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A Synthetic Chenodeoxycholic Acid Derivative, HS-1200-induced Apoptosis of RBL-2H3 Cells
Byung-Chan Koo,Jeong-Soo Kim,Hyun-Ho Kwak,In-Ryoung Kim,Seung-Eun Lee,Gyoo-Cheon Kim,Hongsuk Suh1,Bong-Soo Park 대한해부학회 2009 Anatomy & Cell Biology Vol.42 No.1
Bile acids and synthetic bile acid derivatives induced apoptosis in various kinds of cancer cells and anticancer effects. Although synthetic chenodeoxycholic acid (CDCA) derivatives have been demonstrated to induce apoptosis of various cancer cells, there is no report on their effect on RBL-2H3 basophilic leukemia cell line to date. Therefore, this study was undertaken to examine in vitro effects of cytotoxicity and growth inhibition, and the molecular mechanism underlying induction of apoptosis in RBL-2H3 cells treated with a synthetic CDCA derivative, HS-1200. The viability and the growth inhibition of RBL-2H3 cells were assessed by MTT assay and clonogenic assay respectively. The Hoechst staining and DNA electrophoresis were conducted to observe RBL-2H3 cells undergoing apoptosis. RBL-2H3 cells were treated with HS-1200, and Western blotting, immunocytochemistry, confocal microscopy, DNA hypoploidy assay, MMP activity and proteasome activity were performed. HS-1200 treatment of RBL-2H3 cells resulted in a time- and does-dependent decrease of cell viability and a does-dependent inhibition of cell growth, and induced apoptotic cell death. Furthermore, HS-1200 treatment result in the alteration of G1 cell cycle-related proteins. And tested RBL-2H3 cells showed several lines of apoptotic manifestation.We presented data indicating that HS-1200 induces apoptois via the proteasome, mitochondria and caspase pathway, and induces the alteration of the G1 cell cycle-related proteins in RBL-2H3 cells. Therefore our data provide the possibility that HS-1200 could be as a novel therapeutic strategy in the allergy treatment.
변속 원활감 향상을 위한 DETENT PIN GROVE 형상 최적화
서홍석(Hongsuk Suh) 한국자동차공학회 2009 한국자동차공학회 부문종합 학술대회 Vol.2009 No.4
In Europe, the proportion of manual transmission cars is over 80%. That is why development of manual transmission considering Europe is important from now on. So in this paper the preferred gearshift feeling in Europe was studied and the principal control factors were selected considering engineering. From the selected control factor, Detent Pin Groove profile was chosen as the key control factor for its analysis was unsatisfied and it has a great influence in improving gearshift feeling. Detent Pin Groove profile was optimized to gain accurate and simple operation of shifting gears. Therefore, improvement of groove profile applying optimization can gain effective results in developing gearshift feeling considering specific region.
( Hongsuk Choi ),( Subin Kim ),( Hayong Song ),( Seokho Suh ),( Hyeong-jin Kim ),( Kwangsup Eom ) 한국부식방식학회 2021 Corrosion Science and Technology Vol.20 No.5
In this work, we proposed a facile method to fabricate the three-dimensional porous copper current collector (3D Cu CC) for a Si-dominant anode in a Li-ion battery (LiB). The 3D Cu CC was prepared by combining chemical etching and thermal reduction from a planar copper foil. It had a porous layer employing micro-sized Cu balls with a large surface area. In particular, it had strengthened attachment of Si-dominant active material on the CC compared to a planar 2D copper foil. Moreover, the increased contact area between a Si-dominant active material and the 3D Cu could minimize contact loss of active materials from a CC. As a result of a battery test, Si-dominant active materials on 3D Cu showed higher cyclic performance and rate-capability than those on a conventional planar copper foil. Specifically, the Si electrode employing 3D Cu exhibited an areal capacity of 0.9 mAh cm<sup>-2</sup> at the 300<sup>th</sup> cycles (@ 1.0 mA cm<sup>-2</sup>), which was 5.6 times higher than that on the 2D copper foil (0.16 mAh cm<sup>-2</sup>).
