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An He,Perucho Jose AU,Chiu Keith WH,Hui Edward S,Chu Mandy MY,Ngu Siew Fei,Ngan Hextan YS,Lee Elaine YP 대한영상의학회 2022 Korean Journal of Radiology Vol.23 No.5
Objective: To investigate the association between functional tumor burden of peritoneal carcinomatosis (PC) derived from diffusion-weighted imaging (DWI) and overall survival in patients with advanced ovarian carcinoma (OC). Materials and Methods: This prospective study was approved by the local research ethics committee, and informed consent was obtained. Fifty patients (mean age ± standard deviation, 57 ± 12 years) with stage III–IV OC scheduled for primary or interval debulking surgery (IDS) were recruited between June 2016 and December 2021. DWI (b values: 0, 400, and 800 s/mm2) was acquired with a 16-channel phased-array torso coil. The functional PC burden on DWI was derived based on K-means clustering to discard fat, air, and normal tissue. A score similar to the surgical peritoneal cancer index was assigned to each abdominopelvic region, with additional scores assigned to the involvement of critical sites, denoted as the functional peritoneal cancer index (fPCI). The apparent diffusion coefficient (ADC) of the largest lesion was calculated. Patients were dichotomized by immediate surgical outcome into high- and low-risk groups (with and without residual disease, respectively) with subsequent survival analysis using the Kaplan-Meier curve and log-rank test. Multivariable Cox proportional hazards regression was used to evaluate the association between DWI-derived results and overall survival. Results: Fifteen (30.0%) patients underwent primary debulking surgery, and 35 (70.0%) patients received neoadjuvant chemotherapy followed by IDS. Complete tumor debulking was achieved in 32 patients. Patients with residual disease after debulking surgery had reduced overall survival (p = 0.043). The fPCI/ADC was negatively associated with overall survival when accounted for clinicopathological information with a hazard ratio of 1.254 for high fPCI/ADC (95% confidence interval, 1.007–1.560; p = 0.043). Conclusion: A high DWI-derived functional tumor burden was associated with decreased overall survival in patients with advanced OC.
Effect of MoS2-Based Composite Coatings on Tribological Behavior and Efficiency of Gear
Hui-Bo He,Hua-Ying Li,Zhe-Zhu Xu,Donguk Kim,류성기 한국정밀공학회 2010 International Journal of Precision Engineering and Vol. No.
MoS2-based Ti composite coatings were deposited on the SCM420 alloy and gears using an RF magnetron sputtering (RFMS) system. While MoS2 coating had been coated on the silicon substrate. The coatings structures were compared to each other to find the effect of Ti. The composite coatings have been tested in a ball-on-disk tribometer to investigate tribological behavior at various conditions. The scratch test was conducted to characterize adhesion force between composite coatings and substrates. The structure of the coatings has been extensively studied by a variety of techniques, including optical microscopy, X-ray diffraction (XRD) and scanning electron microscopy (SEM), etc. The composite coatings were also applied to the gears of a reduction gearbox. The efficiency of uncoated and MoS2-based Ti coated gear was measured and compared at various input rotating speed under absorption oil film condition. It was found that the efficiency of gear had significantly improved after MoS2-based Ti composite coatings deposition.
Effect of $MoS_2$-Based Composite Coatings on Tribological Behavior and Efficiency of Gear
He, Hui-Bo,Li, Hua-Ying,Xu, Zhe-Zhu,Kim, Dong-Uk,Lyu, Sung-Ki 한국정밀공학회 2010 International Journal of Precision Engineering and Vol.11 No.6
$MoS_2$-based Ti composite coatings were deposited on the SCM420 alloy and gears using an RF magnetron sputtering (RFMS) system. While $MoS_2$ coating had been coated on the silicon substrate. The coatings structures were compared to each other to find the effect of Ti. The composite coatings have been tested in a ball-on-disk tribometer to investigate tribological behavior at various conditions. The scratch test was conducted to characterize adhesion force between composite coatings and substrates. The structure of the coatings has been extensively studied by a variety of techniques, including optical microscopy, X-ray diffraction (XRD) and scanning electron microscopy (SEM), etc. The composite coatings were also applied to the gears of a reduction gearbox. The efficiency of uncoated and $MoS_2$-based Ti coated gear was measured and compared at various input rotating speed under absorption oil film condition. It was found that the efficiency of gear had significantly improved after $MoS_2$-based Ti composite coatings deposition.
