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Hitomi Suzuki,Koichiro Matsuo Asia Association for Disability and Oral Health 2020 대한장애인치과학회지 Vol.16 No.1
Introduction: Recently, everolimus has been used as a treatment for subependymal giant cell astrocytomas and renal angiomyolipoma in patients with tuberous sclerosis. Oral everolimus application often causes oral mucositis. However, dentists and dental hygienists do not yet fully understand the adverse events and how to deal with them. This report aimed to describe the successful oral health management of a tuberous sclerosis complex (TSC) patient with oral mucositis under everolimus. Case presentation: A 26-year-old man with TSC was referred by a urologist to our dental outpatient clinic for oral examination before commencing oral everolimus for the treatment of renal angiomyolipoma. Other TSC comorbidities included subependymal giant cell astrocytomas, epilepsy, and severe mental retardation. His oral condition was poor since he had not visited a dental office for an extended time due to extremely uncooperative behavior. Periodontal and caries treatments were carried out under behavior management techniques and immobilization by his mother and dental staff. Proper management of oral mucositis and oral care procedures were also instructed to the mother. His oral hygiene status improved and multiple oral mucositis lesions by everolimus did not deteriorate to cause infection or delayed healing. Conclusion: To prevent the deterioration of oral hygiene and oral mucositis by medication, dental professionals should be involved in a team-based approach to TSC treatment.
Mikiko Asai-Sato,Nao Suzuki,Hitomi Sakai,Yoshio Itani,Shinya Satoh,Masayuki Futagami,Yoshio Yoshida 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.1
Objective: This study aimed to assess gynecologic oncologists (GOs)’ perceptions and attitudes toward cancer survivorship to help improve survivor care. Methods: We conducted a web-based questionnaire survey about survivorship issues for the GOs belonging to the Japan Gynecologic Oncology Group. We analyzed the proactiveness of the participants toward addressing 25 survivor issues. In addition, the practice patterns and barriers to care for survivors’ long-term health issues, such as second primary cancer (SPC) and lifestyle-related diseases (LSRD), and return-to-work (RTW) support were assessed. Results: We received 313 responses. The respondents had a mean of 22 years of physician experience. The ratio of men to women was approximately 7:3, and 84.7% worked at facilities for multidisciplinary cancer treatment. The respondents’ proactiveness for addressing psychosocial problems was significantly lower than physical and gynecological issues (p<0.01 by χ2 test). However, most GOs tried to contribute to such issues according to patients’ demands. Women GOs were more proactively involved in some survivorship issues than the men (p<0.05 by logistic regression analysis). The rates of the respondents who proactively discussed SPC, LSRD, and RTW were unexpectedly high (60.7%, 36.1%, and 52.4%, respectively). However, the GOs only provided verbal support for these issues in many cases. Conclusion: The Japanese GOs were enthusiastic about survivorship care. However, their tendency to deal with survivors’ problems through their own knowledge and judgments raises concerns about the quality of care. Therefore, creating survivorship care guidelines and enhancing multidisciplinary collaboration should be prioritized.
( Norio Akuta ),( Yusuke Kawamura ),( Yasuji Arase ),( Fumitaka Suzuki ),( Hitomi Sezaki ),( Tetsuya Hosaka ),( Masahiro Kobayashi ),( Mariko Kobayashi ),( Satoshi Saitoh ),( Yoshiyuki Suzuki ),( Kenj 대한간학회 2016 Gut and Liver Vol.10 No.3
