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Jang, Ki-ryong,Park, Ji-Won,Nam, Kiseok 대한물리치료학회 2020 대한물리치료학회지 Vol.32 No.2
Purpose: Some patients who have undergone surgery due to lumbar disc herniation still complain of leg pain and other abnormal sensations. Therefore, the study examined the effects of the neurodynamics on pain and other abnormal nerve sensations in post-operated patients with lumbar disc herniation. Methods: The participants of this study comprised 20 adults (10 males and 10 females) who were diagnosed with lumbar disc herniation. The subjects were classified into two groups of 10 patients each in the lower extremity neurodynamics (LEN) and lumbar stabilization exercise (LSE) groups. Each intervention was applied twice a day for one week and was composed of two different exercise patterns; one was applied by a therapist, and the other was performed by the patients themselves. The data were analyzed using assessment methods of Digital Infrared Thermal Imaging (DITI), Toronto clinical neuropathy scoring system (TCNSS), Sympathetic Skin Response (SSR) test, and Oswestry Disability Index (ODI) scale. Results: Significant differences in TCNSS, DITI, ODI scale were observed between the LEN and LSE group (p<0.01). On the other hand, there was no significant difference in the SSR test between pre and post-treatment (p>0.05). Conclusion: The results indicated that neurodynamics treatment is effective in pain reduction and abnormal sensations, such as leg muscle cramps, in post-operated patients with lumbar disc herniation.
( Ki-ryong Jang ),( Ji-won Park ),( Kiseok Nam ) 대한물리치료학회 2020 대한물리치료학회지 Vol.32 No.2
Purpose: Some patients who have undergone surgery due to lumbar disc herniation still complain of leg pain and other abnormal sensations. Therefore, the study examined the effects of the neurodynamics on pain and other abnormal nerve sensations in post-operated patients with lumbar disc herniation. Methods: The participants of this study comprised 20 adults (10 males and 10 females) who were diagnosed with lumbar disc herniation. The subjects were classified into two groups of 10 patients each in the lower extremity neurodynamics (LEN) and lumbar stabilization exercise (LSE) groups. Each intervention was applied twice a day for one week and was composed of two different exercise patterns; one was applied by a therapist, and the other was performed by the patients themselves. The data were analyzed using assessment methods of Digital Infrared Thermal Imaging (DITI), Toronto clinical neuropathy scoring system (TCNSS), Sympathetic Skin Response (SSR) test, and Oswestry Disability Index (ODI) scale. Results: Significant differences in TCNSS, DITI, ODI scale were observed between the LEN and LSE group (p<0.01). On the other hand, there was no significant difference in the SSR test between pre and post-treatment (p>0.05). Conclusion: The results indicated that neurodynamics treatment is effective in pain reduction and abnormal sensations, such as leg muscle cramps, in post-operated patients with lumbar disc herniation.
Yun Kyung Jung,Kiseok Jang,Seung Sam Paik,Yong Jin Kwon,Han Jun Kim,Kyeong Geun Lee,Hwon Kyum Park,Dongho Choi 대한외과학회 2016 Annals of Surgical Treatment and Research(ASRT) Vol.91 No.1
Purpose: Previous studies have shown the role of Sal-like protein 4 (SALL4) as a biomarker in hepatocellular carcinoma (HCC), and some studies have shown the relationship between SALL4 and prognosis. Given the debates in study groups differences in terms of etiologic causes between Western and Asian HCC and detection methods, we attempted to verify the features of SALL4 immunoreactivity and its clinical correlation in Korean HCC patients. Methods: Immunohistochemical staining of SALL4 of tissue microarrays (TMAs) consisting of 213 surgically resected HCC patients’ tissue were scored in a semiquantitative scoring system with immunoreactive score and the results analyzed with clinical outcome, in addition to general demographics and clinical characteristics. Results: SALL4 immunoreactivity was expressed in 50 cases. Relevance between SALL4 and α-FP correlated significantly (P= 0.002). Also, the SALL4-positive patients had considerably higher tumor grade (P < 0.001). The survival analysis showed negative correlation with SALL4 immunoreactivity in all HCC patient groups, but SALL4 immunoreactivity in T3 and T4 HCC correlated with poor prognosis. Conclusion: Here, we found that positive immunostaining of SALL4 is correlated with poor patient survival outcome in large and undifferentiated Korean HCC. SALL4 expression showed close relationship with clinical outcomes of HCCs in Korean patients.
