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Ji Yeon Kim,Jin Soo Kim,Moo Jun Baek,Chang Nam Kim,Won Jun Choi,Dong Kook Park,Hwan Namgung,Sang Chul Lee,Sang-Jeon Lee 대한외과학회 2013 Annals of Surgical Treatment and Research(ASRT) Vol.85 No.4
Purpose: This study evaluated the efficacy of neoadjuvant chemotherapy combining 5-flurouracil/folinic acid with irinotecan (FOLFIRI) in colorectal multiple liver metastases regardless of resectability. Methods: Forty-four patients with multiple (at least two) colorectal liver metastases were enrolled at seven tertiary referral hospitals between May 2007 and September 2010. All patients received the FOLFIRI chemotherapeutic regimen. Response to chemotherapy was assessed after three cycles (6 weeks) and once more after six cycles (12 weeks) of treatment. Results: Objective response was noted in 27 patients (61.4%) and 4 patients (9.1%) had progressive disease. Of 44 patients, 10 patients (22.7%) underwent curative surgery (R0 resection) and 34 patients did not receive R0 resection. Grades 3 to 4 hematological toxicity was noted in 12 patients (27.3%) and grades 3 to 4 nonhematologic toxicity was identified in 5 patients (11.4%). Conclusion: FOLFIRI chemotherapy as a neoadjuvant chemotherapy for multiple colorectal liver metastases regardless of resectability demonstrated the possibility of R0 resection, high rate of objective response, and tolerable toxicities in this study.
( Baek Gyu Jun ),( Young Don Kim ),( Gab Jin Cheon ),( Jeong-ju Yoo ),( Sang Gyune Kim ),( Young Seok Kim ),( Soung Won Jeong ),( Jae Young Jang ),( Ji Hye Lee ),( Hong Soo Kim ),( Sae Hwan Lee ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: It remains uncertain whether antiviral treatment improve surivival in hepatitis B virus (HBV)-hepatocellular carcinoma (HCC) patients receiving palliative therapy. The purpose of this study is to evaluate the role of antiviral therapy in HBV-HCC patients after diagnosis of HCC. Methods: This retrospective study analyzed 113 HBV-HCC patients who underwent transarterial chemoembolization (TACE) in two university hospital. Overall survival (OS) was compared in patients treated with/without antiviral treatment after diagnosis of HCC. Subgroup analysis and Cox regression analysis were performed to determine the efficiency of antiviral treatment and prognostic factors for OS. Results: OS was not different between the patients treated with antiviral treatment (n = 67) and the patients who received no antiviral treatment (n = 46) (P=0.103). Barcelona Clinic Liver Cancer (BCLC) was independent prognostic factors for OS of HBV-related HCC patients who were treated with TACE. By subgroup analysis, antiviral therapy achieved better survival improvement in BCLC stage B and C (P<0.001) but had no survival improvement in BCLC stage 0 and A (P=0.605). Antiviral therapy was one of the independent prognostic factors for patients with BCLC stage B and C (HR 0.230, 95% CI 0.094-0.565, P=0.001). Conclusions: Antiviral therapy did not improve survival of HBV-related HCC patients treated with TACE. However, antiviral therapy shows survival benefit only in BCLC stage B and C disease.
Photocatalytic degradation of azo dye using TiO2 supported on spherical activated carbon
Ji-Won Yoon,서정권,Mi-Hwa Baek,Ji-Sook Hong,Chang-Yong Lee 한국화학공학회 2012 Korean Journal of Chemical Engineering Vol.29 No.12
TiO2 supported on spherical activated carbon (TiO2/SAC) was prepared through an ion-exchange method followed by a heat-treatment process. The adsorption characteristic of TiO2/SAC was evaluated using azo dye methyl orange (MO) as a target substance, and the photocatalytic degradation of MO under UV irradiation was also discussed. A synergistic effect of both the adsorption capacity of activated carbon and the photoactivity of TiO2 on the removal of MO from aqueous solution was observed. Experimental results revealed that the photocatalytic degradation of MO improved with increasing photocatalyst dosage and followed a pseudo-first order kinetic. After five-cycle runs, TiO2/SAC still exhibited relatively high photocatalytic characteristic for the degradation of MO. Besides, the prepared TiO2/SAC can be helpful in the easy separation of photocatalyst from solution after photocatalysis of MO. Furthermore,the use of liquid chromatography/mass spectrometry (LC/MS) technique, identified three intermediates as degradation products during the photocatalytic reaction of MO with TiO2/SAC.
