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Yuji Hotta,Naoya Ieda,Ayako Fukamoto,Tomoya Kataoka,Yoshihiro Kawade,Yasuhiro Maeda,Hidehiko Nakagawa,Kazunori Kimura 대한비뇨의학회 2016 Investigative and Clinical Urology Vol.57 No.3
Purpose: To investigate whether relaxation of the rat penile corpus cavernosum could be controlled with NOBL-1, a novel, light-controllable nitric oxide (NO) releaser. Materials and Methods: Fifteen-week-old male Wistar-ST rats were used. The penile corpus cavernosum was prepared and used in an isometric tension study. After noradrenaline (10-5 M) achieved precontraction, the penile corpus cavernosum was irradiated by light (470–500 nm) with and without NOBL-1 (10-6 M). In addition, we noted rats' responses to light with vardenafil (10-6 M), a phosphodiesterase-5 (PDE-5) inhibitor. Next, responses to light in the presence of a guanylate cyclase inhibitor, ODQ (1H-[1,2,4] oxadiazolo[4,3-a]quinoxalin-1-one) (10-5 M), were measured. All measurements were performed in pretreated L-NAME (10-4 M) conditions to inhibit endogenous NO production. Results: Corpus cavernosal smooth muscle, precontracted with noradrenaline, was unchanged by light irradiation in the absence of NOBL-1. However, in the presence of NOBL-1, corpus cavernosal smooth muscle, precontracted with noradrenaline, relaxed in response to light irradiation. After blue light irradiation ceased, tension returned. In addition, the light response was obviously enhanced in the presence of a PDE-5 inhibitor. Conclusions: This study showed that rat corpus cavernosal smooth muscle relaxation can be light-controlled using NOBL-1, a novel, light sensitive NO releaser. Though further in vivo studies are needed to investigate possible usefulness, NOBL-1 may be prove to be a useful tool for erectile dysfunction therapy, specifically in the field of penile rehabilitation.
GROWTH RATE MEASUREMENT OF C60 FULLERENE NANOWHISKERS
KAYOKO HOTTA,KUN’ICHI MIYAZAWA 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2008 NANO Vol.3 No.5
The growth rate of C60 fullerene nanowhiskers (C60NWs) prepared by the liquid–liquid interfacial precipitation method is measured and the growth mechanism is discussed. The growth of C60NWs is investigated from the data obtained at the growth temperatures of 5, 10, 15 and 20°C. It is found that the convection of the solution scarcely influences the growth rate, suggesting that a surface reaction of C60 molecules dominates the growth process. The activation energy of C60NWs' growth is estimated at about 52.8 kJ/mol from their initial stage of growth. This activation energy is much greater than that of C60 diffusion in solutions found in the literature. This result suggests that the desolvation process of C60 on the whisker surface governs the growth of C60NWs.