Classical beauty

Jiang Siyu 한국콘텐츠학회 2023 ICCC International Digital Design Invitation Exhib Vol.2023 No.5

Fully Distributed Event-triggered Semi-global Consensus of Multi-agent Systems with Input Saturation and Directed Topology

Siyu Chen,Haijun Jiang,Zhiyong Yu 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.12

This paper studies the consensus problem of multi-agent systems with input saturation and directed communication topology, by utilizing the low-gain feedback method and the event-triggered control laws. Two event-triggered control laws, the centralized and the distributed laws, are proposed to guarantee semi-global consensus of the multi-agent systems. Then, a sufficient condition is presented to prove strictly positive low bound of inner-event time, i.e., the Zeno behavior can be avoided. Finally, the effectiveness of the proposed event-triggered laws is further verified by an example.

20(S)-ginsenoside Rh2 ameliorates ATRA resistance in APL by modulating lactylation-driven METTL3

Siyu Cheng,Langqun Chen,Jiahui Ying,Ying Wang,Wenjuan Jiang,Qi Zhang,Hong Zhang,Jiahe Wang,Chen Wang,Huimin Wu,Jing Ye,Liang Zhang 고려인삼학회 2024 Journal of Ginseng Research Vol.48 No.3

Background: 20(S)-ginsenoside Rh2(GRh2), an effective natural histone deacetylase inhibitor, can inhibit acute myeloid leukemia (AML) cell proliferation. Lactate regulated histone lactylation, which has different temporal dynamics from acetylation. However, whether the high level of lactylation modification that we first detected in acute promyelocytic leukemia (APL) is associated with all-trans retinoic acid (ATRA) resistance has not been reported. Furthermore, Whether GRh2 can regulate lactylation modification in ATRA-resistant APL remains unknown. Methods: Lactylation and METTL3 expression levels in ATRA-sensitive and ATRA-resistant APL cells were detected by Western blot analysis, qRT-PCR and CO-IP. Flow cytometry (FCM) and APL xenograft mouse models were used to determine the effect of METTL3 and GRh2 on ATRA-resistance. Results: Histone lactylation and METTL3 expression levels were considerably upregulated in ATRA-resistant APL cells. METTL3 was regulated by histone lactylation and direct lactylation modification. Overexpression of METTL3 promoted ATRA-resistance. GRh2 ameliorated ATRA-resistance by downregulated lactylation level and directly inhibiting METTL3. Conclusions: This study suggests that lactylation-modified METTL3 could provide a promising strategy for ameliorating ATRA-resistance in APL, and GRh2 could act as a potential lactylation-modified METTL3 inhibitor to ameliorate ATRA-resistance in APL.

Fe-curcumin Nanozyme-Mediated Immunosuppression and Anti-inflammation in Experimental Autoimmune Uveitis

Zhengxuan Jiang,Kun Liang,Xiang Gao,Fan Cao,Guangqi An,Siyu Gui,Weiwei Tang,Liping Du,Liming Tao,Xianwen Wang 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

Background EAU is an inflammatory disease usually characterized by autoinflammation and autoimmunity and is aggravated by excessive generation of ROS. Conventional hormone therapy often has more adverse effects. It is urgent to find a therapeutic drug with higher efficiency and fewer adverse effects. Methods We developed an Fe-curcumin nanozyme in which natural antioxidants coordinate with Fe3+ to form nanoparticles with excellent solubility for directing anti-inflammatory and ROS scavenging effects to treat EAU. Several experiments were used to detect the characteristics of nanozymes. EAU model rats were used to detect the abilities of decreasing autoinflammation and autoimmunity. PBMCs were used to detect the ability to inhibit cell proliferation. Results Free radical scavenging experiments showed that nanozymes decreased the level of free radicals at low concentrations. In vitro and in vivo experiments revealed that the group treated with Fe-curcumin nanozymes had lower inflammatory reactions and ROS levels than the control group, as reflected by the downregulated levels of several critical inflammatory cytokines, such as IFN-γ, IL-17, and TNF-α; decreased H2O2 release; inhibited proliferation of Th1 and Th17 cells; and alleviated pathological changes in the eye. Importantly, the Fe-curcumin nanozyme was detected in the retina using Prussian blue staining. Additionally, Fe-curcumin nanozyme is noncytotoxic when directing these biological activities. Conclusion This study has demonstrated the feasibility of using the Fe-curcumin nanozyme as a nanodrug to inhibit inflammatory reactions and scavenge ROS in the treatment of EAU, indicating that it may serve as a promising therapeutic agent in clinical treatment.

