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Pham Hoang Hien(Pham Hoang Hien ),Tran Thanh Tuan(Tran Thanh Tuan ) People&Global Business Association 2023 Global Business and Finance Review Vol.28 No.3
Purpose: This research investigates the role of employee trust and job satisfaction in the relationship between organizational culture and employee loyalty. Design/methodology/approach: The study was conducted among 355 healthcare professionals working in a private healthcare system in southern cities of Vietnam, including doctors, nurses, and other medical staff. The research method employed was partial least squared structure equation modeling (PLS-SEM) with SmartPLS software for data analysis. Findings: The findings indicate that organizational culture has a direct positive impact on employee loyalty and also affects employee trust and job satisfaction positively. Furthermore, employee trust and job satisfaction act as intermediaries and positively influence employee loyalty toward the organization. Research limitations/implications: The research acknowledges the limitation of the limited sample size and encourages further exploration of these relationships in other contexts. In addition, this study provides valuable insights for the management board of private healthcare organizations in southern cities of Vietnam on how to improve employee loyalty by cultivating a positive organizational culture, promoting employee trust, and enhancing job satisfaction. Originality/value: Overall, this research contributes significantly to the existing literature by examining the interplay between employee trust, organizational culture, job satisfaction, and employee loyalty.
Hien D. Le,Jeng L. Huang,Hien D. Le 사단법인 한국계산역학회 2013 Computers and Concrete, An International Journal Vol.12 No.6
Ready-mixed soil material, known as a kind of controlled low-strength material, is a new way of soil cement combination. It can be used as backfill materials. In this paper, artificial neural network and non-linear regression approach were applied to predict the compressive strength of ready-mixed soil material containing Portland cement, slag, sand, and soil in mixture. The data used for analyzing were obtained from our testing program. In the experiment, we carried out a mix design with three proportions of sand to soil (e.g., 6:4, 5:5, and 4:6). In addition, blast furnace slag partially replaced cement to improve workability, whereas the water-to-binder ratio was fixed. Testing was conducted on samples to estimate its engineering properties as per ASTM such as flowability, strength, and pulse velocity. Based on testing data, the empirical pulse velocity–strength correlation was established by regression method. Next, three topologies of neural network were developed to predict the strength, namely ANN-I, ANN-II, and ANN-III. The first two models are back-propagation feed-forward networks, and the other one is radial basis neural network. The results show that the compressive strength of ready-mixed soil material can be well-predicted from neural networks. Among all currently proposed neural network models, the ANN-I gives the best prediction because it is closest to the actual strength. Moreover, considering combination of pulse velocity and other factors, viz. curing time, and material contents in mixture, the proposed neural networks offer better evaluation than interpolated from pulse velocity only.
Hien Thi Nguyen,박찬혁 한국막학회 2017 한국막학회 총회 및 학술발표회 Vol.2017 No.11
탄화규소(Silicon Carbide, SiC) 세라믹 멤브레인은 알루미나 원료의 세라믹 멤브레인보다 높은 친수성을 나타내어 동일한 압력 하에 높은 수투과도 유지가 가 능하다. 이러한 탄화규소 세라믹 멤브레인을 혐기성 생물막 반응조(Anaerobic Membrane Bioreactor, AnMBR)에 설치하여 고농도의 생물반응조 운전에도 불구하고 낮고 안정된 운전압력을 유지할 수 있었으며, 막오염 현상의 획기적인 저감이 가능하였다. 본 연구에서는 도시하수와 음폐수를 혼합 처리함에 있어서 탄화규소 세라믹 멤브레인을 적용한 AnMBR의 운전결과를 알루미나 세라믹 멤브레인을 적용한 경우와 비교 평가하였다.
A Review of Electrical Impedance Characterization of Cells for Label-Free and Real-Time Assays
Hien T. Ngoc Le,김준섭,박진수,조성보 한국바이오칩학회 2019 BioChip Journal Vol.13 No.4
The aim of this review is to discuss label- free and real-time assays characterizing the electrical impedance of cells for biomedical and pharmacological applications. Electrical impedance measurements can be used to non-destructively monitor cellular behavior by analyzing the electrical cell-substrate impedance, which is determined by cellular morphology and distribution on the sensing electrode. Cellular electrical impedance measurements can be used to analyze the effects of various therapeutic agents, nanoparticles, naturally derived bioactive compounds, chemotaxins, or other stimulants on cellular cytotoxicity, motility, migration, invasion, and proliferation. This method is becoming increasingly widespread, with applications ranging from basic studies of the cell cycle, cell signaling, chronic disease, and pathophysiological mechanisms to smart cell monitoring and high-throughput screening, which are required by the pharmacological industry.
