Discrepancy between Clinician-rated and Self-reported Depression Severity is Associated with Adverse Childhood Experience, Autistic-like Traits, and Coping Styles in Mood Disorders

Risa Yamada(Risa Yamada ),Takeshi Fujii(Takeshi Fujii ),Kotaro Hattori(Kotaro Hattori ),Hiroaki Hori(Hiroaki Hori ),Ryo Matsumura(Ryo Matsumura ),Tomoko Kurashimo(Tomoko Kurashimo ),Naoko Ishihara(Nao 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.2

Objective: This study aimed to determine if the discrepancy between depression severity rated by clinicians and that reported by patients depends on key behavioral/psychological features in patients with mood disorders. Methods: Participants included 100 patients with mood disorders. First, we examined correlations and regressions between scores on the Hamilton Depression Rating Scale (HAMD) and Beck Depression Inventory (BDI). Second, we divided the participants into those who provided 1) greater ratings for the BDI compared with the HAMD (BDI relative- overrating, BO) group, 2) comparable ratings for the BDI and HAMD (BDI relatively concordant, BC) group, or 3) less ratings for the BDI (BDI relative-underrating, BU) group. Adverse childhood experiences, autistic-like traits, and coping styles were evaluated with a six-item short version of the Childhood Trauma Questionnaire (CTQ-6), the Social Responsiveness Scale for Adults (SRS-A), and the Ways of Coping Checklist (WCCL), respectively. Results: A significant correlation was found between HAMD and BDI scores. Total and emotional abuse subscale scores from the CTQ-6, and the self-blame subscale scores from the WCCL were significantly higher for the BO group compared with the BU group. The BO group also elicited significantly higher SRS-A total scores than did the other groups. Conclusion: These findings suggest that patients with adverse emotional experiences, autistic-like traits, and self-blame coping styles perceive greater distress than that evaluated objectively by clinicians. The results indicate the need for inclusion of subjective assessments to effectively evaluate depressive symptoms in patients deemed to have these psycho- behavioral concerns.

Study of the cartilage matrix production-promoting effect of chicken leg extract and identification of the active ingredient

Yamada, Hiroaki,Nakamura, Utano,Nakamura, Toshio,Uchida, Yoshikazu,Yamatsu, Atsushi,Kim, Mujo The Korean Nutrition Society 2019 Nutrition Research and Practice Vol.13 No.6

BACKGROUND/OBJECTIVES: Osteoarthritis (OA) is a major public health issue in Japan and other countries, and foods that prevent or treat OA are in strong demand. Proteins and peptides in chicken meat and bones are known for being rich in functional and nutritional ingredients for the improvement of osteoporosis. We speculated that chicken legs, a food consumed in many regions of the world, may also contain such ingredients. In this study, we aim to (i) evaluate the effect of chicken leg extract (CLE) on the promotion of cartilage matrix production and (ii) identify the active ingredient in CLE that contributes to this function. MATERIALS/METHODS: Artificial CLE digest was prepared, and the acid mucopolysaccharide production-promoting activity of the CLE digest was evaluated by alcian blue staining of ATDC5 cells. CLE was orally administered to rabbits with burr holes in the knee joint of the femur, and the degree of regeneration of cartilage matrix was evaluated. Furthermore, we investigated orally administered CLE-derived peptides in human plasma using LC-MS. From measuring the acid mucopolysaccharide production-promotion activity of these peptides, a molecule considered to be an active ingredient in the CLE digest was identified. RESULTS: CLE digest promoted acid mucopolysaccharide production and facilitated regeneration of cartilage matrix in in vitro and in vivo experiments. Four peptides including phenylalanyl-hydroxyproline (Phe-Hyp) were detected as CLE-derived peptides in human plasma. The effect of CLE was inferred to be due to Phe-Hyp, which was confirmed to be present in the CLE digest. CONCLUSIONS: It was shown that CLE stimulated the production of articular cartilage matrix both in vitro and in vivo, and that CLE could be an effective food for preventing or treating OA. Furthermore, only Phe-Hyp was confirmed as the active compound in the CLE digest, suggesting that the activity of CLE was due to Phe-Hyp.

