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Elution of amikacin and vancomycin from a calcium sulfate/chitosan bone scaffold
Doty, Heather A.,Courtney, Harry S.,Jennings, Jessica A.,Haggard, Warren O.,Bumgardner, Joel D. Techno-Press 2015 Biomaterials and Biomechanics in Bioengineering Vol.2 No.3
Treatment of polymicrobial infected musculoskeletal defects continues to be a challenge in orthopaedics. This research investigated single and dual-delivery of two antibiotics, vancomycin and amikacin, targeting different classes of microorganism from a biodegradable calcium sulfate-chitosan-nHA microsphere composite scaffold. The addition of chitosan-nHA was included to provide additional structure for cellular attachment and as a secondary drug-loading device. All scaffolds exhibited an initial burst of antibiotics, but groups containing chitosan reduced the burst for amikacin at 1hr by 50%, and vancomycin by 14-25% over the first 2 days. Extended elution was present in groups containing chitosan; amikacin was above MIC ($2-4{\mu}g/mL$, Pseudomonas aeruginosa) for 7-42 days and vancomycin was above MIC ($0.5-1{\mu}g/mL$ Staphylococcus aureus) for 42 days. The antibiotic activity of the eluates was tested against S. aureus and P. aeruginosa. The elution from the dual-loaded scaffold was most effective against S. aureus (bacteriostatic 34 days and bactericidal 27 days), compared to vancomycin-loaded scaffolds (bacteriostatic and bactericidal 14 days). The dual- and amikacin-loaded scaffolds were effective against P. aeruginosa, but eluates exhibited very short antibacterial properties; only 24 hours bacteriostatic and 1-5 hours bactericidal activity. For all groups, vancomycin recovery was near 100% whereas the amikacin recovery was 41%. In conclusion, in the presence of chitosan-nHA microspheres, the dual-antibiotic loaded scaffold was able to sustain an extended vancomycin elution longer than individually loaded scaffolds. The composite scaffold shows promise as a dual-drug delivery system for infected orthopaedic wounds and overcomes some deficits of other dual-delivery systems by extending the antibiotic release.
Elution of amikacin and vancomycin from a calcium sulfate/chitosan bone scaffold
Doty, Heather A.,Courtney, Harry S.,Jennings, Jessica A.,Haggard, Warren O.,Bumgardner, Joel D. Techno-Press 2015 Biomaterials and biomedical engineering Vol.2 No.3
Treatment of polymicrobial infected musculoskeletal defects continues to be a challenge in orthopaedics. This research investigated single and dual-delivery of two antibiotics, vancomycin and amikacin, targeting different classes of microorganism from a biodegradable calcium sulfate-chitosan-nHA microsphere composite scaffold. The addition of chitosan-nHA was included to provide additional structure for cellular attachment and as a secondary drug-loading device. All scaffolds exhibited an initial burst of antibiotics, but groups containing chitosan reduced the burst for amikacin at 1hr by 50%, and vancomycin by 14-25% over the first 2 days. Extended elution was present in groups containing chitosan; amikacin was above MIC ($2-4{\mu}g/mL$, Pseudomonas aeruginosa) for 7-42 days and vancomycin was above MIC ($0.5-1{\mu}g/mL$ Staphylococcus aureus) for 42 days. The antibiotic activity of the eluates was tested against S. aureus and P. aeruginosa. The elution from the dual-loaded scaffold was most effective against S. aureus (bacteriostatic 34 days and bactericidal 27 days), compared to vancomycin-loaded scaffolds (bacteriostatic and bactericidal 14 days). The dual- and amikacin-loaded scaffolds were effective against P. aeruginosa, but eluates exhibited very short antibacterial properties; only 24 hours bacteriostatic and 1-5 hours bactericidal activity. For all groups, vancomycin recovery was near 100% whereas the amikacin recovery was 41%. In conclusion, in the presence of chitosan-nHA microspheres, the dual-antibiotic loaded scaffold was able to sustain an extended vancomycin elution longer than individually loaded scaffolds. The composite scaffold shows promise as a dual-drug delivery system for infected orthopaedic wounds and overcomes some deficits of other dual-delivery systems by extending the antibiotic release.
MOA-2010-BLG-328Lb: A SUB-NEPTUNE ORBITING VERY LATE M DWARF?
