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Jang, Jun-Pil,Hwang, Gwi Ja,Kwon, Min Cheol,Ryoo, In-Ja,Jang, Mina,Takahashi, Shunji,Ko, Sung-Kyun,Osada, Hiroyuki,Jang, Jae-Hyuk,Ahn, Jong Seog American Chemical Society and American Society of 2018 Journal of natural products Vol.81 No.4
<P>Two new cyclic peptides, pentaminomycins A (<B>1</B>) and B (<B>2</B>), were isolated from cultures of <I>Streptomyces</I> sp. RK88-1441. Based on the interpretation of the NMR, UV, IR, and MS data, the planar structures of <B>1</B> and <B>2</B> were elucidated as cyclic pentapeptides with a modified amino acid residue, <I>N</I><SUP>5</SUP>-hydroxyarginine (N5-OH-Arg). The absolute configurations of the constituent amino acid residues were determined by the advanced Marfey’s method. Localization of <SMALL>L</SMALL>- and <SMALL>D</SMALL>-amino acids in the sequence was ascertained by chiral analysis of the fragment peptide obtained from a partial hydrolysate; amino acids were identified by LC-MS. Pentaminomycin A (<B>1</B>) reduced α-MSH-stimulated melanin synthesis by suppressing the expression of melanogenic enzymes including tyrosinase, tyrosinase-related protein-1 (TRP-1), and tyrosinase-related protein-2 (TRP-2).</P> [FIG OMISSION]</BR>
Jang, Jun-Pil,Hwang, Gwi Ja,Jang, Mina,Takahashi, Shunji,Ko, Sung-Kyun,Osada, Hiroyuki,Jang, Jae-Hyuk,Ahn, Jong Seog American Chemical Society and American Society of 2018 Journal of natural products Vol.81 No.9
<P>A chemical investigation of a culture extract from a soil-derived <I>Streptomyces</I> sp. RK88-1441 led to the isolation and characterization of two new glycosylated anthraquinones, aturanosides A (<B>1</B>) and B (<B>2</B>), and a new anthraquinone derivative, aturanocin (<B>3</B>). The structures of these compounds were elucidated by detailed NMR and MS spectroscopic analyses. The absolute configurations of the sugar units, based on the magnitudes of the coupling constants, ROESY correlations, and chemical derivatization, from <B>1</B> and <B>2</B> are 6-<I>O</I>-[<I>N</I>-acetyl-α-<SMALL>D</SMALL>-glucosamino-(1→2)-α-<SMALL>L</SMALL>-rhamnoside] and 6-<I>O</I>-α-<SMALL>L</SMALL>-rhamnoside, respectively. Compounds <B>1</B> and <B>2</B> showed no cytotoxicity against human umbilical vein endothelial cells (HUVECs), but significantly suppressed vascular endothelial growth factor (VEGF)-induced tube formation and invasion of HUVECs. The down-regulation of both the phosphorylation of VEGF receptor 2 and the expression of vascular endothelial cadherin at the protein level were also observed.</P> [FIG OMISSION]</BR>
Evidence for a role of CaMKIV in the development of opioid analgesic tolerance
Ko, Shanelle W.,Jia, Yongheng,Xu, Hui,Yim, Se-Jeong,Jang, Dong-Hyuk,Lee, Yong-Seok,Zhao, Ming-Gao,Toyoda, Hiroki,Wu, Long-Jun,Chatila, Talal,Kaang, Bong-Kiun,Zhuo, Min Blackwell Publishing Ltd 2006 The European journal of neuroscience Vol.23 No.8
<P>Abstract</P><P>cAMP response-element binding protein (CREB), a transcription factor involved in learning, memory and drug addiction, is phosphorylated by calcium–calmodulin-dependent protein kinase IV (CaMKIV). Here, we show that CaMKIV-knockout (KO) mice developed less analgesic tolerance after chronic morphine administration with no alteration in physical dependence or acute morphine-induced analgesia. The increase in phosphorylated CREB expression observed in wild-type mice after chronic morphine was absent in CaMKIV-KO mice, while there was no difference in the expression or phosphorylation of the µ-opioid receptor between groups. Morphine-treated CaMKIV-KO mice showed less G-protein uncoupling from the µ-opioid receptor than did wild-type mice, while uncoupling was similar in control wild-type and KO mice. In addition, morphine reduced inhibitory transmission to a greater degree in CaMKIV-KO mice than in controls after chronic morphine exposure. Our results provide novel evidence for the role of CaMKIV in the development of opioid analgesic tolerance but not physical dependence.</P>
