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Bayesian estimation of median household income for small areas with some longitudinal pattern
Lee, Jayoun,Kim, Dal Ho The Korean Data and Information Science Society 2015 한국데이터정보과학회지 Vol.26 No.3
One of the main objectives of the U.S. Census Bureau is the proper estimation of median household income for small areas. These estimates have an important role in the formulation of various governmental decisions and policies. Since direct survey estimates are available annually for each state or county, it is desirable to exploit the longitudinal trend in income observations in the estimation procedure. In this study, we consider Fay-Herriot type small area models which include time-specific random effect to accommodate any unspecified time varying income pattern. Analysis is carried out in a hierarchical Bayesian framework using Markov chain Monte Carlo methodology. We have evaluated our estimates by comparing those with the corresponding census estimates of 1999 using some commonly used comparison measures. It turns out that among three types of time-specific random effects the small area model with a time series random walk component provides estimates which are superior to both direct estimates and the Census Bureau estimates.
Park, Hyunkyung,Lee, Yoo Jin,Shin, Sang-Jin,Lee, Jayoun,Park, Silvia,Kim, Inho,Moon, Joon-ho,Lee, Hyewon,Jang, Jun Ho,Yoon, Sung-Soo,Koh, Youngil Elsevier 2018 Leukemia research Vol.69 No.-
<P><B>Abstract</B></P> <P>A substantial proportion of patients requiring allogeneic stem cell transplantation (alloSCT) do not have a human leukocyte antigen-matched sibling donor and need an alternative donor. In this multicenter retrospective study, we compared the outcomes of 176 patients with myelodysplastic syndrome and acute leukemia undergoing alloSCT from haploidentical (<I>n</I> = 121) and international (<I>n</I> = 55) donors between 2002 and 2016. For recipients of haploidentical and international donors, the 2-year overall survival rates were 33.4% and 35.3%, respectively (<I>P</I> = 0.347), and relapse-free survival rates were 31.7% and 34.4% (<I>P</I> = 0.264), respectively. In addition, there were no significant differences in the cumulative incidences of acute and chronic graft versus host disease or incidences of infection within 30 days (all <I>P ></I> 0.05). Similarly, there were no significant differences in these measures for acute leukemia patients (<I>n</I> = 143; all <I>P ></I> 0.05). A multivariate analysis revealed that the donor type was not an independent prognostic or predictive factor. These data suggest that both haploidentical and international donors are feasible alternative sources for alloSCT when a matched donor is not available domestically.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Haploidentical and international donor recipients have similar survival rates. </LI> <LI> Transplant-related complications occur similarly with both donor types. </LI> <LI> Both donor types are alternatives if a matched donor is not available domestically. </LI> </UL> </P>
Joint Identification of Genetic Variants for Physical Activity in Korean Population
Kim, Jayoun,Kim, Jaehee,Min, Haesook,Oh, Sohee,Kim, Yeonjung,Lee, Andy H.,Park, Taesung MDPI 2014 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.15 No.7
<P>There has been limited research on genome-wide association with physical activity (PA). This study ascertained genetic associations between PA and 344,893 single nucleotide polymorphism (SNP) markers in 8842 Korean samples. PA data were obtained from a validated questionnaire that included information on PA intensity and duration. Metabolic equivalent of tasks were calculated to estimate the total daily PA level for each individual. In addition to single- and multiple-SNP association tests, a pathway enrichment analysis was performed to identify the biological significance of SNP markers. Although no significant SNP was found at genome-wide significance level via single-SNP association tests, 59 genetic variants mapped to 76 genes were identified via a multiple SNP approach using a bootstrap selection stability measure. Pathway analysis for these 59 variants showed that maturity onset diabetes of the young (MODY) was enriched. Joint identification of SNPs could enable the identification of multiple SNPs with good predictive power for PA and a pathway enriched for PA.</P>
이자연,김달호,Lee, Jayoun,Kim, Dal Ho 한국통계학회 2015 응용통계연구 Vol.28 No.2
한국의 고령화는 매우 빠른 속도로 진행되고 있고, 노인자살은 노인의 주요 사망원인이며 노인은 다른 연력층보다 자살의 고위험군으로 알려져있다. 고령화 시대에서 노인의 자살은 사회적인 문제로 대두되고 있으며 이를 예방하기 위해 노인자살에 대한 위험요인을 파악하고, 지역적 차이를 확인하는 것이 중요하다. 특히 노인의 자살문제에서는 지역사회와의 통합결여 등이 큰 원인으로 고려되기 때문이다. 따라서, 본 논문에서는 공간적 상관관계를 고려하여 추정된 표준화사망률을 이용하여 질병지도를 작성하고자 하였다. 공간적 상관관계를 고려하기 위해서 simultaneous CAR model을 사용하였다. 2006년부터 2010년까지 통계청 사망자료를 이용하여 국내 시군구별 노인자살자수에 대해 두 모형을 적합시켜본 결과, 공간적 상관관계를 고려하지 않은 모형보다 공간적 상관관계를 고려한 모형이 더 좋은 모형임을 보였다. 또한 효율적인 베이지안 추론을 위해 격자망 방법 등을 고려하였다. Elderly suicide rates tend to be high in Korea. Suicide by the elderly is no longer a personal problem; consequently, further research on risk and regional factors is necessary. Disease mapping in epidemiology estimates spatial patterns for disease risk over a geographical region. In this study, we use a simultaneous conditional autoregressive model for spatial correlations between neighboring areas to estimate standard mortality ratios and mapping. The method is illustrated with cause of death data from 2006 and 2010 to analyze regional patterns of elderly suicide in Korea. By considering spatial correlations, the Bayesian spatial models, mean educational attainment and percentage of the elderly who live alone was the significant regional characteristic for elderly suicide. Gibbs sampling and grid method are used for computation.
