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Genome-wide association study of recalcitrant atopic dermatitis in Korean children
Kim, K.W.,Myers, R.A.,Lee, J.H.,Igartua, C.,Lee, K.E.,Kim, Y.H.,Kim, E.J.,Yoon, D.,Lee, J.S.,Hirota, T.,Tamari, M.,Takahashi, A.,Kubo, M.,Choi, J.M.,Kim, K.E.,Nicolae, D.L.,Ober, C.,Sohn, M.H. Mosby 2015 The Journal of allergy and clinical immunology Vol.136 No.3
Background: Atopic dermatitis (AD) is a heterogeneous chronic inflammatory skin disease. Most AD during infancy resolves during childhood, but moderate-to-severe AD with allergic sensitization is more likely to persist into adulthood and more often occurs with other allergic diseases. Objective: We sought to find susceptibility loci by performing the first genome-wide association study (GWAS) of AD in Korean children with recalcitrant AD, which was defined as moderate-to-severe AD with allergic sensitization. Methods: Our study included 246 children with recalcitrant AD and 551 adult control subjects with a negative history of both allergic disease and allergic sensitization. DNA from these subjects was genotyped; sets of common single nucleotide polymorphisms (SNPs) were imputed and used in the GWAS after quality control checks. Results: SNPs at a region on 13q21.31 were associated with recalcitrant AD at a genome-wide threshold of significance (P < 2.0 x 10<SUP>-8</SUP>). These associated SNPs are more than 1 Mb from the closest gene, protocadherin (PCDH)9. SNPs at 4 additional loci had P values of less than 1 x 10<SUP>-6</SUP>, including SNPs at or near the neuroblastoma amplified sequence (NBAS; 2p24.3), thymus-expressed molecule involved in selection (THEMIS; 6q22.33), GATA3 (10p14), and S-phase cyclin A-associated protein in the ER (SCAPER; 15q24.3) genes. Further analysis of total serum IgE levels suggested 13q21.31 might be primarily an IgE locus, and analyses of published data demonstrated that SNPs at the 15q24.3 region are expression quantitative trait loci for 2 nearby genes, ISL2 and proline-serine-threonine phosphatase interacting protein 1 (PSTPIP1), in immune cells. Conclusion: Our GWAS of recalcitrant AD identified new susceptibility regions containing genes involved in epithelial cell function and immune dysregulation, 2 key features of AD, and potentially extend our understanding of their role in pathogenesis.
Matsui, A.,Katsuki, R.,Fujikawa, H.,Kai, M.,Kubo, K.,Hiraga, A.,Asai, Y. Asian Australasian Association of Animal Productio 2004 Animal Bioscience Vol.17 No.7
The objectives of this study were to evaluate the digestible energy intake and energy expenditure in yearling horses on different training protocols (uphill- and level-track exercise training protocols). Twenty-four thoroughbred yearlings (12 males and 12 females, aged 27.0$\pm$0.9 months) were divided into two groups based on their training on two different tracks: the uphill (with a gradient of about 3%) training group (uphill training) and the level training group (level training). The digestible energy (DE) intake and energy expenditure (EE) during exercise were measured in both the groups. It was found that the DE intake in the uphill training and the level training groups was 5.1$\pm$3.1 and 36.9$\pm$4.8 Mcal/day, respectively. The EE during exercise in the two groups was 3.05$\pm$0.51 and 2.07 $\pm$0.56 Mcal, respectively. Thus, there was a significant difference in the EE (p<0.05), but not in the DE intake between the animals of the two training groups. The EE for a given intensity of exercise was greater in the uphill training group than in the level training group, but the DE intake was not affected by the exercise intensity. The DE intake was not generally affected by the intensity of exercise in this study, but a daily negative gain of body weight was observed in the uphill training group, particularly in the females. Thus, the energy requirement may be higher in yearlings undergoing uphill training than in those undergoing level training.
