모세관 전기영동법을 이용한 프로프라놀올-시클로덱스트린 포접화합물의 안정도상수 결정

임환미,최종혁,박경래,강종성 충남대학교 약학대학 의약품개발연구소 2002 藥學論文集 Vol.17 No.-

The stability constants (K_st) for the inclusion complexes between propranolol and three types of cyclodextrin (CD) such as β-CD, methyl (ME)-β-CD and hydroxypropyl (HP)-β-CD were determined by capillary electrophoresis (CE). The enantiomers of propranolol possess relatively high affinity towards ME-β-CD with stability constants of 78 and 76 M^-1 for (R)- and (S)-propranolol, respectively. The affinity of propranolol in HP-β-CD was relatively low compared with that in ME-β-CD, i.e. 39 and 36 M^-1 for (R)- and (S)-propranolol, respectively. In spite of the lower affinity, the K_R/K_S ratio of propranolol in HP-β-CD (K_R/K_S = 1.08) was higher than that in ME-β-CD (K_R/K_S = 1.03) indicating that HP-β-CD would be more efficient than ME-β-CD or β-CD in chiral separation of propranolol by CE.

성숙한 Longissimus Dorsi근과 Soleus근의 근원섬유단백질의 특성비교

양융,최혁준,윤창훈,신완철,오상환 한국노화학회 1991 한국노화학회지 Vol.1 No.1

比較憲法에 관한 硏究 : 民主主義國家의 憲法과 共産主義國家의 憲法을 中心으로

金水暎,黃革周,權光植,吳再煥,崔聖俊,金益鉉,金永休,王任東 朝鮮大學校 法政大學 1977 法政大論文集 Vol.4 No.-

This paper aims to make clear the fundamental differences between the constitutions of two political systems, constitutional democracy and communism. (1) Fundamental Human Rights The recognition and the protection of fundamental liberties are the essences of the political system of constitutional democacy. The reality of individual liberties is the only reliable criterion that differentiates the two political systems, since the institutional apparatus of both government, assemblies, elections, parties, bureaucracies have become stereotyped to the point of identity. Recognition or nonrecognition of fundemental guaranties are closely related to the ideological telos of either system. In the constitutional democracy they crystallize the supreme values of human self-realization and dignity. In the communist states they are denied legitimacy not only because they may function as foci of opposition against monolithic power but also because they could obstruct the ideology of economic planning under collectivism. The idelolgical foundation and functional purpose of classical fundamentalism underwent a fa -reaching transformation in the Marxian society. The Russian Revolution preaches and practices the primacy of the collectivity over the individual. Instesd of being "inalienable" interpreted as obligations of the state toward the laboring masses. The attitude of Marxism in the U.S.S.R. and the so-called "People's Democracies" toward fundamental liberties is altogether different. All constitutions in the Soviet orbit contain elaborate statements on fundamental rights of the citizens, characteristically coupled with provisions concerning their duties toword the state and the community. Civil liberties in the classical sense, which the constitution of communist states merely summarizes, are overshadowed by the new social and economic rights. The guaranty of the civil rights proper is hedged in by the rubber clause that they are guaranteed " in conformity with the interests of the working class" and "in order to strenghthen the socialist system". Especially political rights of the suffrage are converted into compulsory mass participation in the political process directed by the party hierarchy. And its single party (communist party)was the straight negation of all political liberty. (2) Patterns of Governament In the modern democratic-constitutional state the essence of the power process consists in the attempt to establish an equilibrium between the various competitive plural forces within in state society, with due regard to the free unfolding of the human personality. In communist state, social control and political power are monopolized by a single power holder, subordinating the individual to the ideological requirements of the group domination the state. The basic difference between the two political systema conists in whether, in the various stages of the governmental process, political power, is distributed among and shared by several independent power holders or whether political power is concentrated in and monoploized by a single power holder, be it an individual person, and assembly, or a party. Assembly government system revived in the Stalin constitution of 1936 in the U.S.S.R. from where it spread, after the Second World War, to all satellite states, as well as East Germany, Red China, North Korea. No communist state fails to conform to this standard pattern. Assembly government, by its own biological laws. easily transforms itself into a regime in which a single power holder exercises the monopoly of political power. This may well be the intrinsic reason for the communist preference. By necessity the communist state is a plice state. Another indispensable instrument of social control is the single party. The governmental techniques of a communist regime are necessarily authoritarian. But the regime does much more than exclude the power addressees from their legitimate share in the formation of the will of the state. It attempts to mold the private life, the soul, the spirit and the mores of the citizens to a dominant ideology that the various instrumentalities of the power process force on the non-conformists.

