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( Chen-hua Liu ),( Chi-yi Chen ),( Wei-wen Su ),( Chun-jen Liu ),( Ching-chu Lo ),( Ke-jhang Huang ),( Jyh-jou Chen ),( Kuo-chih Tseng ),( Chi-yang Chang ),( Cheng-yuan Peng ),( Yu-lueng Shih ),( Chia 대한간학회 2021 Clinical and Molecular Hepatology(대한간학회지) Vol.27 No.4
Background/Aims: Real-world studies assessing the effectiveness and safety of sofosbuvir/velpatasvir (SOF/VEL) plus ribavirin (RBV) for Child-Pugh B/C hepatitis C virus (HCV)-related cirrhosis are limited. Methods: We included 107 patients with Child-Pugh B/C HCV-related cirrhosis receiving SOF/VEL plus RBV for 12 weeks in Taiwan. The sustained virologic response rates at off-treatment week 12 (SVR<sub>12</sub>) for the evaluable population (EP), modified EP, and per-protocol population (PP) were assessed. The safety profiles were reported. Results: The SVR<sub>12</sub> rates in the EP, modified EP and PP were 89.7% (95% confidence interval [CI], 82.5-94.2%), 94.1% (95% CI, 87.8-97.3%), and 100% (95% CI, 96.2-100%). Number of patients who failed to achieve SVR<sub>12</sub> were attributed to virologic failures. The SVR<sub>12</sub> rates were comparable regardless of patient characteristics. One patient discontinued treatment because of adverse events (AEs). Twenty-four patients had serious AEs and six died, but none were related to SOF/VEL or RBV. Among the 96 patients achieving SVR<sub>12</sub>, 84.4% and 64.6% had improved Child-Pugh and model for endstage liver disease (MELD) scores. Multivariate analysis revealed that a baseline MELD score ≥15 was associated with an improved MELD score of ≥3 (odds ratio, 4.13; 95% CI, 1.16-14.71; P=0.02). Patients with chronic kidney disease (CKD) stage 1 had more significant estimated glomerular filtration rate declines than patients with CKD stage 2 (-0.42 mL/min/1.73 ㎡/month; P=0.01) or stage 3 (-0.56 mL/min/1.73 ㎡/month; P<0.001). Conclusions: SOF/VEL plus RBV for 12 weeks is efficacious and well-tolerated for Child-Pugh B/C HCV-related cirrhosis. (Clin Mol Hepatol 2021;27:575-588)
Tsung-Hua Lu(Tsung-Hua Lu),Shih-Hsien Lin(Shih-Hsien Lin),Huai-Hsuan Tseng(Huai-Hsuan Tseng),Yen Kuang Yang(Yen Kuang Yang),Nan Tsing Chiu(Nan Tsing Chiu),Po See Chen(Po See Chen) 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.4
Objective: Bipolar disorder (BD) is characterized by the poor sleep quality. Whether the striatal dopamine transporter (DAT) availability is related to sleep quality among patients with BD is unclear. Methods: Fifty-three euthymic patients with BD (24 BD-I and 29 BD-II) and sixty-eight healthy controls were enrolled. The Chinese Version of the Pittsburgh Sleep Quality Index (PSQI) was used, and the availability of DAT was assessed by single-photon emission computed tomography (SPECT) using [99mTc] TRODAT-1. Results: The sleep disturbance component of the PSQI was significantly associated with the level of DAT availability among patients with BD. Conclusion: The striatal dopaminergic activity that contributes to resilience to adversity was associated with sleep pattern among patients with BD.
Tsung-Hua Lu(Tsung-Hua Lu),Shih-Hsien Lin(Shih-Hsien Lin),Mei Hung Chi(Mei Hung Chi),Ching-Lin Chu(Ching-Lin Chu),Dong-Yu Yang(Dong-Yu Yang),Wei Hung Chang(Wei Hung Chang),Po See Chen(Po See Chen),Yen 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1
Objective: Hypoactivity in the reward system among patients with attention deficit hyperactivity disorder (ADHD) is a well-known phenomenon. Whether the activity in the reward pathway is related to harm avoidance, such as in sensitivity to punishment, is unclear. Evidence regarding the potential difference between ADHD patients and controls in terms of this association is scarce. Methods: Event-related functional magnetic resonance imaging was conducted on subjects performing the Iowa gambling test. Fourteen adults with ADHD and 14 controls were enrolled in the study. Results: Harm avoidance was found to be positively correlated with the activities of the bilateral orbitofrontal cortex and right insula in individuals with ADHD. A group difference was also confirmed. Conclusion: Understanding the roles of harm avoidance and brain activation during risk tasks is important.
