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Timing of Recanalization and Functional Recovery in Acute Ischemic Stroke
Georgios Tsivgoulis,Maher Saqqur,Vijay K Sharma,Alejandro Brunser,Jürgen Eggers,Robert Mikulik,Aristeidis H. Katsanos,Theodore N. Sergentanis,Konstantinos Vadikolias,Fabienne Perren,Marta Rubiera,Reza 대한뇌졸중학회 2020 Journal of stroke Vol.22 No.1
Background and Purpose Although onset-to-treatment time is associated with early clinical recovery in acute ischemic stroke (AIS) patients treated with intravenous tissue plasminogen activator (tPA), the effect of the timing of tPA-induced recanalization on functional outcomes remains debatable. Methods We conducted a multicenter, prospective observational cohort study to determine whether early (within 1-hour from tPA-bolus) complete or partial recanalization assessed during 2-hour real-time transcranial Doppler monitoring is associated with improved outcomes in patients with proximal occlusions. Outcome events included dramatic clinical recovery (DCR) within 2 and 24-hours from tPA-bolus, 3-month mortality, favorable functional outcome (FFO) and functional independence (FI) defined as modified Rankin Scale (mRS) scores of 0–1 and 0–2 respectively. Results We enrolled 480 AIS patients (mean age 66±15 years, 60% men, baseline National Institutes of Health Stroke Scale score 15). Patients with early recanalization (53%) had significantly (P<0.001) higher rates of DCR at 2-hour (54% vs. 10%) and 24-hour (63% vs. 22%), 3-month FFO (67% vs. 28%) and FI (81% vs. 39%). Three-month mortality rates (6% vs. 17%) and distribution of 3-month mRS scores were significantly lower in the early recanalization group. After adjusting for potential confounders, early recanalization was independently associated with higher odds of 3-month FFO (odds ratio [OR], 6.19; 95% confidence interval [CI], 3.88 to 9.88) and lower likelihood of 3-month mortality (OR, 0.34; 95% CI, 0.17 to 0.67). Onset to treatment time correlated to the elapsed time between tPA-bolus and recanalization (unstandardized linear regression coefficient, 0.13; 95% CI, 0.06 to 0.19). Conclusions Earlier tPA treatment after stroke onset is associated with faster tPA-induced recanalization. Earlier onset-to-recanalization time results in improved functional recovery and survival in AIS patients with proximal intracranial occlusions.
Sharma, A.,Varshney, M.,Shin, H.J.,Chae, K.H.,Won, S.O. Elsevier 2016 Current Applied Physics Vol.16 No.10
<P>Tin oxide nanostructures are nontoxic in nature and biocompatible. However, they exhibit weak emission characteristics that limit their applications in cellular and biology fields. Therefore, it is important to enhance luminescence properties in this oxide and establish a relationship between the local electronic structure and emission characteristics. In this report, we demonstrate significant advancement in the photoluminescence (PL) properties in the Eu incorporated SnO2-SnO nanocomposites. Eu: SnO2-SnO nanocomposites were synthesized by chemical precipitation method. X-ray diffraction (XRD), X-ray absorption near edge structure (XANES) and PL measurements were performed to investigate the structural, electronic structure and emission properties of the samples. Eu3+ ions, as confirmed by the Eu M-5,M-4-edge XANES studies, lead to defect formation and local electronic structural perturbation in the nanocomposites. The O K-edge and Sn M-5,M-4-edge XANES studies confirm a net decrease in the hybridization of O 2p and Sn 5s/5p states and formation of Sn defects, upon Eu doping. Significant enhancement in the Eu3+ related interband transitions (D-5(0)-F-7(J); J = 0,1,2,3,4) is achieved upon increasing the Eu concentrations, indicating synthesis of emission characteristic rich SnO2-SnO nanocomposites. (C) 2016 Elsevier B.V. All rights reserved.</P>
Stepwise regression data envelopment analysis for variable reduction
Sharma, M.J.,Yu, S.J. Elsevier [etc.] 2015 Applied Mathematics and Computation Vol.253 No.-
In this paper, we develop stepwise regression data envelopment model to select important variables. We formulate null hypothesis to understand the importance of each variable and use Kruskal-Wallis test for this purpose. If the Kruskal-Wallis test does not reject the null hypothesis then we can conclude that all the variables are of equal importance as their presence and on the other hand absence of other variable does not create huge fluctuations in efficiency scores in fact give a complete ranking relative to base model. If the Kruskal-Wallis test does reject the null hypothesis this will imply there is significant fluctuation in the efficiency score relative to base model. And therefore we have to further check the pair of variables that causes the fluctuation in order to determine its importance using Conover-Inman test. The results of the proposed models are compared with the results of previously published models of the same dataset. The proposed models helps understand the extent of misclassification decision making units as efficient/inefficient when variables are retained or discarded alongside provides useful managerial prescription to make improvement strategies.
