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Test공정의 Test Tray 내 Device 안착 향상을 위한 Drop Height 최적화 연구
정다우,노창균(Noh Chang kyun),박현수(Park Hyun su),강영호(Kang Young ho),김일현(Kim Ill Hyeon),정병욱(Jung Byung wook),김유경(Kim yu kyeong) 대한전자공학회 2022 대한전자공학회 학술대회 Vol.2022 No.11
검사공정에서는 Package 완료된 Device를 Test하여 성능 및 동작 여부를 판단하는데 Test하기 위해서는 Test-Tray에 디바이스를 옮겨 담아야 한다. 이 과정에서 디바이스를 최대한 정확하게 안착시키기 위해 디바이스가 낙하하는 최적의 높이를 찾아서 양산 공정에 적용함으로써 디바이스 로딩 미스의 문제를 해결하고자 한다. 디바이스가 낙하하는 과정에서 주요 인자들을 분석하고 실험하여 최적의 Drop Height 범위를 찾아내었다. 관련하여 운동 방정식을 적용하여 모델링하였고 실험한 연구 결과를 바탕으로 양산 적용하여 로딩 미스 변화를 비교하였다. 기존 Drop Height 2.5mm~3.0mm에서 최적의 Drop Height값을 적용 후 로딩 미스 불량률은 23% 감소, 핸들러 일별 Error 건수는 47%로 감소시킬 수 있었다. In the inspection process, the packaged device is tested to determine performance and operation, and in order to test, the device must be transferred to the Test-Tray. In this process, in order to settle the device as accurately as possible, the optimal height at which the device drops is found and applied to the mass production process to solve the problem of device loading mistakes. The optimal Drop Height range was found by analyzing and experimenting with major factors in the process of the device dropping. In this regard, the equation of motion was modeled by applying it, and the change in loading mistakes was compared by applying mass production based on the experimental research results. After applying the optimal Drop Height value of 2.5mm–3.0mm to the existing Drop Height, the loading error defect rate could be reduced by 23% and the number of errors per day of Handler could be reduced by 47%.
Direct visualization of single-molecule membrane protein interactions in living cells
Kim, Do-Hyeon,Park, Soyeon,Kim, Dong-Kyun,Jeong, Min Gyu,Noh, Jungeun,Kwon, Yonghoon,Zhou, Kai,Lee, Nam Ki,Ryu, Sung Ho Public Library of Science 2018 PLoS biology Vol.16 No.12
<▼1><P>Interactions between membrane proteins are poorly understood despite their importance in cell signaling and drug development. Here, we present a co-immunoimmobilization assay (Co-II) enabling the direct observation of membrane protein interactions in single living cells that overcomes the limitations of currently prevalent proximity-based indirect methods. Using Co-II, we investigated the transient homodimerizations of epidermal growth factor receptor (EGFR) and beta-2 adrenergic receptor (β2-AR) in living cells, revealing the differential regulation of these receptors’ dimerizations by molecular conformations and microenvironment in a plasma membrane. Co-II should provide a simple, rapid, and robust platform for visualizing both weak and strong protein interactions in the plasma membrane of living cells.</P></▼1><▼2><P><B>Author summary</B></P><P>Protein–protein interactions govern cellular processes. The majority of these physical interactions previously identified are strong/permanent interactions, which typically remain unbroken even after purification. The weak/transient interactions between proteins have been implicated in the control of dynamic cellular process that maintain cellular homeostasis and trigger signaling cascades upon environmental changes. However, these interactions are poorly investigated, mainly due to the methodological limitations. Here, we have developed a co-immunoimmobilization assay called Co-II that enables the direct visualization of protein–protein interactions in the membrane of living cells at the single-molecule level. Co-II is based on the intuitive concept that if the protein of interest is immobilized, the interacting protein must be co-immobilized. The use of intrinsic protein diffusivity fundamentally overcomes the limitations of proximity-based methods. Using Co-II, we study the transient homodimerizations of EGFR and β2-AR in living cells, which have been implicated in several types of cancers and heart diseases. We show that the dimerization of these receptors is differently regulated by molecular conformations and the microenvironment in the plasma membrane.</P></▼2>
( Kyeum Han Noh ),( Eun Young Kim ),( Tae Cheon Jeong ),( Min Kyun Na ),( Mon Chang Ba다 ),( Kwang Hyeon Liu ),( Pil Hoon Park ),( Beom Soo Shin ),( Won Ku Kang ) 영남대학교 약품개발연구소 2012 영남대학교 약품개발연구소 연구업적집 Vol.22 No.0
Glimepiride, a second-generation sulfonylurea, is a glucose-lowering agent widely used to treat diabetes mellitus. It is converted into metabolite M1 by CYP2C9, and M1 is then transformed into the carboxyl derivative M2 by cytosolic enzymes. In this study, we introduce a sensitive liquidchromatography/tandem mass spectrometry (LC/MS/MS) method for determining glimepiride, M1, and M2 in human plasma. After simple protein precipitation with acetonitrile, the analytes were chromatographed on a reversed-phase CN column with a mobile phase of 10 mM ammonium acetate aqueous solution and acetonitrile (1:1, v/v). The accuracy and precision of the assay were in accordance with FDA regulations for the validation of bioanalytical methods. This method was used to measure the concentrations of glimepiride, M1, and M2 in plasma after a single oral 2-mg dose ofglimepiride in volunteers.