Study of the cartilage matrix production-promoting effect of chicken leg extract and identification of the active ingredient

Hiroaki Yamada,Utano Nakamura,Toshio Nakamura,Yoshikazu Uchida,Atsushi Yamatsu,Mujo Kim 한국영양학회 2019 Nutrition Research and Practice Vol.13 No.6

BACKGROUND/OBJECTIVES: Osteoarthritis (OA) is a major public health issue in Japan and other countries, and foods that prevent or treat OA are in strong demand. Proteins and peptides in chicken meat and bones are known for being rich in functional and nutritional ingredients for the improvement of osteoporosis. We speculated that chicken legs, a food consumed in many regions of the world, may also contain such ingredients. In this study, we aim to (i) evaluate the effect of chicken leg extract (CLE) on the promotion of cartilage matrix production and (ii) identify the active ingredient in CLE that contributes to this function. MATERIALS/METHODS: Artificial CLE digest was prepared, and the acid mucopolysaccharide production-promoting activity of the CLE digest was evaluated by alcian blue staining of ATDC5 cells. CLE was orally administered to rabbits with burr holes in the knee joint of the femur, and the degree of regeneration of cartilage matrix was evaluated. Furthermore, we investigated orally administered CLE-derived peptides in human plasma using LC-MS. From measuring the acid mucopolysaccharide production-promotion activity of these peptides, a molecule considered to be an active ingredient in the CLE digest was identified. RESULTS: CLE digest promoted acid mucopolysaccharide production and facilitated regeneration of cartilage matrix in in vitro and in vivo experiments. Four peptides including phenylalanyl-hydroxyproline (Phe-Hyp) were detected as CLE-derived peptides in human plasma. The effect of CLE was inferred to be due to Phe-Hyp, which was confirmed to be present in the CLE digest. CONCLUSIONS: It was shown that CLE stimulated the production of articular cartilage matrix both in vitro and in vivo, and that CLE could be an effective food for preventing or treating OA. Furthermore, only Phe-Hyp was confirmed as the active compound in the CLE digest, suggesting that the activity of CLE was due to Phe-Hyp.

Electronic Transport Property of a YbMnO_3/ZnO Heterostructure

Hiroaki Yamada,Tadahiro Fukushima,Takeshi Yoshimura,Norifumi Fujimura 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.58 No.4

The electronic transport property of a YbMnO_3/ZnO heterostructure was investigated. Since ZnO is a polar semiconductor, which has a spontaneous polarization, the spontaneous polarization of YbMnO3 can be expected to affect the carrier transport of the ZnO layer and to interact with that of ZnO. To investigate the effect of the spontaneous polarization of YbMnO_3, we characterized the temperature dependences of the conduction properties of the YbMnO_3/ZnO heterostructure by using Hall-effect measurement and analyzed them by using various scattering effects including polar optical phonon scattering, acoustic phonon scattering through the deformation potential and the piezoelectric potential, ionized impurity scattering and grain boundary scattering. The analysis revealed that the predominant scattering mechanism was changed from grain boundary scattering to ionized impurity scattering by the deposition of YbMnO_3. The change in the scattering mechanism is attributed to a partly depletion of ZnO induced by the spontaneous polarization of YbMnO_3.

Photocatalytic hydrogen evolution with Ni nanoparticles by using 2-phenyl-4-(1-naphthyl)quinolinium ion as a photocatalyst

Yamada, Yusuke,Miyahigashi, Takamitsu,Kotani, Hiroaki,Ohkubo, Kei,Fukuzumi, Shunichi The Royal Society of Chemistry 2012 ENERGY AND ENVIRONMENTAL SCIENCE Vol.5 No.3

