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RISS 인기검색어
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- 저자 : Akihiro HORI (검색결과 3 건)
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Tsuda, Tohru,Morimoto, Yasuo,Yamato, Hiroshi,Fujino, Akihiro,Hori, Hajime,Kido, Masamitsu,Higashi, Toshiaki,Tanaka, Isamu 가톨릭대학교 산업의학센터 2001 韓國의 産業醫學 Vol.40 No.1
The primary concern of our study is to elucidate the development and pathophysiological mechanisms of occupational and environmental lung disease. The results of these studies are applied in the field of occupational health. Therefore, particular focuses are; 1) To introduce molecular-biomarkers into the risk assessment system of occupational exposed particles, 2) To apply molecular-biomarkers into conventional research methods, for the purpose of preventing and detecting early effects caused by occupational exposure to particles. Among fibrous materials, asbestos has been shown to cause diseases such as asbestosis, lung cancer and mesothelioma. On the other hand, there are many industries utilizing asbestos because of the many advantages as an industrial resource. The attempt to replace asbestos by man-made mineral fibres (MMFs) is fast in making progress because the industrial and economic gains are becoming certain. MMFs are thought to possess the same adverse biological effects as asbestos because of their similar physiochemical properties. Current data are now available showing that the new MMFs are not all nuisance particulate. No epidemiological studies are involving MMFs, and the results of animal studies on the adverse effects of MMFs are conflicting. Moreover, the toxic potentials of MMFs developed most are recently not always understood. Asia is a region which depends heavily on industrial development to sustain its growing population. Risk assessment of MMFs is a justifiable strategy to adopt particularly in this region. We have been constructing the risk assessment system of MMFs along following steps: study of physicochemical properties (1), in vitro study, intratracheal instillation study and acute to chronic inhalation study. We have compared the results of these steps with individual step and reached the final decision of toxicity to human. On the other hand, lung is one of the most important organ that is directly contact with the work environment. For this reason, factors concerning pathogenesis of occupational or work-related lung disease would be multiple. Thus, evaluating the environmental factors including smoking are also important.
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Sashida, Yasunori,Kayo, Munefumi,Hachiman, Hironobu,Hori, Kazuki,Kanda, Yukihiro,Nagoya, Akihiro Korean Society of Plastic and Reconstructive Surge 2018 Archives of Plastic Surgery Vol.45 No.4
In this report, we present a case of successful treatment of a bowel fistula in the open abdomen by perforator flaps and an aponeurosis plug. A 70-year-old man underwent total gastrectomy and developed anastomotic leakage and dehiscence of the abdominal wound a week later. He was dependent upon extracorporeal membrane oxygenation, continuous hemodiafiltration, and a respirator. Bowel fluids contaminated the open abdomen. Two months after the gastric operation, a plastic surgery team, in consultation with general surgeons, performed perforator flaps on both sides and constructed, as it were, a bridge of skin sealing the orifice of the fistula. The aponeurosis of the external oblique muscle was elevated with the flap to be used as a plug. The perforators of the flaps were identified on preoperative and intraoperative ultrasonography. This modality allowed us to locate the perforators precisely and to evaluate the perforators by assessing their diameters and performing a waveform analysis. The contamination decreased dramatically afterwards. The bare areas were gradually covered by skin grafts. The fistula was closed completely 18 days after the perforator flap. An ultrasound-guided perforator flap with an aponeurosis plug can be an option for patients suffering from an open abdomen with a bowel fistula.
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