Ultimate capacity of welded box section columns with slender plate elements

Hong-Xia Shen 국제구조공학회 2012 Steel and Composite Structures, An International J Vol.13 No.1

For an axially loaded box-shaped member, the width-to-thickness ratio of the plate elements preferably should not be greater than 40 for Q235 steel grades in accordance with the Chinese code GB50017- 2003. However, in practical engineering the plate width-to-thickness ratio is up to 120, much more than the limiting value. In this paper, a 3D nonlinear finite element model is developed that accounts for both geometrical imperfections and residual stresses and the ultimate capacity of welded built-up box columns,with larger width-to-thickness ratios of 60, 70, 80, and 100, is simulated. At the same time, the interaction buckling strength of these members is determined using the effective width method recommended in the Chinese code GB50018-2002, Eurocode 3 EN1993-1 and American standard ANSI/AISC 360-10 and the direct strength method developed in recent years. The studies show that the finite element model proposed can simulate the behavior of nonlinear buckling of axially loaded box-shaped members very well. The width-tothickness ratio of the plate elements in welded box section columns can be enlarged up to 100 for Q235 steel grades. Good agreements are observed between the results obtained from the FEM and direct strength method. The modified direct strength method provides a better estimation of the column strength compared to the direct strength method over the full range of plate width-to-thickness ratio. The Chinese code and Eurocode 3 are overly conservative prediction of column capacity while the American standard provides a better prediction and is slightly conservative for b/t = 60. Therefore, it is suggested that the modified direct strength method should be adopted when revising the Chinese code.

On the direct strength and effective yield strength method design of medium and high strength steel welded square section columns with slender plate elements

Hong-Xia Shen 국제구조공학회 2014 Steel and Composite Structures, An International J Vol.17 No.4

The ultimate carrying capacity of axially loaded welded square box section members made of medium and high strength steels (nominal yield stresses varying from 345 MPa to 460 MPa), with large width-to-thickness ratios ranging from 35 to 70, is analyzed by finite element method (FEM). At the same time, the numerical results are compared with the predicted results using Direct Strength Method (DSM), modified DSM and Effective Yield Strength Method (EYSM). It shows that curve a, rather than curve b recommended in Code for design of steel structures GB50017-2003, should be used to check the local-overall interaction buckling strength of welded square section columns fabricated from medium and high strength steels when using DSM, modified DSM and EYSM. Despite all this, EYSM is conservative. Compared to EYSM and modified DSM, DSM provides a better prediction of the ultimate capacities of welded square box compression members with large width-thickness ratios over a wide range of width-thickness ratios, slenderness ratios and steel grades. However, for high strength steels (nominal yield strength greater than 460 MPa), the numerical and existent experimental results indicate that DSM overestimates the load-carrying capacities of the columns with width-thickness ratio smaller than 45 and slenderness ratio less than 80. Further, for the purpose of making it suitable for a wider scope, DSM has been modified (called proposed modified DSM). The proposed modified DSM is in excellent agreement with the numerical and existing experimental results.

Health-related Quality of Life among Breast Cancer Patients and its Influencing Factor in a Chinese Population

Shen, Fang-Rong,Liu, Ming,Zhang, Xia,Feng, Ya-Hong,Zhou, Long-Shu,Chen, You-Guo Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8

Aim: The aim of this study was to investigate the quality of life (QOL) of breast cancer patients by using the Functional Assessment of Cancer Therapy-Breast (FACT-B) questionnaires. Methods: A total of 522 adult patients who were admitted to our hospital with breast cancer were collected during the period of Jun. 2007 to Dec. 2009. Results: Our FACT-B questionnaire study suggested that women below 50 years old, employed, higher education and annual income, lower TNM stage and receiving modified radical mastectomy manifested significantly better QOL using the assessment tool of the FACT-B subscale. Moreover, regression analysis indicated patients with young age, low stage cancer, high education and income were more likely to have high score of QOL, with ORs (95% CI) of 2.8 (1.52-4.56), 2.1 (1.15-3.95), 3.1 (1.45-5.12) and 3.54 (1.54-5.43), respectively. Conclusions: Our study showed younger age, lower stage of cancer, higher education and income could influence the QOL of breast cancer patients in our Chinese population. Further large sample studies are still needed for confirmation.