Selective growth of inorganic nanomaterials on an oxidized graphene scaffold
Sharma, B.K.,Choi, B.,Singh, J.,Yoo, J.,Lim, B.,Ahn, J.H. Pergamon Press ; Elsevier Science Ltd 2014 Carbon Vol.78 No.-
A low-temperature solution method was proposed for the site-selective growth of ZnO nanorods (NRs) and Au nanoparticles by making use of the wettability contrast of a graphene/graphene oxide (G/GO) template. Au nanoparticles were found to nucleate and grow selectively over a GO area of the G/GO template. ZnO NRs selectively grew on graphene regions of the template without growing the seeds required for selective growth. We demonstrated diode-like and field emission behaviors of the ZnO NRs selectively grown on a G/GO template, which showed good optical, electrical, and mechanical properties. These materials are potential candidates for the large-scale fabrication of flexible electrical and optical nano-devices.
3-Naphthylindoles as new promising candidate antioxidant, antibacterial, and antibiofilm agents
Sharma, K.,Baral, E. R.,Akhtar, M. S.,Lee, Y. R.,Kim, S. H.,Wee, Y. J. Springer Science + Business Media 2017 Research on chemical intermediates Vol.43 No.4
<P>Indole derivatives have attracted significant attention in organic synthesis and bioactivity research owing to their substantial biological activity. In the present study, several 3-naphthylindole analogues were synthesized by direct arylation of 1-diazonaphthalene-2-(1H)-ones by rhodium(II)-catalyzed cross-coupling reaction and their antioxidant and antibacterial properties evaluated. Among the analogues tested, compound 3m displayed the highest antioxidant activity [as evaluated by ferric reducing antioxidant power (FRAP) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) tests], whereas compound 3c exhibited the lowest activity. The compounds were also screened against biofilm-forming bacterial species (Gram-negative Escherichia coli and Pseudomonas aeruginosa as well as Gram-positive Staphylococcus aureus and Bacillus cereus). Compounds 3b, i, j, p displayed potent antibacterial activity against E. coli. Similarly, compound 3p exhibited activity superior to quercetin (4.2 mu g/mL) by completely inhibiting biofilm formation by E. coli. Moreover, the half-maximal inhibitory concentration (IC50) values of compounds 3e, j against B. cereus were comparable to that of standard quercetin.</P>
Comprehensive analysis of plant rapid alkalization factor (RALF) genes
Sharma, A.,Hussain, A.,Mun, B.G.,Imran, Q.M.,Falak, N.,Lee, S.U.,Kim, J.Y.,Hong, J.K.,Loake, G.J.,Ali, A.,Yun, B.W. Elsevier Science B.V., Amsterdam. 2016 Plant Physiology and Biochemistry Vol. No.
<P>Receptor mediated signal carriers play a critical role in the regulation of plant defense and development. Rapid alkalization factor (RALF) proteins potentially comprise important signaling components which may have a key role in plant biology. The RALF gene family contains large number of genes in several plant species, however, only a few RALF genes have been characterized to date. In this study, an extensive database search identified 39, 43, 34 and 18 RALF genes in Arabidopsis, rice, maize and soybean, respectively. These RALF genes were found to be highly conserved across the 4 plant species. A comprehensive analysis including the chromosomal location, gene structure, subcellular location, conserved motifs, protein structure, protein-ligand interaction and promoter analysis was performed. RALF genes from four plant species were divided into 7 groups based on phylogenetic analysis. In silico expression analysis of these genes, using microarray and EST data, revealed that these genes exhibit a variety of expression patterns. Furthermore, RALF genes showed distinct expression patterns of transcript accumulation in vivo following nitrosative and oxidative stresses in Arabidopsis. Predicted interaction between RALF and heme ligand also showed that RALF proteins may contribute towards transporting or scavenging oxygen moieties. This suggests a possible role for RALF genes during changes in cellular redox status. Collectively, our data provides a valuable resource to prime future research in the role of RALF genes in plant growth and development. (C) 2016 Elsevier Masson SAS. All rights reserved.</P>
Metachronous Cancer of Breast and Adenocarcinoma of Cervix: A Rare Case Report
( Nalini Sharma ),( J Lalnunnem Thiek ),( Das Rituparna ),( Jaya Mishra ),( Ahanthem Santa Singh ) 대한폐경학회 2017 대한폐경학회지 Vol.23 No.2
The occurrence of a second primary cancer in a cancer survivor is well documented. It may be synchronous or metachronous. Incidence of metachronous cancer involving cervix is 0.82% to 1.33%. One such metachronous cancer is that of breast and cervix. We present a case of a woman who received tamoxifen for invasive ductal cancer of breast following a modified radical mastectomy and subsequently developed adenocarcinoma of cervix after six month of tamoxifen therapy. The role of tamoxifen in pathogenesis of cervical cancer and that of human papillomavirus infection in pathogenesis of both cancer of cervix and breast cancer has been well recognized. In our patient, the adenocarcinoma of cervix (rare occurrence) which is likely due to six month of tamoxifen therapy is a perplexing question. Women diagnosed and treated for breast cancer need to be followed up for development of other metachronous gynecological cancers. (J Menopausal Med 2017;23:131-134)