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- 저자 : J. Nakano (검색결과 28 건)
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중야준삼 한국목재공학회 1980 목재공학 Vol.8 No.3
Fig. 8 summarizes the present status of high yield pulp production and the directions of research on modification. A thick line indicates pulping process presently in use. As mentioned previously, one kind of modification is to introduce hydrophilic groups onto the pulp. Still unsolved is whether or not the introduction of hydrophilic groups should be restricted to lignin only. Goring (28) reported that middle lamella lignin has fewer phenolic hydroxyl groups than cell wall lignin and suggested that such a difference in the lignin may be useful in the removal of middle lamella lignin. The introduction of hydrophilic groups onto pulp may not be enough to modify high yield pulp. The removal of some portion of carbohydrate may be also necessary from the standpoint of softening of pulp fibers. There is no information at what lignin arid carbohydrate, and how much should be removed. The combination with synthetic high polymers may [도표] A: Solvent extraction, polymer coating, grafting, γ-ray irradiation, treatment with various chemicals B: Introduction of hydrophilic group C: Masonite process D: Refining in aq. alkali also be important in modifying high yield pulp. Prof. C. Schuerch of the State University of New York who was a visiting professor at the University of Tokyo in 1974, mentioned that the hydrophilicity of lignin would be promoted, if phenolic hydroxyl or carboxyl groups could be introduced into the aromatic nucleus of lignin. If this were possible, this process would also mean a pulp yield of more than 100%. This idea is just one example of the expectation made possible through lignin chemistry. Instead of the introduction of hydrophilic group, the oxidative degradation of aromatic nucleus of lignin may also be useful in promoting the hydrophilicity of pulp. In this case, ozone may be an excellent chemical. However, there are a lot of problems to be solved such as homogeneity of reaction and selectivity of ozone for lignin. The above ideas are summarized in Fig. 9. There are many problems to be solved in the production of an excellent high yield pulp which is comparable to chemical pulp. The information from wood chemistry hopefully will elucidate some of the problems mentioned above. [도표]
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Deep desulfurization of gas oil over NiMoS catalysts supported on alumina coated USY-zeolite
Nakano, K.,Ali, S.A.,Kim, H.J.,Kim, T.,Alhooshani, K.,Park, J.I.,Mochida, I. Elsevier Scientific Pub. Co 2013 Fuel processing technology Vol.116 No.-
A series of NiMoS catalysts supported on USY-zeolite coated with different amounts of alumina were prepared and evaluated for deep hydrodesulfurization (HDS) of gas oil using a flow reactor system in single- and dual-bed configurations. The performance of these catalysts was compared to the conventional HDS catalyst as well as to NiMoS catalyst supported on physical mixture of alumina and USY-zeolite. Physically mixed alumina and USY zeolite showed high HDS activity, but it was accompanied with significant cracking of hydrocarbons. Activity and kinetic analysis showed that heavy coating of alumina on the zeolite resulted in much lower HDS and cracking activity. On the other hand, very light coating of alumina on the zeolite resulted in catalytic behavior similar to that of physical mixture of USY-zeolite and alumina. The general trend was an increase in HDS as well as hydrocracking activity with the decrease in amount of alumina coating over zeolite. Changes in product density, aromatic content, mid-boiling point, cetane index, and molecular weight also reflected this trend. The results of this study indicate that catalysts with neither too low nor too high amount of alumina coating on the USY zeolite are suitable to achieve the balance between high HDS and low cracking activities. The highlight of the present study is that it confirmed the deep HDS activity of USY containing alumina supports in the flow reactor system which is industrially applied. In addition, the stability test confirmed the long-term performance of alumina-coated zeolite catalyst.