Screening of Antifungal Activity of Natural Herbal Extracts Against Malassezia furfur

Hwan-Seok Choi,Se-Hwan Kwon,Kyu-Hyuk Kwun,Hyun-Jae Shin 한국생물공학회 2008 한국생물공학회 학술대회 Vol.2008 No.4

Applicability of Thoracolumbar Injury Classification and Severity Score to Criteria of Korean Health Insurance Review and Assessment Service in Treatment Decision of Thoracolumbar Injury

Choi, Hyuk Jin,Kim, Hwan Soo,Nam, Kyoung Hyup,Cho, Won Ho,Choi, Byung Kwan,Han, In Ho The Korean Neurosurgical Society 2015 Journal of Korean neurosurgical society Vol.57 No.3

Objective : For improving the drawbacks of previous thoracolumbar spine trauma classification, the Spine Trauma Study Group was developed new classification, Thoracolumbar Injury Classification and Severity Score (TLICS). The simplicity of this scoring system makes it useful clinical application. However, considering criteria of Korean Health Insurance Review and Assessment Service (HIRA), the usefulness of TLICS system is still controversial in the treatment decision of thoracolumbar spine injury. Methods : Total 100 patients, who admitted to our hospital due to acute traumatic thoracolumbar injury, were enrolled. In 45, surgical treatment was performed and surgical treatment was decided following the criteria of HIRA in all patients. With assessing of TLICS score and Denis's classification, the treatment guidelines of TLICS and Denis's classification were applied to the criteria of Korean HIRA. Results : According to the Denis's three-column spine system, numbers of patients with 2 or 3 column injuries were 94. Only 45 of 94 patients (47.9%) with middle column injury fulfilled the criteria of HIRA. According to TLICS system, operation required fractures (score>4) were 31 and all patients except one fulfilled the criteria of HIRA. Conservative treatment required fractures (score<4) were 52 and borderline fracture (score=4) were 17. Conclusion : The TLICS system is very useful system for decision of surgical indication in acute traumatic thoracolumbar injury. However, the decision of treatment in TLICS score 4 should be carefully considered. Furthermore, definite criteria of posterior ligamentous complex (PLC) injury may be necessary because the differentiation of PLC injury between TLICS score 2 and 3 is very difficult.

A Study on the Properties of 36,000lb Porcelain Insulators by Contained Alumina of Raw Materials

Choi In-Hyuk,Choi Jang-Hyun,Jung Yoon-Hwan,Lee Dong-Il The Korean Institute of Electrical Engineers 2005 KIEE International Transactions on Electrophysics Vol.5C No.1

In order to analyze the properties of domestically produced 36,000lb porcelain insulators by change of the alumina addition to raw materials, 36000lb ball socket type suspension insulators that were manufactured in 1989, 1995 and 2001 were removed from transmission lines and an experiment was performed. The results indicated that 8 [wt.%] alumina, which influences the mechanical properties and arc resistance properties in the case of insulators that were manufactured in 1989 was contained, and the relative density and the fracture toughness of insulators appeared by 94.2% and 1.4 [MpaㆍM/sup 1/2/], respectively. However, 12 [wt.%] alumina was contained in the case of insulators that were manufactured in 1995, and the relative density and the fracture toughness of insulators appeared preferably lower by 92% and 1.3 [MpaㆍM/sup 1/2/], respectively. The greatest amount of alumina was contained by 17 [wt.%] in the case of insulators that were manufactured in 2001. It was confirmed that the electrical and mechanical characteristics such as the relative density and the fracture toughness appeared remarkably by 96% and 1.7 [Mpaㆍm/sup 1/2/], respectively.

Comparison of a novel bedside portable endoscopy device with nasogastric aspiration for identifying upper gastrointestinal bleeding.

Choi, Jong Hwan,Choi, Jae Hyuk,Lee, Yoo Jin,Lee, Hyung Ki,Choi, Wang Yong,Kim, Eun Soo,Park, Kyung Sik,Cho, Kwang Bum,Jang, Byoung Kuk,Chung, Woo Jin,Hwang, Jae Seok WJG Press 2014 World journal of gastroenterology Vol.20 No.25

<P>To compare outcomes using the novel portable endoscopy with that of nasogastric (NG) aspiration in patients with gastrointestinal bleeding.</P>

[화학] 신속 BOD 측정장치의 개발 및 시험

오혁(Hyuk Oh),최돈수(Don-Soo Choi),정혁(Hyuk Jeong),최준환(Ju-Hwan Choi),김해동(Hai-Dong Kim) 한국분석과학회 1997 분석과학 Vol.10 No.2

HCV, Acute, LT : Changing Characteristics of Pyogenic Liver Abscess in Daegu Area