Polymorphic Variation of Inflammation-related Genes and Risk of Non-Hodgkin Lymphoma for Uygur and Han Chinese in Xinjiang

Gu, Xia,Shen, Yan,Fu, Ling,Zuo, Hong-Yun,Yasen, Halida,He, Ping,Guo, Xin-Hong,Shi, Yu-Wei,Yusufu, Muhabaiti Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21

Polymorphisms of inflammation-related genes have been found to be associated with non-Hodgkin lymphoma (NHL) or some of its subtypes, but only a few relevant data have been reported in China. In this study, the Snapshot method was used to assess genetic variation; a total of 14 single nucleotide polymorphisms (SNPs) for 6 inflammatory factors in 157 NHL cases (64 Uygur ethnic subjects, 93 Han Chinese) and 435 controls (231 Uygur and 204 Han Chinese) were studied from the Xinjiang province of China. Haplotype distribution was estimated using PHASE 2.3 software. Statistical differences in the genotype and haplotype frequencies between case and control groups were also considered and estimated. For the Han population, the geneotype distributions for TNF-${\alpha}rs1800629$, TNF-${\alpha}rs1800630$, IL-6 rs1800795, IL-6 rs1800797, NF-KB1 rs1585215 and TLR-4 rs4986790 showed significant differences between the case and control groups (p<0.05). The TNF-${\alpha}$ gene frequencies of ACG and CCA haplotypes in the cases were higher than in the controls (OR=2.45, 95% CI: 1.55-3.89, p=0.0002, OR=2.53, 95% CI: 1.10-5.80, p=0.029, respectively), and the same findings were detected for TNF-${\beta}$ gene CA haplotype (OR=1.87, 95% CI: 1.21-2.90, p=0.0054). However, for the Uygur population, no such significant differences were detected within the gene-type distribution of the 14 SNPs. The TNF-${\alpha}$ gene frequency of the CCA haplotype between the two groups (OR=1.98, 95% CI: 1.11-3.51, p=0.021) revealed a statistically significant difference. Our results showed that polymorphic variations of inflammation-related genes could be important to the NHL etiology of the Han population, and that these may only have limited influence on the Uygur population.

The Risk Factors and Outcomes for Radiological Abnormalities in Early Convalescence of COVID-19 Patients Caused by the SARS-CoV-2 Omicron Variant: A Retrospective, Multicenter Follow-up Study

Wang Hong,Yang Qingyuan,Li Fangfei,Wang Huiying,Yu Jing,Ge Xihong,Gao Guangfeng,Xia Shuang,Xing Zhiheng,Shen Wen 대한의학회 2023 Journal of Korean medical science Vol.38 No.8

