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Tomohiro Kondo,Suguru Yoshida,Hiroaki Nagai,Ai Takeshita,Masaki Mino,Hiroshi Morioka,Takayuki Nakajima,Ken Takeshi Kusakabe,Toshiya Okada 대한수의학회 2018 Journal of Veterinary Science Vol.19 No.4
In Mongolian gerbils, bilateral common carotid artery occlusion (BCCAO) for several minutes induces ischemia, due to an incomplete circle of Willis, resulting in delayed neuronal cell death in the Cornet d’Ammon 1 (CA1) region of the hippocampus. Neuronal cell death in the hippocampus and changes in behavior were examined after BCCAO was performed for 5 min in the gerbils. One day after BCCAO, the pyramidal neurons of the CA1 region of the hippocampus showed degenerative changes (clumped chromatin in nuclei). At 5 and 10 days after BCCAO, extensive neuronal cell death was observed in the hippocampal CA1 region. Cognitive performance was evaluated by using the radial maze and passive avoidance tests. In the radial maze test, which examines win-stay performance, the number of errors was significantly higher in ischemic gerbils than in sham-operated gerbils on days 1 and 2 post-operation. In the passive avoidance test, the latency and freezing times were significantly shorter in ischemic gerbils than in sham-operated gerbils on the days 1, 2, and 4–6 post-operation. These results indicate that transient forebrain ischemia impairs cognitive performance, even immediately after the ischemic insult when there are only subtle signs of neuronal cell death.
Hiroshi Kawada,Masayuki Kanematsu,Satoshi Goshima,Hiroshi Kondo,Haruo Watanabe,Yoshifumi Noda,Yukichi Tanahashi,Nobuyuki Kawai,Hiroaki Hoshi 대한영상의학회 2015 Korean Journal of Radiology Vol.16 No.2
To evaluate the multiphase contrast-enhanced magnetic resonance (MR) imaging features of Bacillus Calmette-Guérin (BCG)-induced granulomatous prostatitis (GP). Magnetic resonance images obtained from five patients with histopathologically proven BCGinduced GP were retrospectively analyzed for tumor location, size, signal intensity on T2-weighted images (T2WI) and diffusion-weighted images (DWI), apparent diffusion coefficient (ADC) value, and appearance on gadolinium-enhanced multiphase images. MR imaging findings were compared with histopathological findings. Bacillus Calmette-Guérin-induced GP (size range, 9–40 mm; mean, 21.2 mm) were identified in the peripheral zone in all patients. The T2WI showed lower signal intensity compared with the normal peripheral zone. The DWIs demonstrated high signal intensity and low ADC values (range, 0.44–0.68 x 10-3 mm2/sec; mean, 0.56 x 10-3 mm2/sec), which corresponded to GP. Gadolinium-enhanced multiphase MR imaging performed in five patients showed early and prolonged ring enhancement in all cases of GP. Granulomatous tissues with central caseation necrosis were identified histologically, which corresponded to ring enhancement and a central low intensity area on gadolinium-enhanced MR imaging. The findings on T2WI, DWI, and gadolinium-enhanced images became gradually obscured with time. Bacillus Calmette-Guérin-induced GP demonstrates early and prolonged ring enhancement on gadoliniumenhanced MR imaging which might be a key finding to differentiate it from prostate cancer.