( Ji Soo Kim ),( Won Kon Kim ),( Kyoung-jin Oh ),( Eun-woo Lee ),( Baek Soo Han ),( Sang Chul Lee ),( Kwang-hee Bae ) 한국미생물생명공학회(구 한국산업미생물학회) 2019 Journal of microbiology and biotechnology Vol.29 No.4
Brown adipocytes have an important role in the regulation of energy balance through uncoupling protein-1 (UCP-1)-mediated nonshivering thermogenesis. Although brown adipocytes have been highlighted as a new therapeutic target for the treatment of metabolic diseases, such as obesity and type II diabetes in adult humans, the molecular mechanism underlying brown adipogenesis is not fully understood. We recently found that protein tyrosine phosphatase receptor type B (PTPRB) expression dramatically decreased during brown adipogenic differentiation. In this study, we investigated the functional roles of PTPRB and its regulatory mechanism during brown adipocyte differentiation. Ectopic expression of PTPRB led to a reduced brown adipocyte differentiation by suppressing the tyrosine phosphorylation of VEGFR2, whereas a catalytic inactive PTPRB mutant showed no effects on differentiation and phosphorylation. Consistently, the expression of brown adipocyte-related genes, such as UCP-1, PGC-1α, PRDM16, PPAR-γ, and CIDEA, were significantly inhibited by PTPRB overexpression. Overall, these results suggest that PTPRB functions as a negative regulator of brown adipocyte differentiation through its phosphatase activity-dependent mechanism and may be used as a target protein for the regulation of obesity and type II diabetes.
Synthesis of SnS Thin Films by Atomic Layer Deposition at Low Temperatures
Baek, In-Hwan,Pyeon, Jung Joon,Song, Young Geun,Chung, Taek-Mo,Kim, Hae-Ryoung,Baek, Seung-Hyub,Kim, Jin-Sang,Kang, Chong-Yun,Choi, Ji-Won,Hwang, Cheol Seong,Han, Jeong Hwan,Kim, Seong Keun American Chemical Society 2017 Chemistry of materials Vol.29 No.19
<P>Two-dimensional (2-D) metal chalcogenides have received great attention because of their unique properties, which are different from bulk materials. A challenge in implementing 2-D metal chalcogenides in emerging devices is to prepare a well-crystallized layer over large areas at temperatures compatible with current fabrication processes. Tin monosulfide, a <I>p</I>-type layered semiconductor with a high hole mobility, is a promising candidate for realizing large-area growth at low temperatures because of its low melting point. However, tin sulfides exist in two notable crystalline phases, SnS and SnS<SUB>2</SUB>. Therefore, it is imperative to control the oxidation state of Sn to achieve a pure SnS film. Here, the synthesis of SnS thin films by atomic-layer-deposition (ALD) is demonstrated using bis(1-dimethylamino-2-methyl-2-propoxy)tin(II) and H<SUB>2</SUB>S as Sn and S sources, respectively, over a wide temperature window (90–240 °C). Impurities such as carbon, oxygen, and nitrogen were negligibly detected. The morphological evolution of plate-like orthorhombic SnS grains was observed above 210 °C. Moreover, properties of thin film transistors and gas sensors using SnS films as the active layers were investigated. The SnS ALD process would provide promising opportunities to exploit the intriguing properties of the 2-D metal chalcogenides for realizing emerging electronic devices.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/cmatex/2017/cmatex.2017.29.issue-19/acs.chemmater.7b01856/production/images/medium/cm-2017-018563_0010.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cm7b01856'>ACS Electronic Supporting Info</A></P>
Large Dose Dexmedetomidine in a Patient during Sedation for Invasive Oral Procedure
Baek, In Yeob,Yoon, JiUk,Kim, Nam Won,Ri, Hyun Su,Kim, Cheul Hong,Yoon, Ji Young The Korean Dental Society of Anesthsiology 2012 Journal of Dental Anesthesia and Pain Medicine Vol.12 No.3
Certain oral procedures require a sedated patient who is responsive to allow for the mouth opening and position change. Dexmedetomidine is a relatively selective alpha2-adrenoceptor agonist with sedative, analgesic, amnestic, and anesthetic-sparing effects. Large dose dexmedetomidine is suitable as a single agent for sedation and anxiolysis for plate removal in a patient with bilateral sagittal split osteotomy and Lefort 1 osteotomy with genioplasty.