Ik Jang Ko,Jin Hwan Park,Gyeong Woo Kim,Raju Lampande,Jang Hyuk Kwon 한국정보디스플레이학회 2019 Journal of information display Vol.20 No.3
In this paper, we report a full-color reflective display device by combining reflective electrochromic device (ECD) and different color production units (conventional color filter (CF) and transmittance controllable electrochromic color filter (TCECF)). A full-color reflective device with TCECF showed an excellent diffuse reflectance of 47.2% in the white state owing to the high transmittance of TCECF in the bleached state than that of CF (19.5%). This device structure can easily provide various colors with high brightness and saturation with a broad grayscale. Particularly, in the colored state, TCECF and CF-based full-color reflective device displayed color coordinates of (0.59, 0.34), (0.31, 0.66), (0.24, 0.30) and (0.65, 0.33), (0.27, 0.61), (0.15, 0.06), for red, green and blue, respectively, and alongside also exhibited color gamut of 36.8% (for TCECF) and 73.1% (for CF) for full color reflective devices.
RK-270D and E, Oxindole Derivatives from Streptomyces sp. with Anti-Angiogenic Activity
( Jun-pil Jang ),( Mina Jang ),( Toshihiko Nogawa ),( Shunji Takahashi ),( Hiroyuki Osada ),( Jong Seog Ahn ),( Sung-kyun Ko ),( Jae-hyuk Jang ) 한국미생물 · 생명공학회 2022 Journal of microbiology and biotechnology Vol.32 No.3
A chemical investigation of a culture extract from Streptomyces sp. RK85-270 led to the isolation and characterization of two new oxindoles, RK-270D (1) and E (2). The structures of 1 and 2 were determined by analyzing spectroscopic and spectrometric data from 1D and 2D NMR and High-resolution electrospray ionization mass spectrometry (HRESIMS) experiments. Compound 1 exhibited anti-angiogenic activities against human umbilical vein endothelial cells (HUVECs) without cytotoxicity. Results of Western blot analysis revealed that 1 inhibits VEGF-induced angiogenesis in the HUVECs via VEGFR2/ p38 MAPK-mediated pathway.
Jang, Jung Eun,Ko, Myoung Seok,Yun, Ji-Young,Kim, Mi-Ok,Kim, Jin Hee,Park, Hye Sun,Kim, Ah-Ram,Kim, Hyuk-Joong,Kim, Bum Joong,Ahn, Young Eun,Oh, Jin Sun,Lee, Woo Je,Harris, Robert A.,Koh, Eun Hee,Lee, American Diabetes Association 2016 Diabetes Vol. No.
<P>Fibrosis of adipose tissue induces ectopic fat accumulation and insulin resistance by inhibiting adipose tissue expandability. Mechanisms responsible for the induction of adipose tissue fibrosis may provide therapeutic targets but are poorly understood. In this study, high-fat diet (HFD)-fed wild-type (WT) and iNOS(-/-) mice were used to examine the relationship between nitric oxide (NO) produced by macrophages and adipose tissue fibrosis. In contrast to WT mice, iNOS(-/-) mice fed an HFD were protected from infiltration of proinflammatory macrophages and adipose tissue fibrosis. Hypoxia-inducible factor 1 alpha (HIF-1 alpha) protein level was increased in adipose tissue of HFD-fed WT mice, but not iNOS(-/-) mice. In contrast, the expression of mitochondrial biogenesis factors was decreased in HFD-fed WT mice, but not iNOS(-)/(-) mice. In studies with cultured cells, macrophage-derived NO decreased the expression of mitochondrial biogenesis factors, and increased HIF-1 alpha protein level, DNA damage, and phosphorylated p53 in preadipocytes. By activating p53 signaling, NO suppressed peroxisome proliferator-activated receptor gamma coactivator is expression, which induced mitochondrial dysfunction and inhibited preadipocyte differentiation in adipocytes. The effects of NO were blocked by rosiglitazone. The findings suggest that NO produced by macrophages induces mitochondrial dysfunction in preadipocytes by activating p53 signaling, which in turn increases HIF-1 alpha protein level and promotes a profibrogenic response in preadipocytes that results in adipose tissue fibrosis.</P>