Background/Aims: It is important to determine the noninvasive parameters of histological features in nonalcoholic fatty liver disease (NAFLD). The aim of this study was to investigate the value of genetic variations as surrogate markers of histological features. Methods: The parameters that affected the histological features of NAFLD were investigated in 211 Japanese patients with biopsy-proven NAFLD. The relationships between genetic variations in PNPLA3 rs738409 or TM6SF2 rs58542926 and histological features were analyzed. Furthermore, the impact of genetic variations that affected the pathological criteria for the diagnosis of nonalcoholic steatohepatitis (NASH) (Matteoni classification and NAFLD activity score) was evaluated. Results: The fibrosis stage of PNPLA3 GG was significantly more progressive than that of CG by multiple comparisons. Multivariate analysis identified PNPLA3 genotypes as predictors of fibrosis of stage 2 or more, but the impact tended to decrease at stage 3 or greater. There were no significant differences among the histological features of the three genotypes of TM6SF2. PNPLA3 genotypes partly affected the definition of NASH by the NAFLD activity score, but TM6SF2 genotypes did not affect the definition of NASH. Conclusions: In Japanese patients with biopsy-proven NAFLD, PNPLA3 genotypes may partly affect histological features, including stage of fibrosis, but the TM6SF2 genotype does not affect histological features. (Gut Liver 2016;10:437-445)
Oikawa, T.,Hoque, M.A.,Hitomi, T.,Suzuki, K.,Uchida, H. Asian Australasian Association of Animal Productio 2006 Animal Bioscience Vol.19 No.5
Genetic parameters for performance traits on 409 bulls and growth and carcass traits on 591 of their steer progeny were estimated in Japanese Black cattle with Gibbs sampling. Traits of bulls included body weight at the start (BWS) and finish (BWF) of test, daily gain (DG), concentrate, roughage and TDN intake, and TDN conversion ratio. Progeny traits were BWS, BWF, DG, rib eye area, marbling score (MSR), dressing percentage and subcutaneous fat thickness (SFT). In bulls, heritabilities were high for BWS (0.50) and BWF (0.63) and moderate for concentrate (0.48) and TDN intake (0.45), while in progeny, the heritability for all the studied traits was moderate to high (ranging from 0.30 to 0.73), highlighting the potential for genetic improvement of these traits. Genetic correlations between TDN intake and growth traits (BWS, BWF and DG) in bulls were highly positive (ranging from 0.77 to 0.94). The weak but negative genetic correlation (-0.20) between MSR and SFT in progeny indicated that improvement of beef marbling without increasing subcutaneous fat deposition could be possible. The estimated genetic correlations of roughage intake of bulls with body weights (BWS and BWF) and MSR of their progeny were moderate (ranging from 0.35 to 0.52). On the basis of the selection for bulls, growth traits and TDN intake correlated positively with SFT (ranging from 0.43 to 0.53) of their progeny, suggesting the necessity of controlling the increase of SFT in selection programs.
Awareness among Dental Hygienists with Regard to Treatment Options for Halitosis
Masahiro Yoneda,Natsuki Kashio,Hatsumi Uchida,Nao Suzuki,Hiroshi Matsuura,Toru Naito,Chihiro Koga,Hitomi Yasukochi,Masaro Matsuura,Takao Hirofuji 대한예방치과학회 2012 International Journal of Clinical Preventive Denti Vol.8 No.3
Introduction: A growing number of people are expressing concern about breath odor, so it is important that dental hygienists have basic knowledge on the etiology and treatment of halitosis. Objective: The general level of awareness of this condition is unclear and quantification is important in targeting specific educational resources at this group. Methods: We performed a questionnaire survey on 31 dental hygienists of Fukuoka Dental College Medical and Dental Hospital. We also examined how their job experience affected their knowledge and awareness of halitosis treatment. The subjects were divided into two groups. Results: “Experienced” and “less experienced”, having five or more years and less than five years of experience, respectively. Both groups of dental hygienists had encountered oral malodor in patients during dental treatment, and many were consulted specifically regarding this condition. The hygienists generally felt competent in explaining the causes of oral malodor but less felt able to describe the treatments. The “less experienced” group had particularly low confidence in providing this information. However, more than 78% of the “less experienced” dental hygienists believed that they should actively participate in treating halitosis, although fewer of the “experienced” group felt that this was part of their role. Conclusion: From these results, we conclude that although dental hygienists are aware of the importance of halitosis treatment, their knowledge and ability to deliver this therapy varies relative to their level of experience.
