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Roles of Immunohistochemical Staining in Diagnosing Pulmonary Squamous Cell Carcinoma
Yan, Yue,Zhang, Ya-Xiong,Fang, Wen-Feng,Kang, Shi-Yang,Zhan, Jian-Hua,Chen, Nan,Hong, Shao-Dong,Liang, Wen-Hua,Tang, Yan-Na,He, Da-Cheng,Wu, Xuan,Zhang, Li Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2
Background: Differentiating morphologic features based on hematoxylin-eosin (HE) staining is the most common method to classify pathological subtypes of non-small-cell lung cancer (NSCLC). However, its accuracy and inter-observer reproducibility in pathological diagnosis of poorly differentiated NSCLC remained to be improved. Materials and Methods: We attempted to explore the role of immunohistochemistry (IHC) staining in diagnosing pulmonary squamous cell carcinoma (SQCC) with poorly differentiated features by HE staining or with elevated serum adenocarcinoma-specific tumor markers (AD-TMs). We also compared the difference of epidermal growth factor receptor (EGFR) mutation rate between patients with confirmed SQCC and those with revised pathological subtype. Logistic regression analyses were used to test the association between different factors and diagnostic accuracy. Results: A total of 132 patients who met the eligible criteria and had adequate specimens for IHC confirmation were included. Pathological revised cases in poor differentiated subgroup, biopsy samples and high-level AD-TMs cases were more than those with high/moderate differentiation, surgical specimens and normal-level AD-TMs. Moreover, biopsy sample was a significant factor decreasing diagnostic accuracy of pathological subtype (OR, 4.037; 95% CI 1.446-11.267, p=0.008). Additionally, EGFR mutation rate was higher in patients with pathological diagnostic changes than those with confirmed SQCC (16.7% vs 4.4%, p=0.157). Conclusions: Diagnosis based on HE staining only might cause pathological misinterpretation in NSCLC patients with poor differentiation or high-level AD-TMs, especially those with biopsy samples. HE staining and IHC should be combined as pathological diagnostic standard. The occurrence of EGFR mutations in pulmonary SQCC might be overestimated.
He, Xin-Feng,Xu, Yong-Chun,He, Zhen The Youngnam Mathematical Society 2011 East Asian mathematical journal Vol.27 No.1
In this paper, we consider an iterative scheme for finding a common element of the set of fixed points of a asymptotically quasi nonexpansive mapping and the set of solutions of the variational inequality for an inverse strongly monotone mapping in a Hilbert space. Then we show that the sequence converges strongly to a common element of two sets. Using this result, we consider the problem of finding a common fixed point of a asymptotically quasi-nonexpansive mapping and strictly pseudocontractive mapping and the problem of finding a common element of the set of fixed points of a asymptotically quasi-nonexpansive mapping and the set of zeros of an inverse-strongly monotone mapping.
ON THE EXISTENCE OF SOLUTIONS OF EXTENDED GENERALIZED VARIATIONAL INEQUALITIES IN BANACH SPACES
He, Xin-Feng,Wang, Xian,He, Zhen The Youngnam Mathematical Society 2009 East Asian mathematical journal Vol.25 No.4
In this paper, we study the following extended generalized variational inequality problem, introduced by Noor (for short, EGVI) : Given a closed convex subset K in q-uniformly smooth Banach space B, three nonlinear mappings T : $K\;{\rightarrow}\;B^*$, g : $K\;{\rightarrow}\;K$, h : $K\;{\rightarrow}\;K$ and a vector ${\xi}\;{\in}\;B^*$, find $x\;{\in}\;K$, $h(x)\;{\in}\;K$ such that <Tx-$\xi$, g(y)-h(x)> $\geq$ 0, for all $y\;{\in}\;K$, $g(y)\;{\in}\;K$. [see [2]: M. Aslam Noor, Extended general variational inequalities, Appl. Math. Lett. 22 (2009) 182-186.] By using sunny nonexpansive retraction $Q_K$ and the well-known Banach's fixed point principle, we prove existence results for solutions of (EGVI). Our results extend some recent results from the literature.
He, Xin-Feng,Xu, Yong-Chun,He, Zhen The Youngnam Mathematical Society Korea 2008 East Asian mathematical journal Vol.24 No.1
The approximate solvability of a generalized system for non-linear variational inequality in Hilbert spaces was studied, based on the convergence of projection methods. But little research was done in Banach space. The primary reason was that projection mapping lacked preferably property in Banach space. In this paper, we introduced the generalized projection methods. By using these methods, the results presented in this paper extended the main results of S. S. Chang [3] from Hilbert spaces to Banach space.
Review of the Molecular Pathogenesis of Osteosarcoma
He, Jin-Peng,Hao, Yun,Wang, Xiao-Lin,Yang, Xiao-Jin,Shao, Jing-Fan,Guo, Feng-Jin,Feng, Jie-Xiong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15
Treating the osteosarcoma (OSA) remains a challenge. Current strategies focus on the primary tumor and have limited efficacy for metastatic OSA. A better understanding of the OSA pathogenesis may provide a rational basis for innovative treatment strategies especially for metastases. The aim of this review is to give an overview of the molecular mechanisms of OSA tumorigenesis, OSA cell proliferation, apoptosis, migration, and chemotherapy resistance, and how improved understanding might contribute to designing a better treatment target for OSA.
