The association of disease activity, pro-inflammatory cytokines, and neurotrophic factors with depression in patients with rheumatoid arthritis

Cheon, Yun-Hong,Lee, Seung-Geun,Kim, Mingyo,Kim, Hyun-Ok,Sun Suh, Young,Park, Ki-Soo,Kim, Rock Bum,Yang, Hyun-Su,Kim, Ji-Min,Son, Chang-Nam,Kyoung Park, Eun,Kim, Sang-Hyon,Lee, Sang-Il Elsevier 2018 Brain, behavior, and immunity Vol.73 No.-

<P><B>Abstract</B></P> <P>Inflammation and trophic factors (brain-derived neurotrophic factor [BDNF], vascular endothelial growth factor, glial cell line-derived neurotrophic factor, and insulin-like growth factor-1) are associated with depression in the general population. Rheumatoid arthritis (RA) is a chronic representative inflammatory autoimmune disease; however, the association of disease activity, pro-inflammatory cytokines, and neurotrophic factors with depression has not been sufficiently investigated. Therefore, we determined the prevalence of depression and risk factors for depression and deterioration of depressive symptoms in RA patients. In addition, we analyzed the association between disease activity, pro-inflammatory cytokines, trophic factors, and depression in RA (N = 474). Demographic and laboratory data were examined, and routine assessment of patient index data 3 (RAPID 3) and disease activity score 28-joint count C-reactive protein (DAS 28-CRP) was performed to assess disease activity of RA. Depression was measured using the Korean version of the Beck Depression Inventory-second edition (K-BDI II). A K-BDI score ≥18 was considered the cut-off for depression in accordance with a previous validation study. The serum level of pro-inflammatory cytokines and neurotrophic factors was assessed by enzyme-linked immune sorbent assay. The prevalence of depression was 32.4% in patients with RA. The severity of disease activity of RA (RAPID 3 score [OR 2.34; 95% confidence interval, CI 1.22–4.51], DAS 28-CRP [≥3.2] [OR 1.60, 95% CI 1.01–2.53]) and severity of fatigue (OR 1.26 95% CI 1.15–1.38) were associated with depression and deterioration of depressive symptoms in the multivariate analysis. Among the components of RAPID 3 and DAS 28-CRP, patient assessment for global health and abilities for daily performance were more related to depression. The level of pro-inflammatory cytokines (IL-1β, IL-6, TNF-alpha) was not related to depression. The level of BDNF was significantly lower in RA patients with depression and was negatively correlated with K-BDI II score. Depression was related with the level of fatigue, low expression of BDNF, and high RA disease activity, which was associated with impaired ability to perform activities of daily life. Strict control of fatigue and disease activity to improve one’s capacity to perform daily life activities would be important to regulate depression. The level of BDNF might be one of the possible biomarkers to predict or monitor depression in patients with RA.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Prevalence of depression in patients with rheumatoid arthritis (RA) was analyzed. </LI> <LI> Risk factors for depression and deterioration of depressive symptoms and were analyzed. </LI> <LI> Depression was related with disease activity in RA. </LI> <LI> Depression in RA was associated with impaired ability to perform activities of daily life. </LI> <LI> Among neurotrophic factors, the level of BDNF was related with depression in RA patients. </LI> <LI> The level of pro-inflammatory cytokines were not related with depression in RA patients. </LI> </UL> </P>

Paradoxical psoriasis induced by biologic therapies

( Hyun Yi Suh ),( Hong Lim Kim ),( Kyung Ho Kim ),( Jae Wook Jeon ),( Ji Young Ahn ),( Mi Youn Park ),( Jai Il Youn ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Biologic therapies currently approved for the treatment of moderate-to-severe plaque psoriasis work well. Administrations of those are beneficial in a variety of chronic inflammatory conditions. Recent reports have illustrated the paradoxical development of psoriasis after biologic therapies. A 30-year-old man presented widespread scaly erythematous patches on the whole body involvement after treatment with the third dose of infliximab. He was diagnosed with palmoplantar psoriasis 6 years ago. The patients had been treated either neotigason or cyclosporine with eximer phototherapy for 2 years 6 months before visiting our psoriasis clinic. He was started on the injections of infliximab, but there was no improvement after the first dose. After receiving third dose of infliximab, the patient had experienced worsening of his plaque psoriasis on the whole. We changed other biologics, ustekinumab, anti-IL-12/23 p40 monoclonal antibody. He was treated with ustekinumab. Although receiving the second dose of ustekinumab, the skin lesions were not improved and worsening of appearing pustules on the palm and sole. We treated with cyclosporin and with calcipotriol agent (Daivonex® cream) for his skin lesion. Herein, we report this impressive case of induced paradoxical psoriasis after treating on TNF-a inhibitor and IL-12/23 inhibitor.

