왼쪽 한계값을 갖는 정렬 문제에 대한 병렬 알고리즘

주홍돈(Hong Don Joo),박상옥(Sang Wook Park),장직현(Jik Hyun Chang) 한국정보과학회 1993 한국정보과학회 학술발표논문집 Vol.20 No.2

본 논문에서는 변형된 정렬 문제로서, 정렬의 대상이 되는 원소와 각 원소에 주어진 왼쪽 한계값이 정렬된 후의 그 원소가 위치할 수 있는 자리를 제한하는 정렬 문제를 생각한다. Heap을 이용하여 문제를 해결하는 O(nlogn)의 시간복잡도를 가지는 순차 알고리즘은 이미 알려져있다. 여기에서는 주어진 문제를 해결하는 3가지의 병렬 알고리즘을 제시한다. 먼저 순차 알고리즘에서 Heap을 병렬화하여 O(logn)의 프로세서를 가지고 O(n)시간에 해결하는 병렬 알고리즘과 Heap을 이용하지 않는 알고리즘으로 O(n²/logn)의 프로세서를 가지고 O(logn)시간에 해결하는 병렬 알고리즘과 O(n)의 프로세서를 가지고 O(log²n) 시간에 해결하는 병렬 알고리즘을 제시한다.

KRC 408, inhibitor of hepatic growth factor receptor (c-Met) suppress growth of gastric cancer through antiproliferation and antianigogenic antitumor activity

ZHENG Hong-Mei,HONG Sang-Won,CHOI Myung-Joo,KIM Da-Young,AHN Su-Mi,SHIN Moon-Geun,CHO Sung-Yun,KIM Hyoung-Rae,LEE Jong-Kook,LEE Don-Haeng,HONG Soon-Sun 大韓藥學會 2012 大韓藥學會 總會 및 學術大會 Vol.2012 No.1

In vitro and In vivo Anti-Helicobacter pylori Activities of Centella asiatica Leaf Extract

Hong-Mei Zheng,Myung-Joo Choi,Jae Min Kim,Kye Wan Lee,Yu Hwa Park,Don Haeng Lee 한국식품영양과학회 2016 Preventive Nutrition and Food Science Vol.21 No.3

Helicobacter pylori infection is associated with an increased risk of developing upper gastrointestinal tract diseases. However, treatment failure is a major cause of concern mainly due to possible recurrence of infection, the side effects, and resistance to antibiotics. The aim of this study was to investigate the activities of Centella asiatica leaf extract (CAE) against H. pylori both in vitro and in vivo. The minimum inhibitory concentrations (MICs) against 55 clinically isolated strains of H. pylori were tested using an agar dilution method. The MICs of CAE ranged from 0.125 mg/mL to 8 mg/mL, effectiveness in inhibiting H. pylori growth was 2 mg/mL. The anti-H. pylori effects of CAE in vivo were also examined in H. pylori-infected C57BL/6 mice. CAE was orally administrated once daily for 3 weeks at doses of 50 mg/kg and 250 mg/kg. CAE at the 50 mg/kg dose significantly reduced H. pylori colonization in mice gastric mucosa. Our study provides novel insights into the therapeutic effects of CAE against H. pylori infection, and it suggests that CAE may be useful as an alternative therapy.

돼지의 UCP3 유전자의 단일염기서열 변이와 경제형질과의 연관성 분석

Jae-Don Oh(오재돈),Kun-Woo Lee(오건우),Il-Jung Jung(정일정),Gwang-Joo Jeon(전광주),Hak-Kyo Lee(이학교),Hong-Sik Kong(공홍식) 한국생명과학회 2011 생명과학회지 Vol.21 No.1