Hua, X.G.,Chen, Z.Q.,Chen, W.,Niu, H.W.,Huang, Z.W. Techno-Press 2015 Wind and Structures, An International Journal (WAS Vol.20 No.2
Higher-mode vertical vortex-induced vibrations (VIV) have been observed on several steel box-girder suspension bridges where different vertical modes are selectively excited in turn with wind velocity in accordance with the Strouhal law. Understanding the relationship of VIV amplitudes for different modes of vibration is very important for wind-resistant design of long-span box-girder suspension bridges. In this study, the basic rectangular cross-section with side ratio of B/D=6 is used to investigate the effect of different modes on VIV amplitudes by section model tests. The section model is flexibly mounted in wind tunnel with a variety of spring constants for simulating different modes of vibration and the non-dimensional vertical amplitudes are determined as a function of reduced velocity U/fD. Two 'lock-in' ranges are observed at the same onset reduced velocities of approximately 4.8 and 9.4 for all cases. The second 'lock-in' range, which is induced by the conventional vortex shedding, consistently gives larger responses than the first one and the Sc-normalized maximum non-dimensional responses are almost the same for different spring constants. The first 'lock-in' range where the vibration frequency is approximately two times the vortex shedding frequency is probably a result of super-harmonic resonance or the "frequency demultiplication". The main conclusion drawn from the section model study, central to the higher-mode VIV of suspension bridges, is that the VIV amplitude for different modes is the same provided that the Sc number for these modes is identical.
Chen, Mei-Hua Institute for Corpus Research 2021 Asia pacific journal of corpus research Vol.2 No.1
Recently, corpus assisted vocabulary instruction has been attracting a lot of interest. Most studies have focused on understanding language learners' receptive vocabulary knowledge. Limited attention has been paid to learners' productive competence. To fill this gap, this study attended to learners' productive lexical development in terms of form, meaning and use respectively. This study introduced EFL learners to the corpus-based language pedagogy to learn COVID-19 theme-based vocabulary. To investigate the gains and views of 33 EFL first-year college students, a sentence completion task and a questionnaire were developed. Learners' productive performances in the three lexical knowledge aspects (i.e., form, meaning and use) were particularly targeted. The results revealed that the students achieved significant gains in all aspects regardless of their proficiency level. In particular, the less proficient students achieved greater knowledge retention compared with their highly proficient counterparts. Meanwhile, students showed positive attitudes towards the corpus-based approach to vocabulary learning.
Hua Ye,Hongyu Wu,Liangyuan Chen,Songhua Ma,Kaifeng Zhou,Guobing Yan,Jiazhong Shen,Dongcheng Chen,Shi‑Jian Su 대한금속·재료학회 2018 ELECTRONIC MATERIALS LETTERS Vol.14 No.2
A series of new small molecules based on symmetric electron-acceptor of 1,3,4-oxadiazole moiety or its asymmetric isomerof 1,2,4-oxadiazole unit were successfully synthesized and applied to solution-processable blue phosphorescent organic lightemittingdiodes for the first time, and their thermal, photophysical, electrochemical properties and density functional theorycalculations were studied thoroughly. Due to the high triplet energy levels (ET, 2.82–2.85 eV), the energy from phosphorescentemitter of iridium(III) bis[(4,6-difluorophenyl)-pyridinate-N,C2′]picolinate (FIrpic) transfer to the host molecules couldbe effectively suppressed and thus assuring the emission of devices was all from FIrpic. In comparison with the para-modeconjugation in substitution of five-membered 1,3,4-oxadiazole in 134OXD, the meta-linkages of 1,2,4-isomer appending withtwo phenyl rings cause the worse conjugation degree and the electron delocalization as well as the lower electron-withdrawingability for the other 1,2,4-oxadiazole-based materials. Noting that the solution-processed device based on 134OXD containing1,3,4-oxadiazole units without extra vacuum thermal-deposited hole/exciton-blocking layer and electron-transportinglayer showed the highest maximum current efficiency (CEmax) of 8.75 cd/A due to the excellent charge transporting ability of134OXD, which far surpassed the similar devices based on other host materials containing 1,2,4-oxadiazole units. Moreover,the device based on 134OXD presented small efficiency roll-off with current efficiency (CE) of 6.26 cd/A at high brightnessup to 100 cd/m2. This work demonstrates different nitrogen and oxygen atom orientations of the oxadiazole-based hostmaterials produce major impact on the optoelectronic characteristics of the solution-processable devices.
