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Shin, Heejun,Na, Kun Elsevier 2019 Biomaterials Vol.197 No.-
<P><B>Abstract</B></P> <P>Anticancer immunotherapy is emerging as a promising tumor treatment that can replace the conventional tumor treatment such as surgery, radiation and chemo drug, but its therapeutic effect against solid tumor is limited due to the tumor microenvironment (TME). Herein, to overcome this limitation, the biocompatibility controllable immuno-sensitizer (BCI) based on polyethylene imine that can be applied to solid tumors is developed. BCI accumulates in the tumors by EPR effect and induces <I>in situ</I> tumor destruction that convert tumors into antigen source by biocompatibility change through surface charge switching in response to the acidic TME. Generated tumor antigens promote the maturation of dendritic cells and recruitment of cytotoxic T cells in tumors. Results from <I>in vitro</I> and <I>in vivo</I> experiments reveal that the BCI effectively induces tumor destruction and antitumor immune response. In consequence, the synergic effect of <I>in situ</I> tumor destruction and antitumor immune response induced by BCI's biocompatibility conversion remarkably enhances immunotherapeutic effect. This study may provide a way to improve immunotherapeutic effect on solid tumors by demonstrating the therapeutic effect of BCI against solid tumor and suggest a platform to control the toxicity of cationic polymer for the its extended biomedical application.</P>
Should Let Them Go? Study on the Emergency Department Discharge of Patients Who Attempted Suicide
Heejun Shin,Ho Jung Kim,Shingyeom Kim,Sunjin Choi,Heeju Oh,Bora Lee 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.6
Objective The purpose of this study was to analyze the characteristics and factors of voluntary discharged patients after suicide attempt and analyze the effectiveness of follow-up measures. Methods Total 504 adult patients aged 14 years and over, who visited a local emergency medical center from September 1, 2013 to December 31, 2015 were enrolled and retrospectively reviewed. We analyzed the relationship with voluntary discharge group (VDG) among basic characteristics, suicidal attempt variables, outcome variables related to suicide attempts, and treatment related variables comparing with normal discharge group (NDG). Results Of the total 504 suicide attempts, three hundred eleven (61.7%) patients were VDG and 193 (38.2%) were NDG. The proportion of patients who completed the community service linkage were 18.7% (36/193) in NDG, compared with 7.7% (24/311) in VDG(p<0.05). In addition, the ratio of the patients who visited psychiatric outpatient department in NDG were 57.0% (110/193), more than four times as likely as 14.5% (45/311) in VDG (p<0.05). Conclusion Over sixty percent of suicide attempters discharged against medical advice. Further various aspects of national supportive measures including strengthening case management service should be considered.
3D 프린터로 제작한 친환경 접촉점화 추진제 점화기 시험
신민규(Minkyu Shin),유이상(Isang Yu),신동해(Donghae Shin),이희준(Heejun Lee),오정화(Jeonghwa Oh),고영성(Youngsung Ko) 한국추진공학회 2018 한국추진공학회 학술대회논문집 Vol.2018 No.5
친환경 접촉점화성 추진제를 평가하기 위하여 Drop-Test를 진행하였고 3D 프린터를 이용하여 제작한 충돌형 인젝터 점화기를 이용하여 점화실험을 하였다. 3D 프린터로 제작한 인젝터의 홀 사이즈는 복잡한 유로를 갖는 경우 0.5 mm이하에서는 홀이 막혔다. Drop-test 결과 산화제를 떨어뜨렸을 경우는 점화지지연시간은 7 ms였으며 연료를 떨어뜨렸을 경우는 16 ms 를 측정하였다. 3D 프린터로 제작한 점화기로 제트 충돌 실험 결과 7 ms의 점화지연시간이 측정되었다. 이를 통해 3D 프린터의 점화기 분야의 적용 가능성을 확인하였으며, 액체로켓 분야에 친환경 접촉점화 추진제의 적용 가능성을 확인하였다. Drop-Test was performed to evaluate the eco-friendly hypergolic propellants, and ignition test was also performed using a collision-type injector made by 3D printer. When the hole size of the injector manufactured by the 3D printer was less than 0.5 mm and the flow path was complicated, the hole was clogged. Drop-test results show that ignition delay time was 7 ms when the oxidant was dropped, and 16 ms when the fuel was dropped. Ignition delay time of 7 ms was measured with the igniter made by 3D printer. This study confirmed the applicability of the 3D printer to the manufacture of ignitor and confirmed the applicability of eco-friendly hypergolic propellants to liquid rocket.