Background: The emergence of the severe acute respiratory syndrome coronavirus 2 omicron variant has been triggering the new wave of coronavirus disease 2019 (COVID-19) globally. However, the risk factors and outcomes for radiological abnormalities in the early convalescent stage (1 month after diagnosis) of omicron infected patients are still unknown. Methods: Patients were retrospectively enrolled if they were admitted to the hospital due to COVID-19. The chest computed tomography (CT) images and clinical data obtained at baseline (at the time of the first CT image that showed abnormalities after diagnosis) and 1 month after diagnosis were longitudinally analyzed. Uni-/multi-variable logistic regression tests were performed to explore independent risk factors for radiological abnormalities at baseline and residual pulmonary abnormalities after 1 month. Results: We assessed 316 COVID-19 patients, including 47% with radiological abnormalities at baseline and 23% with residual pulmonary abnormalities at 1-month follow-up. In a multivariate regression analysis, age ≥ 50 years, body mass index ≥ 23.87, days after vaccination ≥ 81 days, lymphocyte count ≤ 1.21 × 10-9/L, interleukin-6 (IL-6) ≥ 10.05 pg/mL and IgG ≤ 14.140 S/CO were independent risk factors for CT abnormalities at baseline. The age ≥ 47 years, presence of interlobular septal thickening and IL-6 ≥ 5.85 pg/mL were the independent risk factors for residual pulmonary abnormalities at 1-month follow-up. For residual abnormalities group, the patients with less consolidations and more parenchymal bands at baseline could progress on CT score after 1 month. There were no significant changes in the number of involved lung lobes and total CT score during the early convalescent stage. Conclusion: The higher IL-6 level was a common independent risk factor for CT abnormalities at baseline and residual pulmonary abnormalities at 1-month follow-up. There were no obvious radiographic changes during the early convalescent stage in patients with residual pulmonary abnormalities.

Thyroid Hormone Reference Intervals among Healthy Individuals In Lanzhou, China

Yan Lu,Wen-Xia Zhang,De-Hong Li,Lian-Hua Wei,Yu-Jun Zhang,Fu-Na Shi,Shen Zhou 대한내분비학회 2023 Endocrinology and metabolism Vol.38 No.3

Background: The common reference intervals (RIs) for thyroid hormones currently used in China are provided by equipment manufacturers. This study aimed to establish thyroid hormone RIs in the population of Lanzhou, a city in the subplateau region of northwest China, and compare them with previous reports and manufacturer-provided values. Methods: In total, 3,123 individuals (1,680 men, 1,443 women) from Lanzhou, an iodine-adequate area of China, perceived ashealthy were selected. The Abbott Architect analyzer was used to determine the serum concentration of thyroid hormones. The 95%RI was estimated using the 2.5th and 97.5th percentiles as the lower and upper reference limits, respectively. Results: The serum levels of thyroid-stimulating hormone (TSH), total triiodothyronine (TT3), antithyroglobulin (ATG) antibody,and antithyroid peroxidase (ATPO) antibody levels were significantly correlated with sex (P<0.05). TSH, total thyroxine (TT4), andATPO levels were significantly correlated with age (P<0.05). The serum levels of TSH, ATG, and ATPO in men were significantlylower than in women; in contrast, the serum TT3 level was significantly higher in men than in women (P<0.05). Serum TSH, TT3,TT4, and ATG levels differed across age groups (P<0.05), but no such variation was observed for ATG levels (P>0.05). The established RIs of TSH, ATG, and ATPO in this study differed between sexes (P<0.05). The thyroid hormone RIs established herein wereinconsistent with the manufacturer-provided values. Conclusion: The RIs of thyroid hormones in the healthy population of Lanzhou were inconsistent with those in the manufacturer’smanual. Validated sex-specific values are required for diagnosing thyroid diseases.

The Expression Profile of Novel Gene PCIA1 and Its Potential Function on Carcinogenesis

Xiang He,Yang Mei Shen,Hong Xin Deng,Jia Wen Zhang,Rui Wang,Yu Quan Wei,Bing Kan,Yu Bing Xie,Xia Zhao 한국유전학회 2007 Genes & Genomics Vol.29 No.2

Sesquiterpenoids from Farfugium japonicum and Their Inhibitory Activity on NO Production in RAW264.7 Cells

Jiang-He Zhao,Wei-Dong Xie,Tong Shen,Xia Yang,Hong Zhao,Xia Li 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.7

A new eremophilane sesquiterpenoid, namely, 3β-angeloyloxy-6β,8β-dihydroxy-9β-senecioyloxyeremophil-7(11)-en-12,8α-lactone, along with eight known sesquiterpenoids, was isolated from the rhizome of Farfugium japonicum. The structures of all isolates were identified based on analyses of spectroscopic data (HRESIMS, IR, 1D, and 2D NMR) and comparison with literature data. The inhibitory effects of compounds 1-4 on nitric oxide production in lipopolysaccaride-activated mouse macrophages were also evaluated.

