Cone-beam computed tomography based evaluation of rotational patterns of dentofacial structures in skeletal Class Ⅲ deformity with mandibular asymmetry

Hyeong-Seok Ryu,Ki-Yong An,Kyung-Hwa Kang 대한치과교정학회 2015 대한치과교정학회지 Vol.45 No.4

Objective: The purpose of this study was to assess rotational patterns of dentofacial structures according to different vertical skeletal patterns by cone-beam computed tomography (CBCT) and analyze their influence on menton deviation in skeletal Class III deformity with mandibular asymmetry. Methods: The control group consisted of 30 young adults (15 men, 15 women) without any severe skeletal deformity. The asymmetry group included 55 adults (28 men, 27 women) with skeletal Class III deformity and at least 3-mm menton deviation from the midsagittal plane; it was divided into the hyperdivergent and hypodivergent subgroups using a mandibular plane angle cutoff of 35°. Fourteen rotational variables of the dental arches and mandible were measured and compared among the groups. Correlations between menton deviation and the other variables were evaluated. Results: The asymmetry group showed significantly larger measurements of roll and yaw in the mandible than the control group. The hypodivergent subgroup showed significant differences in maxillary posterior measurements of yaw (p < 0.01) and maxillary anterior shift (p < 0.05) compared with the hyperdivergent subgroup. All the mandibular measurements had significant correlations with menton deviation (p < 0.01). Most measurements of roll were positively correlated with one another (p < 0.01). Measurements of yaw and roll in the posterior regions were also positively correlated (p < 0.05). Conclusions: Menton deviation in skeletal Class III deformity with mandibular asymmetry is influenced by rotation of mandibular posterior dentofacial structures. The rotational patterns vary slightly according to the vertical skeletal pattern.

복강경을 이용한 서혜부 탈장 교정술과 기존 탈장교정술의 비교 분석 : 복강을 통한 전복막 접근법의 고찰 Transabdominal Preperitoneal Floor Repair

류석용,이명수,김형국,한세환,김홍주,김영덕,김홍용 인제대학교 1998 仁濟醫學 Vol.19 No.1

인제대학교 상계백병원 외과학교실에서는 복강경하 탈장교정술의 유용성을 확인하고자 복강경수술을 희망한 서혜부 탈장 환자 15명을 대상으로 복강을 통한 전복막 탈장교정술을 시행하였고 비교 분석군으로는 같은 기간 내원하여 기존의 탈장교정술을 시행한 서혜부 탈장 환자 50명을 비교하여 다음과 같은 결과를 얻었다. 1) 남녀 비는 남자 12명, 여자 3명이었고, 기존의 탈장교정술을 시행한 환자에서는 남자 45명, 여자 5명이었다. 2) 나이는 19세부터 80세까지 다양하였고 평균 나이는 51.47세였다. 기존의 탈장교정술을 시행한 환자에서는 17세부터 88세까지로 평균 나이는 53.96세였다. 3) 복강경 시술 환자에서 발생 부위는 우측 6예, 좌측 7예, 양측성 탈장 2예였고, 발생 형태는 간접 탈장이 14예, 직접 탈장이 3예, 재발성 탈장이 1예였다. 4) 기존의 탈장교정술에서는 평균 70.1분의 수술 시간이 소요되었으나 복강경 탈장교정술에서는 투관침 삽입부터 제거까지 50분에서 100분까지 다양하였으며 평균수술 시간은 75.3분이었다. 5) 입원 기간은 기존의 탈장교정술시 평균 5.66일인데 비하여 복강경 탈장교정술시는 2∼7일까지 다양하였고 평균 입원기간은 3일로 나타났다. 6) 합병증은 복강경 시술환자 15명중 1명(6.7%)에서 나타났는데 비교적 경미한 서혜부 혈종이었고 보존적 치료후 호전되어 퇴원하였다. 시술 환자 15명중 재발은 없었다. 그리고 복강을 통한 전복막 접근법시 흔한 합병증 중의 하나인 장유착에 의한 장폐색 및 장관 손상은 관찰 기간동안 발생하지 않았다. 결론적으로 복강을 통한 전복막 탈장교정술은 기존의 탈장교정술에 비해 입원 기간을 단축시킬 수 있고 복벽의 긴장을 필요로 하지 않아 통증 감소의 효과가 있으며 사회경제학적, 미용적인 관점 등 여러 가지 장점을 갖고 있는 효과적인 치료법이라 생각된다. Laparoscopic herniorrhaphy is a new and presently evolving technique applied to the repair of ingunal defects. Currently there are three popular methods of performing laparoscopic herniorrhaphy. These include the intraperitoneal onlay mesh repair(IPOM) , the totally ex-traperitoneal approach(TEPA), and the transabdominal preperitoneal floor repair(TAPP). Laparoscopic inguinal herniorrhaphy has following potential advantages : 1) less postoperative discomfort/pain, 2) reduced recovery time, allowing an earlier return to full activity, 3) easier repair of a recurrent hernia because the repair is performed in tissue that has not been dissected previously, 4) the ability to treat bilateral hernias, 5) the performance of a simultaneous diagnostic laparoscopy, 6) the highest possible ligation of the hernia sac, and 7) an improved cosmesis. The earlier return to full activity is an important socioeconomic factor because the decrease in time away from work could potentially offset the higher operative costs. We performed 15 laparoscopic inguinal herniorrhaphies using transabdominal preperitoneal floor repair at the department of Surgery of Sanggye Paik Hospital from October 1996 to September 1997. In our series, 15 patients had 17 hernia repairs. Of this group, 14 hernias were indirect, 3 direct, 1 recurrent, and 2 bilateral. The results are summerized briefly as follows : 1) The male to female ratio was 12:3 2) The operation time of laparoscopic herniorrhaphy(from Verress needle insertion to removal) varified from 50 minutes to 100 minutes and mean operation time was 75.3 minutes. 3) A minor complication, subcutaneous hematoma in right inguinal area, occurred. 4) There were no other complications such as bowel perforation, adhesive bowel obstruction and bladder injury occurring in TAPP repair. 5) There were no recurrent hernia. In conclusion, laparoscopic inguinal herniorrhaphy is an effective method to correct an inguinal hernia. It can be offered safely to patients undergoing other abdominal procedures.

