Standardizations of training and research of colorectal cancer surgery between Asia and Europe

Hongwei Yao,Zhongtao Zhang 대한외과학회 2019 대한외과학회 학술대회 초록집 Vol.2019 No.10

Transanal Total Mesorectal Excision: Short-term Outcomes of 1,283 Cases from A Nationwide Registry in China

Hongwei Yao,Yongbo An,Hongyu Zhang,Mingyang Ren,Chien-Chih Chen,Qing Xu,Quan Wang,Zhongtao Zhang 대한외과학회 2020 대한외과학회 학술대회 초록집 Vol.2020 No.11

Effects of Ni and Cr on Cryogenic Impact Toughness of Bainite/Martensite Multiphase Steels

Zishan Yao,Guang Xu,Zhengyi Jiang,Junyu Tian,Qing Yuan,Hongwei Ma 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.5

In the present research, the effects of Nickel (Ni) and Chromium (Cr) on cryogenic impact toughness (CIT) of low-carbonbainite/martensite multiphase steels [processed by two different cooling processes: isothermal transformation process (ITP)and continuous cooling process (CCP)] were investigated. It was found that due to the formation of carbides during isothermaltreatment, the addition of Ni and Cr yielded no significant improvements in CIT. However, during CCP treatment, theaddition of Ni manifested a considerable enhancement in CIT, whereas the addition of both Ni and Cr caused a decreasein CIT. Further, after ITP treatment, the microstructure of all steels consisted of bainite and martenite, while Ni + Cr steelcontained the largest amount of bainite. The microstructures of the CCP-treated steels mainly also consisted of bainite andmartensite, but no retained austenite and carbides were observed, thus resulting in a superior CIT.

Group Path Planning Based on Variable Dimension ABC Algorithm

Jie Li,Hongwei Mo,Yao Sun 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.1

Group mobile robot path planning is a multi-objective optimization problem, as the requirement of obstacle avoidance, traditional robot path planning optimization method has the problem of algorithm complexity, large search space and low efficiency, it is difficult to obtain the optimal solution. In order to improve the efficiency and the positioning accuracy of group robot path planning, we put forward a group mobile robot path planning method based on variable dimension artificial bee colony algorithm. Firstly, we take robot working environment to model, then taking group robot path network as nectar source, the ultimate goal of path planning is to find minimal path network, to find an optimal swarm robot moving path network which avoids obstacles through the mutual cooperation between bees. Simulation experiment results show that the path planning method based on variable dimension artificial bee colony algorithm improves the efficiency of swarm robot path planning, it can find optimal solution of swarm robot path planning during the shortest time, and it can avoid obstacles safely, it provides basis to group robot task coordination.

Differences in the gut microbiota between Cercopithecinae and Colobinae in captivity

Zongjin Huan,Yongfang Yao,Jianqiu Yu,Hongwei Chen,Meirong Li,Chaojun Yang,Bo Zhao,Qingyong Ni,Mingwang Zhang,Meng Xie,Huailiang Xu 한국미생물학회 2020 The journal of microbiology Vol.58 No.5

The gut microbiome of captive primates can provide a window into their health and disease status. The diversity and composition of gut microbiota are influenced by not only host phylogeny, but also host diet. Old World monkeys (Cercopithecidae) are divided into two subfamilies: Cercopithecinae and Colobinae. The diet and physiological digestive features differ between these two subfamilies. Accordingly, highthroughput sequencing was used to examine gut microbiota differences between these two subfamilies, using data from 29 Cercopithecinae individuals and 19 Colobinae individuals raised in captivity. Through a comparative analysis of operational taxonomic units (OTUs), significant differences in the diversity and composition of gut microbiota were observed between Cercopithecinae and Colobinae. In particular, the gut microbiota of captive Old World monkeys clustered strongly by the two subfamilies. The Colobinae microbial diversity was higher than that of Cercopithecinae. Additionally, Firmicutes, Lactobacillaceae, Veillonellaceae, and Prevotella abundance were higher in Cercopithecinae, while Bacteroidetes, Ruminococcaceae, Christensenellaceae, Bacteroidaceae, and Acidaminococcaceae abundance were higher in Colobinae. PICRUSt analysis revealed that the predicted metagenomes of metabolic pathways associated with proteins, carbohydrates, and amino acids were significantly higher in Colobinae. In the context of host phylogeny, these differences between Cercopithecinae and Colobinae could reflect adaptations associated with their respective diets. This well-organized dataset is a valuable resource for future related research on primates and gut microbiota. Moreover, this study may provide useful insight into animal management practices and primate conservation.