Chromium(IV)–Peroxo Complex Formation and Its Nitric Oxide Dioxygenase Reactivity
Yokoyama, Atsutoshi,Han, Jung Eun,Cho, Jaeheung,Kubo, Minoru,Ogura, Takashi,Siegler, Maxime A.,Karlin, Kenneth D.,Nam, Wonwoo American Chemical Society 2012 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.134 No.37
<P>The O<SUB>2</SUB> and NO reactivity of a Cr(II) complex bearing a 12-membered tetraazamacrocyclic <I>N</I>-tetramethylated cyclam (TMC) ligand, [Cr<SUP>II</SUP>(12-TMC)(Cl)]<SUP>+</SUP> (<B>1</B>), and the NO reactivity of its peroxo derivative, [Cr<SUP>IV</SUP>(12-TMC)(O<SUB>2</SUB>)(Cl)]<SUP>+</SUP> (<B>2</B>), are described. By contrast to the previously reported Cr(III)–superoxo complex, [Cr<SUP>III</SUP>(14-TMC)(O<SUB>2</SUB>)(Cl)]<SUP>+</SUP>, the Cr(IV)–peroxo complex <B>2</B> is formed in the reaction of <B>1</B> and O<SUB>2</SUB>. Full spectroscopic and X-ray analysis revealed that <B>2</B> possesses side-on η<SUP>2</SUP>-peroxo ligation. The quantitative reaction of <B>2</B> with NO affords a reduction in Cr oxidation state, producing a Cr(III)–nitrato complex, [Cr<SUP>III</SUP>(12-TMC)(NO<SUB>3</SUB>)(Cl)]<SUP>+</SUP> (<B>3</B>). The latter is suggested to form via a Cr(III)–peroxynitrite intermediate. [Cr<SUP>II</SUP>(12-TMC)(NO)(Cl)]<SUP>+</SUP> (<B>4</B>), a Cr(II)–nitrosyl complex derived from <B>1</B> and NO, could also be synthesized; however, it does not react with O<SUB>2</SUB>.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2012/jacsat.2012.134.issue-37/ja307384e/production/images/medium/ja-2012-07384e_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja307384e'>ACS Electronic Supporting Info</A></P>
A Numerical Kano Model for Compliance Customer Needs with Product Development
Md Mamunur Rashid,Jun"ichi Tamaki,A.M.M. Sharif Ullah,Akihiko KUBO 대한산업공학회 2011 Industrial Engineeering & Management Systems Vol.10 No.2
Functional form and dysfunctional form of Kano model are considered as customer need regarding attribute of product. Both functional and dysfunctional forms are: Like, Must-be Neutral, Live-with and Dislike. The answers of customer regarding a product of functional and dysfunctional forms have been applied for selection of customer needs regarding product attribute (Kano evaluation). Filling?up and returning the Questionnaires by the individuals are essential for determining Kano evaluation. But many Questionnaires have not been returned in that case. Moreover, many possible consumers could not get opportunity to fill-up questionnaire. These uncertain or unknown consumers" opinions are also essential for product development. The choices of Kano evaluations have been outlined by: Attractive, One-dimensional, Must-be, Indifferent and Reverse. In this study, choices of evaluation of unknown customer are considered uniform cumulative vector probability (scenario 1). This study is based on the Monte Carlo simulation method, concept of probability and Kano model. This model has also been tested for its soundness and found fairly consistent including existing Kano model (scenario 2) and case survey for headlight of bicycle (scenario 3).
A Numerical Kano Model for Compliance Customer Needs with Product Development
Rashid, Md. Mamunur,Tamaki, Jun'ichi,Sharif Ullah, A.M.M.,Kubo, Akihiko Korean Institute of Industrial Engineers 2011 Industrial Engineeering & Management Systems Vol.10 No.2
Functional form and dysfunctional form of Kano model are considered as customer need regarding attribute of product. Both functional and dysfunctional forms are: Like, Must-be Neutral, Live-with and Dislike. The answers of customer regarding a product of functional and dysfunctional forms have been applied for selection of customer needs regarding product attribute (Kano evaluation). Filling.up and returning the Questionnaires by the individuals are essential for determining Kano evaluation. But many Questionnaires have not been returned in that case. Moreover, many possible consumers could not get opportunity to fill-up questionnaire. These uncertain or unknown consumers' opinions are also essential for product development. The choices of Kano evaluations have been outlined by: Attractive, One-dimensional, Must-be, Indifferent and Reverse. In this study, choices of evaluation of unknown customer are considered uniform cumulative vector probability (scenario 1). This study is based on the Monte Carlo simulation method, concept of probability and Kano model. This model has also been tested for its soundness and found fairly consistent including existing Kano model (scenario 2) and case survey for headlight of bicycle (scenario 3).