Tris(tetraethylammonium) bistrimetaphosphate의 空間群 P1￣와 C2/c의 結晶學的 資料間의 相互變換

徐日煥,李珍昊,林星秀,朴晶蘭,秋錦洪,郭相姬,都暎圭,李海정 충남대학교 기초과학연구소 1994 忠南科學硏究誌 Vol.21 No.1

Tris(tetraethylammonium) bistrimetaphosphate, VP_6N_3O_18C_24H_60 의 結晶構造가 두가지 空間群 P1￣와 C2/c 로 밝혀졌다. 本 論文에서는 이 두가지 空間群의 結晶學的 資料間에 相互變換 關係가 成立함을 보였다. The structure of Tris(tetraethylammonium) bistrimetaphosphate, VP_6N_3O_18C_24H_60, has been elucidate with two space groups P1￣ and C2/c. In this paper, it has been shown that the crystallographic data of the two space groups are mutually transformed.

粉末 回折法을 위한 結晶面의 多重度因子 計算

徐日煥,趙成浩,金光柱,秋錦洪,李珍昊 충남대학교 1991 忠南科學硏究誌 Vol.18 No.1

같은 面間距離롤 갖는 한 面形인 다른 面들의 數로 定義 되는 多重度因子는 紹末回折賽驗에서 理論的인 强度計算을 위한 6個 因子 中의 하나이다. 이 論文에서는 各 Laue群에 대한 面 變換行列을 誘導하여 그 群에 있는 等價面 計算에 사용하였다. 各 Laue群에서 14가지 다른 種類의 面들의 多重度는 等價面들로부터 얻어질 수 있으며 그들을 한 表로 합하여 놓았다. The multiplicity factor, which may be defined as the number of different planes in a plane form having the same spacing, is one of the six factors for the theoretical intensity calculation in powder diffraction experiment. In this paper, the plane transformation matrix for each Laue group was derived and the matrix was used for the calculation of the equivalent planes in the group. The multiplicity factors for the fourteen different kinds of planes in each Laue group were able to obtain from the equivalent planes and they were summarized in a table.

21個 非對稱中心點群의 等價逆格子點

徐日煥,秋錦洪,李珍昊,朴晶蘭,郭相姬,金文執,李正秀,申容賢 충남대학교 자연과학연구소 1994 忠南科學硏究誌 Vol.21 No.2

32개 點群은 中心對稱(centrosymmetric)을 갖는 11가지 點群(Laue群)과 21個의 非對稱中心(noncentrosymmetric)點群으로 이루어졌다. 本 硏究에서는 21個 非對稱中心點群 各各의 等價回折面(等價逆格子點)들을 誘導하였다. The thirty two point groups consist of eleven Laue groups (centrosymmetric point groups) and twenty one noncentrosymmteric point groups. In this paper, the reciprocal lattice points equivalent under the operations of 21 noncentrosymmetric point groups are derived.

規則的 反射條件으로 分類된 空間群

徐日煥,金光柱,秋錦洪,李珍昊,林星秀,柳保盈,金文執 충남대학교 자연과학연구소 1992 忠南科學硏究誌 Vol.19 No.1

各 結晶格子는 230個 空間群 中 하나로 記述되는 對稱性을 가지고 있으며 그 結晶의 構造를 밝히기 爲하여는 그 結晶이 屬한 空間群을 반드시 알아야 한다. 이 論文에서는 230個 空間群을, 그 結晶이 가지고 있는 反射條件에 依하여 明白히 決定되는 空間群과 空間群間의 共通的인 反射條件 때문에 結晶의 構造가 밝혀진 後에야 밝혀지는 空間群으로 分類하여 놓았다. Every crystal lattice has a symmetry which is described by one of the 230 space groups and the space group of a crystal must be known in order to elucidate its structure. In this paper the 230 space groups are classified into two categories, i.e., the space groups that are explicitly determined by the reflection conditions the crystals have and the others that are determined only after the elucidation of the crystal structures because of the common systematic reflection conditions between the space groups.