Uncoupling protein (UCP) 3 유전자는 갈색지방세포의 미토콘드리아 내막에 존재하며 탈공역 산소(uncoupling oxygen)를 통해 ATP를 생산하는 것으로 알려져 있다. 이는 세포 내의 과다 에너지를 열로 발산시키는 기능을 하고 있다. 본 연구는 돼지의 UCP 3 유전자 내 missense mutation의 유전자형을 조사하고 경제형질과의 연관성을 분석하기 위하여 실시하였다. 돼지의 UCP3 유전자의 염기서열 분석을 통해 1405 bp 지역에서(accession number: AY739704) G염기가 A염기로 치환되는 변이를 확인하였다. 확인된 변이지역은 G가 A로 치환됨으로 인해 150번째 아미노산 서열이 glycine (GGG)에서 arginine (AGG)으로 바뀌는 missense mutation임을 확인하였다. 각 유전자형의 빈도는 0.164(GG), 0.587(GR) 그리고 0.249(RR)로 확인되었으며, 각 대립유전자의 빈도는 0.458(G)과 0.542(R)로 확인되었다. 돼지 UCP3의 G150R 유전자형과 경제형질 간의 연관성을 분석한 결과 등지방두께에 있어 유의적인 연관성이 검출되고 일당증체량과 90 kg 도달일령에서는 유의적인 값이 검출되지 않았다. Uncoupling protein (UCP) 3 has a number of proposed roles in the regulation of fatty acid metabolism. A number of polymorphisms in the human UCP3 gene have been identified, and the correlation with obesity related phenotypes evaluated. The objective of this study was to identify SNP in porcine UCP3 gene and to investigate the effect of the SNP on economic traits. The sequencing analysis method was used to identify nucleotide polymorphisms at position 1405 bp (Genebank accession No : AY739704) in porcine UCP3 gene. The SNP (G150R), located in the exon 3, changed the amino acid to glycine (GGG) from arginine (AGG). This G150R showed three genotypes - GG, GR and RR - by digestion with the restriction enzyme Sma Ⅰ using the PCR-RFLP method. The G150R showed significant effects only on back fat (P<0.05). Animals with the genotype GG had significantly higher back fat thickness (1.358 ㎝) than animals with the genotype GR (1.288 ㎝, P<0.05) and RR (1.286 ㎝, P<0.05). However, the genotypes had no significant association with ADG and days to 90㎏. According to results of this study, a G allele of the G150R was found to have a significant effect on back fat thickness. It will be possible to use SNP markers on selected pigs to improve backfat thickness, an important economic trait.

ITU-R의 방송위성계획 개정결과 고찰

박주홍(Joo-Hong PARK),양왕렬(Wang-Yeol YANG),조성돈(Seong-Don CHO),성향숙(Hyangsuk SEONG) 한국통신학회 2000 한국통신학회 학술대회논문집 Vol.2000 No.11

토종닭 순계와 실용계의 유전적 특성 및 품종식별력 분석

Jae-Don Oh(오재돈),Kun-Woo Lee(이건우),Ok-Suk Seo(서옥석),Byung-Wook Cho(조병욱),Gwang-Joo Jeon(전광주),Hak-Kyo Lee(이학교),Hong-Sik Kong(공홍식) 한국생명과학회 2010 생명과학회지 Vol.20 No.7

본 연구는 토종닭 순계(적갈계통, 황갈계통), 토종닭 실용계와 오골계 및 외래품종(Hy-Line Brown: HB, White Leghorn: WL)을 대상으로 13종의 MS marker (ADL0309, ADL181, ADL190, ADL279, LEI0073, LEI0192, MCW083, MCW120, MCW153, MCW214, MCW217, MCW226, MCW322)을 활용하여 집단 및 품종간의 유전적 다양성을 분석 하였다. 13종의 MS marker 내에서 총 120개의 대립유전자를 확인 하였으며 평균 9.2개의 대립유전자를 보유한 것으로 나타났다. 관측된 이형질성, 기대되는 이형질성 및 PIC의 평균값은 각각 0.63, 0.72 그리고 0.678로 확인되었다. 가장 많은 평균대립유전자를 보유한 집단은 토종닭 실용계집단이 5.9로 확인 되었으며 기대되는 이형질성이 0.629로 비교적 높게 나타났다. 이는 토종닭 순계 집단을 이용한 3원 교잡을 통해 실용계집단을 생산하는 과정에서 기인한 것으로 추정된다. 집단 및 품종간의 유전적 유연관계를 분석한 결과 토종닭 순계집단 (R, Y)과 실용계집단(C)은 서로간에 가까운 유전적 거리를 유지하고 있는 것으로 확인되었다. 각 MS marker별 품종간의 이형접합률을 이용하여 각 개체들의 집단 내에서 품종을 식별 할 수 있는 확률인 누적품종식별력(CPD) 값을 계산한 결과 13종의 MS marker를 이용하여 개체의 품종을 구분할 수 있는 확률이 99.461%로 나타났다. To estimate the genetic characteristics and cumulative power of discrimination (CPD) within Korean native commercial chicken, we used a total of 395 genomic DNAs from six breeds population (Korean Native Red chicken: R, Korean Native Yellow chicken: Y, Korean native Commercial Chicken: C, Ogal chicken: S, Hy-Line Brown: H, White Leghorn: W). Genetic diversity indices including mean allele number among loci, unbiased heterozygosity (hi) within locus, effective number of alleles (Ne) and polymorphism information content (PIC) as well as the unbiased average heterozygosity (H) among loci in the populations were calculated using the generated allele frequencies by each marker. Frequencies of microsatellites markers were used to estimate heterozygosities and genetic distances. The nearest distance (0.119) was observed between the C and Y strains. The generated unbiased average heterozygosity among loci in each population was integrated to the global formula of CPD and the result demonstrated that the CPD within the six chicken populations was 99.461%.