Chen, Jin-Lian,Sun, Shi-Zhong,Miao, Cui-Ping,Wu, Kai,Chen, You-Wei,Xu, Li-Hua,Guan, Hui-Lin,Zhao, Li-Xing The Korean Society of Ginseng 2016 Journal of Ginseng Research Vol.40 No.4
Background: Biocontrol agents are regarded as promising and environmental friendly approaches as agrochemicals for phytodiseases that cause serious environmental and health problems. Trichoderma species have been widely used in suppression of soil-borne pathogens. In this study, an endophytic fungus, Trichoderma gamsii YIM PH30019, from healthy Panax notoginseng root was investigated for its biocontrol potential. Methods: In vitro detached healthy roots, and pot and field experiments were used to investigate the pathogenicity and biocontrol efficacy of T. gamsii YIM PH30019 to the host plant. The antagonistic mechanisms against test phytopathogens were analyzed using dual culture, scanning electron microscopy, and volatile organic compounds (VOCs). Tolerance to chemical fertilizers was also tested in a series of concentrations. Results: The results indicated that T. gamsii YIM PH30019 was nonpathogenic to the host, presented appreciable biocontrol efficacy, and could tolerate chemical fertilizer concentrations of up to 20%. T. gamsii YIM PH30019 displayed antagonistic activities against the pathogenic fungi of P. notoginseng via production of VOCs. On the basis of gas chromatography-mass spectrometry, VOCs were identified as dimethyl disulfide, dibenzofuran, methanethiol, ketones, etc., which are effective ingredients for antagonistic activity. T. gamsii YIM PH30019 was able to improve the seedlings' emergence and protect P. notoginseng plants from soil-borne disease in the continuous cropping field tests. Conclusion: The results suggest that the endophytic fungus T. gamsii YIM PH30019 may have a good potential as a biological control agent against notoginseng phytodiseases and can provide a clue to further illuminate the interactions between Trichoderma and phytopathogens.
Chen-Ming Chen,Ming-Hua Chung,Tsung-Eong Hsieh,Bohr-Ran Huang,Huai-En Hsieh,Fuh-Shyang Juang,Yu-Sheng Tsai,Mark O. Liu,Jen-Lien Lin 한국물리학회 2009 Current Applied Physics Vol.9 No.4
The lifetimes of organic light emitting diodes (OLEDs) have been successfully enhanced with the modulation of LiF thickness and the utilization of encapsulating adhesives, which have been successfully and quickly synthesized with UV irradiation. Experimental results demonstrate that LiF and lab-made encapsulating adhesives can block the invasion of moisture as well as oxygen in the atmosphere into the OLEDs so that the lifetimes of devices with their encapsulation are 18-folds longer than those without encapsulation. The lifetimes of organic light emitting diodes (OLEDs) have been successfully enhanced with the modulation of LiF thickness and the utilization of encapsulating adhesives, which have been successfully and quickly synthesized with UV irradiation. Experimental results demonstrate that LiF and lab-made encapsulating adhesives can block the invasion of moisture as well as oxygen in the atmosphere into the OLEDs so that the lifetimes of devices with their encapsulation are 18-folds longer than those without encapsulation.
Absence of EZH2 Gene Mutation in Chronic Myeloid Leukemia Patients in Blast Crisis
Chen, Hao-Yue,Yao, Hong,Wu, Ling-Yu,Liu, Can-Jun,Zhu, Jian-Qin,Liu, Chun-Hua,Wang, Wei,Dong, Sha-Sha,Ping, Na-Na,Chen, Su-Ning,Sun, Miao Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5
Time-dependent reliability analysis of coastal defences subjected to changing environments
Chen, Hua-Peng Techno-Press 2015 Structural monitoring and maintenance Vol.2 No.1
This paper presents a method for assessing the risk of wave run-up and overtopping of existing coastal defences and for analysing the probability of failure of the structures under future hydraulic conditions. The recent UK climate projections are employed in the investigations of the influence of changing environments on the long-term performance of sea defences. In order to reduce the risk of wave run-up and overtopping caused by rising sea level and to maintain the present-day allowances for wave run-up height and overtopping discharge, the future necessary increase in crest level of existing structures is investigated. Various critical failure mechanisms are considered for reliability analysis, i.e., erosion of crest by wave overtopping, failure of seaside revetment, and internal erosions within earth sea dykes. The time-dependent reliability of sea dykes is analysed to give probability of failure with time. The results for an example earth dyke section show that the necessary increase in crest level is approximately double of sea level rise to maintain the current allowances. The probability of failure for various failure modes of the earth dyke has a significant increase with time under future hydraulic conditions.