Development of a variable temperature mechanical loading device for in situ neutron scattering measurements

Yunlai Zhao,Shizhong Zhang,Hongwei Zhao,Guang’ai Sun,Yao Xu 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.8

Understanding the phase transformation and failure mechanism of NiTi shape memory alloys under variable environments of high and low temperatures is critical to the establishment of constitutive properties and to the realization of controllable design. Information regarding the correlation between the phase transformation and deformation can be obtained by in situ neutron scattering measurements. Therefore, a variable temperature mechanical loading device is designed, which can be used for mechanical loading and in situ neutron scattering measurements in a variable temperature environment. Specifically, the device can achieve precise temperature control with a temperature change from -55 °C to 200 °C in a protective atmosphere. The rated load in the axial direction is 6 kN, and the maximum displacement of the unilateral grip is larger than 30 mm. In situ neutron scattering measurements can be performed through neutron windows, and the strain can be measured by digital image correlation technology. Moreover, the force sensor is calibrated to improve test precision. Through an evaluation of temperature uncertainty, the temperature measurement performance is estimated. Tensile tests of the NiTi alloy at variable temperatures are carried out, and preliminary results are given. The four deformation stages of the NiTi alloy can be seen from the stressstrain curve, which corresponds to the existing results. This demonstrates that the designed variable temperature mechanical loading device can supply the testing demands. The device provides a new way to study the relationship between the phase transformation and mechanical properties of NiTi shape memory alloys at variable temperatures.

Tumor evolution and intratumor heterogeneity of an oropharyngeal squamous cell carcinoma revealed by whole-genome sequencing.

Zhang, Xinyi Cindy,Xu, Chang,Mitchell, Ryan M,Zhang, Bo,Zhao, Derek,Li, Yao,Huang, Xin,Fan, Wenhong,Wang, Hongwei,Lerma, Luisa Angelica,Upton, Melissa P,Hay, Ashley,M?ndez, Eduardo,Zhao, Lue Ping Stockton Press 2013 Neoplasia Vol.15 No.12

<P>Head and neck squamous cell carcinoma (HNSCC) is characterized by significant genomic instability that could lead to clonal diversity. Intratumor clonal heterogeneity has been proposed as a major attribute underlying tumor evolution, progression, and resistance to chemotherapy and radiation. Understanding genetic heterogeneity could lead to treatments specific to resistant and metastatic tumor cells. To characterize the degree of intratumor genetic heterogeneity within a single tumor, we performed whole-genome sequencing on three separate regions of an human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma and two separate regions from one corresponding cervical lymph node metastasis. This approach achieved coverage of approximately 97.9% of the genome across all samples. In total, 5701 somatic point mutations (SPMs) and 4347 small somatic insertions and deletions (indels)were detected in at least one sample. Ninety-two percent of SPMs and 77% of indels were validated in a second set of samples adjacent to the discovery set. All five tumor samples shared 41% of SPMs, 57% of the 1805 genes with SPMs, and 34 of 55 cancer genes. The distribution of SPMs allowed phylogenetic reconstruction of this tumor's evolutionary pathway and showed that the metastatic samples arose as a late event. The degree of intratumor heterogeneity showed that a single biopsy may not represent the entire mutational landscape of HNSCC tumors. This approach may be used to further characterize intratumor heterogeneity in more patients, and their sample-to-sample variations could reveal the evolutionary process of cancer cells, facilitate our understanding of tumorigenesis, and enable the development of novel targeted therapies.</P>