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Thien-Hoang Ho,Kyoungho Jung,Inho Lee,Kim-Hung Huynh,Diem-Quynh Nguyen,Hyunjae Park,Sang Hee Lee,Lin-Woo Kang 한국구조생물학회 2017 Biodesign Vol.5 No.1
The emergences of multi-drug resistant bacteria such as Acinetobacter baumanni have emphasized the necessity of new antibiotics. Peptidyl deformylase (PDF) catalyzes the removal of the formyl group from the N-terminal formylated methionine residue present in all nascent polypeptides in bacteria. In this study, the PDF gene from Acinetobacter baumannii K0420859 was cloned and its protein was overexpressed in E. coli, purified, and crystallized. The purified protein was crystallized using the hanging-drop vapour-diffusion method and the crystal diffracted to 2.4 Å resolution. The crystal belonged to the trigonal space group P3 2 with unit cell parameters of a = b= 39.4 Å and c = 187.9 Å. Two protomers were presented in the asymmetric unit with a corresponding V M of 2.10 Å 3 Da -1 and a solvent content of 41.5%.
Hung-Yen Chin,Chin-Jung Wang,Eileen Changchien,Mei-Fung Lin,Chi-Hsin Chiang 연세대학교의과대학 2014 Yonsei medical journal Vol.55 No.4
Purpose: The aim of this study is to explore non-steroid anti-inflammation drugs (NSAIDs) potency for pelvic floor muscle pain by measuring local concentration in a rat model. Materials and Methods: We used nine NSAIDs, including nabumetone,naproxen, ibuprofen, meloxicam, piroxicam, diclofenac potassium, etodolac, indomethacin, and sulindac, and 9 groups of female Wister rats. Each group of rats was fed with one kind of NSAID (2 mg/mL) for three consecutive days. Thereafter, one mL of blood and one gram of pelvic floor muscle were taken to measure drug pharmacokinetics, including partition coefficient, lipophilicity, elimination of half-life (T1/2) and muscle/plasma converting ratio (Css, muscle/Css, plasma). Results: Diclofenacpotassium had the lowest T1/2 and the highest mean Css, muscle/Css, plasma (1.9 hours and 0.85±0.53, respectively). The mean Css, muscle/Css, plasma of sulindac, naproxen and ibuprofen were lower than other experimental NSAIDs. Conclusion: Diclofenac potassium had the highest disposition in pelvic floor muscle in a rat model. The finding implies that diclofenac potassium might be the choice for pain relief in pelvicmuscle.
Delay of Surgery for Spinal Metastasis due to the COVID-19 Outbreak Affected Patient Outcomes
Chia-Jung Hsieh,Chun-Yu Wu,Yen-Heng Lin,Yu-Cheng Huang,Wen-Chi Yang,Tom Wei-Wu Chen,Wei-Li Ma,Wei-Hsin Lin,Feng-Ming Hsu,Furen Xiao,Shih-Hung Yang,Dar-Ming Lai,Chang-Mu Chen,Shin-Yi Chao,Fon-Yih Tsuan 대한척추신경외과학회 2023 Neurospine Vol.20 No.4
Objective: The present study is to analyze the effects of the coronavirus disease 2019 (COVID 2019) outbreak and the subsequent lockdown on the outcomes of spinal metastasis patients. Methods: The study was a retrospective analysis of data from a prospective cohort study. All patients underwent surgical intervention for spinal metastases between January 2019 and December 2021 and had at least 3 months of postoperative follow-up. The primary outcome was overall mortality during the 4 different stages (pre-COVID-19 era, COVID-19 pandemic except in Taiwan, national lockdown, lifting of the lockdown). The secondary outcomes were the oncological severity scores, medical/surgical accessibility, and patient functional outcome during the 4 periods as well as survival/mortality. Results: A total of 233 patients were included. The overall mortality rate was 41.20%. During the Taiwan lockdown, more patients received palliative surgery than other surgical methods, and no total en bloc spondylectomy was performed. The time from surgeon visit to operation was approximately doubled after the COVID-19 outbreak in Taiwan (75.97, 86.63, 168.79, and 166.91 hours in the 4 periods, respectively). The estimated survival probability was highest after the national lockdown was lifted and lowest during the lockdown. In the multivariate analysis, increased risk of mortality was observed with delay of surgery, with emergency surgery having a higher risk with delays above 33 hours, urgent surgery (below 59 and above 111 hours), and elective surgery (above 332 hours). Conclusion: The COVID-19 pandemic and related policies have altered daily clinical practice and negatively impacted the survival of patients with spinal metastases.
