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Edible Red Seaweed Hypnea asiatica Ameliorates High-Fat Diet-Induced Metabolic Diseases in Mice
Shigeru Murakami,Chihiro Hirazawa,Toshiki Mizutani,Takuma Ohya,Rina Yoshikawa,Ning Ma,Takahiko Ikemori,Takashi Ito,Chiaki Matsuzaki 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.11
Metabolic diseases, including obesity, diabetes, and fatty liver disease, are dramatically increasing around theworld. Seaweed is low in calories and rich in many active ingredients that are necessary for maintaining good health, and isexpected to be effective for preventing metabolic diseases. The purpose of this study was to examine the effects of a traditionalJapanese edible seaweed Hypnea asiatica (H. asiatica) on obesity, using a mouse model. H. asiatica was dried andpowdered, mixed with a high-fat diet, and fed to male C57BL/6J mice for 13 weeks. On the last day of the experiment, bloodsamples were collected under anesthesia and biochemical parameters such as lipids and adipokines were measured. Liver andadipose tissue were excised, weighed, and oxidant/antioxidant parameters were measured. Some mice were perfused with afixative solution containing formalin, and tissue specimens were prepared. A glucose tolerance test was used to assess insulinresistance. The inhibition of lipase activity was evaluated in vitro. Thirteen-week supplementation with H. asiatica suppressedbody weight gain, body fat accumulation, and blood glucose levels. H. asiatica also improved fatty liver and hypercholesterolemia,and reduced the oxidant and inflammatory parameters of serum and liver. H. asiatica increased fecal triglycerideexcretion and polyphenol-rich ethanol extract of H. asiatica inhibited lipase activity in vitro. These results suggest thatpolysaccharides and polyphenols in H. asiatica may ameliorate obesity and diabetes by inhibiting intestinal fat absorption andreducing oxidative stress and inflammation. H. asiatica may be useful in preventing metabolic diseases such as obesity,diabetes, and fatty liver.
Model-Based Software Validation for Automotive Control Systems
Yasuhiro Ito,Yasuo Sugure,Shigeru Oho 제어로봇시스템학회 2010 제어로봇시스템학회 국제학술대회 논문집 Vol.2010 No.10
Virtual hardware-in-the-loop simulation (VHILS) simulation was proposed to validate real-time control software. The VHILS simulator integrated entire mechatronic control systems and dealt with multiple technology domains of mechanical, electronic, control and software. A processor simulator ran control software codes in binary format and analyzed accurately their real-time behavior. The VHILS concept was applied to an automotive adaptive cruise control system (ACCS), and driver maneuvering, vehicle dynamics, micro controller operation and CAN communication were modeled. The modeling efficiency of the serial data communication and the data exchange between the CAN model and the multi-domain simulation were identified as the primarily causes of longer computational time. By carefully designing the simulator interface and the CAN model, we successfully built a VHILS for the ACCS that agreed accurately with experimental results and yielded a practical turn-around time.
( Kensuke Sakurai ),( Shigeru Furukawa ),( Takehiko Katsurada ),( Shinsuke Otagiri ),( Kana Yamanashi ),( Kazunori Nagashima ),( Reizo Onishi ),( Keiji Yagisawa ),( Haruto Nishimura ),( Takahiro Ito ) 대한장연구학회 2022 Intestinal Research Vol.20 No.1
Background/Aims: Inflammatory bowel disease (IBD) patients frequently have zinc deficiency. IBD patients with zinc deficiency have higher risks of IBD-related hospitalization, complications, and requiring surgery. This study aimed to examine the effectiveness of zinc acetate hydrate (ZAH; Nobelzin) in IBD patients with zinc deficiency. Methods: IBD patients with zinc deficiency who received ZAH from March 2017 to April 2020 were registered in this 2-center, retrospective, observational study. Changes in serum zinc levels and disease activity (Crohn’s Disease Activity Index [CDAI]) before and after ZAH administration were analyzed. Results: Fifty-one patients with Crohn’s disease (CD, n=40) or ulcerative colitis (UC, n=11) were registered. Median serum zinc level and median CDAI scores significantly improved (55.5-91.0 μg/dL, P<0.001; 171.5-129, P<0.001, respectively) in CD patients 4 weeks after starting ZAH administration. Similarly, median serum zinc levels and CDAI scores significantly improved (57.0-81.0 μg/dL, P<0.001; 177-148, P=0.012, respectively) 20 weeks after starting ZAH administration. Similar investigations were conducted in groups where no treatment change, other than ZAH administration, was implemented; significant improvements were observed in both serum zinc level and CDAI scores. Median serum zinc levels in UC patients 4 weeks after starting ZAH administration significantly improved from 63.0 to 94.0 μg/dL (P=0.002), but no significant changes in disease activity were observed. One patient experienced side effects of abdominal discomfort and nausea. Conclusions: ZAH administration is effective in improving zinc deficiency and may contribute to improving disease activity in IBD. (Intest Res 2022;20:78-89)
Fujimoto Kenjiro,Onoda Kazuhiro,Ito Shigeru 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1
Powder library of pseudo four components Li-Ni-Co-Ti compounds were prepared for exploring the composition region with the single phase of the layer-type structure by using combinatorial high-throuput preparation system "M-ist Combi" based on electrostatic spray deposition method. The new layer-type compounds were found wider composition region than the previous report. This process is promising way to find multi component functional materials.
