http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Role of hair pigmentation in drug incorporation into hair
Yu, Hyerim,Jang, Won-Jun,Jang, Jung-Hee,Park, Byoungduck,Seo, Young Ho,Jeong, Chul-Ho,Lee, Sooyeun Elsevier 2017 Forensic science international Vol.281 No.-
<P><B>Abstract</B></P> <P>Hair analysis has notably expanded its application as a bio-monitor for drug or toxicant exposure. Hair pigmentation is proposed as a major factor affecting drug incorporation into hair; however, the mechanisms underlying the incorporation of drugs into hair are still unclear. In the present study, the effect of hair pigmentation on drug incorporation into hair was examined using rats carrying hair with different melanin status and human cells (SK-Mel-28 cells, HaCaT cells and the co-cultured HaCaT cells with SK-Mel-28 cells) representing the main pigmentary unit in hair. Tramadol, a synthetic opioid analgesic, was selected as a model drug. The distribution of tramadol and its phase I (<I>O</I>-desmethyltramadol [ODMT], <I>N</I>-desmethyltramadol [NDMT] and <I>N</I>,<I>O</I>-didesmethyltramadol [NODMT]) and phase II metabolites (ODMT-glucuronide and NODMT-glucuronide) was investigated in non-pigmented and pigmented hair from Long–Evans rats. Moreover, the incorporation levels of ODMT and ODMT-glucuronide were compared in hair cells. The concentrations of tramadol and its phase I metabolites were significantly higher in pigmented rat hair while those of phase II metabolites did not showed any consistent significant difference depending on the status of hair pigmentation. ODMT was taken up to a greater extent than ODMT-glucuronide by SK-Mel-28 cells, HaCaT cells and the co-cultured HaCaT cells with SK-Mel-28 cells. Notably, the incorporated level of ODMT was higher in SK-Mel-28 cells than HaCaT cells and the concentration difference of ODMT was significantly larger than that of ODMT-glucuronide. This study clearly demonstrated that hair pigmentation played a role as a facilitating factor for the incorporation of basic compounds and provided insight into the drug incorporation process into hair.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The role of hair pigmentation in drug incorporation into hair was investigated. </LI> <LI> Rats carrying hair with different melanin status were used. </LI> <LI> Human cells representing the main pigmentary unit in hair were used. </LI> <LI> Hair pigmentation is a facilitating factor for the incorporation of basic compounds. </LI> <LI> The cell study provided insight into the drug incorporation process into hair. </LI> </UL> </P>
Characterization and genetic mapping of a abaxially rolled leaf mutant in rice.
Hyerim Lee,Yoye Yu,Hee-Jong Koh 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07
Leaves are the organ for photosynthesis, respiration and transpiration, and have a major effect on crop yield. Therefore, leaf shape and structure are important agronomic traits in breeding for ideal type plant. We obtained a new abaxially rolled leaf mutant from Ilpum(Oryza sativa ssp. japonica) by the treatment of ethyl methane sulfonate(EMS). The abaxially rolled leaf mutant showed reduced plant height and panicle length, increased tiller number and panicle number than Ilpum. LRI(Leaf rolling index) analysis showed that the mutant have high value compared to the wild-type. In cross section analysis, the mutant was observed to have increased of bulliform cell number and size, and led to the outcurved leaf rolling. The phenotypes of the F1 plants derived from the cross between the mutant and Ilpum were normal. In F2 population, segregation ratio between the wild type and the mutant was 3:1. This genetic analysis indicated that leaf rolling is controlled by single recessive gene. Bulked segregant analysis(BSA) and genetic mapping were conducted using F2 population derived from the cross between mutant and Milyang23(Oryza sativa ssp. indica). According to the results, the gene was located on the long arm of chromosome2. Fine mapping is in progress.