마늘 성분인 diallyl disulfide의 유방암 세포주(MCF-7)에 대한 세포사멸 유도기전에 관한 연구
박해린(Hai-Lin Park),서정민(Jung-Min Suh),박경숙(Kyungsook Park),장항석(Hang-Seok Chang),남석진(Seok-Jin Nam),배정원(Jungp-Won Bae),이경포(Kyung-Po Lee),양정현(Jung-Hyun Yang),구범환(Bum-Hwan Koo) 대한외과학회 2001 Annals of Surgical Treatment and Research(ASRT) Vol.61 No.2
Optimization of EDM parameters for ZrO2 and Al2O3 ceramics using Taguchi method
Yan-Cherng Lin,Jung-Chou Hung,Han-Ming Chow,A-Cheng Wang 한양대학교 세라믹연구소 2015 Journal of Ceramic Processing Research Vol.16 No.2
Electrical Discharge Machining (EDM) is the most commonly used technique in mold and die manufacturing. The purpose of this investigation was to optimize the machining parameters of EDM on zirconium dioxide (ZrO2) and aluminum oxide (Al2O3). During the EDM process, the surface of electrically nonconductive ceramic was covered with adhesive conductive copper (Cu) and aluminum (Al) foils to attain the threshold of electrical conductivity for the EDM process. The machining characteristics associated with the EDM process such as material removal rate (MRR) and surface roughness (SR) were explored through the experimental study according to an L18 orthogonal array using the Taguchi method. The analysis of variance (ANOVA) was conducted to examine the significant machining parameters which affect the machining characteristics. As the experimental results show, peak current and pulse duration significantly affected MRR and SR. In addition, the optimal combination levels of machining parameters were also determined from the response graph of signal-to-noise (S/N) ratios for each level of machining parameters. A practical and convenient process for shaping the electrically nonconductive ceramics was developed which featured high efficiency, high precision, and high-quality of surface integrity.
( Chie Hwei Hung ),( Hyun Jee Kim ),( Hsin Jung Lin ) 한국유통경영학회(구 한국유통정보학회) 2011 유통정보학회지 Vol.14 No.3
본 연구는 대만의 TV 쇼핑 채널에서 판매되는 보험 상품에 대한 소비자들의 구매 성향과 결정요인을 탐색하였다. TV 쇼핑 채널에서 판매되는 보험 상품의 주요 소비자들은 Momo TV 홈쇼핑 채널을 주로 보며, 옷이나 신발, 핸드백을 TV 홈쇼핑 채널에서 구입해 본 경험이 있고, 13세에서 18세 사이의 자녀를 두고 있는 40세에서 45세 사이 중년 어머니들이였다. TV 쇼핑 채널에서 판매되는 보험 상품을 구입하도록 하는 주요 결정 요인으로는 상품의 편리성, 보험 에이전트를 상대하지 않아도 된다는 점과 TV 홈쇼핑 채널의 인지도가 소비자로 하여금 구매 의도를 증가시켰다. 그리고 TV 쇼핑 채널의 전문성에 대한 불신, 개인 정보 노출에 대한 염려, 지정된 보험 에이전트에게 서비스를 받을 수 없다는 점이 소비자들이 TV 쇼핑 채널에서 판매되는 보험 상품을 구매하지 않는 주요 이유였다. This study explores the determinants and purchase intention of consumers for insurance policies sold on the TV shopping channels in Taiwan. The middle-aged mothers who are at the age between 40 to 45, being used to watch Momo TV shopping channels, having ever purchased clothes, shoes and hand-bags on TV shopping channels, having children at the age between 13 to 18 are the major consumers for the insurance products sold on TV shopping channels. Convenience, without dealing with insurance agent and the reputation of TV shopping channels are the main determinants which make consumers have the intension to purchase insurance sold on TV shopping channels. Distrusting the insurance professional specialty of TV shopping channels, worrying the leakage of personal information security, can not be served by the designated insurance agent are the main reasons why consumers have no intension to purchase insurance sold on TV shopping channels.
Wang Li-Kai,Lin Yao-Tsung,Chen Jui-Tai,Lan Winnie,Hung Kuo-Chuan,Chen Jen-Yin,Liu Kuei-Jung,Yen Yu-Chun,Chou Yun-Yun,Cherng Yih-Giun,Tam Ka-Wai 대한마취통증의학회 2023 Korean Journal of Anesthesiology Vol.76 No.4
Background: Shared decision making using patient decision aids (PtDAs) was established over a decade ago, but few studies have evaluated its efficacy in Asian countries. We therefore evaluated the application of PtDAs in a decision conflict between two muscle relaxant reversal agents, neostigmine and sugammadex, and sequentially analyzed the regional differences and operating room turnover rates.Methods: This multicenter, outcome-assessor-blind, randomized controlled trial included 3,132 surgical patients from two medical centers admitted between March 2020 and August 2020. The patients were randomly divided into the classical and PtDA groups for pre-anesthesia consultations. Their clinicodemographic characteristics were analyzed to identify variables influencing the choice of reversal agent. On the day of the pre-anesthesia consultation, the patients completed the four SURE scale (sure of myself, understand information, risk-benefit ratio, encouragement) screening items. The operating turnover rates were also evaluated using anesthesia records. Results: Compared with the classical group, the PtDA group felt more confident about receiving sufficient medical information (P < 0.001), felt better informed about the advantages and disadvantages of the medications (P < 0.001), exhibited a superior understanding of the benefits and risks of their options (P < 0.001), and felt surer about their choice (P < 0.001). Moreover, the PtDA group had a significantly greater tendency to choose sugammadex over neostigmine (P < 0.001). Conclusions: PtDA interventions in pre-anesthesia consultations provided surgical patients with clear knowledge and better support. PtDAs should be made available in other medical fields to enhance shared clinical decision-making.