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Shin, Seung Ho,Seo, Sang Gwon,Min, Soyun,Yang, Hee,Lee, Eunjung,Son, Joe Eun,Kwon, Jung Yeon,Yue, Shuhua,Chung, Min-Yu,Kim, Kee-Hong,Cheng, Ji-Xin,Lee, Hyong Joo,Lee, Ki Won American Chemical Society 2014 Journal of agricultural and food chemistry Vol.62 No.19
<P>In the present study, we aimed to investigate the antiobesity effect of CAPE in vivo, and the mechanism by which CAPE regulates body weight in vitro. To confirm the antiobesity effect of CAPE in vivo, mice were fed with a high fat diet (HFD) with different concentrations of CAPE for 5 weeks. CAPE significantly reduced body weight gain and epididymal fat mass in obese mice fed a HFD. In accordance with in vivo results, Oil red O staining results showed that CAPE significantly suppressed MDI-induced adipogenesis of 3T3-L1 preadipocytes. FACS analysis results showed that CAPE delayed MDI-stimulated cell cycle progression, thereby contributing to inhibit mitotic clonal expansion (MCE), which is a prerequisite step for adipogenesis. Also, CAPE regulated the expression of cyclin D1 and the phosphorylation of ERK and Akt, which are upstream of cyclin D1. These results suggest that CAPE exerts an antiobesity effect in vivo, presumably through inhibiting adipogenesis at an early stage of adipogenesis.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jafcau/2014/jafcau.2014.62.issue-19/jf405088f/production/images/medium/jf-2013-05088f_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jf405088f'>ACS Electronic Supporting Info</A></P>
Crack-Release Transfer Method of Wafer-Scale Grown Graphene Onto Large-Area Substrates
Lee, Jooho,Kim, Yongsung,Shin, Hyeon-Jin,Lee, ChangSeung,Lee, Dongwook,Lee, Sunghee,Moon, Chang-Yul,Lee, Su Chan,Kim, Sun Jun,Ji, Jae Hoon,Yoon, Hyong Seo,Jun, Seong Chan American Chemical Society 2014 ACS APPLIED MATERIALS & INTERFACES Vol.6 No.15
<P>We developed a crack-release graphene transfer technique for opening up possibilities for the fabrication of graphene-based devices. Graphene film grown on metal catalysts/SiO<SUB>2</SUB>/Si wafer should be scathelessly peeled for sequent transferring to a target substrate. However, when the graphene is grown on the metal catalyst on a silicon substrate, there is a large tensile stress resulting from the difference of the coefficient of thermal expansion in the catalyst and silicon. The conventional methods of detaching graphene from metal catalysts were found to induce considerable mechanical damage on graphene films during separation processes including metal wet etching. Here we report a new technique wherein bubbles generated by electrolysis reaction separate thin metal catalysts from the SiO<SUB>2</SUB>/Si wafer. The dry attachment of graphene to the target wafer was processed utilizing a wafer to wafer bonding technique in a vacuum. We measured the microscopic image, Raman spectra, and electrical properties of the transferred graphene. The optical and electrical properties of the graphene transferred by the bubbles/dry method are better than those of the graphene obtained by mechanical/wet transfer.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2014/aamick.2014.6.issue-15/am502565z/production/images/medium/am-2014-02565z_0005.gif'></P>
ECgene: an alternative splicing database update
Lee, Yeunsook,Lee, Younghee,Kim, Bumjin,Shin, Youngah,Nam, Seungyoon,Kim, Pora,Kim, Namshin,Chung, Won-Hyong,Kim, Jaesang,Lee, Sanghyuk Oxford University Press 2007 Nucleic acids research Vol.35 No.suppl1
<P>ECgene () was developed to provide functional annotation for alternatively spliced genes. The applications encompass the genome-based transcript modeling for alternative splicing (AS), domain analysis with Gene Ontology (GO) annotation and expression analysis based on the EST and SAGE data. We have expanded the ECgene's AS modeling and EST clustering to nine organisms for which sufficient EST data are available in the GenBank. As for the human genome, we have also introduced several new applications to analyze differential expression. ECprofiler is an ontology-based candidate gene search system that allows users to select an arbitrary combination of gene expression pattern and GO functional categories. DEGEST is a database of differentially expressed genes and isoforms based on the EST information. Importantly, gene expression is analyzed at three distinctive levels—gene, isoform and exon levels. The user interfaces for functional and expression analyses have been substantially improved. ASviewer is a dedicated java application that visualizes the transcript structure and functional features of alternatively spliced variants. The SAGE part of the expression module provides many additional features including SNP, differential expression and alternative tag positions.</P>