<P>Photocatalytic hydrogen evolution with 2-phenyl-4-(1-naphthyl)quinolinium ion (QuPh<SUP>+</SUP>–NA) as a photocatalyst and dihydronicotinamide adenine dinucleotide (NADH) as a sacrificial electron donor has been made possible for the first time by using nickel nanoparticles (NiNPs) as a non-precious metal catalyst. The hydrogen evolution rate with the most active Ni nanoparticles (hexagonal close-packed (<I>hcp</I>) structure, 6.6 nm) examined here was 40% of that with commercially available Pt nanoparticles (2 nm) using the same catalyst weight. The catalytic activity of NiNPs depends not only on their sizes but also on their crystal phases. The hydrogen-evolution rate normalized by the catalyst weight increased as the size of NiNPs becomes smaller, with regard to the crystal phase, the hydrogen-evolution rate of the NiNPs with <I>hcp</I> structure is more than 4 times higher than the rate of the NiNPs with face-centred cubic (<I>fcc</I>) structure of similar size. NiNPs act as the hydrogen-evolution catalyst under the pH conditions between 4.5 and 8.0, although the hydrogen-evolution rate at pH > 7.0 was much lower as compared with the hydrogen-evolution rate at pH 4.5. A kinetic study revealed that the rate of electron transfer from photogenerated QuPh&z.rad;–NA to NiNPs was much higher than the rate of hydrogen evolution, indicating that the rate-determining step may be proton reduction or desorption of hydrogen.</P> <P>Graphic Abstract</P><P>Photocatalytic hydrogen evolution with Ni nanoparticles was achieved for the first time. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2ee03106j'> </P>

Catalytic mechanisms of hydrogen evolution with homogeneous and heterogeneous catalysts

Fukuzumi, Shunichi,Yamada, Yusuke,Suenobu, Tomoyoshi,Ohkubo, Kei,Kotani, Hiroaki Royal Society of Chemistry 2011 Energy & environmental science Vol.4 No.8

<P>This perspective focuses on reaction mechanisms of hydrogen (H<SUB>2</SUB>) evolution with homogeneous and heterogeneous catalysts. First, photocatalytic H<SUB>2</SUB> evolution systems with homogeneous catalysts are discussed from the viewpoint of how to increase the efficiency of the two-electron process for the H<SUB>2</SUB> evolution <I>via</I> photoinduced electron-transfer reactions of metal complexes. Two molecules of the one-electron reduced species of [Rh<SUP>III</SUP>(Cp*)(bpy)(H<SUB>2</SUB>O)](SO<SUB>4</SUB>) (bpy = 2,2′-bipyridine) and [Ir<SUP>III</SUP>(Cp*)(H<SUB>2</SUB>O)(bpm)Ru<SUP>II</SUP>(bpy)<SUB>2</SUB>](SO<SUB>4</SUB>)<SUB>2</SUB> (bpm = 2,2′-bipyrimidine) produced by photoinduced electron-transfer reactions are converted to the two-electron reduced complexes suitable for H<SUB>2</SUB> generation by disproportionation. The photocatalytic mechanism of H<SUB>2</SUB> evolution using Pt nanoparticles as a catalyst is also discussed based on the kinetic analysis of the electron-transfer rates from a photogenerated electron donor to Pt nanoparticles, which are comparable to the overall H<SUB>2</SUB> evolution rates. The electron-transfer rates become faster with increasing proton concentrations with an inverse kinetic isotope effect, when H<SUP>+</SUP> is replaced by D<SUP>+</SUP>. The size and shape effects of Pt nanoparticles on the rates of hydrogen evolution and the electron-transfer reaction are examined to optimize the catalytic efficiency. Finally, catalytic H<SUB>2</SUB> evolution systems from H<SUB>2</SUB> storage molecules are described including shape dependent catalytic activity of Co<SUB>3</SUB>O<SUB>4</SUB> particles for ammonia borane hydrolysis and a large tunneling effect observed in decomposition of formic acid with [Ir<SUP>III</SUP>(Cp*)(H<SUB>2</SUB>O)(bpm)Ru<SUP>II</SUP>(bpy)<SUB>2</SUB>](SO<SUB>4</SUB>)<SUB>2</SUB>.</P> <P>Graphic Abstract</P><P>Recent progress in understanding catalytic mechanisms for hydrogen evolution with homogeneous and heterogeneous catalysts is overviewed. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1ee01551f'> </P>

Novel and Simple Current-Ripple Calculation of LCL Filter for Parallel-Connected Three-Phase PWM Rectifiers

Masaya Akase,Hiroaki Yamada,Toshihiko Tanaka,Ryo Okawachi,Kiyoshi Ochi 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5

