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Hwang, Heejun,Kim, Jinwoo,Jeong, Jisu,Chang, Sukbok American Chemical Society 2014 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.136 No.30
<P>Reported herein is the metal-catalyzed regioselective C–H functionalization of quinoline <I>N</I>-oxides at the 8-position: direct iodination and amidation were developed using rhodium and iridium catalytic systems, respectively. Mechanistic study of the amidation revealed that the unique regioselectivity is achieved through the smooth formation of <I>N</I>-oxide-chelated iridacycle and that an acid additive plays a key role in the rate-determining protodemetalation step. While this approach of remote C–H activation using <I>N</I>-oxide as a directing group could readily be applied to a wide range of heterocyclic substrates under mild conditions with high functional group tolerance, an efficient synthesis of zinquin ester (a fluorescent zinc indicator) was demonstrated.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2014/jacsat.2014.136.issue-30/ja5053768/production/images/medium/ja-2014-053768_0016.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja5053768'>ACS Electronic Supporting Info</A></P>
정부 연구개발 정책 및 투자방향 분석에 따른 과학기술정보인프라 발전방안 연구
한희준(Heejun Han),김은진(Eunjin Kim),황명권(Myunggwon Hwang),이용호(Yongho Lee),최희석(Heeseok Choi) 한국경영학회 2018 한국경영학회 통합학술발표논문집 Vol.2018 No.8
4차 산업혁명이 강조되면서 빅데이터와 인공지능, ICT 기술 육성 등을 위한 산업시장 발전정책 및 정부의 연구개발 투자방향은 산업계, 학계, 연구계의 발전 방향에 대한 시사점을 제시한다. 본 연구에서는 정부의 연구개발 추진계획 및 투자방향 내용과 지능정보사회 중장기 종합대책, 정부 국정과제 세부내용을 분석하여 과학기술정보인프라 제공 차원에서의 중점 발전 방안을 도출하였다. 과학기술정보인프라 영역을 관련 인프라 및 하드웨어, 기술, 데이터, 저변 확대, 재난 대응, 기업 지원으로 구분하여 각 영역의 시사점 및 발전방안을 제시하였다.
과학기술정보인프라 분야 창의 아이디어 및 과제를 위한 주제 도출 프레임워크 연구
한희준(Heejun Han),김은진(Eunjin Kim),황명권(Myunggwon Hwang),이수철(Suchul Lee),이용호(Yongho Lee) 한국경영학회 2016 한국경영학회 통합학술발표논문집 Vol.2016 No.8
각 정부출연연구소 및 연구기관은 기관의 연구 영역에서의 역할 강화와 국가, 사회적 요구에 기여할 수 있는 신규 사업 영역의 도출을 위해 창의 아이디어를 사업화하는 노력을 지속적으로 수행하기 위하여 창의 연구과제를 운영하고 있다. 이는 연구기관의 차세대 사업을 발굴하여 지속적 발전 방향을 수립하는데 활용될 뿐만 아니라, 연구원에게 자율성 및 책임감을 고취시키는 효과를 꾀한다. 또한 신규 아이디어의 검증을 통한 양손잡이형 조직 문화를 조성하여 차세대 사업과 연계, 발전시키는 역할을 한다. 본 논문에서는 과학기술정보인프라 분야의 창의 연구과제의 주제군 도출을 위한 프레임워크를 논하며, 이는 기관의 연구영역과 부합하는 창의 아이디어를 효과적으로 도출하기 위한 도구로 활용 가능하다.
Gwon, Donghyeon,Hwang, Heejun,Kim, Hye Kyung,Marder, Seth R.,Chang, Sukbok WILEY‐VCH Verlag 2015 Chemistry Vol.21 No.48
<P><B>Abstract</B></P><P>Described herein is the development of practical routes to 8‐aminoquinolines by using readily installable and easily deprotectable amidating reagents. Two scalable procedures were optimized under Rh<SUP>III</SUP>‐catalyzed conditions: i) the use of pre‐generated chlorocarbamates and ii) a two‐step one‐pot process that directly employs carbamates. Both approaches are highly convenient for the gram‐scale synthesis of 8‐aminoquinolines under mild conditions. Facile deprotection of the synthetically versatile amidating groups was achieved under the Pd‐catalyzed transfer hydrogenation conditions with simultaneous deoxygenation of quinoline <I>N</I>‐oxides, thus yielding 8‐aminoquinolines in excellent overall efficiency.</P>
MATLAB/Simulink를 이용한 자동차용 고분자전해질형 연료전지 시스템의 단순화된 성능 모델링 연구
황태경(Taekyung Hwang),김경일(Kyungil Kim),신동유(Dongyou Shin),윤희준(Heejun Yoon),김한상(Han-Sang Kim) 한국자동차공학회 2011 한국자동차공학회 학술대회 및 전시회 Vol.2011 No.11
This study is primarily concerned with the simplified performance modeling of automotive PEMFC(proton-exchange membrane fuel cell) systems. To this end, the PEMFC stack and BOP components(e.g. turbo blower, humidifier, and cooling circuit etc.) are modeled by using MATLAB/Simulink environment. As a result, the efficiency and performance of the automotive PEMFC system are mainly analyzed with various operating conditions. It is expected that the results of this study will contribute to the development of robust simulation tools for automotive PEMFC system.
Kim Jeong-Soo,Park Heejun,강규태,Ha Eun-Sol,김민수,Hwang Sung-Joo 한국약제학회 2022 Journal of Pharmaceutical Investigation Vol.52 No.3
Purpose In the present study, fenofibrate (a model drug with poor aqueous solubility) was micronized using the supercriticalfluid- assisted spray-drying (SA-SD) process to improve dissolution and biopharmaceutical property. Methods Solid-state characterizations including particle size analysis and dissolution test were carried out. To identify the main effects of SA-SD process parameters (such as pressure, temperature, concentration of drug solution, supercritical carbon dioxide (SC-CO2) injection rate, and drug solution injection rate) on the morphology and particle size distribution of micronized fenofibrate particles, a 27−3 IV fractional factorial screening design was employed. Moreover, the effect of improved dissolution rate via micronization using SA-SD technology on the biopharmaceutical properties of fenofibrate was evaluated in a pharmacokinetic (PK) study in Sprague–Dawley rats. Results The results of the screening design showed that the mean particle size and distribution can be controlled by manipulating the drug solution concentration and CO2 injection rate. The SA-SD process resulted in a significant decrease in mean particle size (1.8–8.33 μm), as compared with that of unprocessed fenofibrate (24.2 ± 0.8 μm). There was a significant enhancement in the dissolution rate of micronized fenofibrate particles smaller than 5 μm compared to that of unprocessed fenofibrate. Moreover, an in vivo PK study in Sprague–Dawley rats showed that the increased dissolution rate improved biopharmaceutical properties (larger area under the curve and maximum serum concentration) of micronized fenofibrate than those of unprocessed fenofibrate. Conclusion Therefore, the SA-SD process is a useful micronization technology for improving both physicochemical and biopharmaceutical properties of poorly water-soluble drugs.