Inter‑diffusion Based Analytical Model for Growth Kinetics of IMC Layers at Roll Bonded Cu/Al Interface During Annealing Process

Fu‑an Hua,Hong‑wu Song,Tao Sun,Jian‑ping Li 대한금속·재료학회 2020 METALS AND MATERIALS International Vol.26 No.3

A model based on inter-diffusion theory was established to predict growth kinetics of the intermetallic compounds (IMCs)formed in roll bonded Al/Cu sheets during annealing process. The model can give good prediction of both IMC layers growthkinetics and element concentration distribution at the interface of roll bonded Cu/Al sheets with different thickness underdifferent annealing conditions with certain roll reduction range. It is revealed that the calculated results of the proposedmodel are depended on the inter-diffusion coefficient of each components, which could be related to the interface bondingstate, i.e., bonding methods or rolling reductions for roll bonding. And there was big difference in inter-diffusion coefficientof Al and Cu matrix under different bonding state, while the inter-diffusion coefficient of IMCs changed slightly.

Sorafenib Continuation after First Disease Progression Could Reduce Disease Flares and Provide Survival Benefits in Patients with Hepatocellular Carcinoma: a Pilot Retrospective Study

Fu, Si-Rui,Zhang, Ying-Qiang,Li, Yong,Hu, Bao-Shan,He, Xu,Huang, Jian-Wen,Zhan, Mei-Xiao,Lu, Li-Gong,Li, Jia-Ping Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7

Background: Sorafenib is a promising drug for advanced hepatocellular carcinoma (HCC); however, treatment may be discontinued for multiple reasons, such as progressive disease, adverse events, or the cost of treatment. The consequences of sorafenib discontinuation and continuation are uncertain. Materials and Methods: We retrospectively analyzed 88 HCC patients treated with sorafenib from July 2007 to January 2013. Overall survival (OS), post-disease progression overall survival (pOS), and time to disease progression (TTP) were compared for survival analysis. Cox proportional hazard regression was performed to assess the effect of important factors on OS in the overall patient population and on pOS in patients who continued sorafenib treatment. Results: Sorafenib was discontinued and continued in 24 and 64 patients, respectively. The median OS (355 vs 517 days respectively; p=0.015) and median post-PD OS (260 vs 317 days, respectively; p=0.020) were statistically different between the discontinuation and continuation groups. Neither the median time to first PD nor the time to second PD were significantly different between the 2 groups. In the discontinuation group, 3 of the 24 patients (12.5%) suffered disease outbreaks. In Cox proportional hazard regression analysis after correction for confounding factors, BCLC stage (p=0.002) and PD site (p=0.024) were significantly correlated with pOS in patients who continued sorafenib treatment. Conclusions: Sorafenib discontinuation may cause HCC flares or outbreaks. It is advisable to continue sorafenib treatment after first PD, particularly in patients with Barcelona Clinic Liver Cancer stage B disease or only intrahepatic PD.

Numerical Analysis and Load-Carrying Capacity Estimation of Reinforced Concrete Slab Culvert Rehabilitated with a Grouted Corrugated Steel Plate

Li Bai-Jian,Fu Wen-Qiang,Fu Xin-Sha,Huang Yan 한국강구조학회 2023 International Journal of Steel Structures Vol.23 No.4

Two laboratory tests were conducted to investigate the mechanical properties and develop a load-carrying capacity estimation method for reinforced concrete (RC) slab culverts rehabilitated with a grouted corrugated steel plate (CSP). Subsequently, 216 numerical models of RC slab culverts rehabilitated with different shapes of CSPs and grout strengths were established to investigate the influence of these parameters and the arch effect on the rehabilitated system. A mechanical model was proposed based on the elastic center method, and a load-carrying capacity estimation method of RC slab culverts rehabilitated with grouted CSPs was established and verified. It was concluded that the load-carrying capacity of the rehabilitated system increased with a decrease in the radius of the side walls and crown at a constant radius of the CSP haunch. At a constant radius of the side walls and CSP crown, the load-carrying capacity of the rehabilitated system increased with an increase in the haunch radius. The most effective way to improve the load-carrying capacity of the rehabilitated system was to increase the radius of the haunches and reduce the radius of the arch crown and side wall. The arch effect of the grout was related to the load type. The load-carrying capacity of the rehabilitated system was the highest when the CSP was similar to or the same as the arch axes of the grout. The most important function of the grout was to provide strong lateral restraint for the CSP, reducing the required span and improving the load-carrying capacity of the CSP. In addition, the shear strength of the grout contributed to improving the load-carrying capacity by exerting an arch effect or experiencing shear failure. The proposed load-carrying capacity estimation method is applicable to rehabilitated systems with a box or arch-type CSP. Our findings provide guidance for engineers to design similar rehabilitated systems.