Hien, Tran Thi,Oh, Won Keun,Nguyen, Phi Hung,Oh, Seok Jeong,Lee, Moo Yeol,Kang, Keon Wook American Society for Pharmacology and Experimental 2011 Molecular pharmacology Vol.80 No.6
<P>We revealed previously that nectandrin B isolated from Myristica fragrans (nutmeg, Myristicaceae) functions as a potent AMP-activated protein kinase (AMPK) activator and showed its antiobesity effect. In this study, we investigated whether nectandrin B affects phosphorylation of endothelial nitric-oxide synthase (eNOS) in human endothelial cells. Nectandrin B increased the phosphorylation of eNOS and nitric oxide (NO) production in a concentration-dependent manner and maximal effect was found at 10 관g/ml. Nectandrin B activates AMPK, presumably via Ca(2+)/calmodulin kinase II activation and nectandrin B-stimulated eNOS phosphorylation was reversed by AMPK inhibition. Both the enzyme activity of phosphatidylinositol 3-kinase (PI3K) and the estrogen receptor (ER)-dependent reporter gene transcription were enhanced by nectandrin B. ER관 inhibition by specific antagonist or small interfering siRNA (siRNA) suppressed nectandrin B-mediated eNOS phosphorylation. Moreover, AMPK inhibition significantly reversed the activation of ER-dependent transcription and PI3K activation in response to nectandrin B. Nectandrin B evoked endothelium-dependent relaxation in rat aortic rings, and this was blocked by inhibition of AMPK, ER, or PI3K. These results suggest that potent AMPK activator nectandrin B enhances NO production via eNOS phosphorylation in endothelial cells and ER관-dependent PI3K activity is required.</P>
Hien-Trung Trinh,Eun-Ah Bae,Jung Joon Lee,Dong-Hyun Kim 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.12
To understand anti-allergic effect of Curcuma aromatica (family Zingerberaceae), which inhibited passive cutenous anaphylaxis (PCA) reaction in preliminary study, we isolated its main constituents, curcumin, demethoxycurcumin and bisdemethoxycurcumin, and investigated their inhibitory effects against PCA reaction and scratching behavior. These curcuminoids inhibited the PCA reaction induced by the IgE-antigen complex (IAC) and the scratching behavior induced by compound 48/80. These curcuminoids also inhibited degranulation, protein expression of TNF-α and IL-4, and transcription factor NF-κB activation in IAC-induced RBL-2H3 cells. Of these curcuminoids, curcumin exhibited the most potent inhibition, followed by demethoxycurcumin and bisdemethoxycurcumin. These findings suggest that curcuminoids, particularly curcumin, can improve the symptoms of allergic diseases, such as anaphylaxis and itching.
( Hien Thi Thu Le ),( Young-chang Cho ),( Sayeon Cho ) 생화학분자생물학회(구 한국생화학분자생물학회) 2017 BMB Reports Vol.50 No.6
Protein tyrosine phosphatases (PTPs) play crucial roles in signal transduction and their functional alteration has been detected in many diseases. PTP inhibitors have been developed as therapeutic drugs for diseases that are related to the activity of PTPs. In this study, PTP inhibitor XIX, an inhibitor of CD45 and PTEN, was investigated whether it inhibits other PTPs. Protein tyrosine phosphatase non-receptor type 2 (PTPN2) was selectively inhibited by the inhibitor in a competitive manner. Drug affinity responsive target stability (DARTS) analysis showed that the inhibitor induces con-formational changes in PTPN2. Phosphorylation levels of signal transducer and activator of transcription 3 (STAT3) at Tyr-705, a crucial site for STAT3 activation and target site of PTPN2, decreased upon exposure to the inhibitor. Our results suggest that PTP inhibitor XIX might be considered as an effective regulator of PTPN2 for treating diseases related to PTPN2. [BMB Reports 2017; 50(6): 329-334]
Effect of Surface Treatment on the Formation of NiO Nanomaterials by Thermal Oxidation
Hien, Vu Xuan,Heo, Young-Woo The Korean Vacuum Society 2016 Applied Science and Convergence Technology Vol.25 No.6
Thermal oxidation has significant potential for use in synthesizing metal-oxide nanostructures from metallic materials. However, this method has limited applicability to the synthesis of multi-morphology NiO from Ni foil. Techniques consisting of mechanical and chemical approaches were used to pre-treat the Ni foil (prior to oxidation) to promote the formation of nanowires and nanoplates on the NiO layer. These morphologies were realized on the Ni foils scratched by sand paper and a knife, respectively, and subsequently heat-treated at $500^{\circ}C$ for 24 h. Small nanowires (diameter: <10 nm) formed on the Ni foil treated by absolute $HNO_3$ and then oxidized at $500^{\circ}C$ for 24 h. The formation of various morphologies (on the pre-treated Ni foil), which differ from that formed in the case of pristine Ni foil after oxidation, may be attributed to the surface melting phenomenon that occurs during the nucleation process.