Characteristic Analysis of DAWs to Derive Heat Treatment Process Conditions
Jihyun Yu,Seonghun Kim,Byungchae Lee,Hyerim Kim,Jonghoa Kim,Jangsoo Suh,Younjung Choi 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.2
Dry active wastes (DAWs) are combustible waste generated during the operation and decommissioning of nuclear facilities, and are known to be generated in the amount of approximately 10,000 to 40,000 drums (based on 200 L) per unit. It consists of various types of protective clothing, paper, and plastic bags, and is stored in radioactive waste storage facilities. Therefore, reducing the volume of DAWs is an important issue in order to reduce storage costs and utilize the limited space of waste storage facilities. Heat treatment such as incineration can dramatically reduce the volume of waste, but as the waste is thermally decomposed, CO2, a global warming gas, is generated and there is a risk of emissions of harmful gases including radionuclides. Therefore, a heat treatment process that minimizes the generation of CO2 and harmful gases is necessary. One of the alternatives to incineration is to carbonize DAWs, dispose of carbonized materials below the release standard as non-radioactive waste, and selectively separate and stabilize inorganic components, including radionuclides, from carbonized DAWs. In this study, 13 types of DAWs generated from nuclear power plants were selected and their thermal decomposition characteristics were investigated to design a heat treatment process that replaces incineration. As a result of TGA analysis, the temperature at which thermal decomposition of each waste begins is 260-300°C for cotton, 320-330°C for paper, 315-420°C for synthetic fiber, 350°C for latex gloves. The mass of most samples decreased to less than 1 % of the initial weight after heat treatment, and dust suit and latex gloves had residues of 13.83% and 13.71% of the initial mass, respectively. The metal components of the residue produced after heat treatment of the sample were analyzed by EDS. According to the EDS results, cotton contains Ca and Al, paper contains Ca, Al and Si, synthetic fiber contains Ca, Cu and Ti, latex gloves contain Ca and Mg. Additionally, ICP analysis was performed to quantify the inorganic components. These results are expected to be applicable to the processing of DAW generated at nuclear facilities in the future.
위혜림(Hyerim Wi),김세영(Seyoung Kim),김호영(Hoyoung Kim),유하진(Hajin Yu),박지연(Jiyeon Park),송예슬(Yeseul Song),양아영(Ayoung Yang),유혜민(Hyemin Yoo) 성신여자대학교 한국지리연구소 2015 應用地理 Vol.- No.32
전 세계적으로 지구 온난화로 인해 지구의 환경이 변화하고 있다. 이는 인간의 활동이 주된 원인으로 꼽히고 있다. 결국 이러한 변화는 모든 생명체에 막대한 영향을 끼치고, 특히 식생에서의 큰 변화를 낳을 것으로 예상된다. 따라서 본 연구는 앞서 발간된 여러 논문들을 바탕으로 기온과 강수량에 초점을 맞춰 세계와 한국의 기후 변화를 알아보고 식생의 분포 변화를 분석하는 형식으로 이루어졌다. 식생의 변화는 분포지가 점차 확대되고 있는 난대성 작물과 분포지가 점점 축소되고 있는 냉대성 작물의 대표적인 작물을 선택하여 연구를 진행하였다. 난대성 작물에서는 대나무와 차나무, 냉대성 작물에서는 배추나무, 구상나무, 사과나무, 그리고 풍혈을 선정하여 각각의 작물 특성과 이에 따른 재배지의 변화를 예측하였다. The environment of the earth is changing globally because of the global warming. The basic cause of this phenomenon is human activities. It is expected that this change will eventually affect all living things, especially vegetation will be affected a lot by this change. Therefore this study investigated the climate change of the world and the South Korea focusing on temperature and precipitation based on preceding research data, and analyzed the change of vegetation distribution. It was proceeded by choosing some samples of flora of warm climate expanding its realm and some samples of flora of subarctic climate decreasing its realm. There are bamboo and tea plant in samples of warm climate and napa cabbage, Korean fir, apple trees and wind-hole in samples of subarctic climate. This study predicted the natures and changes of plantation of each samples.
Combined Intramedullary and Intradural Extramedullary Solitary Fibrous Tumor in Cervical Spine
Park Hyerim,Yoon Yu Sung,Jang Si-Hyong 대한자기공명의과학회 2023 Investigative Magnetic Resonance Imaging Vol.27 No.2
We present a rare case of solitary fibrous tumor (SFT) located in the intramedullary (IM) and intradural extramedullary sites of cervical spine, mimicking thrombosed aneurysm and meningioma. Herein, we present a case of spinal intradural SFT in a 59-year-old woman. She presented to the outpatient clinic with a right-sided motor weakness for over a year. The case was initially misinterpreted as a thrombosed aneurysm of the posterior spinal artery. Cervical spine magnetic resonance imaging revealed a well-circumscribed intradural mass with isosignal intensity on T1 and T2-weighted images with markedly T2 dark signal focus and homogenous intense enhancement at the level of C6. Computed tomography showed a slightly high-density mass without evidence of calcification or cystic component. Surgical removal was performed. However, due to combined IM component with adhesion, incomplete tumor resection was done. Pathologic analysis revealed hypocellular spindle cells with a thick collagenous stroma and immunohistochemical staining confirmed SFT. Spinal intradural SFT is a rare spindle cell tumor. Radiologists should consider SFT as a differential diagnosis if T2-weighted imaging shows an intradural located mass with markedly dark signal intensity focus.