Furusawa, K.,Udalski, A.,Sumi, T.,Bennett, D. P.,Bond, I. A.,Gould, A.,Jørgensen, U. G.,Snodgrass, C.,Prester, D. Dominis,Albrow, M. D.,Abe, F.,Botzler, C. S.,Chote, P.,Freeman, M.,Fukui, A.,Harris, P IOP Publishing 2013 The Astrophysical journal Vol.779 No.2
<P>We analyze the planetary microlensing event MOA-2010-BLG-328. The best fit yields host and planetary masses of M-h = 0.11 +/- 0.01 M-circle dot and M-p = 9.2 +/- 2.2 M-circle dot, corresponding to a very late M dwarf and sub-Neptune-mass planet, respectively. The system lies at D-L = 0.81 +/- 0.10 kpc with projected separation r(perpendicular to) = 0.92 +/- 0.16 AU. Because of the host's a priori unlikely close distance, as well as the unusual nature of the system, we consider the possibility that the microlens parallax signal, which determines the host mass and distance, is actually due to xallarap (source orbital motion) that is being misinterpreted as parallax. We show a result that favors the parallax solution, even given its close host distance. We show that future high-resolution astrometric measurements could decisively resolve the remaining ambiguity of these solutions.</P>
Seo, S.U.,Kamada, N.,Munoz-Planillo, R.,Kim, Y.G.,Kim, D.,Koizumi, Y.,Hasegawa, M.,Himpsl, Stephanie D.,Browne, Hilary P.,Lawley, Trevor D.,Mobley, Harry L.T.,Inohara, N.,Nunez, G. Cell Press 2015 Immunity Vol.42 No.4
The microbiota stimulates inflammation, but the signaling pathways and the members of the microbiota involved remain poorly understood. We found that the microbiota induces interleukin-1β (IL-1β) release upon intestinal injury and that this is mediated via the NLRP3 inflammasome. Enterobacteriaceae and in particular the pathobiont Proteus mirabilis, induced robust IL-1β release that was comparable to that induced by the pathogen Salmonella. Upon epithelial injury, production of IL-1β in the intestine was largely mediated by intestinal Ly6C<SUP>high</SUP> monocytes, required chemokine receptor CCR2 and was abolished by deletion of IL-1β in CCR2<SUP>+</SUP> blood monocytes. Furthermore, colonization with P. mirabilis promoted intestinal inflammation upon intestinal injury via the production of hemolysin, which required NLRP3 and IL-1 receptor signaling in vivo. Thus, upon intestinal injury, selective members of the microbiota stimulate newly recruited monocytes to induce NLRP3-dependent IL-1β release, which promotes inflammation in the intestine.
스크류 프레스의 대두유 착유 (搾油) 성능과 착유유의 연료 성질
서상룡,에프 디 해리스 ( S . R . Suh,F . D . Harris ) 한국농업기계학회 1985 바이오시스템공학 Vol.10 No.2
N/A Performance of a screw press was investigated experimentally with soybeans of various temperatures in order to find out a proper temperature of soybean to extract the oil by the mechanical method. Crude oil extracted by the screw press was chemical analyzed to determine a level of processing the oil for the oil to be used as a fuel for a compression ignition, eagine. The crude on was degummed and dried by a plant type laboratory experimental setup to decicide whether the processes are effective to improve quality of the oil as a fuel. The degummed oil and the degummed and dried oil were also chemically analyzed and were compared with the crude oil and the commercially degummed and dried soybean oil, The results are as follows: 1. In extraction of soybean oil by a screw press, heating soybeans is effective to increase oil production and to decrease energy consumption of the press. A proper temperature of soybean to extract the oil by the press was determined as about 50℃. 2. Soybean oil production and electric energy consumption of the press are about 83 ml and 58 Wh per 1 ㎏ of soybeans heated to about 50℃, respectively. 3. The quality of crude oil produced by the press is similar to that of the commercially degummed and dried oil. The crude oil does not need to be degummed or dried for use as an engine fuel.
USING ORBITAL EFFECTS TO BREAK THE CLOSE/WIDE DEGENERACY IN BINARY-LENS MICROLENSING EVENTS
Shin, I.-G.,Sumi, T.,Udalski, A.,Choi, J. Y.,Han, C.,Gould, A.,Abe, F.,Bennett, D. P.,Bond, I. A.,Botzler, C. S.,Chote, P.,Freeman, M.,Fukui, A.,Furusawa, K.,Harris, P.,Itow, Y.,Ling, C. H.,Masuda, K. IOP Publishing 2013 The Astrophysical journal Vol.764 No.1
<P>Microlensing can provide an important tool to study binaries, especially those composed of faint or dark objects. However, accurate analysis of binary-lens light curves is often hampered by the well-known degeneracy between close (s < 1) and wide (s > 1) binaries, which can be very severe due to an intrinsic symmetry in the lens equation. Here, s is the normalized projected binary separation. In this paper, we propose a method that can resolve the close/wide degeneracy using the effect of a lens orbital motion on lensing light curves. The method is based on the fact that the orbital effect tends to be important for close binaries while it is negligible for wide binaries. We demonstrate the usefulness of the method by applying it to an actually observed binary-lens event MOA-2011-BLG-040/OGLE-2011-BLG-0001, which suffers from severe close/wide degeneracy. From this, we are able to uniquely specify that the lens is composed of K- and M-type dwarfs located similar to 3.5 kpc from the Earth.</P>