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Plant‐expressed Fc‐fusion protein tetravalent dengue vaccine with inherent adjuvant properties
Kim, Mi Young,Copland, Alastair,Nayak, Kaustuv,Chandele, Anmol,Ahmed, Muhammad S.,Zhang, Qibo,Diogo, Gil R.,Paul, Matthew J.,Hofmann, Sven,Yang, Moonx2010,Sik,Jang, Yongx2010,Suk,Ma, Julian Kx20 BLACKWELL 2018 PLANT BIOTECHNOLOGY JOURNAL Vol.16 No.7
<P><B>Summary</B></P><P>Dengue is a major global disease requiring improved treatment and prevention strategies. The recently licensed Sanofi Pasteur Dengvaxia vaccine does not protect children under the age of nine, and additional vaccine strategies are thus needed to halt this expanding global epidemic. Here, we employed a molecular engineering approach and plant expression to produce a humanized and highly immunogenic poly‐immunoglobulin G scaffold (PIGS) fused to the consensus dengue envelope protein III domain (cEDIII). The immunogenicity of this IgG Fc receptor‐targeted vaccine candidate was demonstrated in transgenic mice expressing human FcγRI/CD64, by induction of neutralizing antibodies and evidence of cell‐mediated immunity. Furthermore, these molecules were able to prime immune cells from human adenoid/tonsillar tissue <I>ex vivo</I> as evidenced by antigen‐specific CD4<SUP>+</SUP> and CD8<SUP>+</SUP> T‐cell proliferation, IFN‐γ and antibody production. The purified polymeric fraction of dengue PIGS (D‐PIGS) induced stronger immune activation than the monomeric form, suggesting a more efficient interaction with the low‐affinity Fcγ receptors on antigen‐presenting cells. These results show that the plant‐expressed D‐PIGS have the potential for translation towards a safe and easily scalable single antigen‐based tetravalent dengue vaccine.</P>
Liu, J.,Zhang, D.,Pu, X.,Dong, D.,Cai, P.,Seo, H.J. North-Holland 2014 Materials letters Vol.130 No.-
Magnetically separable Zn<SUB>1-x</SUB>Cd<SUB>x</SUB>S/γ-Fe<SUB>2</SUB>O<SUB>3</SUB> (x=0-1) photocatalysts were synthesized by a one-step combustion method. The structures, morphologies, absorbance, optical and photocatalytic properties of the samples were studied by X-ray powder diffraction, scanning electron microscopy, transmission electron microscopy, ultraviolet-visible spectrophotometry and photoluminescence. The experimental results show that the formation of hexagonal Zn<SUB>1-x</SUB>Cd<SUB>x</SUB>S and γ-Fe<SUB>2</SUB>O<SUB>3</SUB> and the combination of them were one-pot achieved. The Cd<SUP>2+</SUP> content has a significant influence on the absorbance of visible light and fluorescence properties. The magnetic properties of samples ensure the magnetic separation by using a magnet. CdS/γ-Fe<SUB>2</SUB>O<SUB>3</SUB> shows the best photocatalytic performance compared with other samples, ascribed to its small energy band gap and matching energy band structure between CdS and γ-Fe<SUB>2</SUB>O<SUB>3</SUB>. Moreover, no obvious deterioration was observed in the stability tests.