Potential Allelic Association of Microsatellite Markers on Bovine Chromosome 5 with Carcass Traits in Hanwoo (Korean cattle)

Jae-Don Oh(오재돈),Hong-Sik Kong(공홍식),Byung-Wook Cho(조병욱),Mi-Rang Lee(이미랑),Gwang-Joo Jeon(전광주),Hak-Kyo Lee(이학교) 한국생명과학회 2008 생명과학회지 Vol.18 No.9

본 연구는 한우의 5번 염색체 내에 존재하고 있는 10개의 microsatellite marker의 대립유전자 빈도를 이용하여 한우의 경제형질과의 연관성을 지닌 좌위를 탐색하기 위하여 실시하였다. 한우 326두를 대상으로 10개의 유전좌위를 분석한 결과 총 169개의 대립유전자가 검출되었다. 모든 유전좌위에서 다형성이 검출되었으며 각 유전좌위별 대립유전자의 수는 9에서 28개로 나타났으며 평균 16.9로 나타났다. 가장 높은 PIC 값을 가진 유전좌위는 DIK2400(0.908)이었으며 가장 낮은 유전좌위는 DIK2718 (0.603)으로 검출되었다. 관측된 이형접합도에서는 DIK1048 (0.655)가 가장 높게 나타났으며, DIK2400 (0.906)은 가장 낮은 것으로 검출되었다. 분석된 MS marker들의 대립유전자의 빈도를 이용하여 경제형질과의 연관성을 탐색하기 위하여 각 경제형질별 육종가를 대상으로 상위그룹과 하위그룹으로 나누어 Chi-square검정을 실시하였다. 분석결과 DIK2828의 239 대립유전자는 근내지방도에서 상위그룹과 하위그룹의 빈도차가 유의적인 차이를 보이는 것으로 나타났다. BMC1009의 279 대립유전자는 도체중과 등지방두께에서 유의적인 차이를 확인하였으며 285대립유전자는 도체중, 등지방두께 그리고 근내 지방도에서 유의적인 차이가 확인되었다. DIK4329의 200대립유전자는 등심단면적과 등지방두께에서 유의적인 차이가 확인되었다. 본 연구에서 유의적인 차이가 확인된 유전자좌위는 5번 염색체 내 20 (DK2828), 41 (BMC1009) 그리고 95 (DIK4329) cM로 나타났다. A total of 10 polymorphic microsatellite markers on bovine chromosome 5 were used for allelic association tests with phenotypic characteristics in Hanwoo. The data analyzed in this study were collected from 326 steers. Chi-square tests were performed to compare the frequencies of individual alleles between the high and the low breeding value groups. The following breeding values were analyzed for QTL effects. The frequency of allele 239 of DIK2828 showed a significant difference between the high and the low breeding value groups in the breeding value of marbling score (MSBV). The allele 279 of BMC1009 was found to show significant differences in allelic distribution for the breeding value of cold carcass weight (CWBV) and the breeding value of backfat thickness (BFBV) and allele 285 showed significant differences in allelic distribution for CWBV, BFBV, and MSBV. The allele 200 of DIK4329 showed significant differences in allelic distributions for the breeding values of longissimus muscle area (LMABV) and BFBV. In this study, we identified the QTL for carcass traits at around 20 (DIK2828), 41 (BMC1009) and 95 (DIK4329) cM in chromosome 5. The results provided a useful reference for further positional candidate gene research and marker-assisted selection for fat metabolism and carcass traits.

