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      • Significance and Application of Digital Breast Tomosynthesis for the BI-RADS Classification of Breast Cancer

        Cai, Si-Qing,Yan, Jian-Xiang,Chen, Qing-Shi,Huang, Mei-Ling,Cai, Dong-Lu Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9

        Background: Full-field digital mammography (FFDM) with dense breasts has a high rate of missed diagnosis, and digital breast tomosynthesis (DBT) could reduce organization overlapping and provide more reliable images for BI-RADS classification. This study aims to explore application of COMBO (FFDM+DBT) for effect and significance of BI-RADS classification of breast cancer. Materials and Methods: In this study, we selected 832 patients who had been treated from May 2013 to November 2013. Classify FFDM and COMBO examination according to BI-RADS separately and compare the differences for glands in the image of the same patient in judgment, mass characteristics display and indirect signs. Employ Paired Wilcoxon rank sum test was used in 79 breast cancer patients to find differences between two examine methods. Results: The results indicated that COMBO pattern is able to observe more details in distribution of glands when estimating content. Paired Wilcoxon rank sum test showed that overall classification level of COMBO is higher significantly compared to FFDM to BI-RADS diagnosis and classification of breast (P<0.05). The area under FFDM ROC curve is 0.805, while that is 0.941 in COMBO pattern. COMBO shows relation of mass with the surrounding tissues, the calcification in the mass, and multiple foci clearly in breast cancer tissues. The optimal sensitivity of cut-off value in COMBO pattern is 82.9%, which is higher than that in FFDM (60%). They share the same specificity which is both 93.2%. Conclusions: Digital Breast Tomosynthesis (DBT) could be used for the BI-RADS classification in breast cancer in clinical.

      • Low Counts of γδ T Cells in Peritumoral Liver Tissue are Related to More Frequent Recurrence in Patients with Hepatocellular Carcinoma after Curative Resection

        Cai, Xiao-Yan,Wang, Jia-Xing,Yi, Yong,He, Hong-Wei,Ni, Xiao-Chun,Zhou, Jian,Cheng, Yun-Feng,Jin, Jian-Jun,Fan, Jia,Qiu, Shuang-Jian Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2

        Objectives: TCR-gamma-delta+T cells (${\gamma}{\delta}$ T cells) are non-conventional T lymphocytes that can recognize and eradicate tumor cells. Our previous studies showed that infiltration and function of ${\gamma}{\delta}$ T cells were substantially attenuated in hepatocellular carcinoma (HCC). However, their prognostic value was not clarified. Methods: The association between ${\gamma}{\delta}$ T cells and the clinical outcomes was determined by immunohistochemistry (IHC) in a HCC patient cohort (n = 342). Results:Immunohistochemistry showed decreased infiltration of ${\gamma}{\delta}$ T cells in tumoral tissues compared with paired peritumoral tissues. The counts of ${\gamma}{\delta}$ T cells in peritumoral tissues were negatively correlated with tumor size (P = 0.005). Survival analysis showed that the levels of peritumoral ${\gamma}{\delta}$T cells were related to both time to recurrence (TTR) and overall survival (OS) (P = 0.010 and P = 0.036, respectively) in univariate analysis, and related to TTR in multivariate analysis (P = 0.014, H.R. [95% CI] = 0.682 [0.502-0.927]). Furthermore, the level of peritumoral ${\gamma}{\delta}$ T cells showed independent prognostic value for TTR in Barcelona Clinic Liver Cancer (BCLC) stage A patients (P = 0.038, H.R. [95% CI] = 0.727 [0.537-0.984]). However, tumoral ${\gamma}{\delta}$ T cells did not show independent prognostic value for either TTR or OS in HCC patients. Conclusions: Low counts of ${\gamma}{\delta}$ T cells in peritumoral liver tissue are related to a higher incidence of recurrence in HCC and can predict postoperative recurrence, especially in those with early-stage HCC.

      • KCI등재

        Allergic Identification for Ginkgo Kernel Protein in Guinea Pigs

        Cai-e Wu,Jian-Ting Yang,Gong-Jian Fan,Ting-Ting Li,Zhen-Xing Tang,Fu-Liang Cao 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.3

        Ginkgo biloba L. can cause allergic reactions when consumed. In this paper, an allergy test to guinea pig was investigated. Guinea pigs were sensitized with 50 mg/mL of ginkgo kernel protein orally on days 1, 3, and 5, and intraperitoneally challenged with 100mg/mL of the protein on day 7 after the last sensitization. The volume of sensitization and challenge was 0.20mL/100 g weight. The results showed the average allergy grade for guinea pigs reached four and the allergy rate was 100%. The immunoglobulin G and E levels in sera were significantly higher than those in the controls. Footpads swelled distinctly, and the passive cutaneous allergy test manifested a positive response. There were inflammatory changes in the lungs and intestines. In conclusion, the present results may indicate that gingko kernel protein has an allergenic capacity.

