8014) could alleviate the toxicity of rats by inhibiting the AA-induced oxidative damage. Forty-eight adult male SD rats were randomly divided into eight groups: control group, AA group (40 mg/kg), three different doses (1 × 107 CFU/ml, 1 × 108 CFU/ ml, 1 × 109 CFU/ml of Lactobacillus plantarum ATCC8014) of prevention groups and therapeutic groups, respectively. At the end of three-week experiment, AA treatment produced a significant reduction in the rate of weight gain along with the symptoms of hind limb splay and ataxia. Histological examinations revealed various degrees of injury in five tissues. Levels of superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) in group AA rats were significantly decreased, but the level of lipid peroxidation (LPO) was significantly increased (p < 0.05). Both prevention and therapeutic groups with 1 × 109 CFU/ml of Lactobacillus plantarum ATCC8014 could effectively reduce the injury of AA to the body. However, reductions in both groups were not statistically significant.

Production of Transgenic Pigs with an Introduced Missense Mutation of the Bone Morphogenetic Protein Receptor Type IB Gene Related to Prolificacy

Zhao, Xueyan,Yang, Qiang,Zhao, Kewei,Jiang, Chao,Ren, Dongren,Xu, Pan,He, Xiaofang,Liao, Rongrong,Jiang, Kai,Ma, Junwu,Xiao, Shijun,Ren, Jun,Xing, Yuyun Asian Australasian Association of Animal Productio 2016 Animal Bioscience Vol.29 No.7

In the last few decades, transgenic animal technology has witnessed an increasingly wide application in animal breeding. Reproductive traits are economically important to the pig industry. It has been shown that the bone morphogenetic protein receptor type IB (BMPR1B) A746G polymorphism is responsible for the fertility in sheep. However, this causal mutation exits exclusively in sheep and goat. In this study, we attempted to create transgenic pigs by introducing this mutation with the aim to improve reproductive traits in pigs. We successfully constructed a vector containing porcine BMPR1B coding sequence (CDS) with the mutant G allele of A746G mutation. In total, we obtained 24 cloned male piglets using handmade cloning (HMC) technique, and 12 individuals survived till maturation. A set of polymerase chain reactions indicated that 11 of 12 matured boars were transgene-positive individuals, and that the transgenic vector was most likely disrupted during cloning. Of 11 positive pigs, one (No. 11) lost a part of the terminator region but had the intact promoter and the CDS regions. cDNA sequencing showed that the introduced allele (746G) was expressed in multiple tissues of transgene-positive offspring of No.11. Western blot analysis revealed that BMPR1B protein expression in multiple tissues of transgene-positive $F_1$ piglets was 0.5 to 2-fold higher than that in the transgene-negative siblings. The No. 11 boar showed normal litter size performance as normal pigs from the same breed. Transgene-positive $F_1$ boars produced by No. 11 had higher semen volume, sperm concentration and total sperm per ejaculate than the negative siblings, although the differences did not reached statistical significance. Transgene-positive $F_1$ sows had similar litter size performance to the negative siblings, and more data are needed to adequately assess the litter size performance. In conclusion, we obtained 24 cloned transgenic pigs with the modified porcine BMPR1B CDS using HMC. cDNA sequencing and western blot indicated that the exogenous BMPR1B CDS was successfully expressed in host pigs. The transgenic pigs showed normal litter size performance. However, no significant differences in litter size were found between transgene-positive and negative sows. Our study provides new insight into producing cloned transgenic livestock related to reproductive traits.

Clinical Determinants of Weight Loss in Patients with Esophageal Carcinoma During Radiotherapy: a Prospective Longitudinal View

Jiang, Nan,Zhao, Jin-Zhi,Chen, Xiao-Cen,Li, Li-Ya,Zhang, Li-Juan,Zhao, Yue Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5

Purpose: The prevalence of weight loss in esophageal carcinoma patients is high and associated with impairment of physical function, increased psychological distress and low quality of life. It is not known which factors may contribute to weight loss in patients with esophageal carcinoma during radiotherapy in China. The objective of this study was to identify the associated demographic and clinical factors influencing weight loss. Methods: We evaluated 159 esophageal carcinoma patients between August 2010 and August 2013 in a crosssectional, descriptive study. Patient characteristics, tumor and treatment details, psychological status, adverse effects, and dietary intake were evaluated at baseline and during radiotherapy. A multivariate logistic regression analyss was performed to identify the potential factors leading to weight loss. Results: 64 (40.3%) patients had weight loss ${\geq}5%$ during radiotherapy. According to logistic regression analysis, depression, esophagitis, and loss of appetite were adverse factors linked to weight loss. Dietary counseling, early stage disease and total energy intake ${\geq}1441.3$ (kcal/d) were protective factors. Conclusions It was found that dietary counseling, TNM stage, total energy intake, depression, esophagitis, and loss of appetite were the most important factors for weight loss. The results underline the importance of maintaining energy intake and providing dietary advice in EC patients during RT. At the same time, by identifying associated factors, medical staff can provide appropriate medical care to reduce weight loss. Further studies should determine the effect of these factors on weight loss and propose a predictive model.