Pyrrolo[3,2-b]pyrrole-Based Copolymers as Donor Materials for Organic Photovoltaics
Song, Suhee,Ko, Seo-Jin,Shin, Hyunmin,Jin, Youngeup,Kim, Il,Kim, Jin Young,Suh, Hongsuk Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.11
A new accepter unit, pyrrolo[3,2-b]pyrrole-2,5-dione, was prepared and utilized for the synthesis of the conjugated polymers containing electron donor-acceptor pair for OPVs. Pyrrolo[3,2-b]pyrrole-2,5-dione unit, regioisomer of the known pyrrolo[3,4-c]pyrrole-1,4-dione, is originated from the structure of stable synthetic pigment. The new conjugated polymers with 1,4-diphenylpyrrolo[3,2-b]pyrrole-2,5-dione, thiophene and carbazole were synthesized using Suzuki polymerization to generate P1 and P2. The solid films of P1 and P2 show absorption bands with maximum peaks at about 377, 554 and 374, 542 nm and the absorption onsets at 670 and 674 nm, corresponding to band gaps of 1.85 and 1.84 eV, respectively. To improve the hole mobility of the polymer with 1,4-bis(4-butylphenyl)-pyrrolo[3,2-b]-pyrrole-2,5-dione unit, which was previously reported by us, the butyl group at the 4-positions of the N-substituted phenyl group was substituted with hydrogen and methyl group. The field-effect hole mobility of P2 is $9.6{\times}10^{-5}cm^2/Vs$. The device with $P2:PC_{71}BM$ (1:2) showed $V_{OC}$ value of 0.84 V, $J_{SC}$ value of 5.10 $mA/cm^2$, and FF of 0.33, giving PCE of 1.42%.
Synthesis and Photovoltaic Properties of Quinoxaline-Based Semiconducting Polymers with Fluoro Atoms
Song, Suhee,Choi, Hyo Il,Shin, In Soo,Suh, Hongsuk,Hyun, Myung Ho,Lee, Gun Dae,Park, Seong Soo,Park, Sung Heum,Jin, Youngeup Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.8
A new accepter unit, 6,7-difluoro-2,3-dihexylquinoxaline, was prepared and utilized for the synthesis of the conjugated polymers containing electron donor-acceptor pair for OPVs. New series of copolymers with dioctyloxybenzodithiophene as the electron rich unit and 6,7-difluoro-2,3-dihexylquinoxaline as the electron deficient unit are synthesized. The solid films of poly[2,6-(4,8-bis(2-ethylhexyloxy)benzo[1,2-b:4,5-b']dithiophene)-alt-5,8-(6,7-difluoro-2,3-dihexylquinoxaline)] (PBQxF) and poly[2,6-(4,8-bis(2-ethylhexyloxy) benzo[1,2-b:4,5-b']dithiophene)-alt-5,8-(6,7-difluoro-2,3-dihexyl-5,8-di(thiophen-2-yl) quinoxaline)] (PBDTQxF) show absorption bands with maximum peaks at about 599 and 551 nm and the absorption onsets at 692 and 713 nm, corresponding to band gaps of 1.79 and 1.74 eV, respectively. The devices comprising PBQxF with $PC_{71}BM$ (1:2) showed open-circuit voltage ($V_{OC}$) of 0.64 V, short-circuit current density ($J_{SC}$) of $1.58mA/cm^2$, and fill factor (FF) of 0.39, giving power conversion efficiency (PCE) of 0.39%. To obtain absorption in the longer wavelength region, thiophene units without any alkyl group are incorporated as one of the monomers in PBDTQxF, which may result in low solubility of the polymers to lead lower efficiency.
Synthesis and photovoltaic property of copolymers with phenanthrothiadiazole moiety
Song, Suhee,Park, Seijung,Kwon, Sooncheol,Lee, Byoung Hoon,Shim, Joo Young,Lee, Jongjin,Park, Sung Heum,Jin, Youngeup,Kim, Il,Lee, Kwanghee,Suh, Hongsuk Elsevier 2012 Solar energy materials and solar cells Vol.105 No.-
Song, Suhee,Choi, Hyo Il,Shin, In Soo,Hyun, Myung Ho,Suh, Hongsuk,Park, Seong Soo,Park, Sung Heum,Jin, Youngeup Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.10
We report synthesis and photovoltaic properties of two new conjugated copolymers, PCPDTQxF and PDTSQxF, with 6,7-difluoro-2,3-dihexylquinoxaline unit prepared by Stille coupling reaction. The advantage of 6,7-difluoro-2,3-dihexylquinoxaline based copolymer are high PCEs due to lower HOMO energy level, long wavelength absorption and high hole mobility. The solid films of PCPDTQxF and PDTSQxF showed absorption bands with maximum peaks at about 623 and 493 nm and the absorption onsets at 711 and 635 nm, corresponding to band gaps of 1.74 and 1.95 eV, respectively. The oxidation onsets of the PCPDTQxF and PDTSQxF polymers were estimated to be 0.68 and 0.95 V, which correspond to HOMO energy levels of -5.48 and -5.75 eV, respectively. The PDTSQxF has lower HOMO energy level as compared to PCPDTQxF to lead higher $V_{OC}$ value. The device comprising PCPDTQxF:PCBM (1:2) dissolved to a concentration of 1 wt % in ODCB showed $V_{OC}$ value of 0.62 V, $J_{SC}$ value of $1.14mA/cm^2$, and FF of 0.35, which yielded PCE of 0.25%.