This paper proposes a simple current-ripple calculation on the source side of the LCL filter for three-phase pulse width modulated (PWM) rectifiers and the parallel-connected PWM rectifiers. Per-phase-base equivalent-circuits of the LCL filter for PWM rectifiers and parallel-connected three-phase PWM rectifiers are derived theoretically. The transfer function between the output voltages of three-phase PWM rectifiers and parallel-connected three-phase PWM rectifiers and the sourceside ripple currents is derived using the superposition principle, and then Bode plots are drawn. Then, the amplitude ratio of source-side harmonic currents to the output voltages of threephase PWM rectifiers and the parallel-connected three-phase PWM rectifiers is easily calculated from the Bode plots. A digital computer simulation is implemented to confirm the validity and high practicability of the proposed current-ripple calculation of LCL filter using PSIM software. Simulation results demonstrate that the current-ripple calculated with the Bode plots agrees well with the simulation results. It is, therefore, concluded that the proposed current-ripple calculation of the LCL filter is useful for three-phase PWM rectifiers and parallel-connected three-phase PWM rectifiers.

REDUCED-CAPACITY INRUSH CURRENT SUPPRESSOR USING MATRIX CONVERTER IN WIND POWER GENERATION SYSTEM WITH SQUIRREL-CAGE INDUCTION MACHINES

Sho Shibata,Hiroaki Yamada,Toshihiko Tanaka,Masayuki Okamoto 한국신재생에너지학회 2015 AFORE Vol.2015 No.11

Poster Presentation Abstracts ; Intestinal immune system modulating arabino - 3 , 6 - galactan from rhizomes of Atractylodes lancea DC.

(Kwang Won Yu),(Hiroaki Kiyohara),(Tsukasa Matsumoto),(Haruki Yamada),(Han Chul Yang) 한국응용약물학회 1999 학술대회 Vol.1999 No.2

Can Conventional Magnetic Resonance Imaging Substitute Three-Dimensional Magnetic Resonance Imaging in the Diagnosis of Lumbar Foraminal Stenosis?

Hasib Maruf Mohammad,Yamada Kentaro,Hoshino Masatoshi,Yamada Eiji,Tamai Koji,Takahashi Shinji,Suzuki Akinobu,Toyoda Hiromitsu,Terai Hidetomi,Nakamura Hiroaki 대한척추외과학회 2021 Asian Spine Journal Vol.15 No.4

Study Design: Retrospective radiological comparative design.Purpose: To investigate whether conventional magnetic resonance imaging (MRI) could substitute three-dimensional (3D)-MRI for the calculation of the foraminal stenotic ratio (FSR) and clarification of which patients can be assessed more accurately using 3D-MRI.Overview of Literature: Previous studies have indicated that 3D-MRI is useful for diagnosing lumbar foraminal stenosis. The FSR obtained using 3D-MRI, described as the ratio of stenosis length, characterized by perineural fat obliteration, to the length of the entire foramen, could indicate the stenosis severity; however, this method is time-consuming and expensive. The FSR also can be calculated using conventional MRI.Methods: We investigated 154 foramina at L5–S1 in 77 patients. All the patients had degenerative lumbar disorders and had undergone both conventional MRI and 3D-MRI during the same visit. Differences between the FSRs calculated from conventional and 3D-MRI reconstructions and any correlations with the plain radiography findings were assessed.Results: In foramina that had a FSR of <50% on conventional MRI, the difference between the FSR obtained using conventional MRI and 3D-MRI was 5.1%, with a correlation coefficient of 0.777. For foramina with a FSR ≥50% on conventional MRI, the difference was 20.2%, with a correlation coefficient of 0.54. FSR obtained using 3D-MRI was significantly greater in patients who required surgery than in those who were successfully treated with conservative methods (88% and 42%, respectively). Segments with spondylolisthesis or lateral wedging showed higher FSRs than those without these conditions on both types of MRI.Conclusions: FSRs <50% obtained using conventional MRI were sufficiently reliable; however, the results were inaccurate for FSRs ≥50%. Patients with high FSRs on 3D-MRI were more likely to require surgical treatment. Therefore, 3D-MRI is recommended in patients with suspected stenosis detected using conventional MRI or plain radiographs.