MicroRNA-155 Expression has Prognostic Value in Patients with Non-small Cell Lung Cancer and Digestive System Carcinomas

Xu, Tong-Peng,Zhu, Can-Hong,Zhang, Jian,Xia, Rui,Wu, Feng-Lei,Han, Liang,Shen, Hua,Liu, Ling-Xiang,Shu, Yong-Qian Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12

Objective: Published data have shown that microRNAs (miRNAs) could play a potential role as diagnostic and prognostic indicators in cancers. Data for the predictive value of microRNA-155 are inconclusive. The aim of the present analysis was therefore to evaluate the role of miR-155 in prognosis for patients with a variety of carcinomas. Methods: Relevant studies were identified by searching PubMed and EMBASE. Data were extracted from studies comparing overall survival (OS), recurrence-free survival (RFS) or cancer-specific survival (CSS) in patients with carcinoma with higher miR-155 expression and those with lower levels. The pooled hazard ratios (HRs) and 95% confidence intervals (CIs) of miR-155 for clinical outcome were calculated. Results: A total of 15 studies were included. The pooled hazard ratio (HR) for OS of higher miR-155 expression in cancerous tissue was 1.89 (95% CI: 1.20-2.99, P=0.006), which could markedly predict poorer survival in general cancer. For RFS/CSS, elevated miR-155 was also associated with poor prognosis of cancer (HR=1.50, 95% CI: 1.10-2.05, P=0.01). On subgroup analysis, the pooled HR for OS in non-small cell lung cancer (NSCLC) was 2.09 (95% CI: 0.68-6.41, P > 0.05), but for RFS/CSS was 1.28 (95% CI: 1.05-1.55, P=0.015), with statistical significance; the pooled HRs for OS and RFS/CSS in digestive system neoplasms were 3.04 (95% CI: 1.48-6.24, P=0.003) and 2.61 (95% CI: 1.98-3.42, P<0.05), respectively. Conclusions: The results indicated that the miR-155 expression level plays a prognostic role in patients with cancer, especially NSCLCs and digestive system carcinomas.

Malignant Transformation Rate and P53, and P16 Expression in Teratomatous Skin of Ovarian Mature Cystic Teratoma

Zhu, Hai-Li,Zou, Zhen-Ning,Lin, Pei-Xin,Li, Wen-Xia,Huang, Ye-En,Shi, Xiao-Xin,Shen, Hong Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.3

Objective: To investigate the incidence of malignant transformation and P53 and P16 expression in teratomatous skin of ovarian mature cystic teratoma. Materials and Methods: Data on ovarian teratoma specimens in nearly 10 years were reviewed. P53 and P16 expression were detected by immunohistochemistry in 25 cases of teratomatous skin of ovarian mature cystic teratoma, 20 cases of squamous cell carcinoma and 2 cases of squamous cell carcinoma originated from teratomatous skin. Results: Of 1913 cases of ovarian mature cystic teratoma in nearly 10 years, only two cases of squamous cell carcinoma were found in teratomatous skin, with malignant transformation rate of 0.1045%. P53 expression was detected in 2 cases squamous cell carcinoma originated from teratomatous skin and P16 overexpression in one. There were no expressions of P53 and P16 in 25 cases of teratomatous skin of ovarian mature cystic teratoma. Of 20 cases of squamous cell carcinoma P53 overexpression (positive rate of 55%) was detected in 11 cases, P16 overexpression (positive rate of 35%) in 7 cases. The positive rates of P53 and P16 expression in squamous cell carcinomas were significantly higher than that in the teratomatous skins (p< 0.001, p= 0.002). Conclusions: There was low risk of malignant transformation in teratomatous skin of ovarian mature cystic teratoma which can be explained by lower P53 and P16 expressionin teratomas than that in squamous cell carcinoma.