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Hwang Nahee,Yoon Bo Kyung,Chun Kyu-Hye,Kim Hyeonhui,Lee Yoseob,Kim Jae-Won,Jeon Hyeonuk,Kim Tae-Hyun,Kim Mi-Young,Fang Sungsoon,Cheong Jae-Ho,Kim Jae-woo 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Despite advances in cancer therapy, the clinical outcome of patients with gastric cancer remains poor, largely due to tumor heterogeneity. Thus, finding a hidden vulnerability of clinically refractory subtypes of gastric cancer is crucial. Here, we report that chemoresistant gastric cancer cells rely heavily on endocytosis, facilitated by caveolin-1, for survival. caveolin-1 was highly upregulated in the most malignant stem-like/EMT/mesenchymal (SEM)-type gastric cancer cells, allowing caveolin-1-mediated endocytosis and utilization of extracellular proteins via lysosomal degradation. Downregulation of caveolin-1 alone was sufficient to induce cell death in SEM-type gastric cancer cells, emphasizing its importance as a survival mechanism. Consistently, chloroquine, a lysosomal inhibitor, successfully blocked caveolin-1-mediated endocytosis, leading to the marked suppression of tumor growth in chemorefractory gastric cancer cells in vitro, including patient-derived organoids, and in vivo. Together, our findings suggest that caveolin-1-mediated endocytosis is a key metabolic pathway for gastric cancer survival and a potential therapeutic target.
Lim, Jun,Yeo, Hyeonuk,Kim, Seo Gyun,Park, Ok-Kyung,Yu, Jaesang,Hwang, Jun Yeon,Goh, Munju,Ku, Bon-Cheol,Lee, Heon Sang,You, Nam-Ho Elsevier 2017 Composites Part B, Engineering Vol.114 No.-
<P><B>Abstract</B></P> <P>In this paper, we describe a functionalization route for synthesizing pyridine-functionalized reduced graphene oxide (Py-rGO) and the effect in the polymer matrix. In addition, polyimide (PI) nanocomposites with different loadings of Py-rGO are fabricated by in-situ polymerization. Py-rGO can perform as a filler component, which enhances the mechanical properties of the composites as well as promote polycondensation as a catalyst. As a result, the PIs containing Py-rGO are obtained with a high degree of imidization and the nanocomposite films show improved mechanical properties and oxygen barrier properties compared to pure PI. To be specific, the tensile strength and tensile modules of the nanocomposite with 0.5 wt% loading of Py-rGO are enhanced by about 406% (527 MPa) and 928% (59 GPa) in comparison to those of pure PI, respectively. Furthermore, the oxygen barrier properties of the composites are extremely improved.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>