백서에서 Resiniferatoxin이 열대사에 미치는 영향

이태희,김명수,Okane, Naoko,Kobayashi, Akiko,Osaka, Toshimasa,Inoue, Shuji 全南大醫大 2000 전남의대학술지 Vol.36 No.1

Structural analysis of the effects of dietary and lifestyle habits, socioeconomic status, and three healthrelated factors on urban elderly in Japan

Suwen Yang,Tanji Hoshi,Motoyuki Yuasa,Naoko Nakayama,Chika Takagi,Naoko Inoue,Naoko Sakurai,Yoshinori Fujiwara 서울시립대학교 도시과학연구원 2012 도시과학국제저널 Vol.16 No.1

This study aimed to reveal the causal relationships of dietary and lifestyle habits with socio-economic status (SES) and three health-related factors (physical,mental and social health) in elderly urban dwellers in Japan. All the elderly urban dwellers aged 65 years or more in an urban area of Tokyo were surveyed using a self-administered questionnaire in September 2001. There were 13,195 respondents with a response rate of 80.2%. And then, two follow-up surveys were conducted in 2004 and 2007, respectively. Finally, 8162 respondents were included as analysis subjects. Data analysis was performed using factor analysis and structural equation modelling (SEM). As a result of an exploratory factor analysis, three latent variables (‘dietary and lifestyle habits in 2004’, ‘SES in 2001’and ‘three health-related factors in 2001’) were defined and applied in the SEM. From the best-fit models, dietary and lifestyle habits in 2004 were well explained by SES and three health-related factors in 2001 (R2 ¼ 0.44 for elderly men and R2 ¼ 0.61 for elderly women). The results showed that dietary and lifestyle habits in 2004 were not only directly affected by SES and the three health-related factors in 2001, but also indirectly by SES via the three health-related factors. Moreover,the causal relationships between the three latent variables depended on sex and age. In conclusion, SES as a basic determinant – enough income, high education level and good physical, mental and social health – favoured both directly and indirectly the practice of healthy or desirable lifestyle habits of the elderly late in life. It will be necessary to construct a model with higher external validity in a future study.

Validity and Reliability of Seattle Angina Questionnaire Japanese Version in Patients With Coronary Artery Disease

Satomi Seki,Naoko Kato,Naomi Ito,Koichiro Kinugawa,Minoru Ono,Noboru Motomura,Atsushi Yao,Masafumi Watanabe,Yasushi Imai,Norihiko Takeda,Masashi Inoue,Masaru Hatano,Keiko Kazuma 한국간호과학회 2010 Asian Nursing Research Vol.4 No.2

Purpose The aim of this study was to evaluate the validity and reliability of the Seattle Angina Questionnaire, Japanese version (SAQ-J) as a disease-specific health outcome scale in patients with coronary artery disease. Methods Patients with coronary artery disease were recruited from a university hospital in Tokyo. The patients completed self-administered questionnaires, and medical information was obtained from the subjects’medical records. Face validity, concurrent validity evaluated using Short Form 36 (SF-36), known group differences, internal consistency, and test-retest reliability were statistically analyzed. Results A total of 354 patients gave informed consent, and 331 of them responded (93.5%). The concurrent validity was mostly supported by the pattern of association between SAQ-J and SF-36. The patients without chest symptoms showed significantly higher SAQ-J scores than did the patients with chest symptoms in 4 domains. Cronbach’s alpha ranged from .51 to .96, meaning that internal consistency was confirmed to a certain extent. The intraclass correlation coefficient of most domains was higher than the recommended value of 0.70. The weighted kappa ranged from .24 to .57, and it was greater than .4 for 14 of the 19 items. Conclusions The SAQ-J could be a valid and reliable disease-specific scale in some part for measuring health outcomes in patients with coronary artery disease, and requires cautious use. [Asian Nursing Research 2010;4(2):57–63]

An integrated approach to tropical and subtropical island conservation

Hiroya Yamano,Kiyoshi Satake,Tomomi Inoue,Taku Kadoya,Seiji Hayashi,Koichi Kinjo,Daisuke Nakajima,Hiroyuki Oguma,Satoshi Ishiguro,Azusa Okagawa,Shinsuke Suga,Tetsuya Horie,Katsuhito Nohara,Naoko Fukay 한국생태학회 2015 Journal of Ecology and Environment Vol.38 No.2

After the reversion of Okinawa (Ryukyu Islands) to Japan in 1972, extensive urban and agricultural development resulted in a significant increase in sediment discharge to coastal waters. The release of sediment has caused the degradation of freshwater and coastal ecosystems and biodiversity. A consideration for catchment-to-reef continua, as well as agricul¬tural (socioeconomic) factors is necessary to establish proper land-based management plans for the conservation of the island environment. We have set up a framework to integrate biophysics and socioeconomics: 1) setting a conservation target and threshold, 2) identifying the sources and processes, and 3) examining cost-effectiveness and management pri¬orities. The framework may be applicable to other tropical and subtropical islands with similar characteristics.