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Search for dinucleon decay into pions at Super-Kamiokande
Gustafson, J.,Abe, K.,Haga, Y.,Hayato, Y.,Ikeda, M.,Iyogi, K.,Kameda, J.,Kishimoto, Y.,Miura, M.,Moriyama, S.,Nakahata, M.,Nakajima, T.,Nakano, Y.,Nakayama, S.,Orii, A.,Sekiya, H.,Shiozawa, M.,Takeda, American Physical Society 2015 PHYSICAL REVIEW D - Vol.91 No.7
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OCT Findings in Patients With Recanalization of Organized Thrombi in Coronary Arteries
Kang, S.J.,Nakano, M.,Virmani, R.,Song, H.G.,Ahn, J.M.,Kim, W.J.,Lee, J.Y.,Park, D.W.,Lee, S.W.,Kim, Y.H.,Lee, C.W.,Park, S.W.,Park, S.J. Elsevier 2012 JACC CARDIOVASCULAR IMAGING Vol.5 No.7
Objectives: The purpose of this study was to determine the angiographic and optical coherence tomographic (OCT) characteristics of coronary lesions with recanalized thrombi. Background: Although spontaneous recanalization of thrombi has been reported pathologically, it is rarely recognized in clinical practice. Methods: Based on histopathologic features, recanalization of thrombi was defined by characteristics on OCT. Results: Recanalization of thrombi was identified in 6 patients (3 male, 3 female; median age 63 years; age range 54 to 72 years). Based on symptoms, 3 patients were diagnosed with unstable angina; 2 were diagnosed with stable angina; and 1, who had mitral stenosis and huge left atrial thrombi, was diagnosed with post-infarct angina. All had normal serum concentrations of cardiac markers at admission. Angiography showed irregular linear filling defects and haziness. Two patients with near total occlusion had Thrombolysis In Myocardial Infarction (TIMI) flow grade 1 and collaterals, whereas 4 patients had TIMI flow grade 3 and no collaterals. All patients showed OCT findings consistent with recanalized thrombi, which consisted of signal-rich, high backscattered septa that divided the lumen into multiple small cavities communicating with each other. These structures, which had smooth inner borders, created a ''Swiss cheese'' appearance. Percutaneous coronary intervention was performed in 5 patients with angiographic slow flow or inducible-ischemia as documented by invasive or noninvasive stress tests. The remaining 1 patient with restored coronary flow underwent mitral valve surgery and left atrial thrombectomy. Conclusions: OCT provided details on the characteristics of the organization of thrombi in both chronic total occlusion and subtotal narrowing. Coronary lesions containing recanalized thrombi were characterized by multiple small channels, with most showing functional significance.
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Kim, S-H,Kim, E-J,Hitomi, M,Oh, S-Y,Jin, X,Jeon, H-M,Beck, S,Jin, X,Kim, J-K,Park, C G,Chang, S-Y,Yin, J,Kim, T,Jeon, Y-j,Song, J,Lim, Y C,Lathia, J D,Nakano, I,Kim, H Macmillan Publishers Limited 2015 CELL DEATH AND DIFFERENTIATION Vol.22 No.9
Glioblastomas (GBMs) maintain their cellular heterogeneity with glioma stem cells (GSCs) producing a variety of tumor cell types. Here we interrogated the oncogenic roles of Lim domain only 2 (LMO2) in GBM and GSCs in mice and human. High expression of LMO2 was found in human patient-derived GSCs compared with the differentiated progeny cells. LMO2 is required for GSC proliferation both in vitro and in vivo, as shRNA-mediated LMO2 silencing attenuated tumor growth derived from human GSCs. Further, LMO2 is sufficient to induce stem cell characteristics (stemness) in mouse premalignant astrocytes, as forced LMO2 expression facilitated in vitro and in vivo growth of astrocytes derived from Ink4a/Arf null mice and acquisition of GSC phenotypes. A subset of mouse and human GSCs converted into vascular endothelial-like tumor cells both in vitro and in vivo, which phenotype was attenuated by LMO2 silencing and promoted by LMO2 overexpression. Mechanistically, the action of LMO2 for induction of glioma stemness is mediated by transcriptional regulation of Jagged1 resulting in activation of the Notch pathway, whereas LMO2 directly occupies the promoter regions of the VE-cadherin gene for a gain of endothelial cellular phenotype. Subsequently, selective ablation of human GSC-derived VE-cadherin-expressing cells attenuated vascular formation in mouse intracranial tumors, thereby significantly prolonging mouse survival. Clinically, LMO2 expression was elevated in GBM tissues and inversely correlated with prognosis of GBM patients. Taken together, our findings describe novel dual roles of LMO2 to induce tumorigenesis and angiogenesis, and provide potential therapeutic targets in GBMs.