The Effect of Food Waste Compost and Livestock Manure on Chinese Cabbage (Brassica rapa var. glabra) Growth

Young Don Lee,Jae Hong Yoo,Jin Ho Joo 한국토양비료학회 2017 한국토양비료학회지 Vol.50 No.6

Treatment of food waste is becoming a big issue due to their significant quantities. Composting could be an effective alternative for food waste management which could be used as soil conditioner or fertilizer with little concerns about heavy metals and pathogens. The purpose of this research was to evaluate the effect of food waste on Chinese cabbage growth and soil properties. 9 different treatments (two livestock manures, two food wastes, two livestock manures + chemical fertilizer, two food wastes + chemical fertilizer, and control) were applied to Chinese cabbage. All treatments were carried out in 3 replicates. We measured leaf length, leaf width, fresh weight, dry weight, and leaf greenness of Chinese cabbage. Treatment of one of food waste composts significantly increased leaf length and leaf width of Chinese cabbage by 28.6, 26.6, 67.7, and 59.9%, respectively, in comparison to those of control, while no significant differences for leaf greenness were shown. Application of food waste compost resulted in significant increase of EC, available P2O5, CEC, organic matter, and exchangeable cations. However, further researches are needed to reduce NaCl content of food waste.

In vitro and In vivo Anti-Helicobacter pylori Activities of Centella asiatica Leaf Extract

Zheng, Hong-Mei,Choi, Myung-Joo,Kim, Jae Min,Lee, Kye Wan,Park, Yu Hwa,Lee, Don Haeng The Korean Society of Food Science and Nutrition 2016 Preventive Nutrition and Food Science Vol.21 No.3

Helicobacter pylori infection is associated with an increased risk of developing upper gastrointestinal tract diseases. However, treatment failure is a major cause of concern mainly due to possible recurrence of infection, the side effects, and resistance to antibiotics. The aim of this study was to investigate the activities of Centella asiatica leaf extract (CAE) against H. pylori both in vitro and in vivo. The minimum inhibitory concentrations (MICs) against 55 clinically isolated strains of H. pylori were tested using an agar dilution method. The MICs of CAE ranged from 0.125 mg/mL to 8 mg/mL, effectiveness in inhibiting H. pylori growth was 2 mg/mL. The anti-H. pylori effects of CAE in vivo were also examined in H. pylori-infected C57BL/6 mice. CAE was orally administrated once daily for 3 weeks at doses of 50 mg/kg and 250 mg/kg. CAE at the 50 mg/kg dose significantly reduced H. pylori colonization in mice gastric mucosa. Our study provides novel insights into the therapeutic effects of CAE against H. pylori infection, and it suggests that CAE may be useful as an alternative therapy.

급성 백혈병 관해유도요법후 발생한 다발성 비장농양 1예

이홍기,김선운,박경동,이현성,주영돈,손창학 인제대학교 2000 仁濟醫學 Vol.21 No.1

Splenic abscess is a rare illness. Its incidence has ranged from 0.14 to 0.7 % in various autopsies conducted in the US. Even in the most recently published articles, diagnosis was made only in autopsies in 37 % of the cases. While splenic abscess may arise occasionally from contiguous spread of infection or direct trauma to the spleen, usually it develops with hematogenous spread or infection. But, bacterial endocarditis is the most common cause. RUQ pain of abdomen developed in only half of series. Splenomegaly, fever and leucocytosis was also present. When splenic abscesses are being considered in a differential diagnosis, CT scan of the abdomen has been the most sensitive diagnostic tool. Streptococcal species are the most common bacterial isolates from splenic abscesses, S. aureus is the next most common. Salmonella species are seen commonly in patients with sickle cell hemoglobinopathy. Because of the high mortality related for splenic abscess, the treatment of choice is splenectomy with adjunctive antibiotics. However, percutaneous drainage has been successful alternative. We reported a 19-years old female patient who had splenic abscess after remission induction chemotherapy of acute leukemia, successfully treated with splenectomy.