Advantages and operational strategies of Falcon 3EC for high resolution cryo-electron microscopy of biological macromolecules

Hyeong seop Jeong,Jae Sung Woo,Hee seok Kweon,Bum han Ryu 한국구조생물학회 2019 Biodesign Vol.7 No.2

The Falcon 2 camera (Thermo Fisher Scientific Inc., USA) mounted in High Resolution Bio-TEM at Korea Basic Science Institute (KBSI) was upgraded to Falcon 3EC in August 2017 (Jeong et al., 2017). Compared with Falcon 2, Falcon 3EC has better sensitivity and higher frame rate and can be operated in electron counting mode. These changes significantly increase the data quality, thereby increasing the resolution of the 3D structure. In the benchmarking test of this machine, the structure of inhibitor-free beta-galactosidase has been solved at 2.16 Å. Here we introduce main features of the new detector, and discuss about major considerations required for its operation and data collection strategies to achieve the near atomic resolution.

Pathologic outcomes of endoscopic submucosal dissection for gastric epithelial neoplasia

Ryu, Dae Gon,Choi, Cheol Woong,Kang, Dae Hwan,Kim, Hyung Wook,Park, Su Bum,Kim, Su Jin,Nam, Hyeong Seok Wolters Kluwer Health 2018 Medicine Vol.97 No.33

<P><B>Abstract</B></P><P>Endoscopic submucosal dissection (ESD) has been widely implemented for the treatment of gastric superficial neoplasia. However, the final pathologic diagnosis after ESD may be different from that indicated by the results of endoscopic forceps biopsy. This study identified risk factors for gastric epithelial lesions so that early gastric cancer (EGC) could be diagnosed after ESD.</P><P>From December 2008 to January 2017, 1541 lesions (1410 patients) diagnosed as initial adenoma or indefinite for neoplasia by endoscopic forceps biopsy were enrolled. The EGC rate and factors predicting upstaged diagnoses were analyzed retrospectively.</P><P>The diagnostic discrepancy rate was 31.1%. Upstaged and downstaged diagnostic rates after ESD were 23.8% and 7.3%, respectively. The upstaged diagnosis rate for EGC was 18.8%. Gross depression (OR, 16.017) and surface redness (OR, 22.136) were significantly associated with EGC and lesions indefinite for neoplasia during the initial endoscopic forceps biopsy. Central depression (OR, 2.959), nodular surface (OR, 6.581), and surface redness (OR, 6.399) were significantly associated with EGC and lesions with low-grade dysplasia during the initial endoscopic forceps biopsy. Central depression (OR, 1.999), nodular surface (OR, 1.733), surface redness (OR 2.283), lesion location (upper third of the stomach) (OR, 3.989), and tumor size ≥10 mm (OR, 2.200) were significantly associated with EGC and lesions with high-grade dysplasia during the initial endoscopic forceps biopsy.</P><P>Central depression, nodular surface, surface redness, lesion location, and tumors >10 mm were associated with EGC. Gastric epithelial lesions with these characteristics require attention before ESD.</P>

