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Hyun ju Jun,Hoe Song Yang,Young Dae Yoo,So Hui Park,So Hui Park,Hyuk Jegal,Chan Joo Jeong 국제물리치료학회 2015 Journal of International Academy of Physical Ther Vol.6 No.2
The purpose of this study was to investigate the effects of vibration on Golgi tendon organ(GTO) and Hold-Relax of PNF in muscular activity and gait factors on Delayed Onset Muscle Soreness(DOMS). This study was conducted on 20 subjects. they were divided into two groups; Hold-Relax of PNF(n=10), Vibration on GTO(n=10). Both of the group was performed interventions 1 times a day for 3 days. The data was analyzed by the repeated-ANOVA for comparing before, after 24h and after 48h changes of factors in each group and the Independent t-test for comparing the between groups. The results are as follows. There was statistically significant difference of before, after 24h and after 48h vibration on GTO group and Hold-Relax of PNF group in muscular activity and gait factors on DOMS.(p<0.05). There was no statistically significant difference of between vibration on GTO group, but there was statistically significant difference Hold-Relax of PNF group in EMG, step width, step length, stride length(p>0.05). As a results of this study, Hold-Relax of PNF group are effective in improving muscular activity and gait factors
Kyu Hyun Yang(양규현),Si Young Park(박시영),Je Hyun Yoo(유제현),Tae Hwan Kim(김태환),Hui Wan Park(박희완),Jong Hyeon Ryu(유종현),Kyo Seok Choo(추교석) 대한정형외과학회 2005 대한정형외과학회지 Vol.40 No.8
목적: 백서 골다공증 모델에서 파미드로네이트의 장기간 투여가 장관골의 강도와 골절 치유에 미치는 영향을 알아보고자 하였다. 대상 및 방법: 양측성 난소 제거술을 시행하여 골다공증을 유발시킨 생후 3개월된 Sprague-Dawley계 암컷 백서 66마리를 대상으로,3개월 후 무작위로 실험군(n=33)과 대조군(n=33)으로 나누었다. 실험군은 6개월 동안 매달 파미드로네이트(0.5 ㎎/㎏)를 복막내 투여를 하였고, 대조군은 생리 식염수를 투여하였다. 6개월의 투여기간 후에 좌측 대퇴골을 도수 골절 방법으로 골절 시키고 K-wire를 이용하여 골수강내 고정술을 시행하고, 5주 후 양측 대퇴골을 적출하였다. 정상 대퇴골과 골절을 유발시킨 대퇴골사이의 역학적인 특성을 측정하였고, 우측 대퇴골두의 골밀도를 측정하였다. 파미드로네이트의 골내 농도는 high performance liquid chromatography를 이용하여 측정하였다. 결과: 정상 대퇴골에서 최대강도는 실험군에서 154.4±17.5 N, 대조군에서는 129.7±28.0 N였으며(p=0.0002), 강성은 실험군에서 452.5±122.8 N/㎜, 대조군에서는 378.6±126.2 N/㎜였다(p=0.036). 좌측 대퇴골의 가골에 대한 평가는 정상 대퇴골과 비교하여 최대 강도는 실험군에서 22.7±7.2%, 대조군에서는 29.7±3.5%였다(p=0.025). 골밀도 검사에서는 실험군에서 230±9 ㎎/㎠, 대조군에서 219±13 ㎎/㎠였다(p=0.0007). 파미드로네이트의 평균 골내 농도는 62.3±15.2ng/㎎였고 농도와 대퇴골의 최대 강도 사이에는 상관관계를 보였지만 통계적으로 유의하지 않았다 (p=0.067). 결론: 파미드로네이트는 난소 적출술 후 골 흡수로부터 대퇴골을 효과적으로 보호하였고, 강도와 강성을 유지하였지만, 파미드로네이트의 장기 투여로 골절 치유가 지연되었다. Purpose: We investigated the effects of the long-term administration of pamidronate on long bone strength and fracture healing in a rat osteoporosis model. Materials and Methods: We performed bilateral ovariectomies in sixty-six 3-month-old female Sprague-Dawley rats. Three months after the ovariectomies, the animals were randomized into two groups. Disodium pamidronate or saline was injected into the rats every month for 6 months. The left femoral shafts were fractured by a closed fracture technique. Five weeks after the fractures, the rats were euthanized and both femurs were removed. We evaluated the mechanical properties of the normal and fractured femurs and the bone mineral densities of the right femoral heads. Pamidronate concentration was determined by high performance-liquid-chromatography. Results: The maximum strength and stiffness of the right femurs were 154.4±17.5 N, 452.5±122.8 N/㎜ in the pamidronate-treated group and 129.7±28.0 N, 378.6±126.2 N/㎜ in the control group (p<0.05). The maximum strength of the calluses compared with the right femurs and the mean bone mineral density of the right femoral heads were 22.7±7.2%, 230±9 ㎎/㎠ in the pamidronate-treated group and 29.7±13.5%, 219±13 ㎎/㎠ in the control group (p<0.05). Conclusion: Pamidronate effectively protected the femurs from bone resorption and preserved bone strength and stiffness after ovariectomies. However, fracture healing was impaired during the early stage of healing after long-term administration of pamidronate.