Spectral tomographic analysis of Bremsstrahlung X-rays generated in a laser-produced plasma
Rhee, Y.J.,Nam, S.M.,Peebles, J.,Sawada, H.,Wei, M.,Vaisseau, X.,Sasaki, T.,Giuffrida, L.,Hulin, S.,Vauzour, B.,Santos, J.J.,Batani, D.,McLean, H.S.,Patel, P.K.,Li, Y.T.,Yuan, D.W.,Zhang, K.,Zhong, J. Cambridge University Press 2016 Laser and particle beams Vol.34 No.4
<B>Abstract</B><P>A new approach is proposed to analyze Bremsstrahlung X-rays that are emitted from laser-produced plasmas (LPP) and are measured by a stack type spectrometer. This new method is based on a spectral tomographic reconstruction concept with the variational principle for optimization, without referring to the electron energy distribution of a plasma. This approach is applied to the analysis of some experimental data obtained at a few major laser facilities to demonstrate the applicability of the method. Slope temperatures of X-rays from LPP are determined with a two-temperature model, showing different spectral characteristics of X-rays depending on laser properties used in the experiments.</P>
X.M. Chen,Y. Zhang,W.W. Kong,X.B. Bian,J.P. Zhou,P. Liu 한양대학교 세라믹연구소 2010 Journal of Ceramic Processing Research Vol.11 No.4
Barium titanate (BaTiO3, or BT) powders were synthesized via a solid state reaction of BaCO3-TiO2 by combining a highenergy ball milling (HBM) technique and a calcination method. Using X-ray diffraction (XRD) methods with a Rietveld refinement, the effects of calcination temperature on the phase formation and crystallite structure of BT powders were studied. It is found that by means of HBM the synthesis temperature for obtaining BT single phase is decreased to 960 oC, which is much lower than that required by the conventional solid-state reaction process, and the crystallite structure of BT is in the (pseudo)cubic form. As the calcination temperature is increased to 980 oC, the structure of BT crystallites transforms from the (pseudo)cubic to the tetragonal form. With an increase in the calcination temperature, both the tetragonality (c/a-1) and crystallite size are increased.
Zhang, Z.H.,Fan, X.J.,Guo, H.X.,Zhang, W.,Zhang, C.Y.,Luo, F.Y. The Korean Vacuum Society 1998 Applied Science and Convergence Technology Vol.7 No.1
Amorphous ternary $Si_xC_yN-z$ thin films were obtained by plasma enhanced chemical vapor deposition(PECVD) using $N_2, SiH_4 \;and \;C_2H_4$ as the reaction sources. The chemical state were characterized by x-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy(FTIR). The optical properties of the thin films were investigated by UV-visible spectrophotometer and ellipsometer, and the optical band gaps of thin films were determined from corresponding transmittance spectra following Tauc equation.
X. Y. Le,S. Yan,W. J. Zhao,B. H. Han,Y. G. Wang,J. M. Xue,H. T. Zhang 한국진공학회(ASCT) 2002 Journal of Korean Vacuum Science & Technology Vol.6 No.2
In this paper, we treated the Ni₃Al based alloy samples with intense pulsed ion beams (IPIB) at the beam parameters of 250KV acceleration voltage, 100 - 200 A/㎤ current density and 60 ㎱ pulse duration. We simulated the thermal-mechanical process near the surface of Ni₃Al based alloy with our STEIPIB codes. The surface morphology and the cross-section microstructures of samples were observed with SEM, the composition of the sample surface layer was determined by X-ray Energy Dispersive Spectrometry (XEDS) and the microstructure on the surface was observed by Transmission Electron Microscope (TEM). The results show that heating rate increases with the current density of IPIB and cooling rate reached highest value less than 150 A/㎤. The irradiation of IPIB induced the segregation of Mo and adequate beam parameter can improve anti-oxidation property of IC6 alloy. Some craters come from extraneous debris and liquid droplets, and some maybe due to the melting of the intersection region of interphase. Increasing the pulse number enlarges average size of craters and decreases number density of craters.
J. He,Q.Z. Cai,D. Zhu,Q. Luo,D.Q. Zhang,X.W. Li,X. Zhao,W. Sun 한국물리학회 2011 Current Applied Physics Vol.11 No.1
A WO_3/TiO_2 composite film was in-situ prepared in tungstate electrolyte and characterized by Electron microscopy, X-ray diffraction, UV―Vis spectrophotometer and Photoluminescence. The oxide film consists of mixture phases of anatase and rutile, showing porous structures and metallurgical bond with substrate. With the incorporation of WO_3 into TiO_2, the optical absorption edge of TiO_2 filmwas shifted to longer wavelength slightly and the separation between electrons and holes was promoted effectively. WO_3/TiO_2 composite film with increased photo quantum efficiency will be promising in the treatment of environmental pollutants.