Z - R relation for snowfall using small Doppler radar and high sensitive snow gauges
M. Kubo,A. Sougen,K. Muramoto,Y. Fujiyoshi 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
Snowfall data was simultaneously recorded by a weather radar, two high sensitive snow gauges and an imaging system with high accuracy at short time intervals. The snowfall rate R was measured with two gauges and radar reflectivity factor Z was measured using a small bistatic X-band Doppler radar. The images of falling snow particles were used to obtain size and related parameters. Since all the measurements were located in a small area, it can be said that the obtained reference data corresponds well to radar data, and it is possible to analyze snowfall rate variations in sufficient detail for practical purposes. Snowfall was observed in Kanazawa, Japan, in the winter of 2009. A total of 22 snowfall events was extracted for type of snowflake or graupel, varying in duration from 4 to 31 minutes. These were then treated separately to calculate the coefficients of Z - R relation. The observations suggest that parameters of snow particle properties are useful to understand radar measurement.
Extension of the operational regime of the LHD towards a deuterium experiment
Takeiri, Y.,Morisaki, T.,Osakabe, M.,Yokoyama, M.,Sakakibara, S.,Takahashi, H.,Nakamura, Y.,Oishi, T.,Motojima, G.,Murakami, S.,Ito, K.,Ejiri, A.,Imagawa, S.,Inagaki, S.,Isobe, M.,Kubo, S.,Masamune, S IOP 2017 Nuclear fusion. Fusion nucléaire. &n.Illiga Vol.57 No.10
<P>As the finalization of a hydrogen experiment towards the deuterium phase, the exploration of the best performance of hydrogen plasma was intensively performed in the large helical device. High ion and electron temperatures, <I>T</I> <SUB>i</SUB> and <I>T</I> <SUB>e</SUB>, of more than 6 keV were simultaneously achieved by superimposing high-power electron cyclotron resonance heating onneutral beam injection (NBI) heated plasma. Although flattening of the ion temperature profile in the core region was observed during the discharges, one could avoid degradation by increasing the electron density. Another key parameter to present plasma performance is an averaged beta value <img ALIGN='MIDDLE' ALT='$\left\langle \beta \right\rangle $ ' SRC='http://ej.iop.org/images/0029-5515/57/10/102023/nfaa7fc2ieqn001.gif'/>. The high <img ALIGN='MIDDLE' ALT='$\left\langle \beta \right\rangle $ ' SRC='http://ej.iop.org/images/0029-5515/57/10/102023/nfaa7fc2ieqn002.gif'/> regime around 4% was extended to an order of magnitude lower than the earlier collisional regime. Impurity behaviour in hydrogen discharges with NBI heating was also classified with a wide range of edge plasma parameters. The existence of a no impurity accumulation regime, where the high performance plasma is maintained with high power heating >10 MW, was identified. Wide parameter scan experiments suggest that the toroidal rotation and the turbulence are the candidates for expelling impurities from the core region.</P>
h Ninomiya,T. Imai,T. Fujii,T. Suzuki,T. Fujita,T. Yamamoto,Y. Uesugi,Y. Kamada,Y. Takase,Y. Kudo,Y. Miura,Y. Ikeda,Y. M. Miura,A. Shimizu,A. Kimura,A. Morioka,A. Nishimura,A. Sagara,G. Kurita,H. Kubo 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.III
The NCT Program, in which the present JT-60U is being modified into a superconducting coil machine, is discussed under nationwide collaboration in Japan. Its mission is to establish high-beta steady-state operation for DEMO and to contribute to ITER. NCT is designed to have potential to investigate such research.
Characteristics of second harmonic ECCD on CHS
yasuo Yoshimura,H. Matsushita,H. Igami,K. Nagasaki,K. Matsuoka,K. Ohkubo,K. Nagaoka,M. Isobe,S. Kobayashi,S. Okamura,S. Kubo,S. Nishimura,T. Minami,T. Akiyama,T. Notake,T. Shimozuma,A. Shimizu,C. Suzu 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.III
Second harmonic electron cyclotron current drive (ECCD) has been investigated on CHS (Compact Helical System) by using a 2-D steerable EC-beam injection system. The direction of the plasma current, which is the sum of bootstrap current and EC-driven current, is clearly reversed by a reversal of the EC-beam injection direction. The direction of driven current is consistent with expectation in the case of low-field side injection of EC wave. So far, a driven current up to 6 kA has been obtained when bootstrap current is less than 2 kA. It is confirmed that right-hand polarization and low density are effective for ECCD.