( Hyun Jeong Cho ),( Kyung Don Yoo ),( Seung Hee Yang ),( Ran Hui Cha ),( Dong Ki Kim ),( Kwon Wook Joo ),( Yon Su Kim ),( Ha Jeong Lee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: In chronic kidney disease (CKD), lymphangiogenesis is a common feature in tubulointerstitial fi brosis. Vascular endothelial growth factor (VEGF-C) is one of the most effi cient factors in lymphangiogenesis. The aim of study was to understand the role of VEGF-C in CKD progression. Methods: We recruited CKD patients (n=205) and healthy volunteers (n=52) from April 2008 to May 2012. We stratifi ed patients into three groups according to tertiles of VEGF-C levels. Primary outcome was a composite of 50% decline in GFR, doubling of creatinine, progression to end-stage renal disease (ESRD), or all-cause mortality. Secondary outcome was a change of blood pressure. Results: In baseline characteristics, the mean age and gender were 58 ± 15 years and 62.4% men. Underlying causes of CKD were 19% diabetes and 61.5% hypertension. The presence of diabetes in lower VEGF-C group is signifi cantly higher than higher VEGF-C group (30.9% in lower, 14.5% in middle, 11.8% in higher; p=0.009). There were no statistically signifi cant differences in age, gender, body mass index, blood pressure, GFR and proteinuria. VEGF-C levels was not related with GFR (r=0.029, p=0.690). Lower VEGF-C level was a signifi cant predictor for poor renal survival after adjustments for age, gender, body mass index, blood pressure and GFR (Hazard ratio, 2.52; 95% confi dence intervals, 1.11-5.74; p=0.028). However, the signifi cance was lost after adjustment for diabetes. Although it was insignifi cant, lower VEGF-C levels tended to decrease renal survivals in both diabetic (p=0.213) and non-diabetic CKD patients (p=0.989). There were no differences between VEGF-C levels and antihypertensive drug requirements (p=0.348). Conclusion: Lower VEGF-C levels were associated with CKD progression. However, statistical signifi cance was lost after adjustment for diabetes. Diabetes may be a signi fi cant confounder. We need to evaluate the clinical relevance of VEGF-C in diabetic CKD patients.
( Hui Yang ),( Kwang-hoon Oh ),( Hyun Jin Kim ),( Young Ho Cho ),( Yung Choon Yoo ) 한국미생물생명공학회(구 한국산업미생물학회) 2018 Journal of microbiology and biotechnology Vol.28 No.3
It is well known that Korean red ginseng has various biological activities. However, there is little knowledge about the antiviral activity of Korean red ginseng and its ginsenosides. In this study, we addressed whether oral administration of ginsenoside-Rb2 and -Rg3 is able to protect against rotavirus (RV) infection. The protective effect of ginsenosides against RV infection was examined using an in vivo experiment model in which newborn mice (10-dayold) were inoculated perorally (p.o.) with 1.5 × 10<sup>6</sup> plaque-forming units/mouse of RV strain SA11. When various dosages of ginsenoside-Rb2 (25-250 mg/kg) were administered 3days, 2 days, or 1 day before virus challenge, treatment with this ginsenoside at the dosage of 75 mg/kg 3days before virus infection most effectively reduced RV-induced diarrhea. In addition, consecutive administration of ginsenoside-Rb2 (75 mg/kg) at 3 days, 2 days, and 1 day before virus infection was more effective than single administration on day -3. The consecutive administration of ginsenoside-Rb2 also reduced virus titers in the bowels of RVinfected mice. In an experiment to compare the protective activity between ginsenoside-Rb2 and its two hydrolytic products (20(S)- and 20(R)-ginsenoside-Rg3), 20(S)-ginsenoside-Rg3, but not 20(R)-ginsenoside-Rg3, prevented RV infection. These results suggest that ginsenoside-Rb2 and its hydrolytic product, 20(S)-ginsenoside-Rg3, are promising candidates as an antiviral agent to protect against RV infection.
Hyun-Sik Kim,Jun-Hyeok Yang,Sang-Hui Park,Seung-Tak Ryu,Gyu-Hyeong Cho IEEE 2014 IEEE journal of solid-state circuits Vol.49 No.3
<P>This paper presents a 10-bit column driver IC for active-matrix LCDs, with a proposed iterative charge-sharing based (ICSB) capacitor-string that interpolates two output voltages from a resistor-string DAC. Iterative mode change between a capacitive voltage division mode and a charge sharing mode in the ICSB capacitor-string interpolation suppresses the effect of mismatches between capacitors and that of parasitic capacitances; thus, a highly linear capacitor sub-DAC is realized. In addition, the area-sharing layout technique, which stacks the interpolation capacitor-string on top of the R-DAC area, reduces the driver channel size and extends the bit resolution of the gamma-corrected nonlinear main R-DAC. Consequently, the proposed ICSB capacitor-string interpolation scheme provides highly uniform channel performance by passively dividing the coarse voltages from the global resistor-string DAC with high area efficiency, and more effective bit resolution for nonlinear gamma correction. The prototype column driver IC was implemented using a 0.11-μm CMOS process. The area occupation of the DAC and buffer amplifier per channel is only 188 × 15 μm<SUP>2</SUP>, and the static power consumption is 0.9 μA/channel with no additional static power dissipation for the interpolation. The measured maximum DNL and INL are 0.25 LSB and 0.43 LSB, respectively. The measured maximum inter-channel DVO is 5.6 mV. The proposed chip achieves state-of-the-art performance in terms of chip size and channel-to-channel uniformity.</P>