R&D Status of High-current Accelerators at IFP
J. J. Deng,J. S. Shi,W. P. Xie,L. W. Zhang,K. Z. Zhang,S. P. Feng,J. Li,M. Wang,Y. He,L. S. Xia,Z. Y. Dai,H. T. Li,L. Wen,S. F. Chen,X. Li,Q. G. Lai,M. H. Xia,Y. C. Guan,S. Y. Song,L. Chen 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.61
High-current accelerators have many important applications in Z-pinches, high-power microwaves, and free electron lasers, imploding liners and radiography and so on. Research activities on Zpinches, imploding liners, radiography at the Institute of Fluid Physics (IFP) are introduced. Several main high-current accelerators developed and being developed at IFP are described, such as the Linear Induction Accelerator X-Ray Facility Upgrade (LIAXFU, 12 MeV, 2.5 kA, 90 ns), the Dragon-I linear induction accelerator (20 MeV, 2.5 kA, 60 ns), and the Primary Test Stand for Z-pinch (PTS, 10 MA, 120 ns). The design of Dragon-II linear induction accelerator (20 MeV, 2.5 kA, 3 × 60 ns) to be built will be presented briefly.
Zhang, G.,Zhu, M.,Guo, J.,Ma, J.,Wang, X.,Lu, H.,Qiu, L. Elsevier Science 2014 ORGANIC ELECTRONICS Vol.15 No.10
A series of benzodithiophene (BDT) and benzotrithiophene (BTT)-based conjugated polymers (P1-P4), with/without conjugated- and acyl-side chain, have been synthesized by Stille cross-coupling reaction. Their thermal, photophysical, electrochemical properties, devices performances, and microstructure have been investigated. Conjugated-side chain can significantly raise the thermal stability and acyl-side chain can lower HOMO/LUMO energy levels. Organic thin-film transistors (OTFTs) based on conjugated polymers were fabricated and the transistor electrical characterization showed the device performance was sensitive to the conjugated- and acyl-side chain substituent of polymers. A maximum hole mobility of 1.70x10<SUP>-3</SUP>cm<SUP>2</SUP>V<SUP>-1</SUP>s<SUP>-1</SUP> was obtained for P1-based devices, which is an order of magnitude higher than those of P3 and P4-based devices. The corresponding microstructures were investigated by grazing-incidence X-ray diffraction (GIXD) to correlate with conjugated- and acyl-side chain dependent carrier mobility of P1-P4. The results showed that the conjugated- and acyl-side chain have an impact on the polymer packing models and device performances.
Tokamak plasma disruption precursor onset time study based on semi-supervised anomaly detection
X.K. Ai,W. Zheng,M. Zhang,D.L. Chen,C.S. Shen,B.H. Guo,B.J. Xiao,Y. Zhong,N.C. Wang,Z.J. Yang,Z.P. Chen,Z.Y. Chen,Y.H. Ding,Y. Pan Korean Nuclear Society 2024 Nuclear Engineering and Technology Vol.56 No.4
Plasma disruption in tokamak experiments is a challenging issue that causes damage to the device. Reliable prediction methods are needed, but the lack of full understanding of plasma disruption limits the effectiveness of physics-driven methods. Data-driven methods based on supervised learning are commonly used, and they rely on labelled training data. However, manual labelling of disruption precursors is a time-consuming and challenging task, as some precursors are difficult to accurately identify. The mainstream labelling methods assume that the precursor onset occurs at a fixed time before disruption, which leads to mislabeled samples and suboptimal prediction performance. In this paper, we present disruption prediction methods based on anomaly detection to address these issues, demonstrating good prediction performance on J-TEXT and EAST. By evaluating precursor onset times using different anomaly detection algorithms, it is found that labelling methods can be improved since the onset times of different shots are not necessarily the same. The study optimizes precursor labelling using the onset times inferred by the anomaly detection predictor and test the optimized labels on supervised learning disruption predictors. The results on J-TEXT and EAST show that the models trained on the optimized labels outperform those trained on fixed onset time labels.