Byun, Ja Min,Lee, Jayoun,Shin, Sang-Jin,Kang, Minjoo,Yoon, Sung-Soo,Koh, Youngil Korean Society of Hematology; Korean Society of Bl 2018 Blood Research Vol.53 No.2
<P><B>Background</B></P><P>High-dose melphalan (HDMEL) represents the standard conditioning regimen before autologous stem cell transplant (ASCT) in multiple myeloma (MM), but recent updates have suggested combination of melphalan with bulsulfan (BUMEL) is also associated with favorable outcomes. We performed the current study to address the lack of comparative studies between the two conditioning regimens in Asian populations.</P><P><B>Methods</B></P><P>Using the Korean National Health Insurance and Korean Health Insurance Review and Assessment Service databases, 1,304 patients newly diagnosed with MM undergoing ASCT between January 2010 and December 2014 were identified. Patients were divided according to conditioning regimen (HDMEL vs. BUMEL), and after case matching, 428 patients undergoing HDMEL conditioning were compared to 107 patients undergoing BUMEL conditioning with respect to clinical course and treatment outcomes.</P><P><B>Results</B></P><P>The 3-year progression-free survival (PFS) was 52.5% for the HDMEL conditioning group versus 70.3% for the BUMEL conditioning group (<I>P</I>=0.043). The 3-year overall survival (OS) was 82.0% versus 83.5% (<I>P</I>=0.525), respectively. Although not statistically significant, BUMEL conditioning was associated with more platelet transfusion, while HDMEL was associated with more granulocyte colony stimulating factor support. In multivariate analysis, BUMEL conditioning was not inferior to HDMEL conditioning in regard to both PFS and OS.</P><P><B>Conclusion</B></P><P>Our study confirmed that BUMEL is an effective and well-tolerated alternative to HDMEL conditioning, with better PFS.</P>
The Impact of National Surveillance for Liver Cancer: Results from Real-World Setting in Korea
Jin Won Kwon,Ha Jin Tchoe,Jayoun Lee,Jae Kyung Suh,Jeong-Hoon Lee,Sangjin Shin 거트앤리버 소화기연관학회협의회 2020 Gut and Liver Vol.14 No.1
Background/Aims: The National Liver Cancer Surveillance Program (NLCSP) was established in 2003 to reduce the socioeconomic burden imposed by liver cancer (LC). We aimed to investigate the effectiveness of the NLCSP in South Korea with respect to survival benefits and cost, after adjusting for various confounding factors. Methods: We used the National Health Insurance Service claims data linked with the NLCSP from 2004 to 2015. The Cox proportional hazard model and generalized linear model were used to determine the effects of the NLCSP on the early detection of LC, survival, and medical costs. Results: From 2006 to 2010, 66,632 patients (surveillance group: 10,527 and no surveillance group: 56,105) newly diagnosed with LC were included in the study. The odds of the early detection of LC was 1.82 (95% confidence interval [CI], 1.73 to 1.93) times higher among patients who participated in the NLCSP once within the 2-year period prior to the diagnosis of LC than among those who did not participate in the surveillance program. The mortality rate of patients who participated in the NLCSP was 22.0% lower (hazard ratio, 0.78; 95% CI, 0.76 to 0.80) than that of those who did not participate. When compared with the group who did not participate in surveillance, the group who participated in the NLCSP had higher total medical costs; however, their cost per day was lower after adjustment during the follow-up period. Conclusions: This study highlights the survival benefit in patients who participated in the NLCSP and the need for continuous improvements of the NLCSP in South Korea.