Design of THz Detector with Nano-Scale Aperture for Enhanced Performance and Resolution by Near-Field Microscopy Technology

Woo-Seok Kim,Hyeong Ju Jeon,Min Woo Ryu,E-san Jang,Sang Hyo Ahn,Kyung Rok Kim 대한전자공학회 2019 대한전자공학회 학술대회 Vol.2019 No.6

Efficacy and safety of limited endoscopic sphincterotomy before self-expandable metal stent insertion for malignant biliary obstruction

Nam, Hyeong Seok,Kang, Dae Hwan,Kim, Hyung Wook,Choi, Cheol Woong,Park, Su Bum,Kim, Su Jin,Ryu, Dae Gon Baishideng Publishing Group Inc 2017 WORLD JOURNAL OF GASTROENTEROLOGY Vol.23 No.9

<P><B>AIM</B></P><P>To evaluate the safety and efficacy of limited endoscopic sphincterotomy (ES) before placement of self-expandable metal stent (SEMS).</P><P><B>METHODS</B></P><P>This was a retrospective analysis of 244 consecutive patients with unresectable malignant biliary obstruction, who underwent placement of SEMSs following limited ES from December 2008 to February 2015. The diagnosis of malignant biliary obstruction and assessment of patient eligibility for the study was established by a combination of clinical findings, laboratory investigations, imaging and pathological results. All patients were monitored in the hospital for at least 24 h following endoscopic retrograde cholangio pancreatography (ERCP). The incidence of immediate or early post-ERCP complications such as post-ERCP pancreatitis (PEP) and bleeding related to limited ES were considered as primary outcomes. Also, characteristics and complications according to the cancer type were classified.</P><P><B>RESULTS</B></P><P>Among the 244 patients included, the underlying diagnosis was cholangiocarcinoma in 118 patients, pancreatic cancer in 79, and non-pancreatic or non-biliary malignancies in the remaining 47 patients. Early post-ERCP complications occurred in 9 patients (3.7%), with PEP in 7 patients (2.9%; mild, 6; moderate, 1) and mild bleeding in 2 patients (0.8%). There was no significant association between the incidence of post-ERCP complications and the type of malignancy (cholangiocarcinoma <I>vs</I> pancreatic cancer <I>vs</I> others, <I>P</I> = 0.696) or the type of SEMS used (uncovered <I>vs</I> covered, <I>P</I> = 1.000). Patients who had more than one SEMS placed at the first instance were at a significantly higher risk of post-ERCP complications (one SEMS <I>vs</I> two SEMS, <I>P</I> = 0.031). No other factors were predictive of post-ERCP complications.</P><P><B>CONCLUSION</B></P><P>Limited ES is feasible and safe, and effectively facilitates the placement of SEMS, without any significant risk of PEP or severe bleeding.</P>

Endoscopic predictive factors associated with local recurrence after gastric endoscopic submucosal dissection

Nam, Hyeong Seok,Choi, Cheol Woong,Kim, Su Jin,Kang, Dae Hwan,Kim, Hyung Wook,Park, Su Bum,Ryu, Dae Gon Informa UK (TaylorFrancis) 2018 Scandinavian journal of gastroenterology Vol.53 No.8

하수고도처리 ( 3 ) - A 발표장 / A - 19 : Ozoflotation 을 이용한 THM 전구물질 제거에 관한 연구

강형석(Hyeong Seok Kang),정용(Yong Chung),류재근(Jae Keun Ryu) 한국물환경학회 ( 구 한국수질보전학회 ) 2000 한국물환경학회·대한상하수도학회 공동 춘계학술발표회 Vol.2000 No.-

Postgastrectomy pharmacokinetic changes of S-1 in patients with localized advanced gastric cancer.