Hui Tan,Hui Ling,Jie He,Lan Yi,Jianguo Zhou,Min Lin,Qi Su 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.6
We investigated the effects of diallyl disulfide (DADS) on the induction of apoptosis in human Leukemia cell line HL-60 and explored the roles of mitogen-activated protein kinase (ERK and p38 MAPK) pathways in the growth inhibition and apoptosis induced by DADS. MTT assay was used to determine the DADS induced cell growth inhibition in HL-60 cells. Flow cytometry and DNA fragmentation were used to examine the roles of apoptosis in DADS-mediated cell death. Western blot analysis of the expression of phospho-MAPKs (ERK and p38) was employed to elucidate the possible mechanisms of DADS induced apoptosis. We found that growth inhibition of HL-60 cells treated with DADS exhibited a dose-dependent response (P<0.05) and DADS induced significant apoptosis. DADS at the concentration of 10 mg/L persistently activated p38 and simultaneously reduced ERK activity. PD98059, an inhibitor of ERK upstream activators MAPK kinase MKK1 and MKK2, promoted cytotoxicity and apoptosis in HL-60 cells treated with DADS. In contrast, SB203580, an inhibitor of p38, decreased cytotoxicity and apoptosis induced by DADS. Therefore, DADS can effectively inhibit the proliferation and induce apoptosis of human leukemia cell line HL-60. Inhibition of ERK signaling pathways and activation of p38 signaling pathways are likely involved in DADS induced apoptosis in HL- 60 cells.
Hui-Bo He,Wen-Qiang Han,Hua-Ying Li,Dong-Yang Li,Jun Yang,Tao Gu,Tao Deng 한국정밀공학회 2014 International Journal of Precision Engineering and Vol. No.
TiAlN coatings were deposited on the YT15 tungsten carbide inserts by magnetron sputtering technique. The TiAlN coated tools weredeep cryogenic treatment (DCT) at -196oC for 30 h. The dry turning tests of 40Cr steel were carried out to evaluate performancesof uncoated, no cryogenically treated (NCT) and DCT coated tools on the CA6140A lathe. The effect of the three kinds of tools oncutting forces, cutting temperature, surface qualities and tool wear had been investigated to assess the performance of DCT coatedtools. Results of the investigation showed that the cutting forces and cutting temperature obtained by DCT coated tools weresignificantly decreased in comparison with the uncoated and NCT coated tools, especially at higher cutting speeds. Flank wear ofthe DCT coated inserts was less than that of the NCT coated inserts under the same cutting conditions. The DCT coated insertsproduced a good surface finish and yield a tool life of about 65 min. The wear mechanisms of the DCT coated carbide tools are mainlyabrasive and adhesive wear, accompanied with diffusion and oxidation wear.
Analysis of higher order composite beams by exact and finite element methods
He, Guang-Hui,Yang, Xiao Techno-Press 2015 Structural Engineering and Mechanics, An Int'l Jou Vol.53 No.4
In this paper, a two-layer partial interaction composite beams model considering the higher order shear deformation of sub-elements is built. Then, the governing differential equations and boundary conditions for static analysis of linear elastic higher order composite beams are formulated by means of principle of minimum potential energy. Subsequently, analytical solutions for cantilever composite beams subjected to uniform load are presented by Laplace transform technique. As a comparison, FEM for this problem is also developed, and the results of the proposed FE program are in good agreement with the analytical ones which demonstrates the reliability of the presented exact and finite element methods. Finally, parametric studies are performed to investigate the influences of parameters including rigidity of shear connectors, ratio of shear modulus and slenderness ratio, on deflections of cantilever composite beams, internal forces and stresses. It is revealed that the interfacial slip has a major effect on the deflection, the distribution of internal forces and the stresses.