Preparation and evaluation of surfactant-stabilized graphene sheets and piezoresistivity of GPs/cement composite

Zhu Siyue,Qin Xiantao,Zou Zuxu,Zhang Rongtang,Jiang Yi 한국탄소학회 2020 Carbon Letters Vol.30 No.1

For applications in cement-based materials, studies on carbon-based nanomaterials have been almost exclusively on carbon nanotubes, carbon nanofbers, and graphite oxide. Graphene sheets (GPs), as a kind of carbon-based nanomaterials, show unusual mechanical, electrical, optical, and other properties. In this paper, the main focus is to enhance the efect of GPs by improving dispersion through ultrasonication and use of surfactant. Then, dispersion and stability are quantitatively measured by comparing absorbance spectra through spectrophotometry and qualitatively observed through digital imaging and SEM imaging. Therefore, the dispersing protocol is optimized and the most efective and stable dispersion is achieved. At last, the piezoresistivities under compressive load of GPs/cement composites pastes at diferent additions of GPs are studied by comparing with plain cement paste.

基于知识转移的母公司回任人员激励

姜秀珍(Jiang Xiuzhen),徐波(Xubo),金思宇(Jin Siyu) 실천경영학회 2009 실천경영연구 Vol.4 No.1

The experiences and knowledge of the repatriates is the important competitive advantage in the parent-country nationals(PCNs). This paper discussed the incentive mechanism of the repatriates based on the view of knowledge transfer, constructed the theoretical model according to the games and information economics, and pionted out the knowledge transfer was the process of repeated games between the repatriates and employees in the PCNs. The building of incentive mechanism was the result of looking up this games equilibrium, it was (transfer, transfer), and the paper also provided the relative suggestions for promoting the knowledge transfer of the repatriates in the PCNs.

The Development of Catering Giant Haidilao: The Leader in Quality Tracks

Li Xueyi,Jiang Xinmei,Zhang Siyu,Yang Xishe,Yang Yang Academy of Asian Business (AAB) 2022 Academy of Asian Business Review Vol.8 No.1

The purpose of this case study is to analyze the success story of Haidilao, a leading Chinese restaurant company known for its supreme service and innovative business model. The report is presented in three parts. The first part examines the history of Haidilao, discussing the background of its founding, its current position, and important turning points.The second section explores the factors behind Haidilao's success, categorized by internal management and external strategies. The unique corporate values of Asian companies that Haidilao possesses are highlighted. The third section discusses the internal and external challenges faced by Haidilao and the suggested solutions. Finally, this conclusion examines what we can learn from Haidilao's success. Against the backdrop of rapid changes in the world's restaurant industry, this case study hopes to provide insights for the emerging restaurant industry in Asia by analyzing the success story of a hot pot empire. Since Haidilao has a unique Asian-style business strategy in its development process, it is hoped that those Asian companies in the midst of globalization will take the best from the bad and learn from Haidilao's practices in industry chain layout, new technology application, and human resource management while learning valuable lessons from Haidilao's business process.

HVOF Spray Performance Optimization Analysis and Experimental Research of WC–12Co Coating on Ti Alloy

Xinxue Chen,Chang Li,Siyu Li,Xing Han,Haisheng Jiang,Xiaoyu Zhao 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.12