SHIROZU, Takahiro,IWANO, Hiroki,OGISO, Takatoshi,SUZUKI, Toshiyuki,BALBOULA, Ahmed Z.,BAI, Hanako,KAWAHARA, Manabu,KIMURA, Koji,TAKAHASHI, Hitomi,RULAN, Bai,KIM, Sung-Woo,YANAGAWA, Yojiro,NAGANO, Masa 家畜繁殖硏究所 2017 Journal of Reproduction and Development Vol.63 No.3
<P> Interferon tau (IFN-τ) is a ruminant-specific type I IFN secreted by a conceptus before its attachment to the uterus. IFN-τ induces the expression of IFN-stimulated genes (ISGs) via the type I IFN receptor (IFNAR), which is composed of IFNAR1 and IFNAR2 subunits in the endometrium. However, expression patterns of IFNARs during the estrous cycle have not been reported. We hypothesized that the response to a type I IFN changes along with IFNARs and the IFN-regulatory factors (IRFs) driving transcription of IFN signal-related genes and modulating a type I IFN signal during the estrous cycle. We investigated the estrous cycle stage-dependent type I IFN induction of ISGs and expression patterns of IFN signal-related genes in bovine endometrial tissues. Endometrial tissue pieces collected from bovine uteri at each estrous stage (early, mid, and late) were cultured with or without recombinant bovine IFN-α or concentrated pregnant uterine flushing (PUF) on day 18 after confirming the presence of a conceptus. IFN-α and PUF each significantly increased the expression of ISGs in endometrial tissues. The induction levels of the typical ISGs (<I>MX1-a</I> and <I>ISG15</I>) were significantly higher at the mid stage and correlated with high expression of <I>IRFs</I> at the mid stage. The immunostaining of IFNARs showed strong fluorescence intensities in luminal and glandular epithelia at the early and mid stages. Collectively, these results suggest that the endometrium exhibits estrous cycle stage-dependent responsiveness to type I IFN that may be associated with the expression of IFNARs and IRFs for pregnancy recognition.</P>
( Norihiro Imai ),( Kenji Ikeda ),( Yuya Seko ),( Yusuke Kawamura ),( Hitomi Sezaki ),( Tetsuya Hosaka ),( Norio Akuta ),( Masahiro Kobayashi ),( Satoshi Saitoh ),( Fumitaka Suzuki ),( Yoshiyuki Suzuk 대한간학회 2013 Gut and Liver Vol.7 No.2
Miriplatin is a novel lipophilic platinum complex that was developed to treat hepatocellular carcinoma (HCC). Although HCC patients frequently have coexisting chronic renal failure, little prospective data are available regarding the clinical toxicity of chemotherapeutic agents used to treat HCC patients with chronic renal failure. In a phase II study, the plasma concentration of total platinum in patients who received miriplatin was very low, and no severe renal toxicity caused by miriplatin injection was reported. Here, we present three cases of HCC with stage 4 chronic renal failure who received transcatheter arterial chemotherapy with miriplatin. All cases were male, ages 72, 84, and 83 years, and had serum creatinine levels of 2.3, 1.6, and 1.9 mg/dL, respectively. Their estimated glomerular filtration rates were 21.9, 20.3, and 22.2 mL/min, respectively. All cases were treated for unresectable HCC with transcatheter arterial chemotherapy with miriplatin. No serious adverse events were observed, and serum creatinine levels did not elevate, even in the patient who experienced renal failure caused by cisplatin administration. These results might suggest that transcatheter arterial chemotherapy with miriplatin can be safely used in HCC patients with chronic renal failure. (Gut Liver 2013;7:246-251)
( Yusuke Kawamura ),( Kenji Ikeda ),( Taito Fukushima ),( Yuya Seko ),( Tasuku Hara ),( Hitomi Sezaki ),( Tetsuya Hosaka ),( Norio Akuta ),( Masahiro Kobayashi ),( Satoshi Saitoh ),( Fumitaka Suzuki ) The Editorial Office of Gut and Liver 2013 Gut and Liver Vol.7 No.5
Background/Aims: The aim of this study was to determine the pharmacodynamics of cisplatin following three different treatment procedures for intrahepatic arterial infusion thera-py for hepatocellular carcinoma (HCC). Methods: We divided 13 HCC patients into the following three groups: group A, lone injection of cisplatin (n=3); group B, combined injection of cisplatin and lipiodol, with embolization using small gela-tin cubes (GCs) (n=5); and group C, injection of suspended lipiodol with cisplatin powder, with embolization using small GCs (n=5). In each group, the free cisplatin concentration in the hepatic vein was measured at 0, 5, 10, and 30 minutes. Results: The mean free cisplatin concentrations were as fol-lows. For group A, the mean was 48.58 μg/mL at 0 minute, 7.31 mL at 5 minutes, 5.70 mL at 10 minutes, and 7.15 mL at 30 minutes. For the same time points, for group B, the concentrations were 8.66, 4.23, 3.22, and 1.65 μg/mL, respectively, and for group C, the concentrations were 4.81, 2.61, 2.52, and 1.75 mL, respectively. The mean area under the curve (AUC)0-infinity for the free cisplatin concentration was 7.80 in group A, 2.48 in group B, and 2.27 in group C. The AUC0-infinity for the free cisplatin concentration gradually decreased, from group A to group C. Conclusions: These results indicate that the combination of lipiodol and small GCs may be useful for delaying cisplatin drainage from the liver. (Gut Liver 2013;7:576-584)
Biological Effects of Extract from the Mixed Tea (Komori Kan Gen Cha)
Takeo Hasegawa,Yeunhwa Gu,Katuyuki Miyata,Kayoko Maeda,Atsushi Fukuyama,Satoshi Ando,Morikazu Amano,Tomoaki Suzuki,Kousuke Murabayashi,Kazushi Ida,Ohno Yukiko,Hitomi Kitaoka,Michihiro Kureki,Toshifum 한국방사성폐기물학회 2004 한국방사성폐기물학회 학술논문요약집 Vol.2 No.2