( Jong Hwan Choi ),( Woo Jin Chung ),( Jae Hyuk Choi ),( Yu Jin Lee ),( Yu Jin Kang ),( Jung Min Lee ),( Eun Sung Choi ),( Sang Min Lee ),( Byoung Kuk Jang ),( Jae Seok Hwang ),( Eun Soo Kim ),( Kyung 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1

Background: According to data from Korean national health insurance, incidence of liver abscess seems to be increased compared with one or two decades ago. We investigated changing characteristics of pyogenic liver abscess during recent 5 years in Daegu area. Methods: We reviewed retrospectively clinical and laboratory characteristics of patients who were diagnosed as pyogenic liver abscess between January 2007 and September 2012 at keimyung University Dongsan Hospital. Results: 205 patients were enrolled to this study, and male patients were 59.5% and mean age was 63.9 ± 12.7 years. 1. Abundant incidence of pyogenic abscess were 6th decade (29.5%), 7th decade (24.1%), and 5th decade (22.2%). 2. Common underlying diseases were hypertension (36.1%), diabetes (26.8%), biliary stone (14.7%), malignancy (11.7%), old CVA (3.9%). 3. Frequent presenting symptoms were fever (65.4%), chills (52.2%), and right upper quadrant pain (51.7%). Frequent laboratory abnormalities were elevated AST level (108.61 ± 98.54U/L, 70.7%), leukocytosis (18,033.03 ± 5,522.9/uL, 43.9%), and elevated total bilirubin level (3.49 ± 2.34 mg/dL, 37.1%). 4. Abscesses were present in right (67.8%), left (20.0%), and both lobe (12.2%). 71.7% of the abscesses were single and 28.3% were multiple. 5. 165 (80.5%) patients showed positive culture results. Among them, single organism was identified in 95.7%. Identifying organisms were K.pneumonia (67.3%), E.coli (10.9%) and E.faecalis (5.4%). 6. Common treatment modality was percutaneous drainage (78.0%). 18.0% of patients were treated medically, and 4.0% were underwent percutaneous aspiration. 7. The overall mortality rate was 6.8% (14 cases). Causes of death were septic shock (71.4%), and septic pneumonia, hepatic failure, hepatorenal syndrome, DIC (7.15%). Initial thrombocytopenia (80,910 ± 36,170/uL) was the risk factor affecting to the mortality rate. (P=0.008) Conclusions: Our data suggested that the peak age of pyogenic liver abscess was higher than previous Korean data and K.pneumoniae was still predominant etiology. Patients with initial thrombocytopenia required aggressive treatment due to high mortality rate.

Are pet foods safe? From perspective of mycotoxins, preservatives and antioxidants

Kyu-hwan Hwang(Kyu-hwan Hwang),Hye-ra Kim(Hye-ra Kim),Yoon-hwa Choi(Yoon-hwa Choi),Doo-hwan Kim(Doo-hwan Kim),You-Jin Lee(You-Jin Lee),Dong-Hyuk Jeong(Dong-Hyuk Jeong) 한국예방수의학회 2023 예방수의학회지 Vol.47 No.2

The aim of this study was to determine the contamination of mycotoxins and the concentration of preservatives and antioxidants in commercial pet food. 106 pet foods were purchased from online in Korea. Mycotoxin analysis were performed using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) and preservatives and antioxidants were analyzed by high performance liquid chromatography (HPLC). The contamination of the mycotoxins in all samples was proved to comply with the Korea legislation with regards to animal feed, the analyses revealed presence of aflatoxins, ochratoxin A, zearalenone and fumonisins, with values below 1.6 ㎍/㎏, 12.1 ㎍/㎏, 478.5 ㎍/㎏ and 1873.5 ㎍/㎏, respectively. Furthermore, the simultaneous presences of different mycotoxins were observed in most of positive samples. The levels of dehydroacetic acid (DHA), sorbic acid (SA) and benzoic acid (BA) were, respectively, with values below 0.24 g/㎏, 4.82 g/㎏ and 6.35 g/㎏. The concentrations of butylated hydroxy anisole (BHA) and butylated hydroxy toluene (BHT) were demonstrated to be acceptable, with values below 0.04 g/㎏, and 0.02 g/㎏. This indicated the need for further investigation into the potential risk deriving from chronic exposure to low doses of mycotoxins. Additionally, a co-contamination of mycotoxins which interact in synergic manner are more concern. As DHA that not accepted was detected and very high levels of SA were identified in samples, an upper limit for preservatives in pet foods should be established in pet foods. BHA and BHT were detected within the recommended levels for antioxidant content, so these are considered as safe.