One-Loop Master Integral for Order-v2n Relativistic Corrections Γ[J/ψ→e+e-]
Jungil Lee,Chaehyun Yu,Hyeon-Kyun Noh 한국물리학회 2007 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.50 No.2
We show that one-loop scalar integrals contributing to the order-$v^{2n}$ relativistic corrections to the QCD vertex corrections to the spin-triplet $S$-wave heavy-quark-antiquark pair annihilation into a virtual photon can be expressed in terms of a single master integral. With an algebraic reduction combined with the tensor-integral reduction method, we first simplify the scalar integrals as linear combinations of two-point functions. The two-point functions are reduced into a single master integral by using the recurrence relations derived from integration by parts. Order-$v^2$ formulas are explicitly derived, and a strategy to calculate the higher-order relativistic corrections at order $\alpha_s$ is also given. The result may be very useful in calculating the order-$v^{2n}$ relativistic corrections to the leptonic decay width of the spin-triplet $S$-wave heavy quarkonium at order $\alpha_s$.
Jae Keun Park,Ji Hyeon Lee,Dong Hyo Noh,Joo Kyung Park,Kyu Taek Lee,Jong Kyun Lee,Kwang Hyuck Lee,Kee-Taek Jang,Juhee Cho 거트앤리버 소화기연관학회협의회 2020 Gut and Liver Vol.14 No.3
Background/Aims: Recent advances in understanding the genetics of pancreatic ductal adenocarcinoma (PDAC) have led to the potential for a personalized approach. Several studies have described the feasibility of generating genetic profiles of PDAC with next-generation sequencing (NGS) of samples obtained through endoscopic ultrasound-guided tissue acquisition (EUS-TA). The aim of this study was to find the best EUS-TA approach for successful NGS of PDAC. Methods: We attempted to perform NGS with tissues from 190 patients with histologically proven PDAC by endoscopic ultrasound-guided fine-needle aspiration and endoscopic ultrasound-guided fine-needle biopsy at Samsung Medical Center between November 2011 and February 2015. The medical records of these patients were retrospectively reviewed for parameters including tumor factors (size, location, and T stage), EUS-TA factors (needle gauge [G], needle type, and number of needle passes) and histologic factors (cellularity and blood contamination). The sample used for NGS was part of the EUS-TA specimen that underwent cytological and histological analysis. Results: NGS could be successfully performed in 109 patients (57.4%). In the univariate analysis, a large needle G (p=0.003) and tumor located in the body/tail (p=0.005) were associated with successful NGS. The multivariate logistic regression analysis revealed that the needle G was an independent factor of successful NGS (odds ratio, 2.19; 95% confidence interval, 1.08 to 4.47; p=0.031). Conclusions: The needle G is an independent factor associated with successful NGS. This finding may suggest that the quantity of cells obtained from EUS-TA specimens is important for successful NGS.
Oh, Young Jun,Noh, Hyeon-Kyun,Chang, Kee Joo TaylorFrancis 2015 SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS Vol.16 No.3
<P>Oxygen vacancies have been considered as the origin of threshold voltage instability under negative bias illumination stress in amorphous oxide thin film transistors. Here we report the results of first-principles molecular dynamics simulations for the drift motion of oxygen vacancies. We show that oxygen vacancies, which are initially ionized by trapping photoexcited hole carriers, can easily migrate under an external electric field. Thus, accumulated hole traps near the channel/dielectric interface cause negative shift of the threshold voltage, supporting the oxygen vacancy model. In addition, we find that ionized oxygen vacancies easily recover their neutral defect configurations by capturing electrons when the Fermi level increases. Our results are in good agreement with the experimental observation that applying a positive gate bias pulse of short duration eliminates hole traps and thus leads to the recovery of device stability from persistent photoconductivity.</P>