TC18 titanium alloy, with low density, high strength and corrosion resistance, is a significant material for the main loadbearingcomponents of aircraft landing gear and other aviation structures. However, its corrosion resistance and wear resistanceare insufficient when it is serviced in the extreme corrosion environments such as sea salt spray and hygrothermal,which greatly affects its wide application. It is significant to design and develop high-quality anti-corrosion and wear resistantcoatings for TC18 titanium alloy. High Velocity Oxygen Fuel (HVOF) spraying WC–12Co is an ideal strengthening methodto replace surface chromium plating. Quantitatively evaluating the influence of spraying process parameters on the coatingquality is the key to prepare high-quality coatings. In this study, a numerical model of HVOF spraying WC–12Co wasestablished with JP5000 spray gun. The spray combustion reaction model and discrete phase model were solved to reveal theevolution characteristics of combustion flame flow and particle flight behavior in the spraying process. Based on the responsesurface method, the optimum spraying process parameters were determined, and the WC–12Co coatings were prepared. Onthis basis, the coating was tested by the SEM, XRD, hardness, friction and wear, salt spray corrosion and seawater corrosion. The corrosion resistance and wear resistance of the WC–12Co coating were comprehensively evaluated. The experimentshows that the WC–12Co coating prepared by HVOF spraying has great performance, which can effectively improve theprotective performance of TC18 substrate.

Transient Stability Simulation Analysis of Multi Node Power Network with Variable Speed Pumped Storage Units

Zhao Chong,Wang Longze,Ma Yiyi,Xiang Pengfei,Jiang Siyu,Chen Weidong,Zhang Yan,Li Meicheng 대한전기학회 2023 Journal of Electrical Engineering & Technology Vol.18 No.4

The output characteristics of variable speed pumped storage are different from conventional hydropower and constant speed pumped storage units. The continuous increase of installed capacity of variable speed pumped storage, poses a severe challenge to the safe and stable operation of the local power grid. Proposed in this paper is a kind suitable for multi-node containing variable speed pump machine storage unit electric power network transient stability method, considering the variable speed pumped storage units by the end of the instantaneous failure prone to sudden drop transient power, the power network with more nodes each busbar voltage stable operation as the goal, according to the regional power grid data under typical operation modes, Based on the power system analysis software package, an electromechanical simulation model of the 7-node power grid with variable speed pumped storage unit was established. The influence on the transient stability of a 7-node power grid is analyzed by removing variable speed pumped-storage units and three-phase short-circuit faults. The transient stability of the power grid can be maintained under the conditions of removing variable speed pumped-storage units and three-phase short-circuit faults, but some bus voltages are higher than the specified voltage upper limit. The reactive power compensation device is installed to improve the voltage stability of the power grid system, which can prevent the overvoltage accident caused by the fault of the communication system, achieve the purpose of multi-node power network stability, and improve the safety and stability of the regional power system when the fault occurs.

Ganodermanontriol Suppresses the Progression of Lung Adenocarcinoma by Activating CES2 to Enhance the Metabolism of Mycophenolate Mofetil

( Qingfeng Xie ),( Zhuo Cao ),( Weiling You ),( Xiaoping Cai ),( Mei Shen ),( Zhangyong Yin ),( Yiwei Jiang ),( Xin Wang ),( Siyu Ye ) 한국미생물생명공학회 2024 Journal of microbiology and biotechnology Vol.34 No.2

New anti-lung cancer therapies are urgently required to improve clinical outcomes. Since ganodermanontriol (GDNT) has been identified as a potential antineoplastic agent, its role in lung adenocarcinoma (LUAD) is investigated in this study. Concretely, lung cancer cells were treated with GDNT and/or mycophenolate mofetil (MMF), after which MTT assay, flow cytometry and Western blot were conducted. Following bioinformatics analysis, carboxylesterase 2 (CES2) was knocked down and rescue assays were carried out in vitro. Xenograft experiment was performed on mice, followed by drug administration, measurement of tumor growth and determination of CES2, IMPDH1 and IMPDH2 expressions. As a result, the viability of lung cancer cells was reduced by GDNT or MMF. GDNT enhanced the effects of MMF on suppressing viability, promoting apoptosis and inducing cell cycle arrest in lung cancer cells. GDNT up-regulated CES2 level, and strengthened the effects of MMF on down-regulating IMPDH1 and IMPDH2 levels in the cells. IMPDH1 and IMPDH2 were highly expressed in LUAD samples. CES2 was a potential target for GDNT. CES2 knockdown reversed the synergistic effect of GDNT and MMF against lung cancer in vitro. GDNT potentiated the role of MMF in inhibiting tumor growth and expressions of CES2 and IMPDH1/2 in lung cancer in vivo. Collectively, GDNT suppresses the progression of LUAD by activating CES2 to enhance the metabolism of MMF.