신동해(Donghae Shin),유이상(Isang Yu),신민규(Minkyu Shin),이희준(Heejun Lee),박상수(Sangsu Park),고영성(Youngsung Ko) 한국추진공학회 2018 한국추진공학회 학술대회논문집 Vol.2018 No.5
본 연구는 연소불안정 현상을 모사하기 위해 설계된 분리형 연소기 헤드의 성능 검증을 위해서 수행되었다. 분리형 연소기 헤드는 저압(10bar)과 고압(60bar)의 연소 시험을 통해 성능을 검증하였다. 연소시험 결과, 저압 연소 시험에서는 목표 압력을 구현하지 못하였고 고압 연소 시험에서는 정상적인 압력에서부터 점점 압력이 떨어지는 것을 확인하였다. 그 이유는 저압 연소 시험의 경우 충분한 연소실길이 확보가 되지 못한 것으로 확인되었으며, 고압 연소 시험의 경우 연소 초기부터 그라파이트 노즐이 삭마가 진행되어 연소압력이 떨어지는 것을 확인하였다. 하지만, 고압 시험 연소 초기에 연소 성능이 충분히 발휘된 것을 확인하였기에 분리형 헤드의 성능은 충분히 검증되었다고 판단하였다. This study was conducted to verify the performance of a detachable combustor head designed to simulate combustion instability phenomena. The detachable combustor head were verified by combustion tests at low pressure (10 bar) and high pressure (60 bar). As a result of the combustion test, the target pressure could not be realized in the low pressure combustion test. In the high pressure combustion test, the pressure gradually decreased from the normal pressure. The reasons for this are that the combustion chamber length can not be secured in the low pressure combustion test and the graphite nozzle is ablated from the beginning of combustion to lower the combustion pressure in the high pressure combustion test. However, since it is confirmed that the combustion performance is sufficiently exhibited at the early stage of the high-pressure test combustion, we judge that the performance of the detachable combustor head is sufficiently verified.
유이상(Isang Yu),신동해(Donghae Shin),신민규(Minkyu Shin),이희준(Heejun Lee),고영성(Youngsung Ko),신동순(Dongsun Shin) 한국추진공학회 2018 한국추진공학회 학술대회논문집 Vol.2018 No.5
본 연구에서는 터빈배기부의 열교환기 입구 환경을 모사하기 위한 연소기 튜닝 작업을 진행하고 열교환기에 대한 예비 성능 평가시험을 수행하였다. 열교환기 입구 환경모사를 위한 예비 연소시험을 수행한 결과, 연소시험 초기에는 목표 온도 773 K를 구현하지 못 하였으며, 그 이유는 연소 효율을 고려하지 못하여 나타나는 현상으로 확인하였다. 이에 연소 효율을 고려하여 운용 조건을 재조정하였고 그 결과, 목표 온도 773 K를 구현 할 수 있었다. 이후 열교환기를 결합하여 열교환기 성능평가를 위한 예비시험을 수행한 결과, 약 723 K로 가스 질소의 온도가 상승하였지만 여전히 연소 종료 시점 직전까지 온도 상승률이 높은 것을 확인하였다. 이에 충분한 열교환이 이루어 질 수 있는 시간을 확보하여 추후 연소 시험을 수행할 예정이다. In this study, tuning of the combustor to simulate the inlet environment of the heat exchanger of the turbine exhaust was carried out and the preliminary performance evaluation test of the heat exchanger was carried out. As a result of the preliminary combustion test for the inlet environment simulation, the target temperature of 773 K was not realized at the initial stage of the combustion test, and the reason was that the combustion efficiency was not considered. As a result, the target temperature of 773 K was achieved. A preliminary test for evaluating the performance of the heat exchanger by combining a heat exchanger was carried out. As a result, it was confirmed that the temperature of gas nitrogen increased to about 723 K, but the temperature increase rate was still high until just before the end of combustion. In this way, sufficient time for heat exchange can be ensured and the combustion test will be conducted later.