Decentralized Robust H∞ Output Feedback Control for Value Bounded Uncertain Large-scale Interconnected Systems

Zhao-Hui Jiang,Yong-Fang Xie,Wei-Hua Gui,Can Huang 제어·로봇·시스템학회 2010 International Journal of Control, Automation, and Vol.8 No.1

In this paper, decentralized robust H∞ output feedback control problem for large-scale interconnected system with value bounded uncertainties in the state, control input and interconnection matrices is investigated. A new bounded real lemma for the large-scale interconnected systems is derived by Lyapunov stability theory and linear matrix inequality method. Based on the new bounded real lemma, a sufficient condition expressed as matrix inequalities for the existence of a decentralized robust H∞ output feedback controller is obtained. The controller which enables the closed-loop large-scale system robust stable and satisfies the given H∞ performance is designed through a homotopy iterative method. Finally, a numerical example is given to illustrate the effectiveness of the proposed method.

Power Quality Optimal Control of Railway Static Power Conditioners Based on Electric Railway Power Supply Systems

Jiang, Youhua,Wang, Wenji,Jiang, Xiangwei,Zhao, Le,Cao, Yilong The Korean Institute of Power Electronics 2019 JOURNAL OF POWER ELECTRONICS Vol.19 No.5

Aiming at the negative sequence and harmonic problems in the operation of railway static power conditioners, an optimization compensation strategy for negative sequence and harmonics is studied in this paper. First, the hybrid RPC topology and compensation principle are analyzed to obtain different compensation zone states and current capacities. Second, in order to optimize the RPC capacity configuration, the minimum RPC compensation capacity is calculated according to constraint conditions, and the optimal compensation coefficient and compensation angle are obtained. In addition, the voltage unbalance ${\varepsilon}_U$ and power factor requirements are satisfied. A PSO (Particle Swarm Optimization) algorithm is used to calculate the three indexes for minimum compensating energy. The proposed method can precisely calculate the optimal compensation capacity in real time. Finally, MATLAB simulations and an experimental platform verify the effectiveness and economics of the proposed algorithm.

Research of Enterprise Private Cloud Computing Platform Based on OpenStack

Jiang Yunxia,Zhao Bowen,Wang Shuqi,Sun Dongnan 보안공학연구지원센터 2014 International Journal of Grid and Distributed Comp Vol.7 No.5

The demand for computing resources is growing, but the input costs of the enterprise information system construction of the traditional way is too high, and has not the high utilization of the resources. In order to solve this contradiction, the enterprise private cloud platform architecture has been put forward based on open source system. By analyzing the mainstream open source cloud projects, the basis to choose OpenStack has been given. From the perspective of classification of the enterprise personnel, combining with the components of OpenStack, this paper expounds manufacture of the virtual image and distribution, monitor, and use of the virtual machine. At last, the user interface design is also given.

The effect of the spinning conditions on the structure of mesophase pitch-based carbon fibers by Taguchi method

Zhao Jiang,Ting Ouyang,Xiangdong Yao,Youqing Fei 한국탄소학회 2016 Carbon Letters Vol.19 No.-

Taguchi’s experimental design was employed in the melt spinning of molten mesophase pitch to produce carbon fibers. The textures of the obtained carbon fibers were radial with varied crack angles, as observed by scanning electron microscopy and polarized optical imaging. The diameter, crack angle, preferred orientation, and tensile modulus of the produced samples were examined to investigate the influence of four spinning variables. The relative importance of the variables has been emphasized for each characteristic. The results show that thicker carbon fiber can be obtained with a smaller entry angle, a higher spinning temperature, a reduced winding speed, and an increased extrusion pressure. The winding speed was found to be the most significant factor in relation to the fiber diameter. While it was observed that thicker carbon fiber generally shows improved preferred orientation, the most important variable affecting the preferred orientation was found to be the entry angle. As the entry angle decreased from 120° to 60°, the shear flow was enhanced to induce more ordered radial alignment of crystallite planes so as to obtain carbon fibers with a higher degree of preferred orientation. As a consequence, the crack angle was increased, and the tensile modulus was improved.