Ko Byuk Sung,Ryoo Seung Mok,Han Eunah,Chang Hyunglan,Yune Chang June,Lee Hui Jai,Suh Gil Joon,Choi Sung-Hyuk,Chung Sung Phil,Lim Tae Ho,Kim Won Young,Sohn Jang Won,Jeong Mi Ae,Hwang Sung Yeon,Shin Tae 대한의학회 2023 Journal of Korean medical science Vol.38 No.50
Background: There is a need to update the cardiovascular (CV) Sequential Organ Failure Assessment (SOFA) score to reflect the current practice in sepsis. We previously proposed the modified CV SOFA score from data on blood pressure, norepinephrine equivalent dose, and lactate as gathered from emergency departments. In this study, we externally validated the modified CV SOFA score in multicenter intensive care unit (ICU) patients. Methods: A multicenter retrospective observational study was conducted on ICU patients at six hospitals in Korea. We included adult patients with sepsis who were admitted to ICUs. We compared the prognostic performance of the modified CV/total SOFA score and the original CV/total SOFA score in predicting 28-day mortality. Discrimination and calibration were evaluated using the area under the receiver operating characteristic curve (AUROC) and the calibration curve, respectively. Results: We analyzed 1,015 ICU patients with sepsis. In overall patients, the 28-day mortality rate was 31.2%. The predictive validity of the modified CV SOFA (AUROC, 0.712; 95% confidence interval [CI], 0.677–0.746; P < 0.001) was significantly higher than that of the original CV SOFA (AUROC, 0.644; 95% CI, 0.611–0.677). The predictive validity of modified total SOFA score for 28-day mortality was significantly higher than that of the original total SOFA (AUROC, 0.747 vs. 0.730; 95% CI, 0.715–0.779; P = 0.002). The calibration curve of the original CV SOFA for 28-day mortality showed poor calibration. In contrast, the calibration curve of the modified CV SOFA for 28-day mortality showed good calibration. Conclusion: In patients with sepsis in the ICU, the modified SOFA score performed better than the original SOFA score in predicting 28-day mortality.
Development of Vitamin D Determination in Infant Formula by Column-Switching HPLC with UV Detector
Ko, Jin-Hyouk,Kwak, Byung-Man,Ahn, Jang-Hyuk,Shim, Sung-Lye,Kim, Kyong-Su,Yoon, Tae-Hyung,Leem, Dong-Gil,Jeong, Ja-Young Korean Society for Food Science of Animal Resource 2012 한국축산식품학회지 Vol.32 No.5
This study was carried out to develop an analytical method for the determination of vitamin D in infant formula. Vitamin D was determined by column-switching high-performance liquid chromatography (HPLC) equipped with a reversed phase column and UV detector after saponification and extraction of the formula with an organic solvent. A preseparation column ($C_8$), focusing column ($C_{18}$), analytical column ($C_{18}$) and UV-Vis detector (254 nm) were used. The limits of detection (LOD) and the limits of quantification (LOQ) for vitamin D were estimated to be $1.51{\mu}g/kg$ and $4.95{\mu}g/kg$, respectively. The linearity, recovery, precision and accuracy of the analytical method for vitamin D were evaluated through the application of a SRM (Standard Reference Material) 1846 (National Institute of Standard & Technology, USA). The linearity of this method was calculated with a value of the coefficient of determination ($r^2$) ${\geq}0.9999$. The recovery of vitamin D was $85.20{\pm}3.00%$. The intra-assay precision for vitamin D was between $1.68{\pm}0.03%$ and $5.75{\pm}0.33%$, and the inter-assay precision for vitamin D ranged from $1.73{\pm}0.03%$ to $2.96{\pm}0.09%$. The intra-assay accuracy for vitamin D was between $100.03{\pm}2.77%$ and $102.01{\pm}0.59%$, and the inter-assay accuracy for vitamin D ranged from $99.00{\pm}1.53%$ to $102.01{\pm}3.04%$. The proposed method is optimal for the separation and quantification of vitamin D from infant formula.