Ichiro Tateya,Shuko Morita,Seiji Ishikawa,Manabu Muto,Shigeru Hirano,Yo Kishimoto,Nao Hiwatashi,Juichi Ito 대한이비인후과학회 2016 Clinical and Experimental Otorhinolaryngology Vol.9 No.1
Objectives. Endoscopic laryngopharyngeal surgery (ELPS) is a minimally invasive transoral surgery that was developed to treat superficial larygo-pharyngeal cancer, in which a mucosal lesion is resected transorally while preserving deeper structures by subepithelial injection. The purpose of this retrospective study is to evaluate voice outcome in patients who underwent ELPS for superficial hypopharyngeal cancer. As important structures in producing voice, such as intrinsic laryngeal muscles, their fascia, and recurrent laryngeal nerve, are located in the medial side of the piriform sinus and the postcricoid region of the hypopharynx, we focused on patients with cancer lesions involving these regions. Methods. From April 2010 to March 2011, 25 consecutive patients with superficial laryngopharyngeal cancer were treated with ELPS at Kyoto University Hospital. Among the 25 patients, 11 patients with cancer lesions on the medial side of the piriform sinus or the postcricoid area were studied. Preoperative and postoperative voice functions including maximum phonation time (MPT), mean flow rate (MFR), jitter, shimmer, soft phonation index (SPI), and noise-to-harmonic ratio (NHR), were compared retrospectively. Results. Five of 11 cancer lesions had submucosal invasion and no lesion had invaded the muscular layer pathologically. T stage was classified as Tis in 5 cases, T1 in 4 cases, and T2 in 2 cases. All lesions involved the medial side of the piriform sinus and 2 also involved the postcricoid area. Vocal fold movement was normal in all cases after the surgery. Average preoperative and postoperative values for MPT, MFR, jitter, shimmer, SPI, and NHR, were 22.7 seconds and 23.4 seconds, 165 mL/sec and 150 mL/sec, 1.53% and 1.77%, 3.82% and 5.17%, 35.5 and 36.6, and 0.13% and 0.14%, respectively. There was no statistical difference between preoperative and postoperative data for all values examined. Conclusion. ELPS is useful in preserving voice function in the treatment of superficial hypopharyngeal cancer. Preserving the deeper structures including intrinsic muscles and their fascia may be important for preserving voice function as long as the lesions are superficial.
Kaneko, Takaaki,Shimpo, Kan,Chihara, Takeshi,Beppu, Hidehiko,Tomatsu, Akiko,Shinzato, Masanori,Yanagida, Takamasa,Ieike, Tsutomu,Sonoda, Shigeru,Futamura, Akihiko,Ito, Akihiro,Higashiguchi, Takashi Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5
High temperature- and pressure-treated garlic (HTPG) has been shown to have enhanced antioxidative activity and polyphenol contents. Previously, we reported that HTPG inhibited 1,2-dimethylhydrazine-induced mucin depleted foci (premalignant lesions) and $O^6$-methylguanine DNA adduct formation in the rat colorectum. In the present study, we investigated the modifying effects of HTPG on N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG)-induced pyloric stomach and small intestinal carcinogenesis in mice. Male C57BL/6 mice were given ENNG (100 mg/l) in drinking water for the first 4 weeks, then a basal diet or diet containing 2% or 5% HTPG for 30 weeks. The incidence and multiplicity of pyloric stomach and small intestinal (duodenal and jejunal) tumors in the 2% HTPG group (but not in the 5% HTPG group) were significantly lower than those in the control group. Cell proliferation of normal-appearing duodenal mucosa was assessed by MIB-5 immunohistochemistry and shown to be significantly lower with 2% HTPG (but again not 5% HTPG) than in controls. These results in dicate that HTPG, at 2% in the diet, inhibited ENNG-induced pyloric stomach and small intestinal (especially duodenal) tumorigenesis in mice, associated with suppression of cell proliferation.