Disruption of ecdysis in Leptinotarsa decemlineata by knockdown of chitin deacetylase 1

Jian-Jian Wu,Li-Li Mu,Zhong-Chao Chen,Kai-Yun Fu,Wen-Chao Guo,Chao Li,Guo-Qing Li 한국응용곤충학회 2019 Journal of Asia-Pacific Entomology Vol.22 No.2

Chitin deacetylases (CDAs) catalyze N-deacetylation of chitin, a crucial process for chitin modification. In the present paper, LdCDA1 was identified in Leptinotarsa decemlineata. It was copiously expressed in larval foregut, hindgut and epidermis. Just before the molt in the first, second and third larval instars, the mRNA levels of LdCDA1 were high. In the fourth (final)-instar larvae, a peak occurred 4 days after ecdysis. In vivo results revealed that LdCDA1 transcriptionally responded, positively and negatively respectively, to 20-hydroxyecdysone and juvenile hormone titers. Moreover, knockdown of LdCDA1 significantly reduced foliage consumption, lengthened developing period and prevented growth in the final instar larvae. Three distinct lethal phenotypes were noted in the LdCDA1 RNAi larvae. About 30% of the RNAi larvae became moribund and finally died; approximately 50% of deformed pupae died as pharate adults; and around 20% of LdCDA1 depleted pupae finally emerged as abnormal adults and eventually died within 1 week after emergence. Furthermore, chitin content was low and the mRNA levels of five chitin biosynthesis transcripts (LdUAP1, LdUAP2, LdChSAa, LdChSAb and LdChSB) were significantly declined in the LdCDA1 RNAi larvae. In addition, glucose, trehalose and glycogen contents were increased in the LdCDA1 depleted hypomorphs, along with highly expressed genes coding for trehalose and glycogen synthesis enzymes. The findings provide a compelling piece of evidence that CDA1 is critical for chitin deposition in L. decemlineata. Moreover, LdCDA1 may be a potential target for control of the larvae.

Bronchopulmonary Infection of Lophomonas blattarum

Jian Xue,Ying-Li Li,Xue-Mei Yu,Dai-Kun Li,Ming-Fang Liu,Jing-Fu Qiu,Jian-Jiang Xue 대한기생충학열대의학회 2014 The Korean Journal of Parasitology Vol.52 No.5

Research on the motion characteristics of a trans-media vehicle when entering water obliquely at low speed

Li, Yong-li,Feng, Jin-fu,Hu, Jun-hua,Yang, Jian The Society of Naval Architects of Korea 2018 International Journal of Naval Architecture and Oc Vol.10 No.2

This paper proposes a single control strategy to solve the problem of trans-media vehicle difficult control. The proposed control strategy is just to control the vehicle's air navigation, but not to control the underwater navigation. The hydrodynamic model of a vehicle when entering water obliquely at low speed has been founded to analyze the motion characteristics. Two methods have been used to simulate the vehicle entering water in the same condition: numerical simulation method and theoretical model solving method. And the results of the two methods can validate the hydrodynamic model founded in this paper. The entering water motion in the conditions of different velocity, different angle, and different attack angle has been simulated by this hydrodynamic model and the simulation has been analyzed. And the change rule of the vehicle's gestures and position when entering water has been obtained by analysis. This entering water rule will guide the follow-up of a series of research, such as the underwater navigation, the exiting water process and so on.

Two New Phenolic Compounds from the Fruiting Bodies of Ganoderma tropicum

Hu, Li-Li,Ma, Qing-Yun,Huang, Sheng-Zhuo,Guo, Zhi-Kai,Guo, Jian-Chun,Dai, Hao-Fu,Zhao, You-Xing Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.3

Chemical investigation of the fruiting bodies of Ganoderma tropicum led to the isolation of two new phenolic compounds, ganodermatropins A (1) and B (2). Their structures were elucidated by spectroscopic techniques (MS, 1D and 2D NMR). Ganodermatropin A exhibited antimicrobial activity against Staphylococcus aureus.