Ji-Sook Kong,Jiseon Lee,Youngjun Kim,Hye Won Woo,Min-Ho Shin,Sang Baek Koh,Hyeon Chang Kim,Yu-Mi Kim,Mi Kyung Kim 한국역학회 2023 Epidemiology and Health Vol.45 No.-
OBJECTIVES: Limited and inconsistent prospective evidence exists regarding the relationship of dietary total antioxidant capacity (dTAC) and antioxidant intake with metabolic syndrome (MetS) risk. We evaluated the associations of the cumulative averages of dTAC and antioxidant intake (in 5 classes: retinol, vitamin C, vitamin E, carotenoids, and flavonoids, as well as 7 flavonoid subclasses) with the risk of MetS. METHODS: This study included 11,379 participants without MetS, drawn from the Korean Genome and Epidemiology Study_CArdioVascular disease Association Study (KoGES_CAVAS). The cumulative average consumption was calculated using repeated food frequency questionnaires. Incidence rate ratios were estimated using a modified Poisson regression model with a robust error estimator. RESULTS: The median follow-up period was 5.16 years, and 2,416 cases of MetS were recorded over 58,750 person-years. In men, significant inverse associations were observed in all 5 antioxidant classes, except for the highest quartile of dTAC. In women, dTAC and total flavonoids were not significantly associated with MetS; however, significant L-shaped associations were found for the remaining 4 antioxidant classes. Of the 7 flavonoid subclasses, only flavones in the highest quartile for men and flavan-3-ols in women lacked significant associations with MetS. The inverse associations were not sex-specific, but they were particularly pronounced among participants with a body mass index (BMI) of 23 kg/m2 or higher. CONCLUSIONS: The findings suggest that most antioxidant classes and flavonoid subclasses, unlike dTAC, exhibit a clear beneficial association with MetS in an L-shaped pattern in both men and women, particularly those with a high BMI.
Baek, Seung Hyun,Park, So Jung,Jeong, Jae In,Kim, Sung Hyun,Han, Jihoon,Kyung, Jae Won,Baik, Sang-Ha,Choi, Yuri,Choi, Bo Youn,Park, Jin Su,Bahn, Gahee,Shin, Ji Hyun,Jo, Doo Sin,Lee, Joo-Yong,Jang, Cho Society for Neuroscience 2017 The Journal of neuroscience Vol.37 No.20
<P>Excessive mitochondrial fission is a prominent early event and contributes to mitochondrial dysfunction, synaptic failure, and neuronal cell death in the progression of Alzheimer's disease (AD). However, it remains to be determined whether inhibition of excessive mitochondrial fission is beneficial in mammal models of AD. To determine whether dynamin-related protein 1 (Drp1), a key regulator of mitochondrial fragmentation, can be a disease-modifying therapeutic target for AD, we examined the effects of Drp1 inhibitor on mitochondrial and synaptic dysfunctions induced by oligomeric amyloid-beta(A beta) in neurons and neuropathology and cognitive functions in A beta precursor protein/presenilin 1 double-transgenic AD mice. Inhibition of Drp1 alleviates mitochondrial fragmentation, loss of mitochondrial membrane potential, reactive oxygen species production, ATP reduction, and synaptic depression in A beta-treated neurons. Furthermore, Drp1 inhibition significantly improves learning and memory and prevents mitochondrial fragmentation, lipid peroxidation, BACE1 expression, and A beta deposition in the brain in the AD model. These results provide evidence that Drp1 plays an important role in A beta-mediated and AD-related neuropathology and in cognitive decline in an AD animal model. Therefore, inhibiting excessive Drp1-mediated mitochondrial fission may be an efficient therapeutic avenue for AD.</P>