Seasonal changes in the reproductive performance in local cows receiving artificial insemination in the Pursat province of Cambodia

Tep Bengthay,Morita Yasuhiro,Matsuyama Shuichi,Ohkura Satoshi,Inoue Naoko,Tsukamura Hiroko,Uenoyama Yoshihisa,Pheng Vutha 아세아·태평양축산학회 2020 Animal Bioscience Vol.33 No.12

Objective: The present study aimed to survey seasonal changes in reproductive performance of local cows receiving artificial insemination (AI) in the Pursat province of Cambodia, a tropical country, to investigate if ambient conditions affect the reproductive performance of cows as to better understand the major problems regarding cattle production. Methods: The number of cows receiving AI, resultant number of calving, and calving rate were analyzed for those receiving the first AI from 2016 to 2017. The year was divided into three seasons: cool/dry (from November to February), hot/dry (from March to June), and wet (from July to October), based on the maximal temperature and rainfall in Pursat, to analyze the relationship between ambient conditions and the reproductive performance of cows. Body condition scores (BCS) and feeding schemes were also analyzed in these seasons. Results: The number of cows receiving AI was significantly higher in the cool/dry season than the wet season. The number of calving and calving rate were significantly higher in cows receiving AI in the cool/dry season compared with the hot/dry and wet seasons. The cows showed higher BCSs in the cool/dry season compared to the hot/dry and wet seasons probably due to the seasonal changes in the feeding schemes: these cows grazed on wild grasses in the cool/dry season but fed with a limited amount of grasses and straw in the hot/dry and wet seasons. Conclusion: The present study suggests that the low number of cows receiving AI, low number of calving, and low calving rate could be mainly due to poor body condition as a result of the poor feeding schemes during the hot/dry and wet seasons. The improvement of body condition by the refinement of feeding schemes may contribute to an increase in the reproductive performance in cows during the hot/dry and wet seasons in Cambodia.

Capsaicin 유사물질인 Resiniferatoxin의 열생산 작용기전에 관한 연구

이태희,김명수,이재우,(NaokoOkane),(AkikoKobayashi),(ToshimasaOsaka),(ShujiInoue) 대한비만학회 2000 The Korean journal of obesity Vol.9 No.2

The effects of adrenodemedullation and propranolol, ruthenium red on thermoregulation by capsaicin analogue resiniferatoxin were studied in male Wistar rats. Thermoregulation was observed by the measurements of oxygen consumption and temperature of colon and skin, simultaneously every 5 minutes for 300 minutes after subcutaneous injection of resiniferatoxin (50 ㎍/kg). The rats were studied at one to four weeks after adrenodemodullation. Propranolol treatments were 2 times of intraperitoneal injections (5 mg/kg) before 30 minutes and at the same time of resiniferatoxin injection. Ruthenium red (10 ㎍/kg) was injected subcutaneously before 15 minutes and after 45 minutes of resiniferatoxin injection. The results were as follows. 1. After resiniferatoxin (50 ㎍/kg s.c.) administration, oxygen consumption showed double-peak response. It reached to the peak level (12.8±0.5 mL/min/kg 0.75) at 50 minutes, then began to decrease. At 100 minutes, it began to increase and maintained elevated level till 300 minutes. After resiniferatoxin injection, colon temperature showed biphasic pattern; it decreased by 0.2 ℃ at 30 minutes, ant then increased. Skin temperature began to increase immediately after resiniferatoxin injection, reached to 30.38±0.45℃ at 50 minutes. Then it decreased slowly, but maintained elevated level till 300 minutes. 2. After resiniferatoxin (50 ㎍/kg) administration in adrenodemedullated rats, oxygen consumption was reduced in early-increasing response of double-peak response but was not changed in late-increasing response. The temperature of colon and skin was not changed after adrenodemedullation, too. 3. Increments of oxygen consumption by resiniferatoxin administration was abolished by the treatment of propranolol till 300 minutes. Changes of skin temperature by resiniferatoxin administration were not affected by propranolol (The peak level of skin temperature was 30.4±0.8℃ at 40 minutes. The temperature of colon was slightly decreased to 36.0±0.2℃ at 50 minutes). 4. Ruthenium red enhanced the increments of oxygen consumption to 14.7±0.8 and 14.9±0.5 mL/min/kg 0.75 at 50 and 100 minutes after resiniferatoxin administration respectively while the decrement of oxygen consumption after the first peak was attenuated by ruthenium red treatment to 14.3±0.6 mL/min /kg 0.75 at 70 minutes. There were no significant changes of skin temperature and colon temperature. Elevation of colon temperature was enhanced to the peak of 37.5±0.2℃ from 140 to 160 minutes. These results suggest that thermogeneses of resiniferatoxin may be caused by catecholamine secreted from the adrenal medulla and β adrenergic receptor binding in peripheral region, and inhibition system of thermogenesis such as VN2 receptor system also may be involved by resiniferatoxin.