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Khan, Shaukat,Ul-Islam, Mazhar,Ikram, Muhammad,Islam, Salman Ul,Ullah, Muhammad Wajid,Israr, Muhammad,Jang, Jae Hyun,Yoon, Sik,Park, Joong Kon Elsevier 2018 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Vol.117 No.-
<P><B>Abstract</B></P> <P>This study reports the fabrication of porogen-induced, surface-modified, 3-dimensionally microporous regenerated bacterial cellulose (rBC)/gelatin (3DMP rBC/G) scaffolds for skin regeneration applications. Round shaped gelatin microspheres (GMS), fabricated using a water-in-oil emulsion (WOE) method, were utilized as the porogen. The dissolution of GMS from the solution casted BC scaffolds led to surface-modified microporous rBC. The scaffolds were characterized using field emission scanning electron microscopy (FE-SEM) and elemental analysis. FE-SEM analysis confirmed the regular microporosity of the 3DMP rBC/G scaffolds, while elemental analysis confirmed the successful surface modification of cellulose with gelatin. <I>In vitro</I> tests showed good adhesion and proliferation of human keratinocytes (HaCaT) on the 3DMP rBC/G scaffolds during 7 days of incubation. Confocal microscopy showed penetration of HaCaT cells into the scaffolds, up to 300 μm in depth. <I>In vivo</I> wound healing and skin regeneration experiments, in experimental mice, showed complete skin regeneration within 2 weeks. The wound closure efficacy of the 3DMP rBC/G scaffolds was much higher (93%) than that of the control (47%) and pure BC-treated (63%) wounds. These results indicated that our 3DMP rBC/G scaffolds represent future candidate materials for skin regeneration applications.</P>
IoT Services and Virtual Objects Management in Hyperconnected Things Network
Ullah, Israr,Sohail Khan, Muhammad,Kim, DoHyeun Hindawi Limited 2018 Mobile information systems Vol.2018 No.-
<P>In recent past, Internet of Things- (IoT-) based applications have experienced tremendous growth in various domains, and billions of devices are expected to be connected to the Internet in near future. The first step for development of IoT-based applications is to virtualize the physical devices by abstracting device properties in virtual objects. Later, these virtual objects can be combined to compose different services for diverse applications. Many existing systems provide virtualization service for physical devices and service composition. But, with the growth of the network, when too many devices and services are added in the IoT network, its management will become a cumbersome task. This paper presents an architecture of IoT services and virtual objects management in hyperconnected things network to facilitate the management tasks. We also have implemented a Service and Virtual Objects Management (SVOM) system prototype to effectively organize and monitor the physical devices through corresponding virtual objects and services composed in the IoT environment. The proposed system also provides interface for user interaction to perform supported control operations on selected device and check device operational and fault status. For scalability analysis of the proposed system, we have performed simulation in the OMNeT++ simulator to study impact of the IoT network size on key performance measures like response time, throughput, and packet delivery ratio. Simulation results reveal that with the growing network size, the gateway nodes become the performance bottleneck. We have also performed resources requirement analysis for virtual objects and control overhead analysis of the proposed management system. Simulation results reveal that control overhead is insignificant in normal scenarios; however, in extreme network conditions, we may have to sacrifice fewer bits which is, in fact, worth nothing when compared to the flexibility and control offered by the proposed management system.</P>
( Faiza Ahmed ),( Israr Khan ),( Nazma Hanif ),( Alaa Hamdan ),( Mohammad Ali Zaidi ),( Zeynep Yukselen ),( Umer Salman ),( Sakshi Mishra ),( Jack Michel ),( Muhammad Haris Khan ),( Andre Thompson ),( 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Background Pralsetinib and selpercatinib are anticancer drugs targeting RET fusions (oncogenic drivers) in non-small cell lung cancer (NSCLC). The US FDA approved both drugs in 2020 for the treatment of RET-fusion positive NSCLC. Methods We assessed the efficacy & safety of pralsetinib versus selpercatinib in RET fusion-positive NSCLC in two clinical trials: phase1/2 ARROW trial (n=354) and phase 1/2 LIBRETTO-001 trial (n=144). Results In patients who had previously received platinum-based therapy (n=105), Drilon et al., 2020 showed an overall response rate (ORR) of 64% (95% CI, 54-73) and a median duration of response (mDOR) of 17.5 months (95% CI, 12.0-NE) with selpercatinib in phase 1/2 LIBRETTO-001 trial. Furthermore, a complete response (CR) of 2%, partial response (PR) of 62%, stable disease (SD) of 29%, and median progression-free survival (mPFS) of 16.5 months ( 95% CI, 13.7 - NE) were reported. Treatment naive patients (n=39) demonstrated an ORR of 85% (95% CI, 70-94) and PR of 85%. The responses were determined by the independent review committee. Lee et al., 2019 (n=111) demonstrated a rapid lowering of RET circulating tumor DNA (ctDNA) in 81% of NSCLC patients with pralsetinib therapy. A phase 1/2 ARROW trial (n= 116) exhibited a median follow-up of 8.8 months in patients who received pralsetinib 400 mg daily. Additionally, ORR was 65%, CR 6%, disease control rate 93 (95% CI, 87 - 97), and resulted in overall tumor size reduction in 96% of patients. Refer to (Table 1) for further details. Conclusion Pralsetinib and Selpercatinib have shown promising anti-tumor activity and an acceptable safety profile in RET fusion-positive NSCLC. However, we cannot draw a firm conclusion regarding which one is better due to insufficient data. Clinical trials, including AcceleRET, are still ongoing, and data is pending. Further comparative studies are needed to derive meaningful survival outcomes.