      • KCI등재

        High alcohol-soluble MoOx gel for interfacial layer in organic solar cells

        Jian Xiong,Zhen He,Shiping Zhan,Bingchu Yang,Xiaowen Zhang,Ping Cai,Cong Xu,Xiaogang Xue,Jian Zhang 한국물리학회 2017 Current Applied Physics Vol.17 No.8

        Water-free solvent soluble, low-temperature processed metal oxides are important for preparing efficient and stable electronic devices, as well as the convenience in simplifying the device production process. Here we reported a facile approach with the features of low-temperature and solution-based process for the formation of a MoOx (s-MoOx) film as interface layer in polymer solar cells (PSCs). The absorbability, elementary composition, electronic property and surface microstructure of the s-MoOx are investigated in detail by ultravioletevisible spectrophotometer (UVevis), X-ray photoelectron spectrometry (XPS), ultraviolet photo-electron spectrometer (UPS) and atomic force microscopy (AFM). These investigations confirmed that such MoOx xerogel has high solubility in the organic alcohol solvents, such as ethanol and methanol. Meanwhile, this s-MoOx can be applied as the interfacial layer in organic solar cells via a low-temperature treatment (about 100 C) due to its proper physical properties, and a power conversion efficiency (PCE) over 3% was achieved. In addition, the devices with s-MoOx shows excellent air-stability, and the PCE efficiency can maintain about 84% of its initial value after 100 h exposure in air, which is dramatically enhanced comparing with the common devices with PEDOT:PSS layer.

      • Young Girl Bra’s Market Research and Product Development Based on Functionality Value Study

        Cai, Jian-mei;Wen, Yingyu;Gan, Wen-yun 한양대학교 2011 韓國 生活 科學 硏究 Vol.31 No.1

        The young girl bra market awaked, it created the industrial value would be unable to estimate. This study sets out to focus on the analysis of young girl bra’s market research and product development based on functionality value. The methodology for this research involves multiple case studies involving girl bra target consumers. Functionality value and related theory guide product development concept as the key point. The research has identified young girl bra market is a size able blank in China. How to guide consumers’consumption awareness correctly by developing the functionality girl bra would be this research’s achievement. The paper linked scientific theory with practical market demand closely, comprehensive analysis of characteristics of adolescent girls in perfect underwear market segment, correct guidance bra consumer market, meet the girl consumer demand, and on the basis of functionality value in girls bra development would better reflected. The observations and analyses of girl bra functionality value would be the core of this paper, which is rarely known by people.

      • KCI등재후보

        Six-party Talks and the Establishment of a Northeast Asian Regional Security Mechanism

        Jian Cai 사단법인 한국평화연구학회 2007 평화학연구 Vol.8 No.2

        This paper examines the likelihood of establishing a Northeast Asian regional security mechanism which based on the successful conclusion of the Six-party talks on the Korean nuclear issues. Firstly, it starts with a brief review on the existing security state of Northeast Asia which points out that the security situations in this area is worse and worse and threatening the peace and stability of Northeast Asia seriously. All the concerned countries recognized the necessity to establish a peace and security mechanism to keep the peace in this area. Secondly, this paper reviews the origin, the process and the achievements of the Six-party Talks so far. According to the reviews the paper concluded that the Six-party talks is the historical choice to solve the Korean nuclear crisis and maybe even the best way to solve the Korean issues. Six-party talks not only emphasizing the concerns of all parties on a nuclear free Korean Peninsula, but also paying more and more attention on establishing a peace and security mechanism in northeast Asia. Thirdly, it continues with a discussion on how far the Six-party talks can go ahead. During the past five years, the contents and topics for discussion of Six-party talks is gradually developed and deepened, at first the six-party talks is just a mechanism for crisis which aimed at DPRK’s nuclear issue, but now it is gradually becoming a multilateral cooperative platform to establish the peace and security mechanism in northeast Asia. But how far can six-party talks go ahead? According to the analysis this paper concluded that though the six-party promoted the process of establishing the peace and security mechanism in northeast Asia and even if it can solving the Korean nuclear crisis successfully at last, we can hardly derive a peace and security mechanism from it. This paper examines the likelihood of establishing a Northeast Asian regional security mechanism which based on the successful conclusion of the Six-party talks on the Korean nuclear issues. Firstly, it starts with a brief review on the existing security state of Northeast Asia which points out that the security situations in this area is worse and worse and threatening the peace and stability of Northeast Asia seriously. All the concerned countries recognized the necessity to establish a peace and security mechanism to keep the peace in this area. Secondly, this paper reviews the origin, the process and the achievements of the Six-party Talks so far. According to the reviews the paper concluded that the Six-party talks is the historical choice to solve the Korean nuclear crisis and maybe even the best way to solve the Korean issues. Six-party talks not only emphasizing the concerns of all parties on a nuclear free Korean Peninsula, but also paying more and more attention on establishing a peace and security mechanism in northeast Asia. Thirdly, it continues with a discussion on how far the Six-party talks can go ahead. During the past five years, the contents and topics for discussion of Six-party talks is gradually developed and deepened, at first the six-party talks is just a mechanism for crisis which aimed at DPRK’s nuclear issue, but now it is gradually becoming a multilateral cooperative platform to establish the peace and security mechanism in northeast Asia. But how far can six-party talks go ahead? According to the analysis this paper concluded that though the six-party promoted the process of establishing the peace and security mechanism in northeast Asia and even if it can solving the Korean nuclear crisis successfully at last, we can hardly derive a peace and security mechanism from it.

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