Statistical-Mechanical Entropy by the Thin-Layer Method
He Feng,김성원 한국물리학회 2003 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.42 No.III
G. 't Hooft first studied the statistical-mechanical entropy of a scalar field in a Schwarzschild black hole background by the brick-wall method and hinted that the statistical-mechanical entropy is the statistical origin of the Bekenstein-Hawking entropy of the black hole. However, according to our viewpoint, the statistical-mechanical entropy is only a quantum correction to the Bekenstein-Hawking entropy of the black hole. The brick-wall method based on thermal equilibrium at a large scale cannot be applied to the cases out of equilibrium such as a nonstationary black hole. The statistical-mechanical entropy of a scalar field in a nonstationary black hole background is calculated by the thin-layer method. The condition of local equilibrium near the horizon of the black hole is used as a working postulate and is maintained for a black hole which evaporates slowly enough and whose mass is far greater than the Planck mass. The statistical-mechanical entropy is also proportional to the area of the black hole horizon. The difference from the stationary black hole is that the result relies on a time-dependent cutoff.
He Guo-Feng,Zhou Zi-Chun,Luo Shuang,Li Gou-Jiao 대한전기학회 2024 Journal of Electrical Engineering & Technology Vol.19 No.3
Aiming at the problem that the DC component in the output voltage of the T-type three-level inverter in the island mode is obvious, due to its hardware diferences, a nonlinear control strategy combining the backstepping method, sliding mode theory, and the principle of the second-order generalized integrator (SOGI) is proposed. Firstly, the DC component in the output voltage of the inverter is regarded as a disturbance, and the mathematical model of the inverter with DC component disturbance is established. Secondly, the detected neutral point potential deviation of the DC side of the inverter is compensated to the modulation signal by proportional–integral (PI) control, to maintain the normal operating state of the three-level inverter. Then, the backstepping-sliding mode controller is constructed to improve the robustness T-type three-level inverter. And the SOGI is utilized to overcome the shortcomings of backstepping control which is easy to amplify the measurement noise and cause diferential explosion. Meanwhile, the stability of the designed controller is analyzed by using the Lyapunov stability principle. Finally, the efectiveness of the proposed control strategy is verifed by 10 kW prototype. The experimental results show that the proposed control strategy can not only efectively suppress the DC component of the inverter output voltage and improve the robustness of the system, but also has fast dynamic characteristics.
He, Feng,Wen, Hai-Shen,Li, Ji-Fang,Yu, Da-Hui,Ma, Rui-Qin,Shi, Dan,Mu, Wei-Jie,Zhang, Yuan-Qing,Hu, Jian,Liu, Miao,Han, Wei-Guo,Zhang, Jia-Nan,Wang, Qing-Qing,Yuan, Yu-Ren,Liu, Qun Asian Australasian Association of Animal Productio 2011 Animal Bioscience Vol.24 No.4
Gonadotropin-releasing hormone receptor (GnRHR) gene is expressed at the anterior pituitary gland and plays a key role in gonad development. This study aimed to investigate molecular genetic characteristics of the GnRHR gene and elucidate the effects of single nucleotide polymorphisms (SNPs) of GnRHR gene on sex steroid level in Japanese flounder (Paralichthys olivaceus). We used polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) and sequencing of the GnRHR gene in 75 individuals. We identified three SNPs in the GnRHR gene: P1 locus (C759A and C830T) in the coding region of exon2 which were both linked together and P2 locus (G984T) in the coding region of exon3, which added a new transcript factor (ADR1) and a new methylation site (CG). Only C830T of P1 leads to amino acid changes Thr266Ile. Statistical analysis showed that P1 was significantly associated with $17{\beta}$-estradiol ($E_2$) level (p<0.01) and gonadosomatic index (GSI) (p<0.05). Individuals with genotype BB of P1 had significantly higher serum $E_2$ levels (p<0.01) and GSI (p<0.05) than those of genotype AA or AB. Another SNP, P2, synonymous mutation, was significantly associated with GSI (p<0.05). Individuals with genotype AB of P2 had significantly higher GSI (p<0.05) than that of genotype AA. In addition, there was a significant association between one diplotype based on three SNPs and reproductive traits. The genetic effects for both serum $E_2$ level and GSI of diplotype D4 were super diplotypes (p<0.05). These results suggest that the SNPs in Japanese Flounder GnRHR are associated with $E_2$ level and GSI.
PROXIMAL POINTS METHODS FOR GENERALIZED IMPLICIT VARIATIONAL-LIKE INCLUSIONS IN BANACH SPACES
He, Xin-Feng,Lou, Jian,He, Zhen The Youngnam Mathematical Society 2012 East Asian mathematical journal Vol.28 No.1
In this paper, we study generalized implicit variational-like inclusions and $J^{\eta}$-proximal operator equations in Banach spaces. It is established that generalized implicit variational-like inclusions in real Banach spaces are equivalent to fixed point problems. We also establish relationship between generalized implicit variational-like inclusions and $J^{\eta}$-proximal operator equations. This equivalence is used to suggest a iterative algorithm for solving $J^{\eta}$-proximal operator equations.