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Interleukin-20 targets podocytes and is upregulated in experimental murine diabetic nephropathy
Yu-Hsiang Hsu,Hsing-Hui Li,Junne-Ming Sung,Wei-Yu Chen,Ya-Chin Hou,Yun-Han Weng,Wei-Ting Lai,Chih-Hsing Wu,Ming-Shi Chang 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Interleukin (IL)-20, a proinflammatory cytokine of the IL-10 family, is involved in acute and chronic renal failure. The aim of this study was to elucidate the role of IL-20 during diabetic nephropathy development. We found that IL-20 and its receptor IL-20R1 were upregulated in the kidneys of mice and rats with STZ-induced diabetes. In vitro, IL-20 induced MMP-9, MCP-1, TGF-β1 and VEGF expression in podocytes. IL-20 was upregulated by hydrogen peroxide, high-dose glucose and TGF-β1. In addition, IL-20 induced apoptosis in podocytes by activating caspase-8. In STZ-induced early diabetic nephropathy, IL-20R1-deficient mice had lower blood glucose and serum BUN levels and a smaller glomerular area than did wild-type controls. Anti-IL-20 monoclonal antibody (7E) treatment reduced blood glucose and the glomerular area and improved renal functions in mice in the early stage of STZ-induced diabetic nephropathy. ELISA showed that the serum IL-20 level was higher in patients with diabetes mellitus than in healthy controls. The findings of this study suggest that IL-20 induces cell apoptosis of podocytes and plays a role in the pathogenesis of early diabetic nephropathy.
A Pediatric Oncology Diverse Learning Course on Caring for nursing students’ reflection
Miao Hsing Chen,Shu-Chuan Chang,Yu-Ping Huang,Yueh Chih Chen 한국간호과학회 2021 한국간호과학회 학술대회 Vol.2021 No.10
Aim(s): This study aimed to determine if a pediatric oncology diverse learning course could enhance nursing students’ theoretical knowledge and understanding of clinical care for children with leukemia and their families. Method(s): This was a qualitative retrospective study. Data were collected in July 2016. Participants were college nursing students (N = 33) enrolled in a diverse learning course in pediatric oncology, which was taught between November 2014 and January 2015 at a science and technology university in Taiwan. The three-part course included reading picture books, participating in role-playing, and watching a cancer-related family movie. Focus group discussions occurred during each part. Students maintained written reflections during the course, which were submitted to an e-learning website. Reflections were analyzed using content analysis. Result(s): Students’ reflections resulted in five main themes: (1) Pediatric oncology nursing knowledge and skills learned; (2) Understanding children with leukemia and their families suffering; (3) Empathy parents’ and children’s reactions to the effects of leukemia; (4) Nursing skills necessary for caring for children with leukemia; and (5) Expect future role as a pediatric oncology nurse. Conclusion(s): The pediatric oncology simulation course employed multiple teaching strategies. The improvements in student cognition, empathy, and understanding of care requirements of children with leukemia and emotional needs of families as pediatric oncology nurses suggest the teaching objectives of enhancing student learning were achieved. The knowledge and skills acquired could assist students in developing professional competencies and values in nursing.
Development of IGZO TFTs and Their Applications to Next-Generation Flat-Panel Displays
Hsing-Hung Hsieh,Hsiung-Hsing Lu,Hung-Che Ting,Ching-Sang Chuang,Chia-Yu Chen,Yusin Lin 한국정보디스플레이학회 2010 Journal of information display Vol.11 No.4
Organic light-emitting devices (OLEDs) have shown superior characteristics and are expected to dominate the nextgeneration flat-panel displays. Active-matrix organic light-emitting diode (AMOLED) displays, however, have stringent demands on the performance of the backplane. In this paper, the development of thin-film transistors (TFTs) based on indium gallium zinc oxide (IGZO) on both Gen 1 and 6 glasses, and their decent characteristics, which meet the AMOLED requirements,are shown. Further, several display prototypes (e.g., 2.4” AMOLED, 2.4” transparent AMOLED, and 32” AMLCD) using IGZO TFTs are demonstrated to confirm that they can indeed be strong candidates for the next-generation TFT technology not only of AMOLED but also of AMLCD (active-matrix liquid crystal display)
Is Real Appreciation or More Government Debt Contractionary? The Case of the Philippines
Yu Hsing,Yun-Chen Morgan 동아시아경상학회 2016 The East Asian Journal of Business Economics Vol.4 No.4
This paper finds that aggregate output in the Philippines has a positive relationship with real appreciation during 2006.Q4 - 2016.Q1, the stock price and the lagged real oil price and a negative relationship with real appreciation during 1998.Q1 - 2006.Q3, government debt as a percent of GDP and the real interest rate. Therefore, real appreciation may be contractionary or expansionary, and more government debt as a percent of GDP dampens economic growth.
Tai, Yu-Tzu,Horton, Holly M.,Kong, Sun-Young,Pong, Erik,Chen, Hsing,Cemerski, Saso,Bernett, Matthew J.,Nguyen, Duc-Hanh T.,Karki, Sher,Chu, Seung Y.,Lazar, Greg A.,Munshi, Nikhil C.,Desjarlais, John R American Society of Hematology 2012 Blood Vol.119 No.9
<B>Abstract</B><P>HM1.24, an immunologic target for multiple myeloma (MM) cells, has not been effectively targeted with therapeutic monoclonal antibodies (mAbs). In this study, we investigated in vitro and in vivo anti-MM activities of XmAb5592, a humanized anti-HM1.24 mAb with Fc-domain engineered to significantly enhance FcγR binding and associated immune effector functions. XmAb5592 increased antibody-dependent cellular cytotoxicity (ADCC) several fold relative to the anti-HM1.24 IgG1 analog against both MM cell lines and primary patient myeloma cells. XmAb5592 also augmented antibody dependent cellular phagocytosis (ADCP) by macrophages. Natural killer (NK) cells became more activated by XmAb5592 than the IgG1 analog, evidenced by increased cell surface expression of granzyme B-dependent CD107a and MM cell lysis, even in the presence of bone marrow stromal cells. XmAb5592 potently inhibited tumor growth in mice bearing human MM xenografts via FcγR-dependent mechanisms, and was significantly more effective than the IgG1 analog. Lenalidomide synergistically enhanced in vitro ADCC against MM cells and in vivo tumor inhibition induced by XmAb5592. A single dose of 20 mg/kg XmAb5592 effectively depleted both blood and bone marrow plasma cells in cynomolgus monkeys. These results support clinical development of XmAb5592, both as a monotherapy and in combination with lenalidomide, to improve patient outcome of MM.</P>