Virtual Reality-based Intelligent Table Lamp

Yingjie Fu,Dongjie Li,Jian Song,Yujia Sheng 보안공학연구지원센터 2014 International Journal of Control and Automation Vol.7 No.10

With the development of modern technology, the intelligent household appliances are more and more popular among people. However, now the lamps on the market are mostly ordinary lamps, and they can not meet the requirements of users. Because of that situation, in this paper, an intelligent lamp based on virtual reality and face/book and voice recognition is designed. Firstly, the master control circuit and peripheral functional circuit of the intelligent lamp are designed with the key of ATMEGA2560 micro dips, and the body of the lamp is designed. At the same time, the virtual environment carrying virtual three-dimensional model is developed using Java (based on cell phone) and C++ (based on personal computer). The Open CV algorithms are used to identify images of objects that the intelligent lamp uploads. Users can interact with intelligent lamp between peripheral functional circuit and virtual environment. There are many characteristics of this intelligent lamp, such as, variety of control mode, high intelligent, stable performance, simple operation, high degree of user experience and so on. Users can modify the PC code and add related module at the reserved ports of the lamp to achieve more functions.

Research on the motion characteristics of a trans-media vehicle when entering water obliquely at low speed

Yong-li Li,Jin-fu Feng,Jun-hua Hu,Jian Yang 대한조선학회 2018 International Journal of Naval Architecture and Oc Vol.10 No.2

This paper proposes a single control strategy to solve the problem of trans-media vehicle difficult control. The proposed control strategy is just to control the vehicle's air navigation, but not to control the underwater navigation. The hydrodynamic model of a vehicle when entering water obliquely at low speed has been founded to analyze the motion characteristics. Two methods have been used to simulate the vehicle entering water in the same condition: numerical simulation method and theoretical model solving method. And the results of the two methods can validate the hydrodynamic model founded in this paper. The entering water motion in the conditions of different velocity, different angle, and different attack angle has been simulated by this hydrodynamic model and the simulation has been analyzed. And the change rule of the vehicle's gestures and position when entering water has been obtained by analysis. This entering water rule will guide the follow-up of a series of research, such as the underwater navigation, the exiting water process and so on.

Morphological Factors and Cardiac Doses in Whole Breast Radiation for Left-sided Breast Cancer

Guan, Hui,Dong, Yuan-Li,Ding, Li-Jie,Zhang, Zi-Cheng,Huang, Wei,Liu, Cheng-Xin,Fu, Cheng-Rui,Zhu, Jian,Li, Hong-Sheng,Li, Miao-Miao,Li, Bao-Sheng Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.7

Background: To investigate the impact of the breast size, shape, maximum heart depth (MDH), and chest wall hypotenuse (the distance connecting middle point of the sternum and the length of lung draw on the selected transverse CT slice) on the volumetric dose to heart with whole breast irradiation (WBI) of left-sided breast cancer patients. Materials and Methods: Fifty-three patients with left-sided breast cancer undergoing adjuvant intensity-modulated radiotherapy (IMRT) were enrolled in the study. The primary breast size and shape, MHD and DCWH (chest wall hypotenuse) were contoured on radiotherapy (RT) planning CT slices. The dose data of hearts were obtained from the dose-volume histograms (DVHs). Data were analyzed by one-way analysis of variance (ANOVA), Student's t-test and linear regression analysis. Results: Breast size was independent of heart dose, whereas breast shape, MHD and DCWH were correlated with heart dose. The shapes of breasts were divided into four types, as the flap type, hemisphere type, cone type and pendulous type with heart mean dose being $491.8{\pm}234.6cGy$, $752.7{\pm}219.0cGy$, $620.2{\pm}275.7cGy$, and $666.1{\pm}238.0cGy$, respectively. The flap type of breasts shows a strong statistically reduction in heart dose, compared to others (p=0.008 for V30 of heart). DCWH and MHD were found to be the most important parameters correlating with heart dose in WBI. Conclusions: More attention should be paid to the heart dose of non-flap type patients. The MHD was found to be the most important parameter to correlate with heart dose in tangential WBI, closely followed by the DCWH, which could help radiation oncologists and physicsts evaluate heart dose and design RT plan in advance.