結晶學에 關한 論題(Ⅲ)

徐日煥,趙成浩,朴倧序,金光柱,秋錦洪,李珍昊 충남대학교 1991 忠南科學硏究誌 Vol.18 No.1

本 論題에서는 (1) 結圖格子에 存在하는 3個의 回빼輪이 서로 交叉할 때 滿足하는 Euler關係式을 誘導하고, (2) 結晶內의 原子가 熱振動을 하므로써 생기는 非等方性 溫度因子를 3가지 모양으로 表示하고,이를 國際結晶學會에서 勸奬하는 等價 等方性 變位因子로 나타내었으며, (3) 7個 結晶系에 該當하는 原子間 距離 計算式과, 結合角 및 비틀림角 計算方法을 보였고, (4) 分解能에 따른 Miller指數 範圍, 測定時間의 節約을 위한 hkl의 變化順序, 對稱中心이 생기는 位置, 浮游法, goniometer head에 있는 孤의 曲率半慶計算, 2θBrag角, simple cube, bcc, fcc, diamond, hcp의 原子의 配位數 및 충진율, fcc를 trigonal로 變換 했을때 輪間角, 直接法에 使用되는 Cauchy의 不等式을 다루었다. 1. 交叉하는 두 回轉輪 Xl, X2를 回轉角 α, β만큼 回轉하면 回轉角 r의 第3의 回轉輪 X_3가 생기며, Xl, X2輪사이角을 C라 하고,X2, X3輪 사이角을 A라하며, Xl, X3사이 角을 B라 할때 A, B, C, α, β, r사이에는 다음 關係가 있다. cos A=(cos(β/2)cos(r/2)+cos(α/2))/(sin(β/2)sin(r/2)) cos B=(cos(r/2)cos(α/2)+cos(β/2))/(sin(r/2)sin(α/2)) cos C=(cos(α/2)cos(β/2)+cos(r/2))/(sin(α/2)sin(β/2))

Reciprocal Lattice Explorer의 原理와 使用法

徐日煥,李珍昊,秋錦洪,林星秀,柳保盈,朴晶蘭,金文執,趙素羅,金憲俊,李正秀,成百石 충남대학교 자연과학연구소 1993 忠南科學硏究誌 Vol.20 No.2

Reciprocal lattice explorer는 de Jong-Bouman camera와 Buerger precession camera를 合친것이다. 이 explorer를 使用하면 goniometer에 한번 固定한 試料를 使用하여 그 試料의 空間群을 決定하는데 必要한 모든 寫眞을 撮影할 수 있으며 그들은 찌그러지지 않은 逆格子面의 寫眞들이다. 本 論文에서는 de Jong-Bouman 과 Buerger precession 寫眞術의 原理와 使用法을 記述 하였고 또한 de Jong-Bouman의 振動寫眞과 zeroth layer 寫眞으로부터 11個 Laue群의 識別方法도 提示하였다. The reciprocal lattice explorer is an instrument which incorporates the principles of both the Buerger precession and the de Jong-Bouman methods. On the explorer all photographs which are necessary for a space group determination can be taken with a single setting of a crystal and the photographs show undistorted pictures of the reciprocal lattice planes. In this paper, the principles and the usages of the de Jong-Bouman and the Buerger precession photography are described, and a method of 11 Laue group identification using the de Jong-Bouman oscillation and zeroth layer photographs is shown.

結晶學에 關한 論題(Ⅳ)

徐日煥,李珍昊,秋錦洪,李正秀,成百石,林星秀,柳保盈,朴晶蘭 충남대학교 자연과학연구소 1993 忠南科學硏究誌 Vol.20 No.1

Scale Factor들을 고려한 투시 변환 매트릭스에 의한 카메라 캘리브레이션 방법

서일홍,김태원,여희주,김재현,이찬호 한양대학교 공학기술연구소 1993 공학기술논문집 Vol.2 No.1

A novel Camera Calibration Method is proposed by employing the perspective transformation matrix with scale factors for the accurate Robot Vision System, where the calibrated scale factors are horizontal scale factor, computer image center coordinate, and camera lens distortion coefficient. By using those factors, the image coordinate with distortion in computer frame grabber is transformed to the undistorted coordinate, in which calibration is performed. To show the validities of the proposed method, several experimental results are illustrated with comparison of the other calibration methods.