Lee, Dong Eun,Shin, Bong Jik,Hur, Haeng Jeon,Kim, Jong Hun,Kim, Jiyoung,Kang, Nam Joo,Kim, Dae Ok,Lee, Chang Yong,Lee, Ki Won,Lee, Hyong Joo Cambridge University Press 2010 The British journal of nutrition Vol.104 No.2
<P>We evaluated the effects of the two main kiwifruit cultivars (gold kiwifruit (GOK) and green kiwifruit (GRK)) and their active phenolic compound, quercetin, on H2O2-induced inhibition of gap-junction intercellular communication (GJIC) in WB-F344 rat liver epithelial cells. We found that both GOK and GRK protect WB-F344 cells from H2O2-induced inhibition of GJIC. The extracellular signal-regulated protein kinase 1/2 (ERK1/2)-connexin 43 (Cx43) signalling pathway is crucial for the regulation of GJIC, and both GOK and GRK blocked the H2O2-induced phosphorylation of Cx43 and ERK1/2 in WB-F344 cells. Quercetin alone attenuated the H2O2-mediated ERK1/2-Cx43 signalling pathway and consequently reversed H2O2-mediated inhibition of GJIC in WB-F344 cells. A free radical-scavenging assay using 1,1-diphenyl-2-picrylhydrazyl showed that the scavenging activity of quercetin was higher than that of a synthetic antioxidant, butylated hydroxytoluene, per mol, suggesting that the chemopreventive effect of quercetin on H2O2-mediated inhibition of ERK1/2-Cx43 signalling and GJIC may be mediated through its free radical-scavenging activity. Since the carcinogenicity of reactive oxygen species such as H2O2 is attributable to the inhibition of GJIC, GOK, GRK and quercetin may have chemopreventive potential by preventing the inhibition of GJIC.</P>
복막투석 중단없이 성공적으로 치료한 복막투석 치료 중인 당뇨병성 만성신부전 환자에서 발생한 고삼투압성 혼수 2 예
강형주(Hyong Ju Kang),박철휘(Cheol Whee Park),이소연(So Yeon Lee),최현철(Hyun Cheul Choi),이정록(Jeong Rok Lee),손장명(Jang Myung Son),신영신(Young Shin Shin),장윤식(Yoon Sik Chang),방병기(Byung Kee Bang) 대한신장학회 2001 Kidney Research and Clinical Practice Vol.20 No.3
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Poster Session : Small RNA and Gene Regulation ; ECgene: and alternative splicing database update
( Yeun Sook Lee ),( Young Hee Lee ),( Bum Jin Kim ),( Young Ah Shin ),( Seung Yoon Nam ),( Pora Kim ),( Nam Shin Kim ),( Won Hyong Chung ),( Jae Sang Kim ),( Sang Hyuk Lee ) 한국생화학분자생물학회 (구 한국생화학회) 2007 생화학분자생물학회 춘계학술발표논문집 Vol.2007 No.-
Ahn, Jun Hyong,Lee, Sang Hyun,Kim, Sohee,Joo, Jungnam,Yoo, Heon,Lee, Seung Hoon,Shin, Sang Hoon,Gwak, Ho-Shin Journal of Neurosurgery Publishing Group 2012 Journal of Neurosurgery Vol.116 No.5
<B>Object</B><P>Surgical spillage has been one of the causative factors for the development of leptomeningeal seeding (LMS) after resection of brain metastases. In this paper, the authors' goal was to define the factors related to the development of LMS and to evaluate the difference according to tumor location.</P><B>Methods</B><P>The authors retrospectively analyzed 242 patients who had undergone resection for brain metastases. The factors investigated included tumor location with proximity to the CSF pathway (that is, contacting, involved with, or separated from the CSF pathway), the method of resection, and the use of the Cavitron Ultrasonic Surgical Aspirator (CUSA).</P><B>Results</B><P>A total of 39 patients (16%) developed LMS at a median of 6.0 months (range 1-42 months) after resection. The risk of developing LMS was significantly higher in patients whose tumors were resected piecemeal than in those whose tumors were removed en bloc, with a hazard ratio (HR) of 4.08 (p < 0.01). The incidence of LMS was significantly higher in patients in whom the CUSA was used, and the HR was 2.64 (p < 0.01). The proximity of tumor to the CSF pathway in the involved group conferred an increased risk of LMS compared with the separated group (HR 11.36, p < 0.01). The risk of piecemeal resection for LMS was significant only in involved lesions (p < 0.01), and the use of the CUSA in both contact and involved lesions increased the incidence of LMS (p < 0.01 and p < 0.03, respectively).</P><B>Conclusions</B><P>The authors suggest that piecemeal resection using the CUSA should be limited because of the risk of postsurgical LMS, especially when the tumor is in contact with the CSF pathway.</P>
정상초음파가 개재하는 프로판/공기 예혼합화염의 슐리렌기법에 의한 가시화
이상신(Sang Shin Lee),김정수(Jeong Soo Kim),이도형(Do Hyong Lee) 한국가시화정보학회 2013 한국가시화정보학회지 Vol.11 No.1
An investigation into the influence of ultrasonic standing wave on the structural behavior of propane/ air premixed flame has been made to get a clue to the combustion reaction acceleration and combustion instability. Visualization technique utilizing the Schlieren photography was employed for the observation of structural variation of the flame reaction zone. Evolutionary characteristics of the flame front were caught by the high-speed Schlieren image, through which local flame velocity of the moving front were analyzed in detail.