Ahn, Sang Bong,Jang, Kiseok,Jun, Dae Won,Lee, Byung Hoon,Shin, Kye Jung Plenum Pub. Corp.] 2014 Digestive diseases and sciences Vol.59 No.12
<P>Liver X receptor (LXR) is an oxysterol-activated nuclear receptor involved in the control of major metabolic pathways for cholesterol homeostasis and lipogenesis. Although the role of LXR in hepatic steatosis is well known, its correlation with intrahepatic inflammation and fibrosis has not been thoroughly studied. We investigated the association between LXRα, hepatic inflammation, and fibrosis, as well as its correlation with other intrahepatic lipid transporters in patients with nonalcoholic fatty liver disease (NAFLD).</P>
Saeed, Waqar Khalid,Jun, Dae Won,Jang, Kiseok,Ahn, Sang Bong,Oh, Ju Hee,Chae, Yeon Ji,Lee, Jai Sun,Kang, Hyeon Tae Baishideng Publishing Group Inc 2018 WORLD JOURNAL OF GASTROENTEROLOGY Vol.24 No.48
<P><B>AIM</B></P><P>To validate the effects of receptor interacting protein kinase-3 (RIP3) deletion in non-alcoholic fatty liver disease (NAFLD) and to clarify the mechanism of action.</P><P><B>METHODS</B></P><P>Wild-type (WT) and RIP3 knockout (KO) mice were fed normal chow and high fat (HF) diets for 12 wk. The body weight was assessed once weekly. After 12 wk, the liver and serum samples were extracted. The liver tissue expression levels of RIP3, microsomal triglyceride transfer protein, protein disulfide isomerase, apolipoprotein-B, X-box binding protein-1, sterol regulatory element-binding protein-1c, fatty acid synthase, cluster of differentiation-36, diglyceride acyltransferase, peroxisome proliferator-activated receptor alpha, tumor necrosis factor-alpha (TNF-α), and interleukin-6 were assessed. Oleic acid treated primary hepatocytes from WT and RIP3KO mice were stained with Nile red. The expression of inflammatory cytokines, including chemokine (C-X-C motif) ligand (CXCL) 1, CXCL2, and TNF-α, in monocytes was evaluated.</P><P><B>RESULTS</B></P><P>RIP3KO HF diet fed mice showed a significant gain in body weight, and liver weight, liver to body weight ratio, and liver triglycerides were increased in HF diet fed RIP3KO mice compared to HF diet fed WT mice. RIP3KO primary hepatocytes also had increased intracellular fat droplets compared to WT primary hepatocytes after oleic acid treatment. RIP3 overexpression decreased hepatic fat content. Quantitative real-time polymerase chain reaction analysis showed that the expression of very-low-density lipoproteins secretion markers (microsomal triglyceride transfer protein, protein disulfide isomerase, and apolipoprotein-B) was significantly suppressed in RIP3KO mice. The overall NAFLD Activity Score was the same between WT and RIP3KO mice; however, RIP3KO mice had increased fatty change and decreased lobular inflammation compared to WT mice. Inflammatory signals (CXCL1/2, TNF-α, and interleukin-6) increased after lipopolysaccharide and pan-caspase inhibitor (necroptotic condition) treatment in monocytes. Neutrophil chemokines (CXCL1, and CXCL2) were decreased, and TNF-α was increased after RIP3 inhibitor treatment in monocytes.</P><P><B>CONCLUSION</B></P><P>RIP3 deletion exacerbates steatosis, and partially inhibits inflammation in the HF diet induced NAFLD model.</P>
( Ho Hyun Nam ),( Dae Won Jun ),( Kiseok Jang ),( Joo Hyun Sohn ),( Jae Yoon Jeong ),( Chang Hong Lee ),( Waqar Khalid Saeed ),( Jai Sun Lee ),( Hyeon Tae Kang ),( Yeon Ji Chae ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Protective effects of granulocyte colony stimulating factor (G-CSF) on nonalcoholic fatty liver disease (NAFLD) have been reported in animal models. However, the therapeutic effect of G-CSF has been suggested via marrow stem cell mobilization. We investigated the direct effect of G-CSF on hepatocytes in NAFLD. Methods: G-CSFr expression was evaluated in various liver disease model (NAFLD, alcoholic hepatitis, toxic hepatitis, chronic liver disease model). Two kinds of NAFLD models (high fat (HF), methionine choline deficient (MCD)) were used. In HF model included five arms as follows: control, HF, and three HF+G-CSF (30μg/kg, i.p) treatment groups (G1, G-CSF once weekly from 8th~12th week; G2, once daily for 5 days only in 9th week; G3, twice weekly from 9th to 12th week). In MCD model, four groups were included as follows; control, MCD, short and long acting G-CSF were tested. Long acting G-CSG was injected once a month. For in vitro experiments, the HepG2 cells were treated with palmitic acid (PA) 400μM, oleic acid (OA) 800μM, and G-CSF 100ng/ml. Cell viability (MTT) and oxidative stress (ROS), G-CSF receptor (IF, RT-PCR) were also measured. Results: The G-CSFr expression increased significantly in HF (14.7 times), alcohol hepatitis (7.1 times), chronic thioacetamide (TAA) (2.4 times), and ischemia reperfusion (IR) (6.8 times) groups as compared to the control. In HF induced NAFLD model, G-CSF treatment did not decrease the body weight compared to control groups. Continuous low dose group which can’t mobilize marrow stem cell (G3 group) showed significantly reduced intrahepatic fat accumulation as well as liver chemistry compare to HF induced NAFLD model without changing of body weight and liver to body weight ratio. Low dose long acting G-CSF with once a month injection also improved intrahepatic fat amount as well as degree of intrahepatic inflammation. Low dose long acting G-CSF treatment reduced the mRNA expression for hepatic de novo triglycerides synthesis (SREBP1c, FAS, SCD-1), cholesterol synthesis (SREBP2, HMG-CoA reductase) and inflammatory markers (MCP-1 TNF-a). G-CSF treatment increased cell proliferation markers (p-PI3 kinase, p-Akt), while decreased apoptosis in MCD diet groups. In Vitro results as follows; G-CSF+PA treatment increased cell viability in both 24h, and 48h treated groups. ROS was also significantly reduced in G-CSF group. Cell viability increased G-CSF group but decreased in G-CSF+PI3 kinase inhibitor and PI3 kinase inhibitor alone groups. Similarly, ROS decreased G-CSF but increased in G-CSF+PI3 kinase inhibitor and PI3 kinase inhibitor alone groups. Conclusions: G-CSF receptor expression in Hepatocytes in various NAFLD model and G-CSF administration of low-density low-frequency improves HF model and long acting G-CSF improves MCD model.