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Homogeneous Electrochemical Assay for Protein Kinase Activity
Shin, Ik-Soo,Chand, Rohit,Lee, Sang Wook,Rhee, Hyun-Woo,Kim, Yong-Sang,Hong, Jong-In American Chemical Society 2014 ANALYTICAL CHEMISTRY - Vol.86 No.22
<P>Herein, we report a homogeneous assay for protein kinase activity using an electrochemistry-based probe. The approach involves a peptide substrate conjugated with a redox tag and the phosphate-specific receptor immobilized on an electrode surface. The peptide substrate phosphorylated by a protein kinase binds to the receptor site of the probe, which results in a redox current under voltammetric measurement. Our method was successfully applied even in the presence of citrated human blood and modified to enable a single-use, chip-based electrochemical assay for kinase activity.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancham/2014/ancham.2014.86.issue-22/ac502549s/production/images/medium/ac-2014-02549s_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ac502549s'>ACS Electronic Supporting Info</A></P>
Sung Bae Hwang(황성배),Min Suk Chung(정민석),Yoon Ik Hwang(황윤익),Hyo Seok Park(박효석),Dong-Hwan Har(하동환),Dong Sun Shin(신동선),Byeong-Seok Shin(신병석),Jin Seo Park(박진서) 대한체질인류학회 2010 해부·생물인류학 (Anat Biol Anthropol) Vol.23 No.4
여성 골반의 절단면영상은 여성 비뇨생식계통의 실감나는 3차원영상을 만들 수 있는 가장 좋은 재료이다. 이 연구의 목적은 여성 골반의 고화질 절단면영상과 테두리영상을 마련해서 여성 비뇨생식계통의 가상해부, 가상수술을 위한 3차원영상을 만드는 데 도움 주는 것이다. 한국 여성 시신의 골반을 대상으로 자기공명영상과 컴퓨터단층사진을 찍었다. 이 골반을 포매한 다음에 수평방향으로 연속절단하였고(간격 0.1 ㎜), 각각의 절단면을 사진 찍어서 절단면영상을 만들었다. 절단면영상에서 보이는 73개 구조물(비뇨생식기관과 주변 구조물)의 테두리를 그려서 테두리영상을 만들었다. 절단면영상과 테두리영상으로 각 구조물의 3차원부피영상, 3차원표면영상을 만들었다. 여성 골반의 자기공명영상 222개(간격 1 ㎜), 컴퓨터단층사진 222개(간격 1 ㎜), 절단면영상 2,220개(화적소 크기 0.1×0.1×0.1㎣, 빛깔 개수 48 bits color), 그리고 테두리영상 222개(간격 1 ㎜)를 만들었으며, 이 영상은 서로 들어맞았다. 절단면영상과 테두리영상으로 만든 3차원영상은 실감나는 가상현실 프로그램을 만드는데 도움 될 것이고, 나아가 여성 골반의 해부학과 임상을 익히는 데 이바지할 것이다. The sectioned images (SIs) of the pelvis from a female cadaver are the best source of realistic threedimensional (3D) models of the female urogenital system. The purpose of this research is to present SIs and outlined images of the female pelvis with improved quality, which may be used to produce 3D models to simulate virtual dissection or surgery of the female urogenital and adjacent structures. A pelvis of Korean female cadaver which preserved buttock curve was scanned with 3T MR and CT machines. The pelvis was embedded and milled at 0.1 ㎜ intervals. All sectioned surfaces were photographed to create horizontal SIs. On the Photoshop, 73 structures were outlined in the SIs to create outlined images. Once the structures were outlined, volume and surface models of the structures could be produced. A total of 222 MRIs and 222 CTs of a female pelvis were obtained. 2,220 SIs of the pelvis were obtained (0.1 ×0.1×0.1㎣-sized voxels; 48 bits color). 222 outlined images of 73 structures were prepared at 1㎜ intervals. Once the structures were outlined, 3D volume and surface models of the structures were produced without the help of the computer programmers using MRIcro and Maya software. We have produced high quality SIs of the female pelvis accompanied by corresponding MRI and CT images. 3D volume and surface models of the female pelvic structures have been constructed. These computerized models may serve as the basis for future realistic medical simulation programs that may enhance clinical understanding of pelvic anatomy.
Alcohol and Liver Living Donor Liver Transplantation For Patients With Alcoholic Liver Disease
( Shin Hwang ),( Sung Gyu Lee ),( Chul Soo Ahn ),( Ki Hun Kim ),( Deok Bog Moon ),( Tae Yong Ha ),( Gi Won Song ),( Dong Hwang Jung ),( Je Ho Ryu ),( Jung Ik Park ),( Hyo Jun Lee ),( Kyoung Hoon Ko ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: Since most transplantation studies for alcoholic liver disease (ALD) were performed on deceased donor liver transplantation, little was known following living donor liver transplantation (LDLT). Methods: The clinical outcome of 18 ALD patients who underwent LDLT from Febraury 1997 to December 2004 in a large-volume liver transplantation center was assessed retrospectively. Results: The model for end-stage liver disease score was 23±11, and mean pretransplant abstinence period was 16±13 months, with 14 (77.8%) patients being abstinent for at least 6 months. Graft types were right lobe grafts in 11, left lobe grafts in 2 and dual grafts in 5. Graft to recipient body weight ratio was 0.94±0.16. The relapse rates in patients who did and did not maintain 6 months of abstinence were 7.1% and 50%, respectively (p=0.097). Younger recipient age was a significant risk factor for alcohol relapse (p=0.027). Five recipients with antibody to hepatitis B surface antigen (HBsAg) received core antibody-positive liver graft, but two of them showed positive HBsAg seroconversion. Overall 5-year patient survival rate following LDLT was 87.8%, with a 5-year relapse rate of 16.7%. Conclusions: Pretransplant abstinence for 6 months appears to be benefical for preventing posttransplant relapse. Life-long prophylactic measure should be followed after use of anti-HBc-positive liver grafts regardless of hepatitis B viral marker status of the recipient.
Characteristics and microstructure of newly designed Al–Zn-based alloys for the die-casting process
Shin, Sang-Soo,Lim, Kyoung-Mook,Park, Ik-Min Elsevier 2016 JOURNAL OF ALLOYS AND COMPOUNDS Vol.671 No.-
<P><B>Abstract</B></P> <P>Al–Zn-based alloys with high strength of >470 MPa for die-casting were successfully fabricated without melt modification and post-casting heat treatment. We designed Al-based alloys containing more than 20 wt% of Zn for the die-casting process. The matrix phase of the alloy was angular α-Al surrounded by a very fine lamellar structure of α-Al and η-Zn. The average grain size of the matrix was relatively small (∼25 μm), and a complex network of eutectoid α + η, supersaturated η, β, and Cu-related intermetallic particles formed at the grain boundaries or non-equilibrium solidification phases. This microstructural feature obtained by the addition of more than 20 wt% Zn significantly enhanced the strength of the Al–Zn-based alloys. Furthermore, we investigated the fluidity and wear properties of the developed alloys, which improved as the Zn content was increased.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The Al–Zn based die casting alloys exhibit 470 MPa UTS and of 3.5% plastic strain. </LI> <LI> The Al–Zn-based alloys show the superior fluidity under gravity-casting conditions. </LI> <LI> The fluidity and wear properties of the Al–Zn-based alloys improved with increasing the Zn content. </LI> </UL> </P>