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Kim, E.,Kim, M.,Woo, D.H.,Shin, Y.,Shin, J.,Chang, N.,Oh, Y.,Kim, H.,Rheey, J.,Nakano, I.,Lee, C.,Joo, K.,Rich, Jeremy N.,Nam, D.H.,Lee, J. Cell Press 2013 Cancer cell Vol.23 No.6
Glioblastoma multiforme (GBM) displays cellular hierarchies harboring a subpopulation of stem-like cells (GSCs). Enhancer of Zeste Homolog 2 (EZH2), the lysine methyltransferase of Polycomb repressive complex 2, mediates transcriptional repression of prodifferentiation genes in both normal and neoplastic stem cells. An oncogenic role of EZH2 as a transcriptional silencer is well established; however, additional functions of EZH2 are incompletely understood. Here, we show that EZH2 binds to and methylates STAT3, leading to enhanced STAT3 activity by increased tyrosine phosphorylation of STAT3. The EZH2-STAT3 interaction preferentially occurs in GSCs relative to non-stem bulk tumor cells, and it requires a specific phosphorylation of EZH2. Inhibition of EZH2 reverses the silencing of Polycomb target genes and diminishes STAT3 activity, suggesting therapeutic strategies.
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Lee, J. W.,Kobayashi, A.,Nakano, T. Springer Science + Business Media 2017 Journal of bone and mineral metabolism Vol.35 No.3
<P>The aim of the present study was to investigate the preferred orientation of biological apatite (BAp) as a new index of the quality of subchondral bone (SB) in knee joint osteoarthritis (OA). Ten OA and five normal knee joints were obtained. Thickness, quantity and bone mineral density (BMD) of SB were analyzed at the medial condyle of the femur in dry conditions by peripheral quantitative computed tomography. In addition, the preferred crystallographic orientation of the c-axis of BAp was evaluated as bone quality parameter using a microbeam X-ray diffractometer technique. BMD and thickness of SB were significantly increased in OA specimens compared to normal knee specimens (P < 0.01), and the preferred orientation of the c-axis of BAp along the normal direction of SB surface was significantly higher in OA specimens (P < 0.01), reflecting the change in stress of concentration in the pathological portion without cartilage. SB sclerosis in OA results in both proliferation of bone tissues and enhanced degree of preferential alignment of the c-axis of BAp. Our findings could have major implications for the diagnosis of clinical studies, including pathologic elucidation in OA.</P>
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Mizutani, K.,Niiyama, M.,Nakano, T.,Yosoi, M.,Nozawa, Y.,Ahn, D. S.,Ahn, J. K.,Chang, W. C.,Chen, J. Y.,Daté,, S.,Gohn, W.,Hamano, H.,Hashimoto, T.,Hicks, K.,Hiraiwa, T.,Hotta, T.,Hwang, S. H.,I American Physical Society 2017 Physical Review C Vol.96 No.6
<P>Differential cross sections at t = t(min) and decay asymmetries for the gamma p -> phi p reaction have been measured using linearly polarized photons in the range 1.5 to 2.9 GeV. These cross sections were used to determine the Pomeron strength factor. The cross sections and decay asymmetries are consistently described by the t-channel Pomeron and pseudoscalar exchange model in the E-gamma region above 2.37 GeV. In the lower energy region, an excess over the model prediction is observed in the energy dependence of the differential cross sections at t = t(min). This observation suggests that additional processes or interference effects between Pomeron exchange and other processes appear near the threshold region.</P>
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