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Retroperitoneal sarcomas: Outcomes of repeated resections
Hyeonuk Hwang,Yoon-Hye Kwon,Han-Ki Lim,Jeesun Kim,Kyu Joo Park 대한종양외과학회 2020 Korean Journal of Clinical Oncology Vol.16 No.2
Purpose: Retroperitoneal sarcomas (RPS) are rare malignant tumors arising from mesenchymal cells. The objective of this study was to review the treatment experiences and to identify prognostic factors for overall survival (OS) after primary resection and subsequent reoperations for recurrences. Methods: The medical records of patients who underwent resection for RPS at our institution between June 2002 and December 2016 were retrospectively reviewed. Univariate and multivariable Cox proportional hazards modeling was used to assess the prognostic factors for OS. Results: A total of 48 patients were enrolled. On multivariable analysis in primary resection group, the FNCLCC (Fédération Nationale des Centres de Lutte Contre le Cancer) grade was a significant prognostic factor for OS (P=0.006). The patients who received chemotherapy after primary resection were significantly associated with poor prognosis (P=0.009). The 5-year OS rate after primary resection (n=48) were 58.1% and the 5-year cumulative reoperation rate after primary resection was 62.5%. After second resection for recurrence after primary resection (n=23), the 5-year OS rate was 64.3%. There was a tendency towards decreased surgery-free survival rate as the number of repeated resections for recurrent RPS increased. In the subset of patients (n=16) who underwent more than 3 repeated resections at our institute, the 5-year OS rate was 75.0%, indicating that repeated resections are not associated with worse outcome. Conclusion: Only low tumor grade was an independent favorable prognostic factor for OS. Although the prognosis for RPS remains poor, repeated resections for recurrence are not associated with poor prognosis. Aggressive surgical strategies for recurred RPS patients are warranted.
Hwang Nahee,Yoon Bo Kyung,Chun Kyu-Hye,Kim Hyeonhui,Lee Yoseob,Kim Jae-Won,Jeon Hyeonuk,Kim Tae-Hyun,Kim Mi-Young,Fang Sungsoon,Cheong Jae-Ho,Kim Jae-woo 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Despite advances in cancer therapy, the clinical outcome of patients with gastric cancer remains poor, largely due to tumor heterogeneity. Thus, finding a hidden vulnerability of clinically refractory subtypes of gastric cancer is crucial. Here, we report that chemoresistant gastric cancer cells rely heavily on endocytosis, facilitated by caveolin-1, for survival. caveolin-1 was highly upregulated in the most malignant stem-like/EMT/mesenchymal (SEM)-type gastric cancer cells, allowing caveolin-1-mediated endocytosis and utilization of extracellular proteins via lysosomal degradation. Downregulation of caveolin-1 alone was sufficient to induce cell death in SEM-type gastric cancer cells, emphasizing its importance as a survival mechanism. Consistently, chloroquine, a lysosomal inhibitor, successfully blocked caveolin-1-mediated endocytosis, leading to the marked suppression of tumor growth in chemorefractory gastric cancer cells in vitro, including patient-derived organoids, and in vivo. Together, our findings suggest that caveolin-1-mediated endocytosis is a key metabolic pathway for gastric cancer survival and a potential therapeutic target.
Lim, Jun,Yeo, Hyeonuk,Kim, Seo Gyun,Park, Ok-Kyung,Yu, Jaesang,Hwang, Jun Yeon,Goh, Munju,Ku, Bon-Cheol,Lee, Heon Sang,You, Nam-Ho Elsevier 2017 Composites Part B, Engineering Vol.114 No.-
<P><B>Abstract</B></P> <P>In this paper, we describe a functionalization route for synthesizing pyridine-functionalized reduced graphene oxide (Py-rGO) and the effect in the polymer matrix. In addition, polyimide (PI) nanocomposites with different loadings of Py-rGO are fabricated by in-situ polymerization. Py-rGO can perform as a filler component, which enhances the mechanical properties of the composites as well as promote polycondensation as a catalyst. As a result, the PIs containing Py-rGO are obtained with a high degree of imidization and the nanocomposite films show improved mechanical properties and oxygen barrier properties compared to pure PI. To be specific, the tensile strength and tensile modules of the nanocomposite with 0.5 wt% loading of Py-rGO are enhanced by about 406% (527 MPa) and 928% (59 GPa) in comparison to those of pure PI, respectively. Furthermore, the oxygen barrier properties of the composites are extremely improved.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>