동아시아 지역의 플럭스 타워 관측지에 대한 MODIS 위성영상 기반의 증발산 평가
Jeong, Seung-Taek,Jang, Keun-Chang,Kang, Sin-Kyu,Kim, Joon,Kondo, Hiroaki,Gamo, Minoru,Asanuma, Jun,Saigusa, Nobuko,Wang, Shaoqiang,Han, Shijie 한국농림기상학회 2009 한국농림기상학회지 Vol.11 No.4
지표 증발산은 육상 생태계의 수문순환의 주요 성분으로서, 지표-대기간의 에너지 교환, 미기후, 지역의 수자원 함량, 식생의 일차생산성 등에 중요한 영향을 미친다. 증발산을 추정하기 위한 방법들 중에서 MODIS를 이용한 방법은 위성 자료만을 사용하여 넓은 지역에 대한 지속적인 증발산 모니터링이 가능하다는 장점을 갖고 있다. 본 연구에서는 MODIS 기반의 증발산 추정 알고리즘을 동아시아 지역에 적용하고, 그 신뢰도를 평가하였으며, 주요 오차요인을 분석하였다. 증발산 평가 결과 여섯 연구지역(GDK, HFK, TKY, TMK, CBS, SKT)에서는 $r^2$가 0.38~0.73, ME 와 RMSE가 각각 $-44{\sim}+31W\;m^{-2}$, $48{\sim}111W\;m^{-2}$로 신뢰할 만한 결과를 나타냈다. 하지만 다른 세 연구지역(HBG, QYZ, MKL)에서는 관측 값과 비교해서 차이를 나타내었고, 과소평가하는 경향을 보였다. HBG, MKL 지역은 MODIS 기상 자료 및 복사요소의 오차가 주요 원인으로 나타났다. 그러나 QYZ지역은 기상 자료와 복사요소가 모두 좋은 일치도를 보였기 때문에, 모형의 모수와 관련된 오차가 주요 원인의 하나로 판단된다. 임관 전도도의 오차가 증발산 오차에 미치는 영향을 분석한 결과, HBG지역을 제외한 다른 연구지 역에서 r값이 0.59~0.82로 관측값과의 상관성이 높은 것을 확인하였다. 또한 MODIS로부터 산출된 순간 증발산을 일 단위로 확장시킨 결과, 순간 증발산의 일치도가 떨어졌던 3개 연구지역을 제외하고 6개 지역에서 $r^2$가 0.44~0.89, ME와 RMSE는 각각 $-0.7{\sim}+0.6mm\;day^{-1}$, $0.5{\sim}1.1mm\;day^{-1}$의 범위로 신뢰도 있는 결과를 나타냈다. Evapotranspiration (ET) is one of the major hydrologic processes in terrestrial ecosystems. A reliable estimation of spatially representavtive ET is necessary for deriving regional water budget, primary productivity of vegetation, and feedbacks of land surface to regional climate. Moderate resolution imaging spectroradiometer (MODIS) provides an opportunity to monitor ET for wide area at daily time scale. In this study, we applied a MODIS-based ET algorithm and tested its reliability for nine flux tower sites in East Asia. This is a stand-alone MODIS algorithm based on the Penman-Monteith equation and uses input data derived from MODIS. Instantaneous ET was estimated and scaled up to daily ET. For six flux sites, the MODIS-derived instantaneous ET showed a good agreement with the measured data ($r^2=0.38$ to 0.73, ME = -44 to $+31W\;m^{-2}$, RMSE =48 to $111W\;m^{-2}$). However, for the other three sites, a poor agreement was observed. The predictability of MODIS ET was improved when the up-scaled daily ET was used ($r^2\;=\;0.48$ to 0.89, ME = -0.7 to $-0.6\;mm\;day^{-1}$, $RMSE=\;0.5{\sim}1.1\;mm\;day^{-1}$). Errors in the canopy conductance were identified as a primary factor of uncertainty in MODIS-derived ET and hence, a more reliable estimation of canopy conductance is necessary to increase the accuracy of MODIS ET.
Switching to systemic therapy after locoregional treatment failure: Definition and best timing
Sadahisa Ogasawara,Yoshihiko Ooka,Keisuke Koroki,Susumu Maruta,Hiroaki Kanzaki,Kengo Kanayama,Kazufumi Kobayashi,Soichiro Kiyono,Masato Nakamura,Naoya Kanogawa,Tomoko Saito,Takayuki Kondo,Eiichiro Suz 대한간학회 2020 Clinical and Molecular Hepatology(대한간학회지) Vol.26 No.2
In patients with unresectable hepatocellular carcinoma (HCC) without both macrovascular invasion and extrahepatic metastasis, the initial treatment choice recommended is transarterial chemoembolization (TACE). Before sorafenib came into wide use, TACE had been pointlessly carried out repeatedly. It was in the early 2010s that the concept of TACE refractory was advocated. Two retrospective studies from Japan indicated that conversion from TACE to sorafenib the day after patients were deemed as TACE refractory improved overall survival compared with continued TACE, according to the definition by the Japan Society of Hepatology. Nowadays, phase 3 trials have shown clinical benefits of several novel molecular target agents. Compared with the era of sorafenib, sequential treatments with these molecular target agents have gradually prolonged patients’ survival and have become major strategies in patients with HCC. Taking these together, conversion from TACE to systemic therapies at the time of TACE refractory, compared with before, may have a greater impact on survival and may be considered deeper in the decisions-making process in patients with unresectable HCC who are candidate for TACE. Up-to-date information on the concept of TACE refractory is summarized in this review. We believe that the survival of patients with unresectable HCC without both macrovascular invasion and extrahepatic metastasis may be dramatically improved by optimal timing of TACE refractory and switching to systemic therapies.