Lim, Hyeong-Seok,Ryu, Keun Won,Lee, Jun Ho,Kim, Young-Woo,Ju Choi, Il,Kim, Mi-Jung,Park, Young-Iee,Hwang, Aekyung,Park, Sook Ryun J.B. Lippincott Co. [etc.] 2015 The Journal of Clinical Pharmacology Vol.55 No.8

<P>S-1 is an oral 5-fluorouracil agent containing tegafur, 5-chloro-2, 4-dihydroxypyridine (CDHP), and potassium oxonate. This study explored the pharmacokinetics of S-1 and pharmacokinetic changes after gastric surgery in patients with resectable gastric cancer who received pre- and postoperative S-1 plus docetaxel. Serial blood was drawn before and after gastrectomy from 37 patients for pharmacokinetic analysis. The pharmacokinetics of tegafur, 5-fluorouracil, and CDHP were analyzed by noncompartmental analysis (NCA) methods and by modeling. In modeling analysis, CHDP concentrations were incorporated in the model as a time-varying covariate that inhibits the clearance of 5-fluorouracil following an inhibitory Emax model. In NCA, the pharmacokinetics of tegafur and 5-FU before and after gastric surgery were similar, although average maximum concentrations of 5-FU were decreased with statistical significance after gastrectomy. Median Tmax of tegafur was shorter after surgery without statistical significance. In modeling analysis, tegafur was best fitted by mixed zero and first-order absorption. The only difference in the final pharmacokinetic model around gastrectomy was the presence of an absorption lag of 0.23 hours before surgery. Incorporation of CDHP concentrations significantly improved the model. Although some pharmacokinetic results showed statistically significant changes after gastrectomy, these differences seem to be too small to have any clinical implication.</P>

Band Selection to Classify the Difference in Canopy Reflectance between Garlic and Onion using Decision Tree Method

( Si-hyeong Jang ),( Chan-seok Ryu ),( Ye-seong Kang ),( Sae-rom Jun ),( Jun-woo Park ),( Tapash Kumar Sarkar ),( Hye-young Song ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1

The objective of this study is to select optimal spectral bands that is possible to classify the difference in canopy reflectance between Garlic and Onion. The Transform Divergence(TDiver) and Decision Tree(DT) were applied as the classification methods based on the machine learning. The canopy reflectance was acquired two types such as multispectral camera mounted on Unmanned Aerial Vehicle(UAV) and hyperspectral camera based on ground. The study was conducted at Hyeonggyeong-myeon, Muan-gun, Jeollanam-do from February to May in 2016 at Garlic and Onion fields. The multispectral images were acquired with an interval of two weeks using the fixed wing UAV(eBee, Sensefly) and the hyperspectral images were acquired with an interval of one month during the growing season. The crop canopies were extracted from the acquired images by Ortho’s method for the homogeneous training sample data. In hyperspectral image, the high dimensional data was averaged into 20, 40, 50 and 80nm of FWHM depending on the commercialized band pass filter in order to develop the multispectral imaging sensor. TDiver was calculated to evaluate the separability of canopy reflectance between Garlic and Onion depending on the growth stages. Separability of TDiver represents classification possibility between garilc and onion. Separability of less than 1700 means low classification possibility and it of more than 1900 means high classification possibility. The method of DT using the averaged of FWHM data was conducted to select spectral band using the training samples of 30% and evaluate the classification accuracy using the test samples of 70%. As a result of multispectral image, the separability of canopy reflectance between Garlic and Onion was shown at three-dimensional spectral band set such as NIR, Red and Green as the best because TDiver value is highest as 1958. It means that it is possible to classify Garlic and Onion on 12^th May as the late growing stage. In the remaining grwoth stages, however, these are difficult to classify Garlic and Onion because TDiver values were lower and less than 1358. In the case of hyperspectral images, the single spectral bands namely green blue and NIR were selectred for FWHM 25nm and 40nm in 22^th March, 19^th April and 12^th May. Alongside, two spectral bands in 12^th May and Green and Blue bands in 22^th March and 19^th April were selected for FWHM 50nm and two spectral bands in 19^th April for FWHM 80nm were selected where Green and NIR bands were selected in 22^th March and 12^th May. The classification accuracy of decision tree developed using the data on 22^th March was clearly classified as overall accuracy 100% using one spectral band for all FWHM. The DT of two spectral bands (460nm, 720nm) selected for FWHM 80nm in 19^th April was the better overall accuracy 94.9% and Kappa 0.892 than it of one spectral band. The DT of two spectral bands (940nm, 430nm) selected for FWHM 50nm in 12^th May was the better accuracy 92.1% and Kappa 0.839 than it of one spectral band.